| Basic information |
| Official Symbol | TTC23 |
| Description | tetratricopeptide repeat domain 23 |
| Other Aliases | HCC8, HCC-8 |
| Other Description | TPR repeat protein 23; cervical cancer proto-oncogene 8 protein; proto-oncogene 8; tetratricopeptide repeat protein 23 |
| Mutation type | premature termination 276:A->TGA, premature termination 284:R->TGA, Delete and frame-shift 366:D->C |
| Location | Scaffold000621_1:44270 77216 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| TTC23 |
ATGCAGGAATCCCAGGAAGCACACGTGTCTGGCCACCTAGAGGAGACAGT GGCTGCGGTCAGCGTCACTCCCAGGAGGAAGCCCCAGAGCAGGCTGCCCC AGACAGCACTGTTCCAGCCGCCGCGAGAGAAGCTGCACCTCTGCGAGAAG GCCACACTCTGCCAGCAGCCACGAGAACAGTATAAACAGGCTGTCCATGA GCTCACGCAGTGGGTGGCACTGACGAGAATTTGCTATGGGGACTCGCACT GGAAGCTCACAGAGGTGCACATCAACCAGGCTCAAGGGTACCTCCAGCTG AAAGGGCTGTCTCTGCAAGCAAAACAACATGCAGAAAAGGCCAGAGACAT CCTCGTCCACGCCATTGTGCCTCCCTACAATGACGACACGGACGTTTTCA GGTGTTCTGTGGAGCTTTTCCATACCCTGGGGAGAGCCTCACTCTCCCTT CAGCAATTTAAGGAAGCATCTGGGAACTTGGTAAAAGTGAAGAGTCTTTC CAAGGAGCTGCTCCAGTGTGGGAGGATCATCCAGGAAGAATGGCCGGAAG TCCAGGTGCGGACCCAGCTGTCGTTTGCACAAGTGTATCAAGGCCAGAAG AAATCAAAAGAAGCTTTGCCCCACTATCAAGAGGCTTTGGAATGTGTCCA GACCAGCAAACGGGACAAGAGTCGGGAGTGCGTGCCGGTTTTAAGGGAAC TAGCAGGTGTGGAGCAAGCCCTGGGGTCCCACGACACAGCCATCGGCCAT CTCTTACAGTCCAAATACATATTATTTTCCAATAGTTCGCGACTGCTGAA AGCTTGCTCCGTTTCCATTTCAAATCTGTGAGCAGTTTTCACATTGTCAT TATGATGCTCTTCTGCAGATGTGGCCGAGCAGTATTTCCAGGAGAGCGTG ACTCCCCTGCAGGACTGCGAGGGGGGGGGAAGAGCCCAATTTCTTTCAAT TCAGGATGAATTTTGCCATTTTCTGCAAATCCCAGGACAAAAAGAGATAG CAACCACAGTCCTGAGGGAGTCCTTGGAAGCCAAAGTGGGTGCATTTGGC GACTTTAGTCCCGAGGTGGCAGAGGCATACCGACTCCTGGGTGGGACTCT GGCACAGGGGAACCACAGCGGGGCCCACAGAAAACTGAAGAAG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 447 | 1 | 381 | Premature termination 276:A->TGA, Premature termination 284:R->TGA, Delete and frame-shift 366:D->C |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetGlnGluSerGlnGluThrHisIleSerAsnHisLeuAspGluValValAlaAlaVal
|||||||||||||||||| ||| ||| |||||| ||| ||||||||||||
MetGlnGluSerGlnGluAlaHisValSerGlyHisLeuGluGluThrValAlaAlaVal
ATGCAGGAATCCCAGGAAGCACACGTGTCTGGCCACCTAGAGGAGACAGTGGCTGCGGTC
SerIleThrHisArgLysLysPheGlnAsnLysLeuLeuGlnThrAlaLeuPheGlnPro
||| ||| ||| ||| ||| ||| |||||||||||||||||||||
SerValThrProArgArgLysProGlnSerArgLeuProGlnThrAlaLeuPheGlnPro
AGCGTCACTCCCAGGAGGAAGCCCCAGAGCAGGCTGCCCCAGACAGCACTGTTCCAGCCG
ProArgGluLysLeuHisLeuCysGluGluLysAlaLysSerTyrSerAsnSer{H} >
||||||||||||||||||||||||||| { }
ProArgGluLysLeuHisLeuCysGluLysAlaThrLeuCysGlnGlnProArg{G}++
CCGCGAGAGAAGCTGCACCTCTGCGAGAAGGCCACACTCTGCCAGCAGCCACGA{G}gt
>>> Target Intron 1 >>>> {is}GluTyrLysGlnAlaValHisGluLeuVal
844 bp { } ||||||||||||||||||||||||
--{lu}GlnTyrLysGlnAlaValHisGluLeuThr
ct{AA}CAGTATAAACAGGCTGTCCATGAGCTCACG
ArgCysValAlaLeuThrArgIleCysTyrGlyAspSerHisTrpLysLeuAlaGluAla
||||||||||||||||||||||||||||||||||||||||||||| |||
GlnTrpValAlaLeuThrArgIleCysTyrGlyAspSerHisTrpLysLeuThrGluVal
CAGTGGGTGGCACTGACGAGAATTTGCTATGGGGACTCGCACTGGAAGCTCACAGAGGTG
HisValAsnLeuAlaGlnGlyTyrLeuGlnLeuLys{G} >>>> Target Intron
||| ||| ||||||||||||||||||||||||{|} 3680 bp
HisIleAsnGlnAlaGlnGlyTyrLeuGlnLeuLys{G}++
CACATCAACCAGGCTCAAGGGTACCTCCAGCTGAAA{G}gt
2 >>>> {ly}LeuSerLeuGlnAlaLysGlnHisAlaGluLysAlaArgGlnIleLeu
{||}||||||||||||||||||||||||||||||||||||||| ||||||
++{ly}LeuSerLeuGlnAlaLysGlnHisAlaGluLysAlaArgAspIleLeu
ag{GG}CTGTCTCTGCAAGCAAAACAACATGCAGAAAAGGCCAGAGACATCCTC
AlaAsnSerIleValProProTyrSerGluAsnThrAspValPheLysPheSerIleGlu
||||||||||||||| |||||||||||| ||| |||
ValHisAlaIleValProProTyrAsnAspAspThrAspValPheArgCysSerValGlu
GTCCACGCCATTGTGCCTCCCTACAATGACGACACGGACGTTTTCAGGTGTTCTGTGGAG
LeuPheHisThrMetGlyArgAlaLeuLeuSerLeuGln{Ly} >>>> Target Int
|||||||||||| ||||||||| ||||||||||||{ } 1461 b
LeuPheHisThrLeuGlyArgAlaSerLeuSerLeuGln{Gl}++
CTTTTCCATACCCTGGGGAGAGCCTCACTCTCCCTTCAG{CA}gt
ron 3 >>>> {s}PheLysGluAlaAlaGluAsnLeuThrLysAlaGluArgLeuSer
p { }|||||||||||| |||||| ||| ||||||
++{n}PheLysGluAlaSerGlyAsnLeuValLysValLysSerLeuSer
ag{A}TTTAAGGAAGCATCTGGGAACTTGGTAAAAGTGAAGAGTCTTTCC
LysGluLeuLeuGlnCysGlyArgIleIleLysGluGluTrpIleGluIleGluAlaArg
|||||||||||||||||||||||||||||| ||||||||| ||| |||
LysGluLeuLeuGlnCysGlyArgIleIleGlnGluGluTrpProGluValGlnValArg
AAGGAGCTGCTCCAGTGTGGGAGGATCATCCAGGAAGAATGGCCGGAAGTCCAGGTGCGG
IleArgLeuSerPheAla{Gl} >>>> Target Intron 4 >>>> {n}ValTyr
||||||||||||{||} 8251 bp {|}||||||
ThrGlnLeuSerPheAla{Gl}++ ++{n}ValTyr
ACCCAGCTGTCGTTTGCA{CA}gt ag{A}GTGTAT
GlnGlyGlnLysLysSerLysGluAlaLeuSerHisTyrGlnAlaAlaLeuGluTyrVal
|||||||||||||||||||||||||||||| ||||||||| ||||||||| |||
GlnGlyGlnLysLysSerLysGluAlaLeuProHisTyrGlnGluAlaLeuGluCysVal
CAAGGCCAGAAGAAATCAAAAGAAGCTTTGCCCCACTATCAAGAGGCTTTGGAATGTGTC
GluIleSerLysGlyGluThrSerArgGluCysValProIleLeuArgGluLeuAlaGly
|||||| |||||||||||||||||| ||||||||||||||||||
GlnThrSerLysArgAspLysSerArgGluCysValProValLeuArgGluLeuAlaGly
CAGACCAGCAAACGGGACAAGAGTCGGGAGTGCGTGCCGGTTTTAAGGGAACTAGCAGGT
ValGluGlnAlaLeuGlyLeuHisAspValSerIleAsnHisPheLeuGln >>>> Ta
|||||||||||||||||| |||||| ||| ||| ||||||
ValGluGlnAlaLeuGlySerHisAspThrAlaIleGlyHisLeuLeuGln++
GTGGAGCAAGCCCTGGGGTCCCACGACACAGCCATCGGCCATCTCTTACAGgt
rget Intron 5 >>>> AlaHisLeuIleIleLeuSerArgSerProSerGlnValG
15785 bp ||| ||| |||
-+SerLysTyrIleLeuPheSerAsnSerSerArgLeuLeuL
tgTCCAAATACATATTATTTTCCAATAGTTCGCGACTGCTGA
luAlaAlaAsp<->SerAlaHisIleValAlaHisAlaAlaValAlaSerGlyArgHisG
||| ||| |||
ysAlaCysSerValSerIleSerAsnLeu***AlaValPheThrLeuSerLeu***CysS
AAGCTTGCTCCGTTTCCATTTCAAATCTGTGAGCAGTTTTCACATTGTCATTATGATGCT
luHisHisAspValAlaGluGlnTyrPheGlnGluSerMetAlaHisLeuLysAspSerG
|||||||||||||||||||||||||||||| ||| ||| |
erSerAlaAspValAlaGluGlnTyrPheGlnGluSerValThrProLeuGlnAspCysG
CTTCTGCAGATGTGGCCGAGCAGTATTTCCAGGAGAGCGTGACTCCCCTGCAGGACTGCG
luGlyMetGlyArgThrLysPheLeuSerIleGlnAspGluPheCysHisPheLeuGlnM
||||| |||||| |||||||||||||||||||||||||||||||||||||||
luGlyGlyGlyArgAlaGlnPheLeuSerIleGlnAspGluPheCysHisPheLeuGlnI
AGGGGGGGGGAAGAGCCCAATTTCTTTCAATTCAGGATGAATTTTGCCATTTTCTGCAAA
etThrGlyGlnLysGlu >>>> Target Intron 6 >>>> ArgAlaThrSerIl
|||||||||||| 1782 bp ||||||
leProGlyGlnLysGlu++ ++IleAlaThrThrVa
TCCCAGGACAAAAAGAGgt agATAGCAACCACAGT
eLeuArgGluSerLeuGluAlaLysValGluAlaPheGlyAspPheSerProGluValAl
||||||||||||||||||||||||||| |||||||||||||||||||||||||||||
lLeuArgGluSerLeuGluAlaLysValGlyAlaPheGlyAspPheSerProGluValAl
CCTGAGGGAGTCCTTGGAAGCCAAAGTGGGTGCATTTGGCGACTTTAGTCCCGAGGTGGC
aGluThrTyrArgLeuLeuGlyGlyAla-AspLeuAlaGlnGlyAsnHisSerGlyAlaA
|||| |||||||||||||||||| # |||||||||||||||||||||||||||
aGluAlaTyrArgLeuLeuGlyGlyThr#---LeuAlaGlnGlyAsnHisSerGlyAlaH
AGAGGCATACCGACTCCTGGGTGGGACTC---CTGGCACAGGGGAACCACAGCGGGGCCC
rgLysLysLeuLysLys
||||||||||||
isArgLysLeuLysLys
ACAGAAAACTGAAGAAG
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