| Basic information |
| Official Symbol | TRMT2B |
| Description | tRNA methyltransferase 2 homolog B (S. cerevisiae) |
| Other Aliases | RP3-341D10.3, CXorf34, dJ341D10.3 |
| Other Description | TRM2 homolog; TRM2 tRNA methyltransferase 2 homolog B; tRNA (uracil(54)-C(5))-methyltransferase homolog; tRNA (uracil-5-)-methyltransferase homolog |
| Mutation type | Insert and frame-shift 171-172:V-G^A, Insert and frame-shift 340-341:T-G^T, Insert and frame-shift 369-370:V-L^TC, Insert and frame-shift 447-448:V-F^T, premature termination 162:R->TGA, premature termination 192:K->TAA, premature termination 39:W->TAG, premature termination 400:Q->TGA, premature termination 80:W->TGA |
| Location | Scaffold143746_1:359995 341967 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| TRMT2B |
ATGGCTGGCCTTAAAAGAAGAGTCCCAATGCACAGCCTGAGGTGCTTCCT CTCCAGAGGGAGTCTCTTTTCCAAACTAGGACTGTTTCCCTGGTGTACTA GAAAGTCACCAAGTTAGTCACAACTCTTTTTGGGCACAGCAAGTAAGGGC AATTTCACCTATGTCATAGCAAAGAGGTGTCAAAGAGGACCAAAAAGTCA GAATAAGCCAAGTCATCTTGGACCACTGAATGGTTCCTGACAGAAAAGGC TGGCTGATGTCCTGATACCACTTGTCTACCAGCTTGTCTTTACCCCACCT CTCCAGGTAAAATTTGAAGCTCAGAAGAAAATTTTACAGAGGATAGAGTC TTACTTCCAAATGCTCAATGGACTCAATATGACAACTACTGCTCCCAAAT CCCAGGGTTTCTGTTGTCGTCTCCATCCTGTTGTACCCTCTCCTCTCATC AATGGCTACGGAAATAAGTCCACCTTCTCTATGAACTGAGGTCCAGATGG CAATCCAAAAACTGGATACTACCTGGGAACTTGGAAAGATGGGAACATCG TCTGTGTACAGTCTTACCATCTATAAAACATCCCTGAGAAACACAGTCAA GTGTCACAGTACTATGAGGCATTCCTTCAACAGTCTCTGATGGCGCCCTG CATTCAGTGTCATGAAGGTGGATACTGGCGGGAGTTTACAGTCCGCACCA ACAGCCAAGGGCACACAATGGCTATCGTCACTTTTCATCTCCAGGAATTA AGTCAGGAGGAGCTCTGTGTTCAGAAGGAGGCTGTAAAGGAATTTTTCAT CAAAGGCCCAGGAGCTGTCTGTGACTTGACCTCACTTTACTTCCAGGAAA GCATCATGACCCATTGCAGCTATCAGCAGTCCCCCTACCAGCTCCTTTTT GGGGAACCCCACATATTTGAAGATCTCTTGGGCTTGAAGATCCACTTCGC TCCAGATGCTTTTTTTCATTTTAACACTGCTGGTGCAGAGATGCTATATC AGACTGTGGGGAAGCTGAGTGGAGTGAATTCTAACAGCATCCTCTTTGAC ATTTTTACTTCTGCAGGTGTGATTGGCCTCTCTCTGGCTCAGCACACATC CAGGCTTGGAATTGAGTTGGTGGAGCAGGCAGTAGAGGATGCCAGGTGGA CTGCATGCAGCCTTCGCATCACCAACTGTGAATTTCACACTGACTGAGCA GAGACAGTTTCACCACAGCTGCTAAAGTCAAAGGAAGATGAGCAGTTAAT TGTTGCAGCGATGAACCCAGCCAGTGCAGGAGTGTATTGCCAGGTAGTTC AAGCCATTCGAAATTGCAGGGTCATCCACACACTCGTTTTTGTTTCCTGC AAGCCCCTTGGTGAAGCCTCAAGTTGTTTCTACAGGCTGTGCTGTCCTCC AAACTCTGCTAAGAAGCTCCTAGGCGAGCCTTTTTTGCTGAGACAAGTTG TACCTGTGGATTTGTTTCCCCACACCAGACACTGTGAGCTGCTGCTCCTC TTCACTCAA |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 504 | 1 | 504 | Insert and frame-shift 171-172:V-G^A, Insert and frame-shift 340-341:T-G^T, Insert and frame-shift 369-370:V-L^TC, Insert and frame-shift 447-448:V-F^T, Premature termination 162:R->TGA, Premature termination 192:K->TAA, Premature termination 39:W->TAG, Premature termination 400:Q->TGA, Premature termination 80:W->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetAlaGlyLeuLysArgArgValProLeuHisSerLeuArgTyrPheIleSerMetVal
||||||||||||||||||||||||||| |||||||||||| ||| |||
MetAlaGlyLeuLysArgArgValProMetHisSerLeuArgCysPheLeuSerArgGly
ATGGCTGGCCTTAAAAGAAGAGTCCCAATGCACAGCCTGAGGTGCTTCCTCTCCAGAGGG
GlyLeuPheSerLysProGlyLeuLeuProTrpTyrAlaArgAsnProProGlyTrpSer
|||||||||||| |||||| |||||| ||| ||| |||
SerLeuPheSerLysLeuGlyLeuPheProTrpCysThrArgLysSerProSer***Ser
AGTCTCTTTTCCAAACTAGGACTGTTTCCCTGGTGTACTAGAAAGTCACCAAGTTAGTCA
GlnLeuPheLeuGlyThrValCysLysGlyAspPheThrArgValIleAlaThrLysCys
|||||||||||||||||| |||||| |||||| ||||||||| |||
GlnLeuPheLeuGlyThrAlaSerLysGlyAsnPheThrTyrValIleAlaLysArgCys
CAACTCTTTTTGGGCACAGCAAGTAAGGGCAATTTCACCTATGTCATAGCAAAGAGGTGT
GlnLysGlyGlnLysSerGlnLysLysProSerHisLeuGlyProLeuAspGlySerTrp
||| ||| ||||||||| |||||||||||||||||||||||| ||||||
GlnArgGlyProLysSerGlnAsnLysProSerHisLeuGlyProLeuAsnGlySer***
CAAAGAGGACCAAAAAGTCAGAATAAGCCAAGTCATCTTGGACCACTGAATGGTTCCTGA
GlnGlu{Ar} >>>> Target Intron 1 >>>> {g}LeuAlaAspValValThr
||| {||} 1156 bp {|}||||||||||||
GlnLys{Ar}++ ++{g}LeuAlaAspValLeuIle
CAGAAA{AG}gt ag{G}CTGGCTGATGTCCTGATA
ProLeu<->TrpArgLeuSerTyrGluGluGlnLeuLys >>>> Target Intron
|||||| ||| ||| 1744 bp
ProLeuValTyrGlnLeuValPheThrProProLeuGln--
CCACTTGTCTACCAGCTTGTCTTTACCCCACCTCTCCAGca
2 >>>> ValLysPheAlaAlaGlnLysLysIleLeuGlnArgLeuGluSerTyrIleG
||||||||| |||||||||||||||||||||||| ||||||||| |
++ValLysPheGluAlaGlnLysLysIleLeuGlnArgIleGluSerTyrPheG
agGTAAAATTTGAAGCTCAGAAGAAAATTTTACAGAGGATAGAGTCTTACTTCC
lnMetLeuAsnGlyValSerValThrThrAlaValProLysSerGluArgLeuSerCysL
|||||||||||||| |||||| ||||||||| |||
lnMetLeuAsnGlyLeuAsnMetThrThrThrAlaProLysSerGlnGlyPheCysCysA
AAATGCTCAATGGACTCAATATGACAACTACTGCTCCCAAATCCCAGGGTTTCTGTTGTC
euLeuHisProIleIleProSer >>>> Target Intron 3 >>>> ProValIl
||||||||| |||||| 793 bp ||| ||
rgLeuHisProValValProSer++ -+ProLeuIl
GTCTCCATCCTGTTGTACCCTCTgt tgCCTCTCAT
eAsnGlyTyrArgAsnLysSerThrPheSerValAsnArgGlyProAspGlyAsnProLy
|||||||||| |||||||||||||||||| ||| ||||||||||||||||||||
eAsnGlyTyrGlyAsnLysSerThrPheSerMetAsn***GlyProAspGlyAsnProLy
CAATGGCTACGGAAATAAGTCCACCTTCTCTATGAACTGAGGTCCAGATGGCAATCCAAA
sThrVal-GlyPheTyrLeuGlyThrTrpArg{A} >>>> Target Intron 4 >>
|||| #||| ||||||||||||||| {|} 1647 bp
sThr---#GlyTyrTyrLeuGlyThrTrpLys{A}++
AACT---AGGATACTACCTGGGAACTTGGAAA{G}gt
>> {sp}GlyAsnValValCysValGlnSerAsnHisLeuLysAsnIleProGluLysH
{||}|||||| ||||||||||||||| |||||| ||||||||||||||||
++{sp}GlyAsnIleValCysValGlnSerTyrHisLeu***AsnIleProGluLysH
ag{AT}GGGAACATCGTCTGTGTACAGTCTTACCATCTATAAAACATCCCTGAGAAAC
isSerGlnValAlaGln >>>> Target Intron 5 >>>> TyrTyrGluValPh
||||||||||| ||| 5904 bp ||||||||| ||
isSerGlnValSerGln++ ++TyrTyrGluAlaPh
ACAGTCAAGTGTCACAGgt agTACTATGAGGCATT
eLeuArgGlnSerProLeuGluProCysLeuValPheHisGluGlyGlyTyrTrpArgGl
|||| |||||| |||||| |||||||||||||||||||||||
eLeuGlnGlnSerLeuMetAlaProCysIleGlnCysHisGluGlyGlyTyrTrpArgGl
CCTTCAACAGTCTCTGATGGCGCCCTGCATTCAGTGTCATGAAGGTGGATACTGGCGGGA
uLeuThrValArgThrAsnSerGlnGlyHisThrMetAlaIleIleThrPheHisProGl
| ||||||||||||||||||||||||||||||||||||||| ||||||||| ||
uPheThrValArgThrAsnSerGlnGlyHisThrMetAlaIleValThrPheHisLeuGl
GTTTACAGTCCGCACCAACAGCCAAGGGCACACAATGGCTATCGTCACTTTTCATCTCCA
nLysLeuSerGln >>>> Target Intron 6 >>>> GluGluLeuHisValGln
| ||||||||| 2107 bp ||||||||| ||||||
nGluLeuSerGln++ ++GluGluLeuCysValGln
GGAATTAAGTCAGgt agGAGGAGCTCTGTGTTCAG
LysGluIleValLysGluPhePheIleArgGlyProGlyAlaAlaCysGlyLeuThrSer
|||||| |||||||||||||||||| |||||||||||| ||| |||||||||
LysGluAlaValLysGluPhePheIleLysGlyProGlyAlaValCysAspLeuThrSer
AAGGAGGCTGTAAAGGAATTTTTCATCAAAGGCCCAGGAGCTGTCTGTGACTTGACCTCA
LeuTyrPheGlnGlu{Se} >>>> Target Intron 7 >>>> {r}ThrMetThr
|||||||||||||||{||} 340 bp {|} ||||||
LeuTyrPheGlnGlu{Se}++ ++{r}IleMetThr
CTTTACTTCCAGGAA{AG}gt ag{C}ATCATGACC
ArgCysSerHisGlnGlnSerProTyrGlnLeuLeuPheGlyGluProTyrIlePheGlu
|||||| |||||||||||||||||||||||||||||||||||| |||||||||
HisCysSerTyrGlnGlnSerProTyrGlnLeuLeuPheGlyGluProHisIlePheGlu
CATTGCAGCTATCAGCAGTCCCCCTACCAGCTCCTTTTTGGGGAACCCCACATATTTGAA
GluLeuLeuSerLeuLysIleArgIleSerProAspAlaPhePheGlnIleAsnThrAla
|||||| ||||||||| ||||||||||||||| |||||||||
AspLeuLeuGlyLeuLysIleHisPheAlaProAspAlaPhePheHisPheAsnThrAla
GATCTCTTGGGCTTGAAGATCCACTTCGCTCCAGATGCTTTTTTTCATTTTAACACTGCT
GlyAlaGluMetLeuTyrArgThrValGlyGluLeuThr-GlyValAsnSerAspThrIl
|||||||||||||||||| ||||||||| ||| #|||||||||||| ||
GlyAlaGluMetLeuTyrGlnThrValGlyLysLeuSer#GlyValAsnSerAsnSerIl
GGTGCAGAGATGCTATATCAGACTGTGGGGAAGCTGAGTTGGAGTGAATTCTAACAGCAT
eLeuLeuAsp{Il} >>>> Target Intron 8 >>>> {e}CysCysGlyThrGl
|||| |||{||} 177 bp {|} ||
eLeuPheAsp{Il}-+ --{e}PheThrSerAlaGl
CCTCTTTGAC{AT}ct tc{T}TTTACTTCTGCAGG
yValIleGlyLeuSerLeuAlaGlnHisThrSerArgVal--LeuGlyIleGluLeuLeu
||||||||||||||||||||||||||||||||||||| ##|||||||||||||||
yValIleGlyLeuSerLeuAlaGlnHisThrSerArg---##LeuGlyIleGluLeuVal
TGTGATTGGCCTCTCTCTGGCTCAGCACACATCCAGG---TCCTTGGAATTGAGTTGGTG
GluGlnAlaValGluAspAlaArgTrpThrAlaAlaPheAsn{G} >>>> Target I
||||||||||||||||||||||||||||||||| { } 1692
GluGlnAlaValGluAspAlaArgTrpThrAlaCysSerLeu{A}+-
GAGCAGGCAGTAGAGGATGCCAGGTGGACTGCATGCAGCCTT{C}ga
ntron 9 >>>> {ly}IleThrAsnSerGluPheHisThrGlyGlnAlaGluLysIle
bp { }||||||||| |||||||||||| ||||||
++{rg}IleThrAsnCysGluPheHisThrAsp***AlaGluThrVal
ag{GC}ATCACCAACTGTGAATTTCACACTGACTGAGCAGAGACAGTT
LeuProGlyLeuLeuLysSerLysGluAspGlyGlnSerIleValAlaValValAsnPro
||| ||||||||||||||||||||| ||| ||||||||| ||||||
SerProGlnLeuLeuLysSerLysGluAspGluGlnLeuIleValAlaAlaMetAsnPro
TCACCACAGCTGCTAAAGTCAAAGGAAGATGAGCAGTTAATTGTTGCAGCGATGAACCCA
AlaArgAlaGlyLeu{H} >>>> Target Intron 10 >>>> {is}TyrLysVa
||| |||||| { } 217 bp { } ||
AlaSerAlaGlyVal{T}++ ++{yr}CysGlnVa
GCCAGTGCAGGAGTG{T}gt ag{AT}TGCCAGGT
lIleGlnAlaIleArgAsnPheArgAlaIleHisThrLeuVal-PheValSerCysLysL
| ||||||||||||||| ||| |||||||||||||||#|||||||||||||||
lValGlnAlaIleArgAsnCysArgValIleHisThrLeuVal#PheValSerCysLysP
AGTTCAAGCCATTCGAAATTGCAGGGTCATCCACACACTCGTTTTTTGTTTCCTGCAAGC
euHisGlyGluSerThr{Ar} >>>> Target Intron 11 >>>> {g}AsnVal
|||||| { } 738 bp { }
roLeuGlyGluAlaSer{Se}-- +-{r}CysPhe
CCCTTGGTGAAGCCTCA{AG}aa at{T}TGTTTC
IleGluLeuCysCysProProAspProAlaLysLysLeuLeuGlyGluProPheValLeu
||||||||||||||| ||||||||||||||||||||||||||| |||
TyrArgLeuCysCysProProAsnSerAlaLysLysLeuLeuGlyGluProPheLeuLeu
TACAGGCTGTGCTGTCCTCCAAACTCTGCTAAGAAGCTCCTAGGCGAGCCTTTTTTGCTG
GlnGlnAlaValProValAspLeuPheProHisThrProHisCysGluLeuValLeuLeu
||| ||||||||||||||||||||||||||| |||||||||||| ||||||
ArgGlnValValProValAspLeuPheProHisThrArgHisCysGluLeuLeuLeuLeu
AGACAAGTTGTACCTGTGGATTTGTTTCCCCACACCAGACACTGTGAGCTGCTGCTCCTC
PheThrArg
||||||
PheThrGln
TTCACTCAA
//
|