| Basic information |
| Official Symbol | TRMT1L |
| Description | tRNA methyltransferase 1 homolog (S. cerevisiae)-like |
| Other Aliases | MSTP070, C1orf25, MST070, TRM1L, bG120K12.3 |
| Other Description | TRM1 tRNA methyltransferase 1-like; TRM1-like protein; TRMT1-like protein |
| Mutation type | Insert and frame-shift 718-719:E-M^T |
| Location | Scaffold000112_1:734021 771866 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| TRMT1L |
TCAGAAAGACACATCTCAATTCAAAGGCAGCTTGCTGACCTTGAGAAGTT AGCTTTTGTAAATGAAGAGGATTTTGACCTTACCAGTTCATTGAATTCAG ACAATCTTGATACAGGAAACAAACAGGCTTGTCCATTGTGCCCTAAAGAA AAATTCCGAGCTTGTAATAGCCATAAGCTTCGTCGTCACCTTCAAAATTT ACACTGGAAAGTCTCAGTTGAATTTGAAGGTTATAGAATGTGCATCTGTC ACTTACCTTGTCTCCCAGTGAAACCAAACATTATTGGAGAACAGATATCC AGTAAAATGGGCGCCCATTATCATTGTATTATTTGTTCAGCAACAATCAC CAGAAGGACTGATATGCTAGGACATGTTAGGCGCCATGTGAATAAAGGAG AGACCAAATCCAGGTATATTGCTGCTTCTACTACTAAACCAGCTAATGAA ATTTTGAAAGAGGCAGACACGGATGTACAAGTTTGTCCTAACTATTCTAT ACCTCAAAAAACAGATTCATATTTTAATCCCAAAATGAAACTAAATCGGC AGCTAATATTCTGCACATTGGCTGCTTTAGCTGAGGAACGAAAACCTTTG GAATGTCTAGATGCCTTTGGAGCCACTGGGATAATGGGATTACAGTGGGC AAAGCATCTTGGAAATGCAGTCAAAGTTACAATTAATGACTTGAATGAAA ACTCTGTGACATTGATTCAGGAAAACTGCCATTTAAACAAATTGAAAGTG GTAGTGGACGGCAAGGATAAGGAAGAGAGTGATGATACTGTGGGAGGAGA AGAAAGCCTCGGCAATATTAAGGTGACCAAAATGGATGCCAATGTACTGA TGCACTTGAGGTCTTTTGATTTCATACACCTAGACCCTTTTGGAACATCA GTGAACTATCTAGACTCTGCATTCAGAAATATAAGAAATCTGGGTATAGT GTCGGTGACTTCTACAGACATCAGTTCCCTCTATGCCAAGGCACAGCATG TGGCCCGACGTCACTATGGCTGTAACATTGTCCGGACCGAATACTACCTA GCCGCCAGGATTGTGGCAGCCGCAGTGGCAAGAGCTGCAGCCCGATGCAA CAAAGGCATAGAAGTCCTGTTCGCGGTGGCCCTGGAGCACTTCGTGTTGG TAGTTGTGAGGGTGCTGAGGGGGCCTTCTTCAGCAGATGAGACAGCCAAG AAGATTCAGTACCTGATCCACTGTCAGTGGTGTGAAGAGAGAATTTTTCA GAAGGATGGTAACATGGTAGAAGAAAACCCATACAAACAGCTGCCATGTA ACTGTCATGGAAACATGCCTGGAAAGACAGCAATAGAACTTGGTCCTCTG TGGTCAAGTTCTCTTTTCAATACTGGATTTCTCAAAAGAATGTTATTTGA ATCTCTTCACCATGGCTTGGAGGACATTCAAACCCTAATAAAAACATTAA TCTTTGAATCAGAATGTACTCCTCAAAGTCAGTTTTCAGTTCATGCATCT TCTGGTCTCAACAAGCAAGAAGAAAATGGTGTATTTATTAAAACTACAGA TGATGCCACAACAGATAATTATACTGCACAAGGAAAGAGAAAAAGTAATG AAACAATCACAAATCTAGCCAAGAAGCAGAAGAGTGATGTCAGTTCTGAA CACCCTCCCTTTTATTACAACATCCATAGACACAGCATTAAAGGAATGAA TATGCCAAAGTTAAAAAAGTTTCTGTGCTATCTTTCTCAAGCAGGCTTTC GAGTCAGCCGAACTCATTTTGACCCCATGGGTGTCCGTACAGATGCACCG CTAATGCAGTTTAAAGCCATCCTTTTAAAGTACAGCACCCCCACCTACAC TGGGGGACAGTCGGAGGGCCACGTGCAGGCAGCACCCGAAGATACAGGAG CTGACAGGGTGAAAGTCAGTGACCACAGAGCGGAAGCGAGCAGCTGCGGG AGGTGG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 733 | 78 | 733 | Insert and frame-shift 718-719:E-M^T |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
SerLysArgHisIleSerIleGlnArgGlnLeuAlaAspLeuGluAsnLeuAlaPheVal
||| ||||||||||||||||||||||||||||||||||||||| ||||||||||||
SerGluArgHisIleSerIleGlnArgGlnLeuAlaAspLeuGluLysLeuAlaPheVal
TCAGAAAGACACATCTCAATTCAAAGGCAGCTTGCTGACCTTGAGAAGTTAGCTTTTGTA
ThrAspGlyAsnPheAspSerAlaSerSerLeuAsnSerAspAsnLeuAspAla{G} >
|||||| ||||||||||||||||||||||||||| {|}
AsnGluGluAspPheAspLeuThrSerSerLeuAsnSerAspAsnLeuAspThr{G}++
AATGAAGAGGATTTTGACCTTACCAGTTCATTGAATTCAGACAATCTTGATACA{G}gt
>>> Target Intron 1 >>>> {ly}AsnArgGlnAlaCysProLeuCysProLys
1583 bp {||}||| ||||||||||||||||||||||||
++{ly}AsnLysGlnAlaCysProLeuCysProLys
ag{GA}AACAAACAGGCTTGTCCATTGTGCCCTAAA
GluLysPheArgAlaCysAsnSerHisLysLeuArgArgHisLeuGlnAsnLeuHisTrp
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GluLysPheArgAlaCysAsnSerHisLysLeuArgArgHisLeuGlnAsnLeuHisTrp
GAAAAATTCCGAGCTTGTAATAGCCATAAGCTTCGTCGTCACCTTCAAAATTTACACTGG
LysValSerValGluPheGlu{G} >>>> Target Intron 2 >>>> {ly}Tyr
|||||||||||||||||||||{|} 2899 bp {||}|||
LysValSerValGluPheGlu{G}++ ++{ly}Tyr
AAAGTCTCAGTTGAATTTGAA{G}gt ag{GT}TAT
ArgMetCysIleCysHisLeuProCysArgProValLysProAsnIleIleGlyGluGln
||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||
ArgMetCysIleCysHisLeuProCysLeuProValLysProAsnIleIleGlyGluGln
AGAATGTGCATCTGTCACTTACCTTGTCTCCCAGTGAAACCAAACATTATTGGAGAACAG
>>>> Target Intron 3 >>>> IleThrSerLysMetGlyAlaHisTyrHisC
2730 bp ||| |||||||||||||||||||||||||
++ ++IleSerSerLysMetGlyAlaHisTyrHisC
gt agATATCCAGTAAAATGGGCGCCCATTATCATT
ysIleIleCysSerAlaThrIleThrArgArgThrAspMetLeuGlyHisValArgArgH
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ysIleIleCysSerAlaThrIleThrArgArgThrAspMetLeuGlyHisValArgArgH
GTATTATTTGTTCAGCAACAATCACCAGAAGGACTGATATGCTAGGACATGTTAGGCGCC
isMetAsnLysGlyGluThrLysSerSerTyrIleAla{A} >>>> Target Intro
|| ||||||||||||||||||||| |||||||||{|} 2751 bp
isValAsnLysGlyGluThrLysSerArgTyrIleAla{A}++
ATGTGAATAAAGGAGAGACCAAATCCAGGTATATTGCT{G}gt
n 4 >>>> {la}SerThrAlaLysProProLysGluIleLeuLysGluAlaAspThrA
{||}|||||| |||||| |||||||||||||||||||||||||
++{la}SerThrThrLysProAlaAsnGluIleLeuLysGluAlaAspThrA
ag{CT}TCTACTACTAAACCAGCTAATGAAATTTTGAAAGAGGCAGACACGG
spValGlnValCysProAsnTyrSerIleProGlnLysThrAspSerTyrPheAsnProL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
spValGlnValCysProAsnTyrSerIleProGlnLysThrAspSerTyrPheAsnProL
ATGTACAAGTTTGTCCTAACTATTCTATACCTCAAAAAACAGATTCATATTTTAATCCCA
ysMetLysLeuAsn{Ar} >>>> Target Intron 5 >>>> {g}GlnLeuIleP
||||||||||||||{||} 759 bp {|}||||||||||
ysMetLysLeuAsn{Ar}++ ++{g}GlnLeuIleP
AAATGAAACTAAAT{CG}gt ag{G}CAGCTAATAT
heCysThrLeuAlaAlaLeuAlaGluGluArgLysProLeuGluCysLeuAspAlaPheG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
heCysThrLeuAlaAlaLeuAlaGluGluArgLysProLeuGluCysLeuAspAlaPheG
TCTGCACATTGGCTGCTTTAGCTGAGGAACGAAAACCTTTGGAATGTCTAGATGCCTTTG
lyAlaThr{G} >>>> Target Intron 6 >>>> {ly}IleMetGlyLeuGlnT
||||||||{|} 6364 bp {||}||||||||||||||||
lyAlaThr{G}++ ++{ly}IleMetGlyLeuGlnT
GAGCCACT{G}gt ag{GG}ATAATGGGATTACAGT
rpAlaLysHisLeuGlyAsnAlaValLysValThrIleAsnAspLeuAsnGluAsnSerV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rpAlaLysHisLeuGlyAsnAlaValLysValThrIleAsnAspLeuAsnGluAsnSerV
GGGCAAAGCATCTTGGAAATGCAGTCAAAGTTACAATTAATGACTTGAATGAAAACTCTG
alThrLeuIleGlnGluAsnCysHisLeuAsnLysLeuLysValValValAspSerLysG
||||||||||||||||||||||||||||||||||||||||||||||||||||| |||
alThrLeuIleGlnGluAsnCysHisLeuAsnLysLeuLysValValValAspGlyLysA
TGACATTGATTCAGGAAAACTGCCATTTAAACAAATTGAAAGTGGTAGTGGACGGCAAGG
luLysGluLysSerAspAspIleLeuGluGluGlyGluLysAsnLeuGlyAsnIleLysV
|||||| ||||||||| |||||| ||||||||||||||||
spLysGluGluSerAspAspThrVal---GlyGlyGluGluSerLeuGlyAsnIleLysV
ATAAGGAAGAGAGTGATGATACTGTG---GGAGGAGAAGAAAGCCTCGGCAATATTAAGG
alThrLysMetAspAlaAsnValLeuMetHisLeuArgSerPheAspPhe{Il} >>>>
||||||||||||||||||||||||||||||||||||||||||||||||||{||}
alThrLysMetAspAlaAsnValLeuMetHisLeuArgSerPheAspPhe{Il}++
TGACCAAAATGGATGCCAATGTACTGATGCACTTGAGGTCTTTTGATTTC{AT}gt
Target Intron 7 >>>> {e}HisLeuAspProPheGlyThrSerValAsnTyrL
869 bp {|}||||||||||||||||||||||||||||||||||
++{e}HisLeuAspProPheGlyThrSerValAsnTyrL
ag{A}CACCTAGACCCTTTTGGAACATCAGTGAACTATC
euAspSerAlaPheArgAsnIleArgAsnLeuGlyIleValSerValThrSerThrAspI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euAspSerAlaPheArgAsnIleArgAsnLeuGlyIleValSerValThrSerThrAspI
TAGACTCTGCATTCAGAAATATAAGAAATCTGGGTATAGTGTCGGTGACTTCTACAGACA
leSerSerLeuTyrAlaLysAlaGlnHisValAlaArgArgHisTyrGlyCysAsnIleV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
leSerSerLeuTyrAlaLysAlaGlnHisValAlaArgArgHisTyrGlyCysAsnIleV
TCAGTTCCCTCTATGCCAAGGCACAGCATGTGGCCCGACGTCACTATGGCTGTAACATTG
alArgThrGluTyrTyrLysGluLeuAlaAlaArgIleValValAlaAlaValAla{Ar}
||||||||||||||||| |||||||||||||||||| ||||||||||||{||}
alArgThrGluTyrTyr------LeuAlaAlaArgIleValAlaAlaAlaValAla{Ar}
TCCGGACCGAATACTAC------CTAGCCGCCAGGATTGTGGCAGCCGCAGTGGCA{AG}
>>>> Target Intron 8 >>>> {g}AlaAlaAlaArgCysAsnLysGlyIleG
2438 bp {|}||||||||||||||||||||||||||||
++ ++{g}AlaAlaAlaArgCysAsnLysGlyIleG
gt ag{A}GCTGCAGCCCGATGCAACAAAGGCATAG
luValLeuPheAlaValAlaLeuGluHisPheValLeuValValValArgValLeuArgG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luValLeuPheAlaValAlaLeuGluHisPheValLeuValValValArgValLeuArgG
AAGTCCTGTTCGCGGTGGCCCTGGAGCACTTCGTGTTGGTAGTTGTGAGGGTGCTGAGGG
lyProThrSerAlaAspGluThrAlaLysLysIleGlnTyrLeuIleHisCysGlnTrpC
||||| ||||||||||||||||||||||||||||||||||||||||||||||||||||
lyProSerSerAlaAspGluThrAlaLysLysIleGlnTyrLeuIleHisCysGlnTrpC
GGCCTTCTTCAGCAGATGAGACAGCCAAGAAGATTCAGTACCTGATCCACTGTCAGTGGT
ysGluGluArgIlePheGlnLysAspGlyAsnMetValGlu{G} >>>> Target In
|||||||||||||||||||||||||||||||||||||||||{|} 4899
ysGluGluArgIlePheGlnLysAspGlyAsnMetValGlu{G}++
GTGAAGAGAGAATTTTTCAGAAGGATGGTAACATGGTAGAA{G}gt
tron 9 >>>> {lu}AsnProTyrArgGlnLeuProCysAsnCysHisGlySerMetP
bp {||}||||||||| |||||||||||||||||||||||| ||||
++{lu}AsnProTyrLysGlnLeuProCysAsnCysHisGlyAsnMetP
ag{AA}AACCCATACAAACAGCTGCCATGTAACTGTCATGGAAACATGC
roGlyLysThrAlaIleGluLeuGlyProLeu{Tr} >>>> Target Intron 10
||||||||||||||||||||||||||||||||{||} 3159 bp
roGlyLysThrAlaIleGluLeuGlyProLeu{Tr}++
CTGGAAAGACAGCAATAGAACTTGGTCCTCTG{TG}gt
>>>> {p}SerSerSerLeuPheAsnThrGlyPheLeuLysArgMetLeuPheGluSer
{|}|||||||||||||||||||||||||||||||||||||||||||||||||||
++{p}SerSerSerLeuPheAsnThrGlyPheLeuLysArgMetLeuPheGluSer
ag{G}TCAAGTTCTCTTTTCAATACTGGATTTCTCAAAAGAATGTTATTTGAATCT
LeuHisHisGlyLeuAspAspIleGlnThrLeuIleLysThrLeuIlePheGluSerGlu
||||||||||||||| ||||||||||||||||||||||||||||||||||||||||||
LeuHisHisGlyLeuGluAspIleGlnThrLeuIleLysThrLeuIlePheGluSerGlu
CTTCACCATGGCTTGGAGGACATTCAAACCCTAATAAAAACATTAATCTTTGAATCAGAA
CysThrProGlnSerGlnPheSerIleHisAlaSerSerAsnValAsnLysGln{G} >
|||||||||||||||||||||||| |||||||||||| |||||||||{|}
CysThrProGlnSerGlnPheSerValHisAlaSerSerGlyLeuAsnLysGln{G}++
TGTACTCCTCAAAGTCAGTTTTCAGTTCATGCATCTTCTGGTCTCAACAAGCAA{G}gt
>>> Target Intron 11 >>>> {lu}GluAsnGlyValPheIleLysThrThrAs
2529 bp {||}|||||||||||||||||||||||||||||
++{lu}GluAsnGlyValPheIleLysThrThrAs
ag{AA}GAAAATGGTGTATTTATTAAAACTACAGA
pAspThrThrThrAspAsnTyrIleAlaGln{G} >>>> Target Intron 12 >>
|||| ||||||||||||||| ||||||{|} 4807 bp
pAspAlaThrThrAspAsnTyrThrAlaGln{G}++
TGATGCCACAACAGATAATTATACTGCACAA{G}gt
>> {ly}LysArgLysSerAsnGluMetIleThrAsnLeuGlyLysLysGlnLysThrA
{||}|||||||||||||||||| |||||||||||| |||||||||||| |
++{ly}LysArgLysSerAsnGluThrIleThrAsnLeuAlaLysLysGlnLysSerA
ag{GA}AAGAGAAAAAGTAATGAAACAATCACAAATCTAGCCAAGAAGCAGAAGAGTG
spValSerThrGluHisProProPheTyrTyrAsnIleHisArgHisSerIleLysGlyM
|||||||| |||||||||||||||||||||||||||||||||||||||||||||||||
spValSerSerGluHisProProPheTyrTyrAsnIleHisArgHisSerIleLysGlyM
ATGTCAGTTCTGAACACCCTCCCTTTTATTACAACATCCATAGACACAGCATTAAAGGAA
etAsnMetPro{Ly} >>>> Target Intron 13 >>>> {s}LeuLysLysPhe
|||||||||||{||} 102 bp {|}||||||||||||
etAsnMetPro{Ly}++ ++{s}LeuLysLysPhe
TGAATATGCCA{AA}gt ag{G}TTAAAAAAGTTT
LeuCysTyrLeuSerGlnAlaGlyPheArgValSerArgThrHisPheAspProMetGly
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuCysTyrLeuSerGlnAlaGlyPheArgValSerArgThrHisPheAspProMetGly
CTGTGCTATCTTTCTCAAGCAGGCTTTCGAGTCAGCCGAACTCATTTTGACCCCATGGGT
ValArgThrAspAlaProLeuMetGlnPheLysSerIleLeuLeuLysTyrSerThrPro
||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||
ValArgThrAspAlaProLeuMetGlnPheLysAlaIleLeuLeuLysTyrSerThrPro
GTCCGTACAGATGCACCGCTAATGCAGTTTAAAGCCATCCTTTTAAAGTACAGCACCCCC
ThrTyrThrGlyGlyGlnSerGluSerHisValGlnSerAlaSerGluAspThrValThr
|||||||||||||||||||||||| ||||||||| ||| |||||||||
ThrTyrThrGlyGlyGlnSerGluGlyHisValGlnAlaAlaProGluAspThrGlyAla
ACCTACACTGGGGGACAGTCGGAGGGCCACGTGCAGGCAGCACCCGAAGATACAGGAGCT
GluArgValGlu-MetSerValAsnAspLysAlaGluAlaSerGlyCysArgArgTrp
|||||| # ||| |||||||||||| ||| ||||||
AspArgValLys#ValSer---AspHisArgAlaGluAlaSerSerCysGlyArgTrp
GACAGGGTGAAATGTCAGT---GACCACAGAGCGGAAGCGAGCAGCTGCGGGAGGTGG
//
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