| Basic information |
| Official Symbol | TRAF6 |
| Description | TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
| Other Aliases | MGC:3310, RNF85 |
| Other Description | E3 ubiquitin-protein ligase TRAF6; RING finger protein 85; TNF receptor-associated factor 6; interleukin-1 signal transducer |
| Mutation type | Insert and frame-shift 481-482:A-L^TG, premature termination 483:R->TAA, premature termination 509:R->TGA |
| Location | Scaffold143910_1:27320 6534 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| TRAF6 |
ATGAGTCTGCTACACTGTGAAAACAGCTGTGGGTCCAGCCAGCCTGGGAG CGACTGCTGTGCTGCCATGGCCAGCTCCTGCAGCATGACAGCCAAGGACG ACAGTGTGAGCGGGACTGCCAGCACAGGGAACCTCTCCAGCTCTTTCATG GAAGAGACCCAGGGCTATGACGTGGAGTTTGACCCGCCCCTGGAGAGCAA GTATGAGTGCCCCATTTGCTTGATGGCATTGCGGGAAGCAGTGCAGACCC CATGTGGCCACAGGTTCTGCAAAGCCTGCATCATCAAATCCATAAGGGAT GCAGGTCACAAATGTCCAGTTGACAATGAAATACTGCTGGAAAGCCAACT GTTTCCTGACAATTTTGCAAAACGAGAGATTCTTTCTCTAATGGTGAAGT GTCCAAATGCAGGTTGTTTGCACAAGATGGAACTGAGGCATCTTGAGGAT CATCAAATACATTGTGAATTTGCTCTTATAAGCTGTCCTCAATGCCAGCG CCCCTTCCAGAAATGCCAACTGGATATTCACATTCTCAAGGATTGTCCAC GGAGGCAGGTTGCATGTACAAATTGCGCTGAATTGATGGCATTTGAAGAA AAAGAGATCCATGACCAGAACTGTCCTTTGGCAAACGTCATCTGTGAATA CTGCAATACCATGCTTATCAGAGAACAGATGCCTAATCATTATGATTTAG ATTGCCCTACGGCCCCAATTCCATGCACTTTCAGCACTTTTGGTTGCCAC GAAAAGATGCAGAGGAACCACTTGGCACGACACCTGCAAGAGAATACGCA GTCGCACATGAGAATGCTGGCCCAGGCTGTTCACAGTTTGAGCCTTGCCC TGACTTCCATCCCTCAGCCTGAGGTCCAGAATTTCCAGGAAACTATTCAG CAGTTAGAGGGTCGCCTTGTAAGACAAGACCATCAGATCCGGGAACTGAC TGCTAAGATGGAAACTCAGAGTATGTATGTAAGCGATCTCAAACGAACTA TTCGAACCCTTGAGGACAAAGTCGCTGAAATTGAAGCACAGCAGTGCAAT GGGATTTATGTCTGGAAGATTGGCAACTTTGGGATGCACTTGAAGTCTCA GGAAGAGGAGAAACCTGTCGTCATCCATAGCCCTGGATTCTACACAGGCA AACCCGGGTACAAACTGTGCATGCGCTTGCACCTGCAGTTACCCACGGCC CAGCGCTGTGCGAACTACATATCTCTCTTTGTCCACACAATGCAAGGAGA GTATGACAGCCACCTCCCTTGGCCCTTCCAGGGAACAATACTCCTTACCA TCCTGGATCAGTCCGAAGCACCTGTAAGGCAAAACCATGAAGAAATAATG GATGCCAAATCGGAGCTGCTTGCCTTCCAGCGACCCACAATCCCACGGAA CCCAAAAGGTTTTGGCTATGTAACTTTTATGCATCTTTTTTAACAAAGAA CCTTTGTTAAGGATGATACATTATTAGTGCACTGTGAAGTCTCTACCTGC TTTGACATGGTTAGCCTCTGAAGGGAGGGCTTCCAGCCACGAAGTACTGA TGCAGGGGTA |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 522 | 1 | 522 | Insert and frame-shift 481-482:A-L^TG, Premature termination 483:R->TAA, Premature termination 509:R->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetSerLeuLeuAsnCysGluAsnSerCysGlySerSerGlnSerGluSerAspCysCys
|||||||||||| ||||||||||||||||||||||||||| ||||||||||||
MetSerLeuLeuHisCysGluAsnSerCysGlySerSerGlnProGlySerAspCysCys
ATGAGTCTGCTACACTGTGAAAACAGCTGTGGGTCCAGCCAGCCTGGGAGCGACTGCTGT
ValAlaMetAlaSerSerCysSerAlaValThrLysAspAspSerValGlyGlyThrAla
||||||||||||||||||||| ||||||||||||||| |||||||||
AlaAlaMetAlaSerSerCysSerMetThrAlaLysAspAspSerValSerGlyThrAla
GCTGCCATGGCCAGCTCCTGCAGCATGACAGCCAAGGACGACAGTGTGAGCGGGACTGCC
SerThrGlyAsnLeuSerSerSerPheMetGluGluIleGlnGlyTyrAspValGluPhe
|||||||||||||||||||||||||||||||||||| |||||||||||||||||||||
SerThrGlyAsnLeuSerSerSerPheMetGluGluThrGlnGlyTyrAspValGluPhe
AGCACAGGGAACCTCTCCAGCTCTTTCATGGAAGAGACCCAGGGCTATGACGTGGAGTTT
AspProProLeuGluSerLysTyrGluCysProIleCysLeuMetAlaLeuArgGluAla
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AspProProLeuGluSerLysTyrGluCysProIleCysLeuMetAlaLeuArgGluAla
GACCCGCCCCTGGAGAGCAAGTATGAGTGCCCCATTTGCTTGATGGCATTGCGGGAAGCA
ValGlnThrProCysGlyHisArgPheCysLysAlaCysIleIleLysSerIle{Ar}
||||||||||||||||||||||||||||||||||||||||||||||||||||||{||}
ValGlnThrProCysGlyHisArgPheCysLysAlaCysIleIleLysSerIle{Ar}++
GTGCAGACCCCATGTGGCCACAGGTTCTGCAAAGCCTGCATCATCAAATCCATA{AG}gt
>>>> Target Intron 1 >>>> {g}AspAlaGlyHisLysCysProValAspAsn
3783 bp {|}||||||||||||||||||||||||||||||
++{g}AspAlaGlyHisLysCysProValAspAsn
ag{G}GATGCAGGTCACAAATGTCCAGTTGACAAT
GluIleLeuLeuGluAsnGlnLeuPheProAspAsnPheAlaLysArgGluIleLeuSer
||||||||||||||| ||||||||||||||||||||||||||||||||||||||||||
GluIleLeuLeuGluSerGlnLeuPheProAspAsnPheAlaLysArgGluIleLeuSer
GAAATACTGCTGGAAAGCCAACTGTTTCCTGACAATTTTGCAAAACGAGAGATTCTTTCT
LeuMetValLysCysProAsnGluGlyCysLeuHisLysMetGluLeuArgHisLeuGlu
||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||
LeuMetValLysCysProAsnAlaGlyCysLeuHisLysMetGluLeuArgHisLeuGlu
CTAATGGTGAAGTGTCCAAATGCAGGTTGTTTGCACAAGATGGAACTGAGGCATCTTGAG
>>>> Target Intron 2 >>>> AspHisGlnAlaHisCysGluPheAlaLeuM
1106 bp ||||||||| ||||||||||||||||||
++ ++AspHisGlnIleHisCysGluPheAlaLeuI
gt agGATCATCAAATACATTGTGAATTTGCTCTTA
etAspCysProGlnCysGlnArgProPheGlnLysPheHisIleAsnIleHisIleLeuL
|||||||||||||||||||||||||||||| |||||||||||||
leSerCysProGlnCysGlnArgProPheGlnLysCysGlnLeuAspIleHisIleLeuL
TAAGCTGTCCTCAATGCCAGCGCCCCTTCCAGAAATGCCAACTGGATATTCACATTCTCA
ysAspCysProArgArgGlnValSerCysAspAsnCysAlaAlaSerMetAlaPheGluA
||||||||||||||||||||||| ||| ||||||||| ||||||||||||
ysAspCysProArgArgGlnValAlaCysThrAsnCysAlaGluLeuMetAlaPheGluG
AGGATTGTCCACGGAGGCAGGTTGCATGTACAAATTGCGCTGAATTGATGGCATTTGAAG
spLysGlu >>>> Target Intron 3 >>>> IleHisAspGlnAsnCysProLe
|||||| 8985 bp |||||||||||||||||||||||
luLysGlu++ ++IleHisAspGlnAsnCysProLe
AAAAAGAGgt agATCCATGACCAGAACTGTCCTTT
uAlaAsnValIleCysGluTyrCysAsnThrIleLeuIleArgGluGln >>>> Targ
||||||||||||||||||||||||||||||| |||||||||||||||
uAlaAsnValIleCysGluTyrCysAsnThrMetLeuIleArgGluGln++
GGCAAACGTCATCTGTGAATACTGCAATACCATGCTTATCAGAGAACAGgt
et Intron 4 >>>> MetProAsnHisTyrAspLeuAspCysProThrAlaProIle
3076 bp ||||||||||||||||||||||||||||||||||||||||||
++MetProAsnHisTyrAspLeuAspCysProThrAlaProIle
agATGCCTAATCATTATGATTTAGATTGCCCTACGGCCCCAATT
ProCysThrPheSerThrPheGlyCysHisGluLys >>>> Target Intron 5 >
|||||||||||||||||||||||||||||||||||| 2218 bp
ProCysThrPheSerThrPheGlyCysHisGluLys++
CCATGCACTTTCAGCACTTTTGGTTGCCACGAAAAGgt
>>> MetGlnArgAsnHisLeuAlaArgHisLeuGlnGluAsnThrGlnSerHisMetA
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
++MetGlnArgAsnHisLeuAlaArgHisLeuGlnGluAsnThrGlnSerHisMetA
agATGCAGAGGAACCACTTGGCACGACACCTGCAAGAGAATACGCAGTCGCACATGA
rgMetLeuAlaGlnAlaValHisSerLeuSerValIleProAspSerGlyTyrIleSer{
|||||||||||||||||||||||||||||||| ||| {
rgMetLeuAlaGlnAlaValHisSerLeuSerLeuAlaLeuThrSerIleProGlnPro{
GAATGCTGGCCCAGGCTGTTCACAGTTTGAGCCTTGCCCTGACTTCCATCCCTCAGCCT{
G} >>>> Target Intron 6 >>>> {lu}ValArgAsnPheGlnGluThrIleH
|} 57 bp {||}||| ||||||||||||||||||
G}-+ ++{lu}ValGlnAsnPheGlnGluThrIleG
G}at ag{AG}GTCCAGAATTTCCAGGAAACTATTC
isGlnLeuGluGlyArgLeuValArgGlnAspHisGlnIleArgGluLeuThrAlaLysM
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnGlnLeuGluGlyArgLeuValArgGlnAspHisGlnIleArgGluLeuThrAlaLysM
AGCAGTTAGAGGGTCGCCTTGTAAGACAAGACCATCAGATCCGGGAACTGACTGCTAAGA
etGluThrGlnSerMetTyrValSerGluLeuLysArgThrIleArgThrLeuGluAspL
|||||||||||||||||||||||||| |||||||||||||||||||||||||||||||
etGluThrGlnSerMetTyrValSerAspLeuLysArgThrIleArgThrLeuGluAspL
TGGAAACTCAGAGTATGTATGTAAGCGATCTCAAACGAACTATTCGAACCCTTGAGGACA
ysValAlaGluIleGluAlaGlnGlnCysAsnGlyIleTyrIleTrpLysIleGlyAsnP
||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||
ysValAlaGluIleGluAlaGlnGlnCysAsnGlyIleTyrValTrpLysIleGlyAsnP
AAGTCGCTGAAATTGAAGCACAGCAGTGCAATGGGATTTATGTCTGGAAGATTGGCAACT
heGlyMetHisLeuLysCysGlnGluGluGluLysProValValIleHisSerProGlyP
||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||
heGlyMetHisLeuLysSerGlnGluGluGluLysProValValIleHisSerProGlyP
TTGGGATGCACTTGAAGTCTCAGGAAGAGGAGAAACCTGTCGTCATCCATAGCCCTGGAT
heTyrThrGlyLysProGlyTyrLysLeuCysMetArgLeuHisLeuGlnLeuProThrA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
heTyrThrGlyLysProGlyTyrLysLeuCysMetArgLeuHisLeuGlnLeuProThrA
TCTACACAGGCAAACCCGGGTACAAACTGTGCATGCGCTTGCACCTGCAGTTACCCACGG
laGlnArgCysAlaAsnTyrIleSerLeuPheValHisThrMetGlnGlyGluTyrAspS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
laGlnArgCysAlaAsnTyrIleSerLeuPheValHisThrMetGlnGlyGluTyrAspS
CCCAGCGCTGTGCGAACTACATATCTCTCTTTGTCCACACAATGCAAGGAGAGTATGACA
erHisLeuProTrpProPheGlnGlyThrIleArgLeuThrIleLeuAspGlnSerGluA
|||||||||||||||||||||||||||||||| |||||||||||||||||||||||||
erHisLeuProTrpProPheGlnGlyThrIleLeuLeuThrIleLeuAspGlnSerGluA
GCCACCTCCCTTGGCCCTTCCAGGGAACAATACTCCTTACCATCCTGGATCAGTCCGAAG
laProValArgGlnAsnHisGluGluIleMetAspAlaLysProGluLeuLeuAlaPheG
||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||
laProValArgGlnAsnHisGluGluIleMetAspAlaLysSerGluLeuLeuAlaPheG
CACCTGTAAGGCAAAACCATGAAGAAATAATGGATGCCAAATCGGAGCTGCTTGCCTTCC
lnArgProThrIleProArgAsnProLysGlyPheGlyTyrValThrPheMetHisLeuG
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnArgProThrIleProArgAsnProLysGlyPheGlyTyrValThrPheMetHisLeu-
AGCGACCCACAATCCCACGGAACCCAAAAGGTTTTGGCTATGTAACTTTTATGCATCTT-
luAla--LeuArgGlnArgThrPheIleLysAspAspThrLeuLeuValArgCysGluVa
## |||||||||||| ||||||||||||||||||||| ||||||||
-----##Phe***GlnArgThrPheValLysAspAspThrLeuLeuValHisCysGluVa
-----TGTTTTAACAAAGAACCTTTGTTAAGGATGATACATTATTAGTGCACTGTGAAGT
lSerThrArgPheAspMetGlySerLeuArgArgGluGlyPheGlnProArgSerThrAs
||||||| ||||||||| |||||| |||||||||||||||||||||||||||||
lSerThrCysPheAspMetValSerLeu***ArgGluGlyPheGlnProArgSerThrAs
CTCTACCTGCTTTGACATGGTTAGCCTCTGAAGGGAGGGCTTCCAGCCACGAAGTACTGA
pAlaGlyVal
||||||||||
pAlaGlyVal
TGCAGGGGTA
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