| Basic information |
| Official Symbol | TNFSF18 |
| Description | tumor necrosis factor (ligand) superfamily, member 18 |
| Other Aliases | RP1-15D23.1, AITRL, GITRL, TL6, hGITRL |
| Other Description | AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand; tumor necrosis factor ligand superfamily member 18 |
| Mutation type | Insert and frame-shift 20-21:S-P^T |
| Location | Scaffold000074_1:5548344 5557726 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| TNFSF18 |
ATGACATTGCCTCATTCACCCATCACTTGTGAATATATGCTTTCTGTAGC TGTCATTCCTCAGAAAATGAGTTTGAGCCACAGGGAGAACATGCCTTCTC AAGGAGCACAGAGGTCATCCTGGAAGCTGTGGCTCTGCTCAATGGGAGCT ATACTGCTATTCCTCGGCTCCTTCAGTATGCTAATCTTTACTTTTCTCCC ACTTAAGGTTGCTAAGGAACCCTGTGTAGCTAAGTTTGGACCTTTACCCT CAAAATGGCAAATTGTATCTCCTGATCCTCCCTGTGTGAATGAAACATCT GACTGGAAGCTGAAGATACTTCAGAAGGGCTTATATTTAATTTACGGCCA AGTGGCTCCCAATGTAACCTATAAAGGACCGGCTCCTTTTGAGGTGCAGC TACGTAGAAACAATGACATCATACAAACTCTAACAAACAACTCTAAAATC CAAAATGTAGGTGGGACTTACGAACTGTTCACTGGAGATATAATAGAATT GTTATTCAACTGGGAACATCAGGTTCTAAAAAATAATACATACTGGGGGA TCATTTTATTGGCAAATCCCCAGTTCCTCTCT |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 199 | 1 | 199 | Insert and frame-shift 20-21:S-P^T |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetThrLeuHisProSerProIleThrCysGluPheLeuPheSerThrAlaLeuIleSer
||||||||| |||||||||||||||||| ||| ||| |||
MetThrLeuProHisSerProIleThrCysGluTyrMetLeuSerValAlaValIlePro
ATGACATTGCCTCATTCACCCATCACTTGTGAATATATGCTTTCTGTAGCTGTCATTCCT
-ProLysMetCysLeuSerHisLeuGluAsnMetProLeuSerHisSerArgThrGlnGl
# |||||| ||||||||| |||||||||||| |||||
#GlnLysMetSerLeuSerHisArgGluAsnMetPro---------------SerGlnGl
TCAGAAAATGAGTTTGAGCCACAGGGAGAACATGCCT---------------TCTCAAGG
yAlaGlnArgSerSerTrpLysLeuTrpLeuPheCysSerIleValMetLeuLeuPheLe
||||||||||||||||||||||||||||||| |||||||||||
yAlaGlnArgSerSerTrpLysLeuTrpLeuCysSerMetGlyAlaIleLeuLeuPheLe
AGCACAGAGGTCATCCTGGAAGCTGTGGCTCTGCTCAATGGGAGCTATACTGCTATTCCT
uCysSerPheSerTrpLeuIlePheIlePheLeuGlnLeuGlu >>>> Target Int
| ||||||||| ||||||||| |||||| ||| 6578 b
uGlySerPheSerMetLeuIlePheThrPheLeuProLeuLys++
CGGCTCCTTCAGTATGCTAATCTTTACTTTTCTCCCACTTAAGgt
ron 1 >>>> ThrAlaLysGluProCysMetAlaLysPhe{G} >>>> Target I
p ||||||||||||||| |||||||||{|} 2222
++ValAlaLysGluProCysValAlaLysPhe{G}++
agGTTGCTAAGGAACCCTGTGTAGCTAAGTTT{G}gt
ntron 2 >>>> {ly}ProLeuProSerLysTrpGlnMetAlaSerSerGluProPro
bp {||}||||||||||||||||||||| ||| ||||||
++{ly}ProLeuProSerLysTrpGlnIleValSerProAspProPro
ag{GA}CCTTTACCCTCAAAATGGCAAATTGTATCTCCTGATCCTCCC
CysValAsnLysValSerAspTrpLysLeuGluIleLeuGlnAsnGlyLeuTyrLeuIle
||||||||| ||||||||||||||| ||||||||| |||||||||||||||
CysValAsnGluThrSerAspTrpLysLeuLysIleLeuGlnLysGlyLeuTyrLeuIle
TGTGTGAATGAAACATCTGACTGGAAGCTGAAGATACTTCAGAAGGGCTTATATTTAATT
TyrGlyGlnValAlaProAsnAlaAsnTyrAsnAspValAlaProPheGluValArgLeu
||||||||||||||||||||| ||| ||||||||||||||| |||
TyrGlyGlnValAlaProAsnValThrTyrLysGlyProAlaProPheGluValGlnLeu
TACGGCCAAGTGGCTCCCAATGTAACCTATAAAGGACCGGCTCCTTTTGAGGTGCAGCTA
TyrLysAsnLysAspMetIleGlnThrLeuThrAsnLysSerLysIleGlnAsnValGly
||| ||| |||||||||||||||||| |||||||||||||||||||||
ArgArgAsnAsnAspIleIleGlnThrLeuThrAsnAsnSerLysIleGlnAsnValGly
CGTAGAAACAATGACATCATACAAACTCTAACAAACAACTCTAAAATCCAAAATGTAGGT
GlyThrTyrGluLeuHisValGlyAspThrIleAspLeuIlePheAsnSerGluHisGln
||||||||||||||| |||||| ||| ||| |||||| |||||||||
GlyThrTyrGluLeuPheThrGlyAspIleIleGluLeuLeuPheAsnTrpGluHisGln
GGGACTTACGAACTGTTCACTGGAGATATAATAGAATTGTTATTCAACTGGGAACATCAG
ValLeuLysAsnAsnThrTyrTrpGlyIleIleLeuLeuAlaAsnProGlnPheIleSer
|||||||||||||||||||||||||||||||||||||||||||||||||||||| |||
ValLeuLysAsnAsnThrTyrTrpGlyIleIleLeuLeuAlaAsnProGlnPheLeuSer
GTTCTAAAAAATAATACATACTGGGGGATCATTTTATTGGCAAATCCCCAGTTCCTCTCT
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