| Basic information |
| Official Symbol | SPINT1 |
| Description | serine peptidase inhibitor, Kunitz type 1 |
| Other Aliases | UNQ223/PRO256, HAI, HAI1, MANSC2 |
| Other Description | HAI-1; hepatocyte growth factor activator inhibitor type 1; kunitz-type protease inhibitor 1; serine protease inhibitor, Kunitz type 1 |
| Mutation type | premature termination 321:G->TAG |
| Location | Scaffold000605_1:2681750 2677916 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| SPINT1 |
GTCCAGCCCCAGGAACCCGTGGTGCTGAAGGGTATGAACTACACAAACTG GCACCTGCTGAAGGGCGACACAGATGTCAGGATAGAGAGGAATGATCCAG ACCAGGTGGAGCTGTGGGGACTCAAGGAAGGCACCTACCTGTTCGAACTG ACCCTGCTGGACTCAGACCAGCCCGAGAACACGGCCAATGTCACGGTCAT CGTGCTGTCCGCCAGGCAGACAGAAGACTACTGCCTCGCCACCAGCAAGG TGGGCCGCTGCCGGGGTGCCTTCCCCCGCTGGTACTATGACCCCAGAGAA CAGATCTGCAAGCGTTTCATCTATGGAGGTTGCTTGGGCAACAAGAACAA CTACTTTTGGGAAGAAGAGTGCATGCTAGCCTGCCGGGATGTGCAAGGTA GGCCTTGGAAGGCAGCTCTGGGCTCAGGGGACTTTGCCCCGGGGTAGTGG TCTTTCCCTGCCACACACGCAGTATGCTCTGGCACCTGTCACCCGAGCCA GTTCCGCTGTGGTGACGGCTGCTGCATCGATGGCTTCCTGGAGTGTGACG ACACCCCCGACTGCTCTGACGCCTCTGATGAGGCCGCCTGTGAAAAATGT GAGAGGTCCCAGCGCTCATGCGCCCCTCTGCCTGCCCCTTGCCCCCCAGG GCACTGCATGGAGCAGCCAGATACAGGACTCTGCCAGGAGAGCATCCCCC GCTGGTACTACAACCCCTTCATGGAGAGCTGCGCCCTCTTCACCTATGGC GGCTGTTACGGCAACAAGAACAACTTCGAGGAGGAGCAGCAGTGCCTGGA GTCCTGTCGCGGCATCTCCAGTGAGCGGGACGGTGGGGGTGGGAAGGACG CGCCCCTTCTCCCCGCAGGCTCTGTGGAGGTTGCCATCGCAGTCCTCCTG GGCACCTGCATCGTGGTAGTGGTAGCCATTCTGGGATACTGCTTCTTCAA GAACCAGAAGAAGGGCTTCCGCAGACACCACCACCGCCACCACCCACCCT CCACCCCTGCCAGCTCCACCATCTCCACCACCGAGGACACGGAGCACCTG GTCTATAATCACACAACCCGACCCCTC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 529 | 173 | 529 | Premature termination 321:G->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
ValGlnProGlnGluProLeuValLeuLysAspValGluAsnThrAspTrpArgLeuLeuAr
|||||||||||||||||| ||||||||| ||| ||| ||||||
ValGlnProGlnGluProValValLeuLysGlyMetAsnTyrThrAsnTrpHisLeuLeuLy
GTCCAGCCCCAGGAACCCGTGGTGCTGAAGGGTATGAACTACACAAACTGGCACCTGCTGAA
gGlyAspThrAspValArgValGlu >>>> Target Intron 1 >>>> ArgLysAs
|||||||||||||||||| ||| 223 bp ||| ||
sGlyAspThrAspValArgIleGlu++ ++ArgAsnAs
GGGCGACACAGATGTCAGGATAGAGgt agAGGAATGA
pProAsnGlnValGluLeuTrpGlyLeuLysGluGlyThrTyrLeuPheGlnLeuThrValT
|||| |||||||||||||||||||||||||||||||||||||||||| ||||||
pProAspGlnValGluLeuTrpGlyLeuLysGluGlyThrTyrLeuPheGluLeuThrLeuL
TCCAGACCAGGTGGAGCTGTGGGGACTCAAGGAAGGCACCTACCTGTTCGAACTGACCCTGC
hrSerSerAspHisProGluAspThrAlaAsnValThrValThrValLeuSerThrLysGln
|||||| |||||| |||||||||||||||||| ||||||||| |||
euAspSerAspGlnProGluAsnThrAlaAsnValThrValIleValLeuSerAlaArgGln
TGGACTCAGACCAGCCCGAGAACACGGCCAATGTCACGGTCATCGTGCTGTCCGCCAGGCAG
ThrGlu{A} >>>> Target Intron 2 >>>> {sp}TyrCysLeuAlaSerAsnLy
||||||{|} 79 bp {||}|||||||||||| ||
ThrGlu{A}++ ++{sp}TyrCysLeuAlaThrSerLy
ACAGAA{G}gt ag{AC}TACTGCCTCGCCACCAGCAA
sValGlyArgCysArgGlySerPheProArgTrpTyrTyrAspProThrGluGlnIleCysL
||||||||||||||||||| |||||||||||||||||||||||| |||||||||||||
sValGlyArgCysArgGlyAlaPheProArgTrpTyrTyrAspProArgGluGlnIleCysL
GGTGGGCCGCTGCCGGGGTGCCTTCCCCCGCTGGTACTATGACCCCAGAGAACAGATCTGCA
ysSerPheValTyrGlyGlyCysLeuGlyAsnLysAsnAsnTyrLeuArgGluGluGluCys
|| ||| ||||||||||||||||||||||||||||||||| ||||||||||||
ysArgPheIleTyrGlyGlyCysLeuGlyAsnLysAsnAsnTyrPheTrpGluGluGluCys
AGCGTTTCATCTATGGAGGTTGCTTGGGCAACAAGAACAACTACTTTTGGGAAGAAGAGTGC
IleLeuAlaCysArgGlyValGlnGlyGlyProLeuArgGlySerSerGlyAlaGlnAlaTh
|||||||||||| ||||||||| ||| |||
MetLeuAlaCysArgAspValGlnGlyArgProTrpLysAlaAlaLeuGlySerGlyAspPh
ATGCTAGCCTGCCGGGATGTGCAAGGTAGGCCTTGGAAGGCAGCTCTGGGCTCAGGGGACTT
rPheProGlnGlyProSerMetGlu{A} >>>> Target Intron 3 >>>> {rg}A
||| ||| { } 480 bp { }
eAlaProGly***TrpSerPhePro{A}++ --{la}T
TGCCCCGGGGTAGTGGTCTTTCCCT{G}gt cc{CC}A
rgHisProValCysSerGlyThrCysGlnProThrGlnPheArgCysSerAsnGlyCysCys
||| |||||||||||||||||| ||| |||||||||||| |||||||||
hrHisAlaValCysSerGlyThrCysHisProSerGlnPheArgCysGlyAspGlyCysCys
CACACGCAGTATGCTCTGGCACCTGTCACCCGAGCCAGTTCCGCTGTGGTGACGGCTGCTGC
IleAspSerPheLeuGluCysAspAspThrProAsnCysProAspAlaSerAspGluAlaAl
|||||| |||||||||||||||||||||||| ||| ||||||||||||||||||||
IleAspGlyPheLeuGluCysAspAspThrProAspCysSerAspAlaSerAspGluAlaAl
ATCGATGGCTTCCTGGAGTGTGACGACACCCCCGACTGCTCTGACGCCTCTGATGAGGCCGC
aCysGluLysTyrThr >>>> Target Intron 4 >>>> SerGlyPheAspGluLe
|||||||||| 1361 bp
aCysGluLysCysGlu++ ++ArgSerGlnArgSerCy
CTGTGAAAAATGTGAGgt agAGGTCCCAGCGCTCATG
uGlnArgIleHisPheProSerAspLysGlyHisCysValAspLeuProAspThrGlyLeuC
||| ||||||||| ||||||||||||||||
sAlaProLeuProAlaProCysProProGlyHisCysMetGluGlnProAspThrGlyLeuC
CGCCCCTCTGCCTGCCCCTTGCCCCCCAGGGCACTGCATGGAGCAGCCAGATACAGGACTCT
ysLysGluSerIleProArgTrpTyrTyrAsnProPheSerGluHisCysAlaArgPheThr
|| ||||||||||||||||||||||||||||||||| ||| |||||| ||||||
ysGlnGluSerIleProArgTrpTyrTyrAsnProPheMetGluSerCysAlaLeuPheThr
GCCAGGAGAGCATCCCCCGCTGGTACTACAACCCCTTCATGGAGAGCTGCGCCCTCTTCACC
TyrGlyGlyCysTyrGlyAsnLysAsnAsnPheGluGluGluGlnGlnCysLeuGluSerCy
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TyrGlyGlyCysTyrGlyAsnLysAsnAsnPheGluGluGluGlnGlnCysLeuGluSerCy
TATGGCGGCTGTTACGGCAACAAGAACAACTTCGAGGAGGAGCAGCAGTGCCTGGAGTCCTG
sArgGlyIleSerLysLysAspValPheGlyLeuArgArg{G} >>>> Target Intro
||||||||||||| ||| { } 615 bp
sArgGlyIleSerSerGluArgAspGlyGlyGlyGlyLys{A}++
TCGCGGCATCTCCAGTGAGCGGGACGGTGGGGGTGGGAAG{G}gt
n 5 >>>> {lu}IleProIleProSerThrGlySerValGluMetAlaValAlaValPhe
{ } ||| |||||||||||| ||| ||||||
--{sp}AlaProLeuLeuProAlaGlySerValGluValAlaIleAlaValLeu
tc{AC}GCGCCCCTTCTCCCCGCAGGCTCTGTGGAGGTTGCCATCGCAGTCCTC
LeuValIleCysIleValValValValAlaIleLeuGlyTyrCysPhePheLysAsnGlnAr
||| |||||||||||||||||||||||||||||||||||||||||||||||||||
LeuGlyThrCysIleValValValValAlaIleLeuGlyTyrCysPhePheLysAsnGlnLy
CTGGGCACCTGCATCGTGGTAGTGGTAGCCATTCTGGGATACTGCTTCTTCAAGAACCAGAA
gLysAspPhe<-><->HisGlyHisHisHisHisProProProThrProAlaSerSerThrV
||| ||| ||| ||| |||||||||||| ||||||||||||||||||
sLysGlyPheArgArgHisHisHisArgHisHisProProSerThrProAlaSerSerThrI
GAAGGGCTTCCGCAGACACCACCACCGCCACCACCCACCCTCCACCCCTGCCAGCTCCACCA
alSerThrThrGluAspThrGluHisLeuValTyrAsnHisThrThrArgProLeu
||||||||||||||||||||||||||||||||||||||||||||||||||||||
leSerThrThrGluAspThrGluHisLeuValTyrAsnHisThrThrArgProLeu
TCTCCACCACCGAGGACACGGAGCACCTGGTCTATAATCACACAACCCGACCCCTC
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