Basic information
Official Symbol SLC4A9
Descriptionsolute carrier family 4, sodium bicarbonate cotransporter, member 9
Other AliasesAE4
Other Descriptionanion exchange protein 4; anion exchanger 4; sodium bicarbonate cotransporter 5; solute carrier family 4, sodium bicarbonate cotransporter-like, member 9
Mutation typeInsert and frame-shift 95-96:S-T^C
LocationScaffold000484_1:1643249 1655848 +

  ±  bp flank
WikiWikipedia GeneCard
Sequence
SLC4A9
AAGATGAAGCTGCCAGACCAGGAGGCGTTTGATGCCTCCAGCACTCATGA
AGATGTTCCTGCAGGGGAGCTGGAGAGTGGCCCTAGCTCAGACCCCAGAC
CTGATGGCCCCTTAGACACAGACAACAAGGAACTGGAGGTACCCAAAGAC
CCTCTGCTCTTCATTCAGCTGAATGAGCTGCTAGGCTGGCCCCAGGCATT
GGAATGGAAAGAGACAGGCAGGCTCTCTGTGTCCCTACTCCTGGATGTAA
GAGAGATGCCCCCAATAACACTGTCACTCCCTTTCCACTGCAGGTGGGTG
CTGTTTGAGGAGAAGCTGGAGGTGGGCGCAGGCCGATGGAGTGCCCCCCA
TGTGCCCACCCTGGCACTACCTAGCCTCCAGAAGCTTCGCAGCCTGCTGG
CCGAGGGCCTGATACTGCTGGACTGTCCAGCTCAGAGCCTCCTGGAGCTC
GTGGAGCAGGTGACCAGGGTGGAGTCACTGAGTCCGGAGCTGAGAGGGCA
GTTGCAGACCTTGCTGCTACAGAGACCCCAGCACCACTTCTCGACCACAG
GCACCAGTCCCTGCTGGGGACCTACTCATCCTAGAAAGGCTTCTTATGAT
GAGGAAGCTCCTCTGAAGGAACAGCGTCAGAACCCCCTGAGACAGAAGCT
GCCTCCAGGAGCTGAGGCAGGGGCTGTGCTGGCAGGGGAGCTGGGCTTCT
TGGCACAGCCCCTGGGGGCCTTTGTGCGACTGCGGGATCCAGTGGTGCTG
GGGCCGCTCACTGAGGTGCCTCTCCCCAGCAGGTTTTTCTGCCTCCTCCT
GGGTCCCCCCATGCTGGGAAGGGGCTACCATGAGATGGGCCGGGCAGCAG
CTGTTCTCCTCAGCGACCCGCAATTCCAGTGGTCAGTTCGTCGAGCCAAC
AGTCTTCATGACCTTCTGGCAGCCTTGGATGCCTTCCTAGAGGAGGTGAC
AGTGCTTCCTCCAGGTCGGTGGGATCCAACAGCCCGGATTTCCCCGCCCA
AATGTCTACCCTCTCAGCATAAAAGGTACCCGGCCCATCATTCCATAGTC
AAGGGCCTGTTGCCCCCACACAGGGCCCCAGCTGAGGACAGGCACCGTGA
TGGGCCCCAGGCGCCCAGCGTGGAGTTGCAGCGAACTGGCAGGCTGTTTG
GGGGCCTTGTTCAGGACGTTCGCAGGAAGGCTTCATGGTACCCCAGCGAT
TTCTTGGATGCCCTGCACCCCCAGTGCTTTTCGGCCATGCTCTACATTTA
CCTAGCCACCATCACGAATGCCATCACATTTGGGGGTTTGCTGGGAGATG
CCACTGGAGGTTCCCAGGGAGTGCTGGAAAGTTTCCTGGGCACAGCAGTG
GCTGGGGCTGCCTTCTGCCTGATGNCCGCCCAGCCACTCACCATCCTCAG
CAGCACTGGGCCAGTGCTGGTCTTCGAGCGTCTGCTCTTCTCTTTCAGCA
GAGATAACAGCCTGGACTACCTGCCCTTCCGTCTGTGGGTGGGCATCTGG
GTGGCCACCTTTTGCCTGGTGTTGGTGGCCACAGAAGCCAGCGTGCTGGT
ACGCTACTTCACCCGCTTCACTGAGGAAGGTTTCTGTGCCCTCATCAGCC
TCATCTTCATCTATGATGCTGTGGGCAAAATGCTGAATTTGACTCATGAC
TATCCTATCCAGAAGCATGGGTCCCCTGCCTATGGCTGCCTCTGCCAATA
CCCAGGTCCAGGAGGAAATGAGTCCCAATGGACGAGGACAAGGCAAAATG
ATAGAGATGACATCTTCAGCATGGACCTCGGCTTGGTCAATGCATCCTTG
CTGCCCCCACCTGAGTGCGTCCAGCGGGGAGGCTACCCTCGTGGCCCTGG
CTGTCATACGGTCCCGGACATTGCCTTCTTCTCCCTCCTCCTCTTCTTTA
CCTCCTTCCTCTTTGCCATGGCCCTCAAGCATGTAAGGACTAGCCGCTTT
TTCCCTTCTGTGGTACGCAAGGTGCTCAGTGACTTCTCCTCAGTCCTGGC
CATCCTCCTGGGCTGTGCTCTTGATGCCTACCTGGGCCTACCCACGCCGA
AGCTCACGGTACCCAGAGAGTTCAAGCCCACACTTCCTGGGCGTGGCTGG
CTGGTGTCACCTTTTGGAGCCAATCCCTGGTGGTTGAGTGTGGTGGCTGC
CCTGCCTGCCCTGCTGCTGTCTATCCTTATCTTCATGGACCAGCAGATCA
CTGCAGTCATCCTCAACCGTCCAGAATACAAATTGCGGAAAGGAGCTGGC
TTCCACCTGGACCTCTTCTGTGTGGCTGTGCTGATGCTGCTCACTTCAGT
CCTTGGGCTGCCCTGGTATGTCTCAGCCACTGTCATCTCTCTGGCCCACA
TGGACAGTCTTCGGAAAGAGAGCAGAGCCTGTTCCCCTGGGGAGCCCCCC
AGTTTCCTGGGTATCAGAGAGCAGAGGCTGACGGGGCTGATGGTGTTCAT
CCTTACTGGAGTCTCCATCTTTCTGGCACCTGTTCTCAAGTTCATCCCGA
TGCCTGTGCTCTATGGCATCTTCCTGTACATGGGGGTGGCAGCACTTAGC
AGTATCCAGTTTATAAAGAGAGTGCAGCTACTATTGATGCCAACAAAACA
CCAGCCAGACCTGCTGCTTTTGCGGCATGTGCCTCTGAGCAGGGTCCACC
TCTTCACAGCCATCCAGCTCGCCTGCCTGGGTCTGCTTTGGATAATCAAG
TCTACCCCTGCAGCTATCATCTTCCCCCTCATGTTACTGGGCCTCGTAGG
AGTCCGAAAGGCACTGGAGTGGGTCTTCTCATCACAGGAACTCCTTTGGC
TTGATGAGCTGATGCCAGAGGAAGAGAGGAGCATCCTTGATAAAGGGCTG
GAACCAGAGCACTCATTCAGTGGAAGTGACAGTGAAGATTCAGAGCTGAT
GTATCAGCCAAAGGCTCCAGAAATCAACATCTCTGTGAAT

Alignment
Align speciePep lengthPep align beginPep align endMutaion type and postion
Human9832983Insert and frame-shift 95-96:S-T^C
 Instructions:
 *** -> premature termination codon;  # -> frame shift 

 Alignment:
 Human     pep sequence --->
 ||||||||||||||||||||||
 Treeshrew pep sequence --->
 Treeshrew cds sequence --->
  
 GluMetLysLeuProGlyGlnGluGlyPheGluAlaSerSerAlaProArgAsnIlePro
    ||||||||||||   ||||||   |||   |||||||||               |||
 LysMetLysLeuProAspGlnGluAlaPheAspAlaSerSerThrHisGluAspValPro
 AAGATGAAGCTGCCAGACCAGGAGGCGTTTGATGCCTCCAGCACTCATGAAGATGTTCCT

 SerGlyGluLeuAspSerAsnProAspProGlyThrGlyProSerProAspGlyProSer
    |||||||||   |||         |||         |||   ||||||||||||   
 AlaGlyGluLeuGluSerGly------ProSerSerAspProArgProAspGlyProLeu
 GCAGGGGAGCTGGAGAGTGGC------CCTAGCTCAGACCCCAGACCTGATGGCCCCTTA

 AspThrGluSerLysGluLeuGlyValProLysAspProLeuLeuPheIleGlnLeuAsn
 ||||||      |||||||||   ||||||||||||||||||||||||||||||||||||
 AspThrAspAsnLysGluLeuGluValProLysAspProLeuLeuPheIleGlnLeuAsn
 GACACAGACAACAAGGAACTGGAGGTACCCAAAGACCCTCTGCTCTTCATTCAGCTGAAT

 GluLeuLeuGlyTrpProGlnAlaLeuGluTrpArgGluThrGly{Se}  >>>> Targ
 |||||||||||||||||||||||||||||||||   |||||||||{  }           
 GluLeuLeuGlyTrpProGlnAlaLeuGluTrpLysGluThrGly{Ar}++         
 GAGCTGCTAGGCTGGCCCCAGGCATTGGAATGGAAAGAGACAGGC{AG}gt         

 et Intron 1 >>>>  {r}SerSerAlaSerLeuLeuLeuAspMetGlyGluMetPro
  268 bp           { }   |||   |||||||||||||||      |||||||||
                 -+{g}LeuSerValSerLeuLeuLeuAspValArgGluMetPro
                 tg{G}CTCTCTGTGTCCCTACTCCTGGATGTAAGAGAGATGCCC

 SerIleThrLeuSer-ThrHisLeuHisHisArgTrpValLeuPheGluGluLysLeuGl
    ||||||||||||#         |||   |||||||||||||||||||||||||||||
 ProIleThrLeuSer#LeuProPheHisCysArgTrpValLeuPheGluGluLysLeuGl
 CCAATAACACTGTCACCTCCCTTTCCACTGCAGGTGGGTGCTGTTTGAGGAGAAGCTGGA

 uValAlaAlaGlyArgTrpSerAlaProHisValProThrLeuAlaLeuProSerLeuGl
 ||||   |||||||||||||||||||||||||||||||||||||||||||||||||||||
 uValGlyAlaGlyArgTrpSerAlaProHisValProThrLeuAlaLeuProSerLeuGl
 GGTGGGCGCAGGCCGATGGAGTGCCCCCCATGTGCCCACCCTGGCACTACCTAGCCTCCA

 nLysLeuArgSerLeuLeuAlaGluGlyLeuValLeuLeuAspCysProAlaGlnSerLe
 |||||||||||||||||||||||||||||||   ||||||||||||||||||||||||||
 nLysLeuArgSerLeuLeuAlaGluGlyLeuIleLeuLeuAspCysProAlaGlnSerLe
 GAAGCTTCGCAGCCTGCTGGCCGAGGGCCTGATACTGCTGGACTGTCCAGCTCAGAGCCT

 uLeuGluLeuVal{G}  >>>> Target Intron 2 >>>>  {lu}GlnValThrAr
 |||||||||||||{|}            274 bp           {||}|||||||||||
 uLeuGluLeuVal{G}++                         ++{lu}GlnValThrAr
 CCTGGAGCTCGTG{G}gt                         ag{AG}CAGGTGACCAG

 gValGluSerLeuSerProGluLeuArgGlyGlnLeuGlnAlaLeuLeuLeuGlnArgPr
 ||||||||||||||||||||||||||||||||||||||||   |||||||||||||||||
 gValGluSerLeuSerProGluLeuArgGlyGlnLeuGlnThrLeuLeuLeuGlnArgPr
 GGTGGAGTCACTGAGTCCGGAGCTGAGAGGGCAGTTGCAGACCTTGCTGCTACAGAGACC

 oGlnHisTyrAsnGlnThrThrGlyThrArgProCysTrp{G}  >>>> Target Int
 |||||||         ||||||||||||   |||||||||{|}            657 b
 oGlnHisHisPheSerThrThrGlyThrSerProCysTrp{G}++               
 CCAGCACCACTTCTCGACCACAGGCACCAGTCCCTGCTGG{G}gt               

 ron 3 >>>>  {ly}SerThrHisProArgLysAlaSerAspAsnGluGluAlaProLe
 p           {||}   |||||||||||||||||||||      ||||||||||||||
           ++{ly}ProThrHisProArgLysAlaSerTyrAspGluGluAlaProLe
           ag{GA}CCTACTCATCCTAGAAAGGCTTCTTATGATGAGGAAGCTCCTCT

 uArgGluGln  >>>> Target Intron 4 >>>>  CysGlnAsnProLeuArgGln
 |   ||||||            134 bp              ||||||||||||||||||
 uLysGluGln++                         -+ArgGlnAsnProLeuArgGln
 GAAGGAACAGgt                         cgCGTCAGAACCCCCTGAGACAG

 LysLeuProProGlyAlaGluAlaGlyThrValLeuAlaGlyGluLeuGlyPheLeuAla
 |||||||||||||||||||||||||||   ||||||||||||||||||||||||||||||
 LysLeuProProGlyAlaGluAlaGlyAlaValLeuAlaGlyGluLeuGlyPheLeuAla
 AAGCTGCCTCCAGGAGCTGAGGCAGGGGCTGTGCTGGCAGGGGAGCTGGGCTTCTTGGCA

 GlnProLeuGlyAlaPheValArgLeuArgAsnProValValLeuGlySerLeuThrGlu
 ||||||||||||||||||||||||||||||   |||||||||||||||   |||||||||
 GlnProLeuGlyAlaPheValArgLeuArgAspProValValLeuGlyProLeuThrGlu
 CAGCCCCTGGGGGCCTTTGTGCGACTGCGGGATCCAGTGGTGCTGGGGCCGCTCACTGAG

 ValSerLeuProSer{Ar}  >>>> Target Intron 5 >>>>  {g}PhePheCys
 |||   |||||||||{||}            251 bp           {|}|||||||||
 ValProLeuProSer{Ar}++                         ++{g}PhePheCys
 GTGCCTCTCCCCAGC{AG}gt                         ag{G}TTTTTCTGC

 LeuLeuLeuGlyProCysMetLeuGlyLysGlyTyrHisGluMetGlyArgAlaAlaAla
 |||||||||||||||   |||||||||   ||||||||||||||||||||||||||||||
 LeuLeuLeuGlyProProMetLeuGlyArgGlyTyrHisGluMetGlyArgAlaAlaAla
 CTCCTCCTGGGTCCCCCCATGCTGGGAAGGGGCTACCATGAGATGGGCCGGGCAGCAGCT

 ValLeuLeuSerAspPro  >>>> Target Intron 6 >>>>  GlnPheGlnTrpS
 ||||||||||||||||||            299 bp           |||||||||||||
 ValLeuLeuSerAspPro++                         ++GlnPheGlnTrpS
 GTTCTCCTCAGCGACCCGgt                         agCAATTCCAGTGGT

 erValArgArgAlaSerAsnLeuHisAspLeuLeuAlaAlaLeuAspAlaPheLeuGluG
 ||||||||||||||      ||||||||||||||||||||||||||||||||||||||||
 erValArgArgAlaAsnSerLeuHisAspLeuLeuAlaAlaLeuAspAlaPheLeuGluG
 CAGTTCGTCGAGCCAACAGTCTTCATGACCTTCTGGCAGCCTTGGATGCCTTCCTAGAGG

 luValThrValLeuProProGlyArgTrpAspProThrAlaArgIleProProProLysC
 |||||||||||||||||||||||||||||||||||||||||||||||   ||||||||||
 luValThrValLeuProProGlyArgTrpAspProThrAlaArgIleSerProProLysC
 AGGTGACAGTGCTTCCTCCAGGTCGGTGGGATCCAACAGCCCGGATTTCCCCGCCCAAAT

 ysLeuProSerGlnHisLysArgLeuProSerGlnGlnArgGlu  >>>> Target In
 |||||||||||||||||||||||   |||                           364 
 ysLeuProSerGlnHisLysArgTyrProAlaHisHisSerIle+-              
 GTCTACCCTCTCAGCATAAAAGGTACCCGGCCCATCATTCCATAgg              

 tron 7 >>>>  IleArgGlyProAlaValProArgLeuThrSerAlaGluAspArgHi
 bp                 |||         |||            ||||||||||||||
            ++ValLysGlyLeuLeuProProHisArgAlaProAlaGluAspArgHi
            agGTCAAGGGCCTGTTGCCCCCACACAGGGCCCCAGCTGAGGACAGGCA

 sArgHisGlyProHisAlaHisSerProGluLeuGlnArgThrGly{Ar}  >>>> Tar
 ||||   ||||||   |||   |||   ||||||||||||||||||{||}          
 sArgAspGlyProGlnAlaProSerValGluLeuGlnArgThrGly{Ar}++        
 CCGTGATGGGCCCCAGGCGCCCAGCGTGGAGTTGCAGCGAACTGGC{AG}gt        

 get Intron 8 >>>>  {g}LeuPheGlyGlyLeuIleGlnAspValArgArgLysVa
   196 bp           {|}|||||||||||||||   ||||||||||||||||||  
                  ++{g}LeuPheGlyGlyLeuValGlnAspValArgArgLysAl
                  ag{G}CTGTTTGGGGGCCTTGTTCAGGACGTTCGCAGGAAGGC

 lProTrpTyrProSerAspPheLeuAspAlaLeuHisLeuGlnCysPheSerAlaValLe
     |||||||||||||||||||||||||||||||||   |||||||||||||||   ||
 aSerTrpTyrProSerAspPheLeuAspAlaLeuHisProGlnCysPheSerAlaMetLe
 TTCATGGTACCCCAGCGATTTCTTGGATGCCCTGCACCCCCAGTGCTTTTCGGCCATGCT

 uTyrIleTyrLeuAlaThrValThrAsnAlaIleThrPheGlyGlyLeuLeuGlyAspAl
 |||||||||||||||||||   ||||||||||||||||||||||||||||||||||||||
 uTyrIleTyrLeuAlaThrIleThrAsnAlaIleThrPheGlyGlyLeuLeuGlyAspAl
 CTACATTTACCTAGCCACCATCACGAATGCCATCACATTTGGGGGTTTGCTGGGAGATGC

 aThrAspGlyAlaGln  >>>> Target Intron 9 >>>>  GlyValLeuGluSer
 ||||   |||   |||            109 bp           |||||||||||||||
 aThrGlyGlySerGln++                         ++GlyValLeuGluSer
 CACTGGAGGTTCCCAGgt                         agGGAGTGCTGGAAAGT

 PheLeuGlyThrAlaValAlaGlyAlaAlaPheCysLeuMet  >>>> Target Intr
 ||||||||||||||||||||||||||||||||||||||||||            204 bp
 PheLeuGlyThrAlaValAlaGlyAlaAlaPheCysLeuMet+-                
 TTCCTGGGCACAGCAGTGGCTGGGGCTGCCTTCTGCCTGATGgc                

 on 10 >>>>  AlaGlyGlnProLeuThrIleLeuSerSerThrGlyProValLeuVal
                   ||||||||||||||||||||||||||||||||||||||||||
           --UnkAlaGlnProLeuThrIleLeuSerSerThrGlyProValLeuVal
           nnNCCGCCCAGCCACTCACCATCCTCAGCAGCACTGGGCCAGTGCTGGTC

 PheGluArgLeuLeuPheSerPheSer{Ar}  >>>> Target Intron 11 >>>> 
 |||||||||||||||||||||||||||{||}            177 bp           
 PheGluArgLeuLeuPheSerPheSer{Ar}++                          +
 TTCGAGCGTCTGCTCTTCTCTTTCAGC{AG}gt                          a

  {g}AspTyrSerLeuAspTyrLeuProPheArgLeuTrpValGlyIleTrpValAlaTh
  {|}|||   ||||||||||||||||||||||||||||||||||||||||||||||||||
 +{g}AspAsnSerLeuAspTyrLeuProPheArgLeuTrpValGlyIleTrpValAlaTh
 g{A}GATAACAGCCTGGACTACCTGCCCTTCCGTCTGTGGGTGGGCATCTGGGTGGCCAC

 rPheCysLeuValLeuValAlaThrGluAlaSerValLeuValArgTyrPheThrArgPh
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 rPheCysLeuValLeuValAlaThrGluAlaSerValLeuValArgTyrPheThrArgPh
 CTTTTGCCTGGTGTTGGTGGCCACAGAAGCCAGCGTGCTGGTACGCTACTTCACCCGCTT

 eThrGluGluGlyPheCysAlaLeuIleSerLeuIlePheIleTyrAspAlaValGlyLy
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 eThrGluGluGlyPheCysAlaLeuIleSerLeuIlePheIleTyrAspAlaValGlyLy
 CACTGAGGAAGGTTTCTGTGCCCTCATCAGCCTCATCTTCATCTATGATGCTGTGGGCAA

 sMetLeuAsnLeuThrHisThrTyrProIleGlnLysProGlySerSerAlaTyrGlyCy
 |||||||||||||||||||   |||||||||||||||   ||||||   |||||||||||
 sMetLeuAsnLeuThrHisAspTyrProIleGlnLysHisGlySerProAlaTyrGlyCy
 AATGCTGAATTTGACTCATGACTATCCTATCCAGAAGCATGGGTCCCCTGCCTATGGCTG

 sLeuCysGlnTyrProGlyProGly{G}  >>>> Target Intron 12 >>>>  {l
 |||||||||||||||||||||||||{|}            1016 bp           {|
 sLeuCysGlnTyrProGlyProGly{G}++                          ++{l
 CCTCTGCCAATACCCAGGTCCAGGA{G}gt                          ag{G

 y}AsnGluSerGlnTrpIleArgThrArgProLysAspArgAspAspIleValSerMet 
 |}|||||||||||||||   |||||||||      |||||||||||||||   |||||| 
 y}AsnGluSerGlnTrpThrArgThrArgGlnAsnAspArgAspAspIlePheSerMet+
 A}AATGAGTCCCAATGGACGAGGACAAGGCAAAATGATAGAGATGACATCTTCAGCATGg

  >>>> Target Intron 13 >>>>  AspLeuGlyLeuIleAsnAlaSerLeuLeuP
            224 bp            ||||||||||||   ||||||||||||||||
 +                          ++AspLeuGlyLeuValAsnAlaSerLeuLeuP
 t                          agGACCTCGGCTTGGTCAATGCATCCTTGCTGC

 roProProGluCysThrArgGlnGlyGlyHisProArgGlyProGlyCysHisThrValP
 ||||||||||||||         ||||||   ||||||||||||||||||||||||||||
 roProProGluCysValGlnArgGlyGlyTyrProArgGlyProGlyCysHisThrValP
 CCCCACCTGAGTGCGTCCAGCGGGGAGGCTACCCTCGTGGCCCTGGCTGTCATACGGTCC

 roAspIleAlaPhePheSerLeuLeuLeuPheLeuThrSerPhePhePheAlaMetAlaL
 ||||||||||||||||||||||||||||||||   |||||||||   |||||||||||||
 roAspIleAlaPhePheSerLeuLeuLeuPhePheThrSerPheLeuPheAlaMetAlaL
 CGGACATTGCCTTCTTCTCCCTCCTCCTCTTCTTTACCTCCTTCCTCTTTGCCATGGCCC

 euLysCysValLysThrSerArgPhePheProSerVal  >>>> Target Intron 1
 |||||   |||   ||||||||||||||||||||||||            132 bp    
 euLysHisValArgThrSerArgPhePheProSerVal++                    
 TCAAGCATGTAAGGACTAGCCGCTTTTTCCCTTCTGTGgt                    

 4 >>>>  ValArgLysGlyLeuSerAspPheSerSerValLeuAlaIleLeuLeuGlyC
         |||||||||   ||||||||||||||||||||||||||||||||||||||||
       ++ValArgLysValLeuSerAspPheSerSerValLeuAlaIleLeuLeuGlyC
       agGTACGCAAGGTGCTCAGTGACTTCTCCTCAGTCCTGGCCATCCTCCTGGGCT

 ysGlyLeuAspAlaPheLeuGlyLeuAlaThrProLysLeuMetValProArgGluPheL
 ||   |||||||||   |||||||||   ||||||||||||   ||||||||||||||||
 ysAlaLeuAspAlaTyrLeuGlyLeuProThrProLysLeuThrValProArgGluPheL
 GTGCTCTTGATGCCTACCTGGGCCTACCCACGCCGAAGCTCACGGTACCCAGAGAGTTCA

 ys  >>>> Target Intron 15 >>>>  ProThrLeuProGlyArgGlyTrpLeuV
 ||            1169 bp           ||||||||||||||||||||||||||||
 ys++                          ++ProThrLeuProGlyArgGlyTrpLeuV
 AGgt                          agCCCACACTTCCTGGGCGTGGCTGGCTGG

 alSerProPheGlyAlaAsnProTrpTrpTrpSerValAlaAlaAlaLeuProAlaLeuL
 |||||||||||||||||||||||||||||   ||||||   |||||||||||||||||||
 alSerProPheGlyAlaAsnProTrpTrpLeuSerValValAlaAlaLeuProAlaLeuL
 TGTCACCTTTTGGAGCCAATCCCTGGTGGTTGAGTGTGGTGGCTGCCCTGCCTGCCCTGC

 euLeuSerIleLeuIlePheMetAspGlnGlnIleThrAlaValIleLeuAsnArgMetG
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||   |
 euLeuSerIleLeuIlePheMetAspGlnGlnIleThrAlaValIleLeuAsnArgProG
 TGCTGTCTATCCTTATCTTCATGGACCAGCAGATCACTGCAGTCATCCTCAACCGTCCAG

 luTyrArgLeuGln  >>>> Target Intron 16 >>>>  LysGlyAlaGlyPheH
 |||||   |||                99 bp            ||||||||||||||||
 luTyrLysLeuArg++                          ++LysGlyAlaGlyPheH
 AATACAAATTGCGGgt                          agAAAGGAGCTGGCTTCC

 isLeuAspLeuPheCysValAlaValLeuMetLeuLeuThrSerAlaLeuGlyLeuProT
 ||||||||||||||||||||||||||||||||||||||||||||   |||||||||||||
 isLeuAspLeuPheCysValAlaValLeuMetLeuLeuThrSerValLeuGlyLeuProT
 ACCTGGACCTCTTCTGTGTGGCTGTGCTGATGCTGCTCACTTCAGTCCTTGGGCTGCCCT

 rpTyrValSerAlaThrValIleSerLeuAlaHisMetAspSerLeuArgArgGluSerA
 ||||||||||||||||||||||||||||||||||||||||||||||||||   |||||||
 rpTyrValSerAlaThrValIleSerLeuAlaHisMetAspSerLeuArgLysGluSerA
 GGTATGTCTCAGCCACTGTCATCTCTCTGGCCCACATGGACAGTCTTCGGAAAGAGAGCA

 rgAlaCysAlaProGlyGluArgProAsnPheLeuGlyIle{Ar}  >>>> Target I
 ||||||||   |||||||||   |||   ||||||||||||{||}            664
 rgAlaCysSerProGlyGluProProSerPheLeuGlyIle{Ar}++             
 GAGCCTGTTCCCCTGGGGAGCCCCCCAGTTTCCTGGGTATC{AG}gt             

 ntron 17 >>>>  {g}GluGlnArgLeuThrGlyLeuValValPheIleLeuThrGly
  bp            {|}|||||||||||||||||||||   ||||||||||||||||||
              ++{g}GluGlnArgLeuThrGlyLeuMetValPheIleLeuThrGly
              ag{A}GAGCAGAGGCTGACGGGGCTGATGGTGTTCATCCTTACTGGA

 AlaSerIlePheLeuAlaProValLeuLys  >>>> Target Intron 18 >>>>  
    |||||||||||||||||||||||||||            2181 bp           
 ValSerIlePheLeuAlaProValLeuLys++                          ++
 GTCTCCATCTTTCTGGCACCTGTTCTCAAGgt                          ag

 PheIleProMetProValLeuTyrGlyIlePheLeuTyrMetGlyValAlaAlaLeuSer
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 PheIleProMetProValLeuTyrGlyIlePheLeuTyrMetGlyValAlaAlaLeuSer
 TTCATCCCGATGCCTGTGCTCTATGGCATCTTCCTGTACATGGGGGTGGCAGCACTTAGC

 SerIleGln  >>>> Target Intron 19 >>>>  PheThrAsnArgValLysLeu
 |||||||||            237 bp            |||      ||||||   |||
 SerIleGln++                          ++PheIleLysArgValGlnLeu
 AGTATCCAGgt                          agTTTATAAAGAGAGTGCAGCTA

 LeuLeuMetProAlaLysHisGlnProAspLeuLeuLeuLeuArgHisValProLeuThr
 ||||||||||||   ||||||||||||||||||||||||||||||||||||||||||   
 LeuLeuMetProThrLysHisGlnProAspLeuLeuLeuLeuArgHisValProLeuSer
 CTATTGATGCCAACAAAACACCAGCCAGACCTGCTGCTTTTGCGGCATGTGCCTCTGAGC

 ArgValHisLeuPheThrAlaIleGlnLeuAlaCysLeuGlyLeuLeuTrpIleIleLys
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ArgValHisLeuPheThrAlaIleGlnLeuAlaCysLeuGlyLeuLeuTrpIleIleLys
 AGGGTCCACCTCTTCACAGCCATCCAGCTCGCCTGCCTGGGTCTGCTTTGGATAATCAAG

 SerThrProAlaAlaIleIlePheProLeuMet  >>>> Target Intron 20 >>>
 |||||||||||||||||||||||||||||||||            627 bp         
 SerThrProAlaAlaIleIlePheProLeuMet++                         
 TCTACCCCTGCAGCTATCATCTTCCCCCTCATGgt                         

 >  LeuLeuGlyLeuValGlyValArgLysAlaLeuGluArgValPheSerProGlnGlu
    ||||||||||||||||||||||||||||||||||||   |||||||||   ||||||
  ++LeuLeuGlyLeuValGlyValArgLysAlaLeuGluTrpValPheSerSerGlnGlu
  agTTACTGGGCCTCGTAGGAGTCCGAAAGGCACTGGAGTGGGTCTTCTCATCACAGGAA

 LeuLeuTrpLeuAspGluLeuMetProGluGluGluArgSerIleProGluLysGlyLeu
 |||||||||||||||||||||||||||||||||||||||||||||      |||||||||
 LeuLeuTrpLeuAspGluLeuMetProGluGluGluArgSerIleLeuAspLysGlyLeu
 CTCCTTTGGCTTGATGAGCTGATGCCAGAGGAAGAGAGGAGCATCCTTGATAAAGGGCTG

 GluProGluHisSerPheSerGlySerAspSerGluAsp  >>>> Target Intron 
 |||||||||||||||||||||||||||||||||||||||            377 bp   
 GluProGluHisSerPheSerGlySerAspSerGluAsp++                   
 GAACCAGAGCACTCATTCAGTGGAAGTGACAGTGAAGATgt                   

 21 >>>>  SerGluLeuMetTyrGlnProLysAlaProGluIleAsnIleSerValAsn
          |||||||||||||||||||||||||||||||||||||||||||||||||||
        ++SerGluLeuMetTyrGlnProLysAlaProGluIleAsnIleSerValAsn
        agTCAGAGCTGATGTATCAGCCAAAGGCTCCAGAAATCAACATCTCTGTGAAT


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