| Basic information |
| Official Symbol | SH2D2A |
| Description | SH2 domain containing 2A |
| Other Aliases | RP11-66D17.12-002, F2771, SCAP, TSAD, VRAP |
| Other Description | SH2 domain protein 2A; SH2 domain-containing protein 2A; T cell specific adapter protein TSAd; T lymphocyte specific adaptor protein; VEGF receptor-associated protein |
| Mutation type | premature termination 336:W->TAA, premature termination 388:R->TGA |
| Location | Scaffold000438_1:1320439 1309738 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| SH2D2A |
AGCCACGAAGCCCCTGCTCCCACCTTCAGCACCTTCCGACCCACGGGCGT GGCCCACAAGAGCTGCCAGAACTCTGCTCCCAACCAGGTGTCTCCCCAGG CCCCAGCGGCCGCCTCCAGCCCAGAGAATGCTGGCAGGGCTGAGGAGGTG CCAGGGGAAGGAGGTCTCTCCCTGCAGGCCGAGATCTGGGAGTGGTTCCA GAAGACTCAGGCCCACCAGCTCCTGCAGCACGGGGCAGCCCCCGCCTGGT TCCACGGCTTCATCACCCGGAGCCCGCTGCCTCTTCCCTCCATTCCCCTC AGGGAGGCTGAGAGGCTGCTGGAGCCCAAGACTCCCGGATGCTACTTAGT GCGGTTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGAGCCTGA CCTGCTGCCGCCACTTCCTGCTGGCCCAGCTCCGGGATGGGCGCCACGTG GTGCTGGGCGAGGACAGCGCCCACGCCAGGCTGCAAGACCTGCTACGCCA CTACACCGAGTGCCCGCTCAGCCCCTACAGGGAGACGCTGACCGAGCCCC TCGCCCGCCAGACTGCGGAGCCTGCGGGACTTTCCCTAAAGTTTGAAGAA CCAGACTCCGGATGCAGAAGCCAGGACCCGAACCCCCAGTACACGCCGGT TATCAAGCCGGGGCAGACTCCAGCTCCCGGGCAGAAAGAAGGAGCCAGAG AGTCAAAGGAGCCCGCCCCGCCCACCCTGCCCAACCCACTCCCTGCCAAG CCGCAGCTGCCCGCAGAAGTCTACACAAGCCCCGCGCCGAGACCCCGCCC GGGCCCACCCCCCGAGCCCACCACTCCTATCTACCATGAGCTCGACGAAC CCATAGCCTTCTACGCCATGGGCCGGGGCAGCCCCGGGGAAGGCCCCAGC AACATCTATGCCGAGGTGGAGGGGCCGCCTGCGCCTGAGCGGCCGCCCGA AAGCCCGCCGACCAGGGCGTAACTAGAACTGCCCTTCTCTCTGCAGAACC CAGAGGGCCCGCAATTACATTCTGAACACTCTGTGGCTGGATTAGGGCCT CCCCTGTTTCCCCAGCCCCCACCTTCCTGGAGGCACACCCTCCCCCACAA ACTTTCTAGACAGGTGCTTCAGGACTGAGGACAGGCGTGGCTGCCCCTTG GGCCTGCTCAG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 399 | 13 | 399 | Premature termination 336:W->TAA, Premature termination 388:R->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
SerHisGluAlaProIleProThrPheSerThrPheGlnIleThrAspMetThrArgArg
||||||||||||||| |||||||||||||||||| |||
SerHisGluAlaProAlaProThrPheSerThrPheArgProThrGlyValAlaHisLys
AGCCACGAAGCCCCTGCTCCCACCTTCAGCACCTTCCGACCCACGGGCGTGGCCCACAAG
SerCysGln >>>> Target Intron 1 >>>> AsnLeuGlyTyrThrAlaAlaS
||||||||| 827 bp ||| |
SerCysGln+- -+AsnSerAlaProAsnGlnValS
AGCTGCCAGgg tgAACTCTGCTCCCAACCAGGTGT
erProGlnAlaProGluAlaAlaSerAsnThrGlyAsnAlaGluArgAlaGluGluValP
|||||||||||||| ||||||||| |||||| ||||||||||||||||
erProGlnAlaProAlaAlaAlaSerSerProGluAsnAlaGlyArgAlaGluGluValP
CTCCCCAGGCCCCAGCGGCCGCCTCCAGCCCAGAGAATGCTGGCAGGGCTGAGGAGGTGC
roGlyGluGlySerLeuPheLeuGlnAlaGluThrArgAlaTrpPheGlnLysThrGlnA
||||||||||| ||| |||||||||||| |||||||||||||||||||
roGlyGluGlyGlyLeuSerLeuGlnAlaGluIleTrpGluTrpPheGlnLysThrGlnA
CAGGGGAAGGAGGTCTCTCCCTGCAGGCCGAGATCTGGGAGTGGTTCCAGAAGACTCAGG
laHisTrpLeuLeuGlnHisGlyAlaAlaProAlaTrpPheHisGlyPheIleThrArg{
||||| |||||||||||||||||||||||||||||||||||||||||||||||||||{
laHisGlnLeuLeuGlnHisGlyAlaAlaProAlaTrpPheHisGlyPheIleThrArg{
CCCACCAGCTCCTGCAGCACGGGGCAGCCCCCGCCTGGTTCCACGGCTTCATCACCCGG{
Ar} >>>> Target Intron 2 >>>> {g}ValArgProProLeuSerValThrH
} 1554 bp { } ||| |||
Se}++ -+{r}ProLeuProLeuProSerIleProL
AG}gt tg{C}CCGCTGCCTCTTCCCTCCATTCCCC
isArgGluAlaGluArgLeuLeuGluProLysProGlnGlyCysTyrLeuValArgPheS
|||||||||||||||||||||||||||||| |||||||||||||||||||||
euArgGluAlaGluArgLeuLeuGluProLysThrProGlyCysTyrLeuValArgPheU
TCAGGGAGGCTGAGAGGCTGCTGGAGCCCAAGACTCCCGGATGCTACTTAGTGCGGTTCN
erGluSerAlaValThrPheValLeuThrTyr{Ar} >>>> Target Intron 3 >
{ } 144 bp
nkUnkUnkUnkUnkUnkUnkUnkUnkUnkUnk{Un}--
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN{NN}nn
>>> {g}SerArgThrCysCysArgHisPheLeuLeuAlaGlnLeuArgAspGlyArgH
{ }||| ||||||||||||||||||||||||||||||||||||||||||||||
++{k}SerLeuThrCysCysArgHisPheLeuLeuAlaGlnLeuArgAspGlyArgH
ag{G}AGCCTGACCTGCTGCCGCCACTTCCTGCTGGCCCAGCTCCGGGATGGGCGCC
isValValLeuGlyGluAspSerAlaHisAlaArgLeuGlnAspLeuLeuLeuHisTyrT
|||||||||||||||||||||||||||||||||||||||||||||||||| |||||||
isValValLeuGlyGluAspSerAlaHisAlaArgLeuGlnAspLeuLeuArgHisTyrT
ACGTGGTGCTGGGCGAGGACAGCGCCCACGCCAGGCTGCAAGACCTGCTACGCCACTACA
hrAlaHisProLeuSerProTyrGlyGluThrLeuThrGluProLeuAlaArgGln >>
|| ||||||||||||||| ||||||||||||||||||||||||||||||
hrGluCysProLeuSerProTyrArgGluThrLeuThrGluProLeuAlaArgGln++
CCGAGTGCCCGCTCAGCCCCTACAGGGAGACGCTGACCGAGCCCCTCGCCCGCCAGgt
>> Target Intron 4 >>>> ThrProGluProAlaGlyLeuSerLeuArgThrGl
4715 bp ||| ||||||||||||||||||||| ||
++ThrAlaGluProAlaGlyLeuSerLeuLysPheGl
agACTGCGGAGCCTGCGGGACTTTCCCTAAAGTTTGA
uGluSerAsnPheGlySerLysSerGlnAspProAsnProGlnTyrSerProIleIleLy
|||| ||| |||||||||||||||||||||||| ||| |||||
uGluProAspSerGlyCysArgSerGlnAspProAsnProGlnTyrThrProValIleLy
AGAACCAGACTCCGGATGCAGAAGCCAGGACCCGAACCCCCAGTACACGCCGGTTATCAA
sGlnGlyGlnAlaProValProMetGlnLysGluGlyAlaGlyGluLysGluPro >>>
| |||||| ||| ||| ||||||||||||||| |||
sProGlyGlnThrProAlaProGlyGlnLysGluGlyAlaArgGluSerLysGlu++
GCCGGGGCAGACTCCAGCTCCCGGGCAGAAAGAAGGAGCCAGAGAGTCAAAGGAGgt
> Target Intron 5 >>>> SerGlnLeuLeuArgProLysProProIleProAla
147 bp ||| ||||||
++ProAlaProProThrLeuProAsnProLeuProAla
agCCCGCCCCGCCCACCCTGCCCAACCCACTCCCTGCC
LysProGlnLeuProProGluValTyrThrIleProValProArgHisArgProAlaPro
||||||||||||||| |||||||||||| ||| |||||| |||||| |||
LysProGlnLeuProAlaGluValTyrThrSerProAlaProArgProArgProGlyPro
AAGCCGCAGCTGCCCGCAGAAGTCTACACAAGCCCCGCGCCGAGACCCCGCCCGGGCCCA
ArgProLysProSerAsnProIleTyrAsnGluProAspGluProIleAlaPheTyrAla
||| ||| ||||||||| ||| ||||||||||||||||||||||||
ProProGluProThrThrProIleTyrHisGluLeuAspGluProIleAlaPheTyrAla
CCCCCCGAGCCCACCACTCCTATCTACCATGAGCTCGACGAACCCATAGCCTTCTACGCC
MetGlyArgGlySerProGlyGluAlaProSerAsnIleTyrValGluValGluAspGlu
|||||||||||||||||||||||| ||||||||||||||| |||||||||
MetGlyArgGlySerProGlyGluGlyProSerAsnIleTyrAlaGluValGluGlyPro
ATGGGCCGGGGCAGCCCCGGGGAAGGCCCCAGCAACATCTATGCCGAGGTGGAGGGGCCG
GlyLeuProAlaThrLeuGlyHisProValLeuArg{Ly} >>>> Target Intron
||| { } 2154 bp
ProAlaProGluArgProProGluSerProProThr{Ar}--
CCTGCGCCTGAGCGGCCGCCCGAAAGCCCGCCGACC{AG}cc
6 >>>> {s}SerTrpSerArgProValProGlyGlyGlnAsnThrGlyGlySerGln
{ } |||||| ||| |||
++{g}Ala***LeuGluLeuProPheSerLeuGlnAsnProGluGlyProGln
ag{G}GCGTAACTAGAACTGCCCTTCTCTCTGCAGAACCCAGAGGGCCCGCAA
LeuHisSerGluAsnSerValIleGlyGlnGlyProProLeuProHisGlnProProPro
|||||||||||| |||||| ||| |||||||||||| ||||||||||||
LeuHisSerGluHisSerValAlaGlyLeuGlyProProLeuPheProGlnProProPro
TTACATTCTGAACACTCTGTGGCTGGATTAGGGCCTCCCCTGTTTCCCCAGCCCCCACCT
AlaTrpArgHisThrLeuProHisAsnLeuSerArgGlnValLeuGlnAspArgGlyGln
||||||||||||||||||||| |||||||||||||||||||||||| ||||||
SerTrpArgHisThrLeuProHisLysLeuSerArgGlnValLeuGlnAsp***GlyGln
TCCTGGAGGCACACCCTCCCCCACAAACTTTCTAGACAGGTGCTTCAGGACTGAGGACAG
AlaTrpLeuProLeuGlyProProGln
||||||||||||||||||||| |||
AlaTrpLeuProLeuGlyProAlaGln
GCGTGGCTGCCCCTTGGGCCTGCTCAG
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