| Basic information |
| Official Symbol | ROS1 |
| Description | c-ros oncogene 1 , receptor tyrosine kinase |
| Other Aliases | RP1-179P9.1, MCF3, ROS, c-ros-1 |
| Other Description | c-Ros receptor tyrosine kinase; proto-oncogene c-Ros; proto-oncogene c-Ros-1; proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1; transmembrane tyrosine-specific protein kinase; v-ros UR2 sarcoma virus oncogene homolog 1; v-ros avian UR2 sarcoma virus oncogene homolog 1 |
| Mutation type | premature termination 599:E->TAA |
| Location | Scaffold000563_1:2676410 2832952 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| ROS1 |
ATGAAGAACATTTACTGGTTTATTCTGACACTTGTCAATTTTGTGACTCT TGGCTGCATATGGATTTCTGGGATACAGTGTACAGTTTTAAACAGCTGCC TAAAGTCATGTGTAACTAACCTGGTAAGTTTCACTTGTTAGTCACCAGTG CCTTGTTGTCCCTTGCAGTGCATCCAAGGATGTCATTTTTGGAACTCTCT AGATCAGGAAAACTGTGCTTTAAAGTGTCGAGAGTCCTGTGAGATCGGCT GCAGCAGCGCGGAAGGTGCATACGAAGAGGAAGTACTGGAAAATGCAGAC CTTCCCACTGCACCCTTTGCTTCTTCTATTGGAAACCACAGTGTGACATT ACGATGGAAACCTGCCAATGTCTCTGGAGTAAAATACATAATCCAGTGGA AATTTGCACAACTCCCGGGAAGTTGGACTTACACGGAGGCTGTGTCCAAG CTCTCATACGTGGTCGAACCCCTGCATCCCTTCACTGGATACATCTTTCG AGTGGTTTGGATCTTCACAGCCCAGCTGCAGCTTTATTCCCCGCCAAGTC CCAGTTATAGGACCCATCCTTATGGAGTTCCTGAAACTGCTCCTCTCATT AGGAATATTGAGAGCTCAAGTCCTGACACTGTGGAAGTCAGCTGGACTCC ACCTCAATTCCCAGGTGGACCCATTTTGGGTTATAATTTAAGGCTAACCA GCAAAAATCAAAAATTAGATTCAGGGACACAGAGAACCAGCTTCCAGTTT TACTCCACACTACCAAATACTACCTACAGGTTTTCTATTGCAGCAGTAAA TGAAGTTGGTGAGGGGCCAGAAGCAGAATCTAGTATTACCACTTCATCCC TAGCAGTACAAGAAGAGGAACAGTGGCTCTTTTTATCCAGAAAATCTTCT TTAAGAAAGAGATCTTTAAAATATTTAGTAGATGAAGCACATTGCCTTTG GTCAGATGCTATACACCATAATATTACAGGAATATCAGTTAATGTCCACC AGCAAGTAGTCTATTTCTCTGAAGGAACTCTCATATGGATGAAAAAGTCT GCCAGCATGTTTGATATGTCTGACCTAAGGATTTTTTACAGAGGTTCAGG ATTCATTTCTTCTATCTCCACAGACTGGCTTTATCAGAGAATGTATTTTA TCATGGATGAACTGGTATGTGTGTGTGACTTAGAGAACTGCTCAAACATT GAAGAAATTACTCCACGCTCTATTAGTGCACCTCAAAAACTTGTGGCTGA TTCATACAATGGGTACATCTTTTATCTCTTGAGAGATGGCATTTACAGAG TGGATCTCCCAGTGCCATCTGGTCGGGACACTCGAGCTGTGCGTATTGTA GAGGGTTTTATGTTAAATGACTTCGCAGTGAAGCCACAGTCCAAGCGAAT CATTTACTTCAATGACACCGCCCAAGTCTTCATGTCAACATTTCTGGATG GTACTGCTTCCCATCTGATCTTACCTCATGTCTCCTTCACTGGTGTGAAG AGCTTTGCTTGTGAAAACAATGACTTCCTTGTCACAAATGGCAAGGCCGT TTTCCAAAAAGACTCTTCGTCTTTTAATGAGTTCATTGTGGGATGTGACC TGAGTCACATAGAAGAATTTGGGTTTGGAAACTTGGTCATCTTTGGCTCA TCTGCCCAGCCATACCCTCTGCCAGGCCACCCACAAGAACTCTCTGTGCT GTTTGGCTCTCACCAGGCCCTTGTTCAATGGAAGCCTCCTGCTCTCGCCA TAGGAGCCAATGTATTCTTGGTTAGTGATATTATTGAACTCTTCTAATTA GGCCCTTCCGCCTGGCAGAACTGGACTTATGAGGTGAAAGTATCAACTCA GGACCTTTCTGAAATCACTCATGTGTTCTCGAACATAAGTGGGACCATGA TGAATGTGCCTGTGCTGCAGAGTGCTACAAAATACAAGGTCTCCGTGAGA GCAAGTTCTCCCAAGGGGACAGGCCCCTGGTCGGAGCCCTCAGTGGGTAC TACCCTGATGCCAGCCGCAGAACCACCATTTATCATGGCTGTGAAAGAAG ATGGGCTTTGGAGTAAACCATTAAACAACTTTGGCCCAGGAGAGTTCCTA TCCTCTGACATAGGAAATGTGTCAGACATGGACTGGTATAACAACAGCCT CTACTACAGTGACACGAAAGGTGATGTTTATGTGTGGCTGCTGAATGGGA CGGATATCTCAGAGAATTATCACATACCCAACATTGCAGGAGCAGGGGCG TTAGCATTTGAGTGGCTGGGTCACTTTCTCTACTGGGCTGGAAAGACATA TGTGATACAAAGGCAGTCTTTGTTGACAGGATATACAGACGTTGTGACTC ATGTGAAGCAGTTGGTGAATGACATGGTGGTGGATTCAGTTGGTGGATAT CTCTACTGGACCACACTCTACTCAGTTGAAAGCACCAGACTAAATGGGGA AAGTTTGCTTGTACTACAGGCCCAGCCTTGGTTTTCTGGGAAAAAGGTAA TTGCTCTAACTTTAGACCTTAGTGATGGACTCCTGTATTGGTTGGTTCAA GACAGTCAGTGTATCCACCTGTATACAGCTGTTCTTCGGGGACAGAGTGC GGGAGATACCACCATCACAGAATTTGCGGCCTGGAGTACTTCTGAAATTT CCCAGAATGCACTGGTGTACTATAGTGGTCGGCTTTTCTGGATCAATGGT TTTAGAGTTATCACAGCTCAGGAAATAGGTCAGAGAACCAGTGTATCTGT TTCCGAACCAGCCAAGTTTACTCAGTTCACAATTATTCAGACATCCCTCA AGCCTCTGCCAGGGAACTTTTCTTTTACCCCTAAGGTTATCCCAGATTCT GTTCAAGAGTCTTCATTTAGGATTGAAGGAAATGCTTCGAGTTTTCAAAT CCTGTGGAATGCTCCCCCTTCAGTGGATTGGGGGGTTGTTTTCTACAGTG TGGAATTCAGTGCTCATTCTAAGTTCCTGGCTAGTGAACAACAGCTTTTA CCTGTATTTATGGTGGAAGGGCTGGAGCCCTATGCTACATTTAATCTTTC TGTCACTCCCTACACCTACTGGGGAAAGGGCCCCAAAACATCCCTATCTC TTCGGGCACCTGAAACAGTTCCATCAGCACCAGAGAACCCCAGAATATTT ATATTACCAAGTGGAAAATACCACAAGAACAAAGTTGTGGTGGAATTTAG ATGGACTAAACCTAAGCATGAAAATGGTGTGTTAACAAGATTTGAAATTT TCTATCAAATATCTAACCAAAGTGACACAAATAAAACATTCAAAGACTGG ATTGCTGTCAATGTCACTCCTTCAGTGATGTCTTTTCAACTTGAAGACAT GAGTCCTGGATACACTGTTGCCTTCCAGGTTCGGGTTTTCACATCTAAAG GGCCAGGACCATTTTCTGACATAGTAAAGTCTAAAACATCAGAAATCAAC CCATTTCCTTACCTCATAACTCTTCTTGGCAACAAGATAATATTTTTAGA TATGGATCGACATCAAGTTGTGTGGACCTTTTCAGTGGAAAGAGATATAA GTGCTGTAGGCTACACGATTGATAATGAGATGGGGTATTATGCTCAAGGA GACTCTCTCTTCCTTCTGAACTTGCACAATCATTCGAGCTCTGAGCTTTT CCGAGATGCAGTGGTTTCTAATGTCACAGCTATTACAATTGACTGGATTT CAAGGCACCTCTACTTTGCACTGAAAGAGTCACAAAATGGAATACAAATT TTTGATGTTGATCTTGAACACAAAGTGAAACGACCCAGGGAGCTAAAGAT TTTCAACAGGAATTCAACAATAATTTCTTTTTATGTATATCCTCTTTTAA GTCGCTTGTATTGGACAGAAGTTTCCGATTTTGGCTATCAGATGTTCTAC TACAGTATTATCAATCACACCTTGCACCGCATTCTGCAACCCACAGCCAC AAACCAACAAACTGGAAGAAGCCAATGTTTTTGTAATGTGACTGAATTTG AATTAAGTGGAGCAATGACTGTTGATACCTCTGACCTGGAGAAACCACAG ATATATTTTGCCAAAGGGCAAGAAATCTGGGCCACAGATCTGGAAGGATG TCAGTGTTGGAGAGTTATCATGATGCCTGGCGTGCTTGCAGAACAAACAC TTGTTAGCTTAACCGTGGATGGAGAATTTATATATTGGATCATCACAGTA AAGGACAGCACAGAGATTTGTCAAGCAAAGAAAAGAAATGGGGCAATCCT CTCCCAAGTGAAGGCCCTAGGGAGCAAGCAAATCTTGGCTTACAGTTCCG TTATGCAGCCTTTTCCAGACAAAGCATTTCTGTCTCTAGCTTCAACTATT GGAGAGCCAGCGCTACTTAATGCTACCAACAGTAGCCTCACCATCAGACT ACCTCCAGCCACAACGAACCTCACATGGAACAGCATTACCAGCCCTACGC CAACATACTTGGTCTGTTACACAGCAGTGAATGGCCGGAAAAACAGCTCT GACAGATGTAGAATGCTGGAATTTCAGGAGAGAATAGCCCTTATTGAAGA TTTACAACCATTTTCAACATATATGATACAAATAGCTGTAAAGAATTATT ACTCAGATCCTTCAGAACATTTACTTCTGGGAAAAGAGATTTGGGGAAAA ACCAAAAGTGGAGTACCAGAGGCAGTATGGCTCATTAACACAACTGTGCA GTCAGACACCAGTCTTATTATATCTTGGAGAGAATCTCACAAGCCAAATG GACCTAAAGAGTTAGTCCGATATCAATTGGCAATCTCACATCTGGGCCTA ATTCCTGAGACTCCTCGAAGACGAAGCGAATTTCCAAATGGAAGGCTTGC TCTGTTTGTTACTGCACTGTCTGGTGGACAATTATATGTGTTAAAGGTTC TGGCCTGCCACTCTGAGGAAATGTGGTGTGCTGAGAGTCATCCTGTCACT GTCAAAATGTTTGACACACCAGAGAAACCTTACGCCTTGGTTCCAGAGAA CACTAGTTTGCAATTAGAGTGGAAGGCTCCATCTAATGTTAACCTCATCA AATTTTGGTTTGAACTCCAGAAGTGGAAATACAACGAGTTTTACCATGCT AAAGCTTCATGCAGCCAAAATCCTGCTTATGTCTGTAACATCTCAAATCT ACAGCCTTATACTTCGTATAATGTTCGAGTAGTTGTGGTTTATGAAACAG GAGAAAACAGTACCTCACTTCCTGAAAGCTTTAAGACAAAAGCTGGAGTT CCAAGTAAACCAGGCATTCCAAAATTATTAGAAGGGAGCAAAAATTCAGT ACAGTGGGAAAAAGCTGAAGATAATGGAAGTAGACTTATGTACTATCTCC TTGAGATCAGAAAAGGCACTTCAAATGATTCAAAGAACCAGAGTTTGAAG TGGAGAATGACATTCAATAGTTCCTGTAGTAGCATTTGCATATGGAAGTC CAATAATCTGAAAGGGACTTTTCAGTTCAGAGTAGCAGCTGCAAATAATC TGGGATTTGGCGAATACAGTGACATCAGTGAGAATATTACATTAGTGGGA GATGGTTTTTGGATACCAGAAACAAGTTTTATACTTACTATTATAATAGG AATATTTCTGGTTGTTATAATTCCATTGGCTTTGGTTTGGCATAGAGGAT TAAAGAATAAGAAAACTTCCAAAGAAGGACTATCAGTTCTCATAAACGAA GACAAAGAGTTGGCTGAGCTGCGAGGCCTGGCGGCTGGAGTAGGACTGGC TAATGCCTGCTATGCCATACATACTCTTCCAACCCAAGAGGAGATTGAAA ATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCTGCGTCTCTTGTTGGGA AGTGGAGCCTTTGGGGAAGTGTATGAAGGGACAGCAGTAGACATCTTAGG AGCTGGAAGTGGAGAAATTAAAGTAGCAGTGAAGACTTTAAAAAAGGGCT CCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGC AAGTTTAATCACCCGAACATTCTGAAACAGCTTGGTGTTTGTCTGCTAAA TGAACCCCAGTACATTATCCTAGAACTGATGGAAGGAGGAGATCTTCTTA CCTATTTGCGTAAAGCCCGCATGACAACGTTTCACGGTCCTTTACTCACC TTGGTTGACCTTGTGGACCTGTGTGTAGATATTTCAAAAGGCTGTGTGTA CTTGGAGCAGATGCACTTCATTCACAGGGATCTGGCGGCTCGGAATTGCC TTGTCTCTGTGAAAGACTATACTAGTCCTTCAAGGATAGTAAAGATTGGA GACTTTGGACTTGCAAGGGACATCTATAAAAATGACTACTACAGAAAGAG AGGGGAAGGCCTGCTCCCTGTTCGCTGGATGGCTCCAGAAAGTCTGATGG ATGGGATCTTCACTACTCAGTCTGATGTATGGTCTTTTGGGATTCTGATT TGGGAGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCT AGATGTTTTAAACCATGTGCAAACAGGAGGGAGACTGGAGCCACCACGAA ATTGTCCTGATGATCTGTGGAATTTAATGACTCAATGCTGGGCTCAAGAA CCTGACCAAAGGCCTACTTTCTATAGCATTCAAGACCAGCTTCAATTATT CAGAAATGTCTCCCTAAATAGTATTTCTCAATGCAGAAGCGAAACAAACA CCAGTGGAATCATAAATGAAGGCTTTGAAGGCGAAGATGCCAATGTGATT TGTTCAAATTCAGATGGTGTTACACCAATTGCTTTAATGGAAGCCAAGAA CCAAGAAGGGCTAAACTATATGGTACTTGCTACAGAAAGCAGCCAAGGCG AAGAAAGTTCTGAGGGTCCTCTGGGCTCCAAGGAATCTGAATCTTGTGGT CTAAGAAAAGAAGAGAAGAAGCAACATGCAGACAAAGATTTCTGCCAAGA AAAACAAGTGGCTTACTGCCCTCCTGGCAAGCCTGAGGGCCTGAACTATG CTTGTCTCACTCACAGTGGATATGGAGATGGGTCTGAT |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 2347 | 1 | 2347 | Premature termination 599:E->TAA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetLysAsnIleTyrCysLeuIleProLysLeuValAsnPheAlaThrLeuGlyCysL
||||||||||||||| ||| |||||||||||| ||||||||||||
MetLysAsnIleTyrTrpPheIleLeuThrLeuValAsnPheValThrLeuGlyCysI
ATGAAGAACATTTACTGGTTTATTCTGACACTTGTCAATTTTGTGACTCTTGGCTGCA
euTrpIleSerValValGlnCysThrValLeuAsnSerCysLeuLysSerCysValTh
||||||||| |||||||||||||||||||||||||||||||||||||||||
leTrpIleSerGlyIleGlnCysThrValLeuAsnSerCysLeuLysSerCysValTh
TATGGATTTCTGGGATACAGTGTACAGTTTTAAACAGCTGCCTAAAGTCATGTGTAAC
rAsnLeuGlyGlnGlnLeuAsp{L} >>>> Target Intron 1 >>>> {eu}
||||||| { } 7773 bp { }
rAsnLeuValSerPheThrCys{*}+- ++{**}
TAACCTGGTAAGTTTCACTTGT{T}ga ag{AG}
GlyThrProHisAsnLeuSerGluProCysIleGlnGlyCysHisPheTrpAsnSerV
||||||||||||||||||||||||||||||
SerProValProCysCysProLeuGlnCysIleGlnGlyCysHisPheTrpAsnSerL
TCACCAGTGCCTTGTTGTCCCTTGCAGTGCATCCAAGGATGTCATTTTTGGAACTCTC
alAspGlnLysAsnCysAlaLeuLysCys >>>> Target Intron 2 >>>>
|||||| |||||||||||||||||| 8614 bp
euAspGlnGluAsnCysAlaLeuLysCys++ ++
TAGATCAGGAAAACTGTGCTTTAAAGTGTgt ag
ArgGluSerCysGluValGlyCysSerSerAlaGluGlyAlaTyrGluGluGluValL
||||||||||||||| ||||||||||||||||||||||||||||||||||||||||
ArgGluSerCysGluIleGlyCysSerSerAlaGluGlyAlaTyrGluGluGluValL
CGAGAGTCCTGTGAGATCGGCTGCAGCAGCGCGGAAGGTGCATACGAAGAGGAAGTAC
eu{G} >>>> Target Intron 3 >>>> {lu}AsnAlaAspLeuProThrAl
||{|} 227 bp {||}||||||||||||||||||||
eu{G}++ ++{lu}AsnAlaAspLeuProThrAl
TG{G}gt ag{AA}AATGCAGACCTTCCCACTGC
aProPheAlaSerSerIleGlySerHisAsnMetThrLeuArgTrpLysSerAlaAsn
|||||||||||||||||||||| ||| ||||||||||||||| ||||||
aProPheAlaSerSerIleGlyAsnHisSerValThrLeuArgTrpLysProAlaAsn
ACCCTTTGCTTCTTCTATTGGAAACCACAGTGTGACATTACGATGGAAACCTGCCAAT
PheSerGlyValLysTyrIleIleGlnTrpLysTyrAlaGlnLeuLeuGlySerTrpT
|||||||||||||||||||||||||||||| ||||||||| ||||||||||
ValSerGlyValLysTyrIleIleGlnTrpLysPheAlaGlnLeuProGlySerTrpT
GTCTCTGGAGTAAAATACATAATCCAGTGGAAATTTGCACAACTCCCGGGAAGTTGGA
hrTyrThrLys >>>> Target Intron 4 >>>> ThrValSerArgProSer
|||||||| 1893 bp |||||| |||
hrTyrThrGlu++ ++AlaValSerLysLeuSer
CTTACACGGAGgt agGCTGTGTCCAAGCTCTCA
TyrValValLysProLeuHisProPheThrGluTyrIlePheArgValValTrpIleP
||||||||| |||||||||||||||||| |||||||||||||||||||||||||
TyrValValGluProLeuHisProPheThrGlyTyrIlePheArgValValTrpIleP
TACGTGGTCGAACCCCTGCATCCCTTCACTGGATACATCTTTCGAGTGGTTTGGATCT
heThrAlaGlnLeuGlnLeuTyrSerProProSerProSerTyrArgThrHisProHi
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
heThrAlaGlnLeuGlnLeuTyrSerProProSerProSerTyrArgThrHisProTy
TCACAGCCCAGCTGCAGCTTTATTCCCCGCCAAGTCCCAGTTATAGGACCCATCCTTA
sGly{V} >>>> Target Intron 5 >>>> {al}ProGluThrAlaProLeu
|||{|} 3356 bp {||}||||||||||||||||||
rGly{V}++ ++{al}ProGluThrAlaProLeu
TGGA{G}gt ag{TT}CCTGAAACTGCTCCTCTC
IleArgAsnIleGluSerSerSerProAspThrValGluValSerTrpAspProProG
|||||||||||||||||||||||||||||||||||||||||||||||| |||||||
IleArgAsnIleGluSerSerSerProAspThrValGluValSerTrpThrProProG
ATTAGGAATATTGAGAGCTCAAGTCCTGACACTGTGGAAGTCAGCTGGACTCCACCTC
lnPheProGlyGlyProIleLeuGlyTyrAsnLeuArgLeuIleSerLysAsnGlnLy
||||||||||||||||||||||||||||||||||||||||| ||||||||||||||
lnPheProGlyGlyProIleLeuGlyTyrAsnLeuArgLeuThrSerLysAsnGlnLy
AATTCCCAGGTGGACCCATTTTGGGTTATAATTTAAGGCTAACCAGCAAAAATCAAAA
sLeuAspAlaGlyThrGlnArgThrSerPheGlnPheTyrSerThrLeuProAsnThr
||||||| ||||||||||||||||||||||||||||||||||||||||||||||||
sLeuAspSerGlyThrGlnArgThrSerPheGlnPheTyrSerThrLeuProAsnThr
ATTAGATTCAGGGACACAGAGAACCAGCTTCCAGTTTTACTCCACACTACCAAATACT
IleTyr{Ar} >>>> Target Intron 6 >>>> {g}PheSerIleAlaAlaV
|||{||} 648 bp {|}||||||||||||||||
ThrTyr{Ar}++ ++{g}PheSerIleAlaAlaV
ACCTAC{AG}gt ag{G}TTTTCTATTGCAGCAG
alAsnGluValGlyGluGlyProGluAlaGluSerSerIleThrThrSerSerSerAl
||||||||||||||||||||||||||||||||||||||||||||||||||||| ||
alAsnGluValGlyGluGlyProGluAlaGluSerSerIleThrThrSerSerLeuAl
TAAATGAAGTTGGTGAGGGGCCAGAAGCAGAATCTAGTATTACCACTTCATCCCTAGC
a{V} >>>> Target Intron 7 >>>> {al}GlnGlnGluGluGlnTrpLeu
|{|} 2106 bp {||}||| |||||||||||||||
a{V}++ ++{al}GlnGluGluGluGlnTrpLeu
A{G}gt ag{TA}CAAGAAGAGGAACAGTGGCTC
PheLeuSerArgLysThrSerLeuArgLysArgSerLeuLysHisLeuValAspGluA
||||||||||||||| |||||||||||||||||||||||| |||||||||||||
PheLeuSerArgLysSerSerLeuArgLysArgSerLeuLysTyrLeuValAspGluA
TTTTTATCCAGAAAATCTTCTTTAAGAAAGAGATCTTTAAAATATTTAGTAGATGAAG
laHisCysLeuArgLeuAspAlaIleTyrHisAsnIleThr{G} >>>> Target
||||||||||| ||||||||| ||||||||||||{|} 25
laHisCysLeuTrpSerAspAlaIleHisHisAsnIleThr{G}++
CACATTGCCTTTGGTCAGATGCTATACACCATAATATTACA{G}gt
Intron 8 >>>> {ly}IleSerValAspValHisGlnGlnIleValTyrPheSer
8 bp {||}||||||||| |||||||||||| ||||||||||||
++{ly}IleSerValAsnValHisGlnGlnValValTyrPheSer
ag{GA}ATATCAGTTAATGTCCACCAGCAAGTAGTCTATTTCTCT
GluGlyThrLeuIleTrpAlaLysLysAlaAlaAsnMetSerAspValSerAspLeuA
|||||||||||||||||| |||||| ||| ||| ||| ||||||||||
GluGlyThrLeuIleTrpMetLysLysSerAlaSerMetPheAspMetSerAspLeuA
GAAGGAACTCTCATATGGATGAAAAAGTCTGCCAGCATGTTTGATATGTCTGACCTAA
rgIlePheTyrArgGlySerGlyLeuIleSerSerIleSerIleAspTrpLeuTyrGl
||||||||||||||||||||||| ||||||||||||||| ||||||||||||||
rgIlePheTyrArgGlySerGlyPheIleSerSerIleSerThrAspTrpLeuTyrGl
GGATTTTTTACAGAGGTTCAGGATTCATTTCTTCTATCTCCACAGACTGGCTTTATCA
nArgMetTyrPheIleMetAspGluLeu >>>> Target Intron 9 >>>> V
|||||||||||||||||||||||||||| 1051 bp |
nArgMetTyrPheIleMetAspGluLeu++ ++V
GAGAATGTATTTTATCATGGATGAACTGgt agG
alCysValCysAspLeuGluAsnCysSerAsnIleGluGluIleThrProProSerIl
|||||||||||||||||||||||||||||||||||||||||||||||||| |||||
alCysValCysAspLeuGluAsnCysSerAsnIleGluGluIleThrProArgSerIl
TATGTGTGTGTGACTTAGAGAACTGCTCAAACATTGAAGAAATTACTCCACGCTCTAT
eSerAlaProGlnLysIleValAlaAspSerTyrAsn{Gl} >>>> Target Int
|||||||||||||||| ||||||||||||||||||{||} 4850
eSerAlaProGlnLysLeuValAlaAspSerTyrAsn{Gl}++
TAGTGCACCTCAAAAACTTGTGGCTGATTCATACAAT{GG}gt
ron 10 >>>> {y}TyrValPheTyrLeuLeuArgAspGlyIleTyrArgAlaAsp
bp {|}||| |||||||||||||||||||||||||||||| |||
++{y}TyrIlePheTyrLeuLeuArgAspGlyIleTyrArgValAsp
ag{G}TACATCTTTTATCTCTTGAGAGATGGCATTTACAGAGTGGAT
LeuProValProSerGlyArgCysAlaGluAlaValArgIleValGluSerCysThrL
||||||||||||||||||||| |||||||||||||||||| |
LeuProValProSerGlyArgAspThrArgAlaValArgIleValGluGlyPheMetL
CTCCCAGTGCCATCTGGTCGGGACACTCGAGCTGTGCGTATTGTAGAGGGTTTTATGT
euLysAspPheAlaIleLysProGlnAlaLysArgIleIleTyrPheAsnAspThrAl
|| ||||||||| ||||||||| |||||||||||||||||||||||||||||
euAsnAspPheAlaValLysProGlnSerLysArgIleIleTyrPheAsnAspThrAl
TAAATGACTTCGCAGTGAAGCCACAGTCCAAGCGAATCATTTACTTCAATGACACCGC
aGlnValPheMetSerThrPheLeuAspGlySerAlaSerHisLeuIleLeuProArg
||||||||||||||||||||||||||||||| |||||||||||||||||||||
aGlnValPheMetSerThrPheLeuAspGlyThrAlaSerHisLeuIleLeuProHis
CCAAGTCTTCATGTCAACATTTCTGGATGGTACTGCTTCCCATCTGATCTTACCTCAT
IleProPheAlaAspValLysSerPheAlaCysGluAsnAsnAspPheLeuValThrA
||| ||||||||||||||||||||||||||||||||||||||||||
ValSerPheThrGlyValLysSerPheAlaCysGluAsnAsnAspPheLeuValThrA
GTCTCCTTCACTGGTGTGAAGAGCTTTGCTTGTGAAAACAATGACTTCCTTGTCACAA
spGlyLysValIlePheGlnGlnAspAlaLeuSerPheAsnGluPheIleValGlyCy
|||||| |||||| ||| ||||||||||||||||||||||||||
snGlyLysAlaValPheGlnLysAspSerSerSerPheAsnGluPheIleValGlyCy
ATGGCAAGGCCGTTTTCCAAAAAGACTCTTCGTCTTTTAATGAGTTCATTGTGGGATG
sAspLeuSerHisIleGluGluPheGlyPheGlyAsnLeuValIlePheGlySerSer
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sAspLeuSerHisIleGluGluPheGlyPheGlyAsnLeuValIlePheGlySerSer
TGACCTGAGTCACATAGAAGAATTTGGGTTTGGAAACTTGGTCATCTTTGGCTCATCT
SerGlnLeuHisProLeuProGlyArgProGlnGluLeuSerValLeuPheGlySerH
||| |||||||||||| |||||||||||||||||||||||||||||||
AlaGlnProTyrProLeuProGlyHisProGlnGluLeuSerValLeuPheGlySerH
GCCCAGCCATACCCTCTGCCAGGCCACCCACAAGAACTCTCTGTGCTGTTTGGCTCTC
isGlnAlaLeuValGlnTrpLysProProAlaLeuAlaIleGlyAla{A} >>>> T
|||||||||||||||||||||||||||||||||||||||||||||||{|}
isGlnAlaLeuValGlnTrpLysProProAlaLeuAlaIleGlyAla{A}++
ACCAGGCCCTTGTTCAATGGAAGCCTCCTGCTCTCGCCATAGGAGCC{A}gt
arget Intron 11 >>>> {sn}ValIleLeuIleSerAspIleIleGluLeuPh
1315 bp {||}||| ||| ||||||||||||||||||||
-+{sn}ValPheLeuValSerAspIleIleGluLeuPh
tg{AT}GTATTCTTGGTTAGTGATATTATTGAACTCTT
eGluLeuGlyProSerAlaTrpGlnAsnTrpThrTyrGluValLysValSerThrGln
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
e***LeuGlyProSerAlaTrpGlnAsnTrpThrTyrGluValLysValSerThrGln
CTAATTAGGCCCTTCCGCCTGGCAGAACTGGACTTATGAGGTGAAAGTATCAACTCAG
AspProProGluValThrHisIlePheLeuAsnIleSerGlyThrMetLeuAsnValP
||| ||| |||||| ||| |||||||||||||||||| |||||||
AspLeuSerGluIleThrHisValPheSerAsnIleSerGlyThrMetMetAsnValP
GACCTTTCTGAAATCACTCATGTGTTCTCGAACATAAGTGGGACCATGATGAATGTGC
roGluLeuGlnSerAlaMetLysTyrLysValSerValArgAlaSerSerProLysAr
|| |||||||||||| ||||||||||||||||||||||||||||||||||||
roValLeuGlnSerAlaThrLysTyrLysValSerValArgAlaSerSerProLysGl
CTGTGCTGCAGAGTGCTACAAAATACAAGGTCTCCGTGAGAGCAAGTTCTCCCAAGGG
gProGlyProTrpSerGluProSerValGlyThrThrLeuValPro{A} >>>> Ta
|||||||||||||||||||||||||||||||||||| |||{|}
yThrGlyProTrpSerGluProSerValGlyThrThrLeuMetPro{A}++
GACAGGCCCCTGGTCGGAGCCCTCAGTGGGTACTACCCTGATGCCA{G}gt
rget Intron 12 >>>> {la}SerGluProProPheIleMetAlaValLysGlu
746 bp {||} ||||||||||||||||||||||||||||||
++{la}AlaGluProProPheIleMetAlaValLysGlu
ag{CC}GCAGAACCACCATTTATCATGGCTGTGAAAGAA
AspGlyLeuTrpSerLysProLeuAsnSerPheGlyProGlyGluPheLeuSerSerA
||||||||||||||||||||||||||| ||||||||||||||||||||||||||||
AspGlyLeuTrpSerLysProLeuAsnAsnPheGlyProGlyGluPheLeuSerSerA
GATGGGCTTTGGAGTAAACCATTAAACAACTTTGGCCCAGGAGAGTTCCTATCCTCTG
spIleGlyAsnValSer{A} >>>> Target Intron 13 >>>> {sp}MetA
|||||||||||||||||{|} 1376 bp {||}||||
spIleGlyAsnValSer{A}++ ++{sp}MetA
ACATAGGAAATGTGTCA{G}gt ag{AC}ATGG
spTrpTyrAsnAsnSerLeuTyrTyrSerAspThrLysGlyAspValPheValTrpLe
||||||||||||||||||||||||||||||||||||||||||||||| ||||||||
spTrpTyrAsnAsnSerLeuTyrTyrSerAspThrLysGlyAspValTyrValTrpLe
ACTGGTATAACAACAGCCTCTACTACAGTGACACGAAAGGTGATGTTTATGTGTGGCT
uLeuAsnGlyThrAspIleSerGluAsnTyrHisLeuProSerIleAlaGlyAlaGly
|||||||||||||||||||||||||||||||||| ||| |||||||||||||||
uLeuAsnGlyThrAspIleSerGluAsnTyrHisIleProAsnIleAlaGlyAlaGly
GCTGAATGGGACGGATATCTCAGAGAATTATCACATACCCAACATTGCAGGAGCAGGG
AlaLeuAlaPheGluTrpLeuGlyHisPheLeuTyrTrpAlaGlyLysThrTyrVal
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AlaLeuAlaPheGluTrpLeuGlyHisPheLeuTyrTrpAlaGlyLysThrTyrVal+
GCGTTAGCATTTGAGTGGCTGGGTCACTTTCTCTACTGGGCTGGAAAGACATATGTGg
>>>> Target Intron 14 >>>> IleGlnArgGlnSerValLeuThrGlyHi
3687 bp ||||||||||||||| |||||||||
+ ++IleGlnArgGlnSerLeuLeuThrGlyTy
t agATACAAAGGCAGTCTTTGTTGACAGGATA
sThrAspIleValThrHisValLysLeuLeuValAsnAspMetValValAspSerVal
|||||| ||||||||||||||| ||||||||||||||||||||||||||||||
rThrAspValValThrHisValLysGlnLeuValAsnAspMetValValAspSerVal
TACAGACGTTGTGACTCATGTGAAGCAGTTGGTGAATGACATGGTGGTGGATTCAGTT
GlyGlyTyrLeuTyrTrpThrThrLeuTyrSerValGluSerThrArgLeuAsnGlyG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GlyGlyTyrLeuTyrTrpThrThrLeuTyrSerValGluSerThrArgLeuAsnGlyG
GGTGGATATCTCTACTGGACCACACTCTACTCAGTTGAAAGCACCAGACTAAATGGGG
luSerSerLeuValLeuGlnThrGlnProTrpPheSerGlyLysLys >>>> Targ
||||| |||||||||||| ||||||||||||||||||||||||
luSerLeuLeuValLeuGlnAlaGlnProTrpPheSerGlyLysLys++
AAAGTTTGCTTGTACTACAGGCCCAGCCTTGGTTTTCTGGGAAAAAGgt
et Intron 15 >>>> ValIleAlaLeuThrLeuAspLeuSerAspGlyLeuLeu
4478 bp |||||||||||||||||||||||||||||||||||||||
++ValIleAlaLeuThrLeuAspLeuSerAspGlyLeuLeu
agGTAATTGCTCTAACTTTAGACCTTAGTGATGGACTCCTG
TyrTrpLeuValGlnAspSerGlnCysIleHisLeuTyrThrAlaValLeuArgGlyG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TyrTrpLeuValGlnAspSerGlnCysIleHisLeuTyrThrAlaValLeuArgGlyG
TATTGGTTGGTTCAAGACAGTCAGTGTATCCACCTGTATACAGCTGTTCTTCGGGGAC
ln{Se} >>>> Target Intron 16 >>>> {r}ThrGlyAspThrThrIleT
||{||} 11720 bp {|} ||||||||||||||||
ln{Se}++ ++{r}AlaGlyAspThrThrIleT
AG{AG}gt ag{T}GCGGGAGATACCACCATCA
hrGluPheAlaAlaTrpSerThrSerGluIleSerGlnAsnAlaLeuMetTyrTyrSe
||||||||||||||||||||||||||||||||||||||||||||||| ||||||||
hrGluPheAlaAlaTrpSerThrSerGluIleSerGlnAsnAlaLeuValTyrTyrSe
CAGAATTTGCGGCCTGGAGTACTTCTGAAATTTCCCAGAATGCACTGGTGTACTATAG
rGlyArgLeuPheTrpIleAsnGlyPheArgIleIleThrThrGlnGluIleGlyGln
||||||||||||||||||||||||||||||| |||||| |||||||||||||||
rGlyArgLeuPheTrpIleAsnGlyPheArgValIleThrAlaGlnGluIleGlyGln
TGGTCGGCTTTTCTGGATCAATGGTTTTAGAGTTATCACAGCTCAGGAAATAGGTCAG
LysThrSerValSerValLeuGluProAlaArgPheAsnGlnPheThrIleIleGlnT
||||||||||||||| ||||||||| ||| |||||||||||||||||||
ArgThrSerValSerValSerGluProAlaLysPheThrGlnPheThrIleIleGlnT
AGAACCAGTGTATCTGTTTCCGAACCAGCCAAGTTTACTCAGTTCACAATTATTCAGA
hrSerLeuLysProLeuPro{G} >>>> Target Intron 17 >>>> {ly}A
||||||||||||||||||||{|} 599 bp {||}|
hrSerLeuLysProLeuPro{G}++ ++{ly}A
CATCCCTCAAGCCTCTGCCA{G}gt ag{GG}A
snPheSerPheThrProLysValIleProAspSerValGlnGluSerSerPheArgIl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
snPheSerPheThrProLysValIleProAspSerValGlnGluSerSerPheArgIl
ACTTTTCTTTTACCCCTAAGGTTATCCCAGATTCTGTTCAAGAGTCTTCATTTAGGAT
eGluGlyAsnAlaSerSerPheGlnIleLeuTrpAsnGlyProProAlaValAspTrp
||||||||||||||||||||||||||||||||||||| |||||| |||||||||
eGluGlyAsnAlaSerSerPheGlnIleLeuTrpAsnAlaProProSerValAspTrp
TGAAGGAAATGCTTCGAGTTTTCAAATCCTGTGGAATGCTCCCCCTTCAGTGGATTGG
GlyValValPheTyrSerValGluPheSerAlaHisSerLys >>>> Target In
|||||||||||||||||||||||||||||||||||||||||| 366
GlyValValPheTyrSerValGluPheSerAlaHisSerLys++
GGGGTTGTTTTCTACAGTGTGGAATTCAGTGCTCATTCTAAGgt
tron 18 >>>> PheLeuAlaSerGluGlnHisSerLeuProValPheThrValGl
bp |||||||||||||||||| |||||||||||| |||||
++PheLeuAlaSerGluGlnGlnLeuLeuProValPheMetValGl
agTTCCTGGCTAGTGAACAACAGCTTTTACCTGTATTTATGGTGGA
uGlyLeuGluProTyrAlaLeuPheAsnLeuSerValThrProTyrThrTyrTrpGly
||||||||||||||||||| ||||||||||||||||||||||||||||||||||||
uGlyLeuGluProTyrAlaThrPheAsnLeuSerValThrProTyrThrTyrTrpGly
AGGGCTGGAGCCCTATGCTACATTTAATCTTTCTGTCACTCCCTACACCTACTGGGGA
LysGlyProLysThrSerLeuSerLeuArgAlaProGluThr{V} >>>> Target
||||||||||||||||||||||||||||||||||||||||||{|} 2
LysGlyProLysThrSerLeuSerLeuArgAlaProGluThr{V}++
AAGGGCCCCAAAACATCCCTATCTCTTCGGGCACCTGAAACA{G}gt
Intron 19 >>>> {al}ProSerAlaProGluAsnProArgIlePheIleLeuP
302 bp {||}|||||||||||||||||||||||||||||||||||||
++{al}ProSerAlaProGluAsnProArgIlePheIleLeuP
ag{TT}CCATCAGCACCAGAGAACCCCAGAATATTTATATTAC
roSerGlyLysCysCysAsnLysAsnGluValValValGluPheArgTrpAsnLysPr
||||||||||| |||||| ||||||||||||||||||||| |||||
roSerGlyLys---TyrHisLysAsnLysValValValGluPheArgTrpThrLysPr
CAAGTGGAAAA---TACCACAAGAACAAAGTTGTGGTGGAATTTAGATGGACTAAACC
oLysHisGluAsnGlyValLeuThrLysPheGluIlePheTyrAsnIleSerAsnGln
||||||||||||||||||||||||| ||||||||||||||| ||||||||||||
oLysHisGluAsnGlyValLeuThrArgPheGluIlePheTyrGlnIleSerAsnGln
TAAGCATGAAAATGGTGTGTTAACAAGATTTGAAATTTTCTATCAAATATCTAACCAA
SerIleThrAsnLysThrCysGluAspTrpIleAlaValAsnValThrProSerValM
||| |||||||||||| ||||||||||||||||||||||||||||||||||
SerAspThrAsnLysThrPheLysAspTrpIleAlaValAsnValThrProSerValM
AGTGACACAAATAAAACATTCAAAGACTGGATTGCTGTCAATGTCACTCCTTCAGTGA
etSerPheGlnLeuGluGlyMetSerProArgCysPheIleAlaPheGln >>>> T
||||||||||||||||| ||||||||| |||||||||
etSerPheGlnLeuGluAspMetSerProGlyTyrThrValAlaPheGln++
TGTCTTTTCAACTTGAAGACATGAGTCCTGGATACACTGTTGCCTTCCAGgt
arget Intron 20 >>>> ValArgAlaPheThrSerLysGlyProGlyProTyr
3420 bp |||||| ||||||||||||||||||||||||
++ValArgValPheThrSerLysGlyProGlyProPhe
agGTTCGGGTTTTCACATCTAAAGGGCCAGGACCATTT
AlaAspValValLysSerThrThrSer{G} >>>> Target Intron 21 >>>>
||| ||||||||| ||||||{|} 308 bp
SerAspIleValLysSerLysThrSer{G}++
TCTGACATAGTAAAGTCTAAAACATCA{G}gt
{lu}IleAsnProPheProHisLeuIleThrLeuLeuGlyAsnLysIleValPheL
{||}||||||||||||||| ||||||||||||||||||||||||||| ||||
++{lu}IleAsnProPheProTyrLeuIleThrLeuLeuGlyAsnLysIleIlePheL
ag{AA}ATCAACCCATTTCCTTACCTCATAACTCTTCTTGGCAACAAGATAATATTTT
euAspMetAspGlnAsnGlnValValTrpThrPheSerAlaGluArgValIleSerAl
||||||||||| ||||||||||||||||||||| |||||| ||||||||
euAspMetAspArgHisGlnValValTrpThrPheSerValGluArgAspIleSerAl
TAGATATGGATCGACATCAAGTTGTGTGGACCTTTTCAGTGGAAAGAGATATAAGTGC
aValCysTyrThrAlaAspAsnGluMetGlyTyrTyrAlaGluGlyAspSerLeuPhe
|||| |||||| |||||||||||||||||||||||| |||||||||||||||
aValGlyTyrThrIleAspAsnGluMetGlyTyrTyrAlaGlnGlyAspSerLeuPhe
TGTAGGCTACACGATTGATAATGAGATGGGGTATTATGCTCAAGGAGACTCTCTCTTC
LeuLeuHisLeuHisAsnArgSerSerSerGlu >>>> Target Intron 22 >
|||||| ||||||||| |||||||||||| 3617 bp
LeuLeuAsnLeuHisAsnHisSerSerSerGlu++
CTTCTGAACTTGCACAATCATTCGAGCTCTGAGgt
>>> LeuPheGlnAspSerLeuValPheAspIleThrValIleThrIleAspTrpIl
|||||| ||| ||| ||| |||||||||||||||||
++LeuPheArgAspAlaValValSerAsnValThrAlaIleThrIleAspTrpIl
agCTTTTCCGAGATGCAGTGGTTTCTAATGTCACAGCTATTACAATTGACTGGAT
eSerArgHisLeuTyrPheAlaLeuLysGluSerGlnAsnGlyMetGlnValPheAsp
||||||||||||||||||||||||||||||||||||||||||| ||| ||||||
eSerArgHisLeuTyrPheAlaLeuLysGluSerGlnAsnGlyIleGlnIlePheAsp
TTCAAGGCACCTCTACTTTGCACTGAAAGAGTCACAAAATGGAATACAAATTTTTGAT
ValAspLeuGluHisLysValLysTyrProArgGluValLysIleHisAsnArgAsnS
|||||||||||||||||||||||| ||||||||| |||||| ||||||||||
ValAspLeuGluHisLysValLysArgProArgGluLeuLysIlePheAsnArgAsnS
GTTGATCTTGAACACAAAGTGAAACGACCCAGGGAGCTAAAGATTTTCAACAGGAATT
erThrIleIleSerPheSerValTyrProLeuLeu{Se} >>>> Target Intro
||||||||||||||||| |||||||||||||||{||} 1271 bp
erThrIleIleSerPheTyrValTyrProLeuLeu{Se}++
CAACAATAATTTCTTTTTATGTATATCCTCTTTTA{AG}gt
n 23 >>>> {r}ArgLeuTyrTrpThrGluValSerAsnPheGlyTyrGlnMetPh
{|}|||||||||||||||||||||||| |||||||||||||||||
++{r}ArgLeuTyrTrpThrGluValSerAspPheGlyTyrGlnMetPh
ag{T}CGCTTGTATTGGACAGAAGTTTCCGATTTTGGCTATCAGATGTT
eTyrTyrSerIleIleSerHisThrLeuHisArgIleLeuGlnProThrAlaThrAsn
|||||||||||||||| |||||||||||||||||||||||||||||||||||||||
eTyrTyrSerIleIleAsnHisThrLeuHisArgIleLeuGlnProThrAlaThrAsn
CTACTACAGTATTATCAATCACACCTTGCACCGCATTCTGCAACCCACAGCCACAAAC
GlnGlnAsnLysArgAsnGlnCysSerCysAsnValThrGluPheGluLeuSerGlyA
|||||| ||| |||||| |||||||||||||||||||||||||||||||
GlnGlnThrGlyArgSerGlnCysPheCysAsnValThrGluPheGluLeuSerGlyA
CAACAAACTGGAAGAAGCCAATGTTTTTGTAATGTGACTGAATTTGAATTAAGTGGAG
laMetAlaIleAspThrSerAsnLeuGluLysProLeuIleTyrPheAlaLysAlaGl
||||| ||||||||| |||||||||||| ||||||||||||||| ||
laMetThrValAspThrSerAspLeuGluLysProGlnIleTyrPheAlaLysGlyGl
CAATGACTGTTGATACCTCTGACCTGGAGAAACCACAGATATATTTTGCCAAAGGGCA
nGluIleTrpAlaMetAspLeuGluGlyCysGlnCysTrpArgValIleThrValPro
||||||||||||| ||||||||||||||||||||||||||||||||| |||
nGluIleTrpAlaThrAspLeuGluGlyCysGlnCysTrpArgValIleMetMetPro
AGAAATCTGGGCCACAGATCTGGAAGGATGTCAGTGTTGGAGAGTTATCATGATGCCT
AlaMetLeu{A} >>>> Target Intron 24 >>>> {la}GlyLysThrLeu
|||{|} 3367 bp {||} ||||||
GlyValLeu{A}++ +-{la}GluGlnThrLeu
GGCGTGCTT{G}gt aa{CA}GAACAAACACTT
ValSerLeuThrValAspGlyAspLeuIleTyrTrpIleIleThrAlaLysAspSerT
||||||||||||||||||||| |||||||||||||||||| ||||||||||
ValSerLeuThrValAspGlyGluPheIleTyrTrpIleIleThrValLysAspSerT
GTTAGCTTAACCGTGGATGGAGAATTTATATATTGGATCATCACAGTAAAGGACAGCA
hrGlnIleTyrGlnAlaLysLysGlyAsnGlyAlaIleValSerGlnValLysAlaLe
|| ||| |||||||||||| |||||||||||| |||||||||||||||||
hrGluIleCysGlnAlaLysLysArgAsnGlyAlaIleLeuSerGlnValLysAlaLe
CAGAGATTTGTCAAGCAAAGAAAAGAAATGGGGCAATCCTCTCCCAAGTGAAGGCCCT
uArgSerArgHisIleLeuAlaTyrSerSerValMetGlnProPhePro{A} >>>>
| ||| ||||||||||||||||||||||||||||||||||||{|}
uGlySerLysGlnIleLeuAlaTyrSerSerValMetGlnProPhePro{A}++
AGGGAGCAAGCAAATCTTGGCTTACAGTTCCGTTATGCAGCCTTTTCCA{G}gt
Target Intron 25 >>>> {sp}LysAlaPheLeuSerLeuAlaSerAspThr
7073 bp {||}||||||||||||||||||||||||
++{sp}LysAlaPheLeuSerLeuAlaSerThrIle
ag{AC}AAAGCATTTCTGTCTCTAGCTTCAACTATT
ValGluProThrIleLeuAsnAlaThrAsnThrSerLeuThrIleArgLeuProLeuA
|||||| ||||||||||||||| ||||||||||||||||||||| |
GlyGluProAlaLeuLeuAsnAlaThrAsnSerSerLeuThrIleArgLeuProProA
GGAGAGCCAGCGCTACTTAATGCTACCAACAGTAGCCTCACCATCAGACTACCTCCAG
laLysThrAsnLeuThrTrpTyrGlyIleThrSerProThrProThrTyrLeuValTy
|| ||||||||||||||| ||||||||||||||||||||||||||||||
laThrThrAsnLeuThrTrpAsnSerIleThrSerProThrProThrTyrLeuValCy
CCACAACGAACCTCACATGGAACAGCATTACCAGCCCTACGCCAACATACTTGGTCTG
rTyrAlaGluValAsnAspArgLysAsnSerSerAspLeuLysTyrArgIleLeu >
||| |||||| |||||||||||||||||| ||| |||
sTyrThrAlaValAsnGlyArgLysAsnSerSerAsp---ArgCysArgMetLeu++
TTACACAGCAGTGAATGGCCGGAAAAACAGCTCTGAC---AGATGTAGAATGCTGgt
>>> Target Intron 26 >>>> GluPheGlnAspSerIleAlaLeuIleGluA
1683 bp ||||||||| ||||||||||||||||
++GluPheGlnGluArgIleAlaLeuIleGluA
agGAATTTCAGGAGAGAATAGCCCTTATTGAAG
spLeuGlnProPheSerThrTyrMetIleGlnIleAlaValLysAsnTyrTyrSerAs
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
spLeuGlnProPheSerThrTyrMetIleGlnIleAlaValLysAsnTyrTyrSerAs
ATTTACAACCATTTTCAACATATATGATACAAATAGCTGTAAAGAATTATTACTCAGA
pProLeuGluHisLeuProProGlyLysGluIleTrpGlyLysThrLysAsnGly{V}
|||| ||||||||| ||||||||||||||||||||||||||| |||{|}
pProSerGluHisLeuLeuLeuGlyLysGluIleTrpGlyLysThrLysSerGly{V}
TCCTTCAGAACATTTACTTCTGGGAAAAGAGATTTGGGGAAAAACCAAAAGTGGA{G}
>>>> Target Intron 27 >>>> {al}ProGluAlaValGlnLeuIleAsn
1382 bp {||}|||||||||||| |||||||||
++ ++{al}ProGluAlaValTrpLeuIleAsn
gt ag{TA}CCAGAGGCAGTATGGCTCATTAAC
ThrThrValArgSerAspThrSerLeuIleIleSerTrpArgGluSerHisLysProA
||||||||| ||||||||||||||||||||||||||||||||||||||||||||||
ThrThrValGlnSerAspThrSerLeuIleIleSerTrpArgGluSerHisLysProA
ACAACTGTGCAGTCAGACACCAGTCTTATTATATCTTGGAGAGAATCTCACAAGCCAA
snGlyProLysGluSerValArgTyrGlnLeuAlaIleSerHisLeuAlaLeuIlePr
|||||||||||||| |||||||||||||||||||||||||||||| ||||||||
snGlyProLysGluLeuValArgTyrGlnLeuAlaIleSerHisLeuGlyLeuIlePr
ATGGACCTAAAGAGTTAGTCCGATATCAATTGGCAATCTCACATCTGGGCCTAATTCC
oGluThrProLeuArgGlnSerGluPheProAsnGlyArgLeuThrLeuLeuValThr
|||||||||| ||| |||||||||||||||||||||||| ||| ||||||
oGluThrProArgArgArgSerGluPheProAsnGlyArgLeuAlaLeuPheValThr
TGAGACTCCTCGAAGACGAAGCGAATTTCCAAATGGAAGGCTTGCTCTGTTTGTTACT
ArgLeuSerGlyGlyAsnIleTyrValLeuLys >>>> Target Intron 28 >
|||||||||||| |||||||||||| 84 bp
AlaLeuSerGlyGlyGlnLeuTyrValLeuLys++
GCACTGTCTGGTGGACAATTATATGTGTTAAAGgt
>>> ValLeuAlaCysHisSerGluGluMetTrpCysThrGluSerHisProValTh
||||||||||||||||||||||||||||||||| |||||||||||||||||
++ValLeuAlaCysHisSerGluGluMetTrpCysAlaGluSerHisProValTh
agGTTCTGGCCTGCCACTCTGAGGAAATGTGGTGTGCTGAGAGTCATCCTGTCAC
rValGluMetPheAsnThrProGluLysProTyrSerLeuValProGluAsnThrSer
|||| |||||| |||||||||||||||||| |||||||||||||||||||||
rValLysMetPheAspThrProGluLysProTyrAlaLeuValProGluAsnThrSer
TGTCAAAATGTTTGACACACCAGAGAAACCTTACGCCTTGGTTCCAGAGAACACTAGT
LeuGlnPheAsnTrpLysAlaProLeuAsnValAsnLeuIleArgPheTrpValGluL
|||||| |||||||||||| ||||||||||||||| |||||| ||||
LeuGlnLeuGluTrpLysAlaProSerAsnValAsnLeuIleLysPheTrpPheGluL
TTGCAATTAGAGTGGAAGGCTCCATCTAATGTTAACCTCATCAAATTTTGGTTTGAAC
euGlnLys >>>> Target Intron 29 >>>> TrpLysTyrAsnGluPheTy
|||||||| 6402 bp ||||||||||||||||||||
euGlnLys++ ++TrpLysTyrAsnGluPheTy
TCCAGAAGgt agTGGAAATACAACGAGTTTTA
rHisValLysThrSerCysSerGlnGlyProAlaTyrValCysAsnIleThrAsnLeu
|||| ||| |||||||||||| ||||||||||||||||||||| ||||||
rHisAlaLysAlaSerCysSerGlnAsnProAlaTyrValCysAsnIleSerAsnLeu
CCATGCTAAAGCTTCATGCAGCCAAAATCCTGCTTATGTCTGTAACATCTCAAATCTA
GlnProTyrThrSerTyrAsnValArgValValValValTyrLysThrGlyGluAsnS
|||||||||||||||||||||||||||||||||||||||||| |||||||||||||
GlnProTyrThrSerTyrAsnValArgValValValValTyrGluThrGlyGluAsnS
CAGCCTTATACTTCGTATAATGTTCGAGTAGTTGTGGTTTATGAAACAGGAGAAAACA
erThrSerLeuProGluSerPheLysThrLys{A} >>>> Target Intron 30
||||||||||||||||||||||||||||||||{|} 1159 bp
erThrSerLeuProGluSerPheLysThrLys{A}++
GTACCTCACTTCCTGAAAGCTTTAAGACAAAA{G}gt
>>>> {la}GlyValProAsnLysProGlyIleProLysLeuLeuGluGlySerLy
{||}||||||||| |||||||||||||||||||||||||||||||||||
++{la}GlyValProSerLysProGlyIleProLysLeuLeuGluGlySerLy
ag{CT}GGAGTTCCAAGTAAACCAGGCATTCCAAAATTATTAGAAGGGAGCAA
sAsnSerIleGlnTrpGluLysAlaGluAspAsnGlyCysArgIleThrTyrTyrIle
||||||| ||||||||||||||||||||||||||| ||| ||||||
sAsnSerValGlnTrpGluLysAlaGluAspAsnGlySerArgLeuMetTyrTyrLeu
AAATTCAGTACAGTGGGAAAAAGCTGAAGATAATGGAAGTAGACTTATGTACTATCTC
LeuGluIle{Ar} >>>> Target Intron 31 >>>> {g}LysSerThrSer
|||||||||{||} 3340 bp {|}||| ||||||
LeuGluIle{Ar}++ ++{g}LysGlyThrSer
CTTGAGATC{AG}gt ag{A}AAAGGCACTTCA
AsnAsnLeuGlnAsnGlnAsnLeuArgTrpLysMetThrPheAsnGlySerCysSerS
||| |||||| ||| ||| |||||||||||| ||||||||||
AsnAspSerLysAsnGlnSerLeuLysTrpArgMetThrPheAsnSerSerCysSerS
AATGATTCAAAGAACCAGAGTTTGAAGTGGAGAATGACATTCAATAGTTCCTGTAGTA
erValCysThrTrpLysSerLysAsnLeuLysGlyIlePheGlnPheArgValValAl
|| ||| ||||||||| |||||||||||| ||||||||||||||| ||
erIleCysIleTrpLysSerAsnAsnLeuLysGlyThrPheGlnPheArgValAlaAl
GCATTTGCATATGGAAGTCCAATAATCTGAAAGGGACTTTTCAGTTCAGAGTAGCAGC
aAlaAsnAsnLeuGlyPheGlyGluTyrSerGlyIleSerGluAsnIleIleLeuVal
||||||||||||||||||||||||||||||| ||||||||||||||| ||||||
aAlaAsnAsnLeuGlyPheGlyGluTyrSerAspIleSerGluAsnIleThrLeuVal
TGCAAATAATCTGGGATTTGGCGAATACAGTGACATCAGTGAGAATATTACATTAGTG
Gly{A} >>>> Target Intron 32 >>>> {sp}AspPheTrpIleProGlu
|||{|} 2680 bp {||} |||||||||||||||
Gly{A}++ ++{sp}GlyPheTrpIleProGlu
GGA{G}gt ag{AT}GGTTTTTGGATACCAGAA
ThrSerPheIleLeuThrIleIleValGlyIlePheLeuValValThrIleProLeuT
|||||||||||||||||||||||| |||||||||||||||||| |||||||||
ThrSerPheIleLeuThrIleIleIleGlyIlePheLeuValValIleIleProLeuA
ACAAGTTTTATACTTACTATTATAATAGGAATATTTCTGGTTGTTATAATTCCATTGG
hrPhe{V} >>>> Target Intron 33 >>>> {al}TrpHisArgArgLeuL
{|} 3599 bp {||}||||||||| ||||
laLeu{V}++ ++{al}TrpHisArgGlyLeuL
CTTTG{G}gt ag{TT}TGGCATAGAGGATTAA
ysAsnGlnLysSerAlaLysGluGlyValThrValLeuIleAsnGluAspLysGluLe
||||| ||| ||||||||| ||||||||||||||||||||||||||
ysAsnLysLysThrSerLysGluGlyLeuSerValLeuIleAsnGluAspLysGluLe
AGAATAAGAAAACTTCCAAAGAAGGACTATCAGTTCTCATAAACGAAGACAAAGAGTT
uAlaGluLeuArgGlyLeuAlaAlaGlyValGlyLeuAlaAsnAlaCysTyrAlaIle
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
uAlaGluLeuArgGlyLeuAlaAlaGlyValGlyLeuAlaAsnAlaCysTyrAlaIle
GGCTGAGCTGCGAGGCCTGGCGGCTGGAGTAGGACTGGCTAATGCCTGCTATGCCATA
{Hi} >>>> Target Intron 34 >>>> {s}ThrLeuProThrGlnGluGlu
{||} 2365 bp {|}|||||||||||||||||||||
{Hi}++ ++{s}ThrLeuProThrGlnGluGlu
{CA}gt ag{T}ACTCTTCCAACCCAAGAGGAG
IleGluAsnLeuProAlaPheProArgGluLysLeuThrLeuArgLeuLeuLeuGlyS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IleGluAsnLeuProAlaPheProArgGluLysLeuThrLeuArgLeuLeuLeuGlyS
ATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCTGCGTCTCTTGTTGGGAA
erGlyAlaPheGlyGluValTyrGluGlyThrAlaValAspIleLeuGlyValGlySe
|||||||||||||||||||||||||||||||||||||||||||||||||| |||||
erGlyAlaPheGlyGluValTyrGluGlyThrAlaValAspIleLeuGlyAlaGlySe
GTGGAGCCTTTGGGGAAGTGTATGAAGGGACAGCAGTAGACATCTTAGGAGCTGGAAG
rGlyGluIleLysValAlaValLys >>>> Target Intron 35 >>>> Thr
||||||||||||||||||||||||| 2426 bp |||
rGlyGluIleLysValAlaValLys++ ++Thr
TGGAGAAATTAAAGTAGCAGTGAAGgt agACT
LeuLysLysGlySerThrAspGlnGluLysIleGluPheLeuLysGluAlaHisLeuM
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuLysLysGlySerThrAspGlnGluLysIleGluPheLeuLysGluAlaHisLeuM
TTAAAAAAGGGCTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGA
et{Se} >>>> Target Intron 36 >>>> {r}LysPheAsnHisProAsnI
||{||} 906 bp {|}|||||||||||||||||||
et{Se}++ ++{r}LysPheAsnHisProAsnI
TG{AG}gt ag{C}AAGTTTAATCACCCGAACA
leLeuLysGlnLeuGlyValCysLeuLeuAsnGluProGlnTyrIleIleLeuGluLe
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
leLeuLysGlnLeuGlyValCysLeuLeuAsnGluProGlnTyrIleIleLeuGluLe
TTCTGAAACAGCTTGGTGTTTGTCTGCTAAATGAACCCCAGTACATTATCCTAGAACT
uMetGluGlyGlyAspLeuLeuThrTyrLeuArgLysAlaArgMetAlaThr >>>>
|||||||||||||||||||||||||||||||||||||||||||||| |||
uMetGluGlyGlyAspLeuLeuThrTyrLeuArgLysAlaArgMetThrThr++
GATGGAAGGAGGAGATCTTCTTACCTATTTGCGTAAAGCCCGCATGACAACGgt
Target Intron 37 >>>> PheTyrGlyProLeuLeuThrLeuValAspLeuV
27365 bp ||| ||||||||||||||||||||||||||||
++PheHisGlyProLeuLeuThrLeuValAspLeuV
agTTTCACGGTCCTTTACTCACCTTGGTTGACCTTG
alAspLeuCysValAspIleSerLysGlyCysValTyrLeuGluArgMetHisPheIl
|||||||||||||||||||||||||||||||||||||||||||| |||||||||||
alAspLeuCysValAspIleSerLysGlyCysValTyrLeuGluGlnMetHisPheIl
TGGACCTGTGTGTAGATATTTCAAAAGGCTGTGTGTACTTGGAGCAGATGCACTTCAT
eHis{Ar} >>>> Target Intron 38 >>>> {g}AspLeuAlaAlaArgAs
||||{||} 496 bp {|}|||||||||||||||||
eHis{Ar}++ ++{g}AspLeuAlaAlaArgAs
TCAC{AG}gt ag{G}GATCTGGCGGCTCGGAA
nCysLeuValSerValLysAspTyrThrSerPro<->ArgIleValLysIleGlyAsp
|||||||||||||||||||||||||||||||||| |||||||||||||||||||||
nCysLeuValSerValLysAspTyrThrSerProSerArgIleValLysIleGlyAsp
TTGCCTTGTCTCTGTGAAAGACTATACTAGTCCTTCAAGGATAGTAAAGATTGGAGAC
PheGlyLeuAlaArgAspIleTyrLysAsnAspTyrTyrArgLysArgGlyGluGlyL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PheGlyLeuAlaArgAspIleTyrLysAsnAspTyrTyrArgLysArgGlyGluGlyL
TTTGGACTTGCAAGGGACATCTATAAAAATGACTACTACAGAAAGAGAGGGGAAGGCC
euLeuProValArgTrpMetAlaProGluSerLeuMetAspGlyIlePheThrThrGl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euLeuProValArgTrpMetAlaProGluSerLeuMetAspGlyIlePheThrThrGl
TGCTCCCTGTTCGCTGGATGGCTCCAGAAAGTCTGATGGATGGGATCTTCACTACTCA
nSerAspVal{Tr} >>>> Target Intron 39 >>>> {p}SerPheGlyIl
||||||||||{||} 1093 bp {|}|||||||||||
nSerAspVal{Tr}++ ++{p}SerPheGlyIl
GTCTGATGTA{TG}gt ag{G}TCTTTTGGGAT
eLeuIleTrpGluIleLeuThrLeuGlyHisGlnProTyrProAlaHisSerAsnLeu
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
eLeuIleTrpGluIleLeuThrLeuGlyHisGlnProTyrProAlaHisSerAsnLeu
TCTGATTTGGGAGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTA
AspValLeuAsnTyrValGlnThrGlyGlyArgLeuGluProProArgAsnCysProA
|||||||||||| |||||||||||||||||||||||||||||||||||||||||||
AspValLeuAsnHisValGlnThrGlyGlyArgLeuGluProProArgAsnCysProA
GATGTTTTAAACCATGTGCAAACAGGAGGGAGACTGGAGCCACCACGAAATTGTCCTG
spAsp{Le} >>>> Target Intron 40 >>>> {u}TrpAsnLeuMetThrG
|||||{||} 8101 bp {|}||||||||||||||||
spAsp{Le}++ ++{u}TrpAsnLeuMetThrG
ATGAT{CT}gt ag{G}TGGAATTTAATGACTC
lnCysTrpAlaGlnGluProAspGlnArgProThrPheHisArgIleGlnAspGlnLe
|||||||||||||||||||||||||||||||||||||| ||||||||||||||
lnCysTrpAlaGlnGluProAspGlnArgProThrPheTyrSerIleGlnAspGlnLe
AATGCTGGGCTCAAGAACCTGACCAAAGGCCTACTTTCTATAGCATTCAAGACCAGCT
uGlnLeuPheArgAsnPhePheLeuAsnSerIleTyrLysSerArgAspGluAlaAsn
|||||||||||||||| |||||||||||| ||| ||| |||
uGlnLeuPheArgAsnValSerLeuAsnSerIleSerGlnCysArgSerGluThrAsn
TCAATTATTCAGAAATGTCTCCCTAAATAGTATTTCTCAATGCAGAAGCGAAACAAAC
AsnSerGlyValIleAsnGluSerPheGlu{G} >>>> Target Intron 41 >
|||||| ||||||||| ||||||{|} 10003 bp
ThrSerGlyIleIleAsnGluGlyPheGlu{G}++
ACCAGTGGAATCATAAATGAAGGCTTTGAA{G}gt
>>> {ly}GluAspGlyAspValIleCysLeuAsnSerAspAspIleMetProValA
{||}|||||| ||||||||| ||||||||| ||| |
++{ly}GluAspAlaAsnValIleCysSerAsnSerAspGlyValThrProIleA
ag{GC}GAAGATGCCAATGTGATTTGTTCAAATTCAGATGGTGTTACACCAATTG
laLeuMetGluThrLysAsnArgGluGlyLeuAsnTyrMetValLeuAlaThrGluCy
||||||||||| |||||| |||||||||||||||||||||||||||||||||
laLeuMetGluAlaLysAsnGlnGluGlyLeuAsnTyrMetValLeuAlaThrGluSe
CTTTAATGGAAGCCAAGAACCAAGAAGGGCTAAACTATATGGTACTTGCTACAGAAAG
sGlyGlnGlyGluGluLysSerGluGlyProLeuGlySerGlnGluSerGluSerCys
|||||||||||| ||||||||||||||||||||| |||||||||||||||
rSerGlnGlyGluGluSerSerGluGlyProLeuGlySerLysGluSerGluSerCys
CAGCCAAGGCGAAGAAAGTTCTGAGGGTCCTCTGGGCTCCAAGGAATCTGAATCTTGT
GlyLeuArgLysGluGluLysGluProHisAlaAspLysAspPheCysGlnGluLysG
||||||||||||||||||||| |||||||||||||||||||||||||||||||
GlyLeuArgLysGluGluLysLysGlnHisAlaAspLysAspPheCysGlnGluLysG
GGTCTAAGAAAAGAAGAGAAGAAGCAACATGCAGACAAAGATTTCTGCCAAGAAAAAC
lnValAlaTyrCysProSerGlyLysProGluGlyLeuAsnTyrAlaCysLeuThrHi
||||||||||||||||| ||||||||||||||||||||||||||||||||||||||
lnValAlaTyrCysProProGlyLysProGluGlyLeuAsnTyrAlaCysLeuThrHi
AAGTGGCTTACTGCCCTCCTGGCAAGCCTGAGGGCCTGAACTATGCTTGTCTCACTCA
sSerGlyTyrGlyAspGlySerAsp
|||||||||||||||||||||||||
sSerGlyTyrGlyAspGlySerAsp
CAGTGGATATGGAGATGGGTCTGAT
//
|