Gene information

Basic information

Official Symbol	RBMS1
Description	RNA binding motif, single stranded interacting protein 1
Other Aliases	C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1
Other Description	RNA-binding motif, single-stranded-interacting protein 1; c-myc gene single strand binding protein 2; cervical cancer oncogene 4; single-stranded DNA-binding protein MSSP-1; suppressor of CDC2 with RNA-binding motif 2; suppressor of cdc 2 (cdc13) with RNA binding motif 2
Mutation type	Insert and frame-shift 307-308:Y-R^C
Location	Scaffold000674_2:2680794 2798834 + ± bp flank
Wiki	Wikipedia GeneCard

Sequence

RBMS1

CAGCAGTCTCTGGTCCCAACGCACCCCATGGCCCCTCCCAGTCCCAGCAC
CACCAGCAGTAATAACAACAGTAGCAGCAGCAGCAACTCAGGATGGGATC
AGCTAAGCAAAACGAACCTCTACATCCGAGGCCTGCCTCCCAACACCACC
GACCAGGACCTGGTGAAACTCTGTCAACCATATGGGAAAATAGTCTCTAC
AAAAGCAATTTTGGATAAGACAACAAACAAATGCAAAGGTTACGGTTTTG
TCGACTTTGACAGTCCTGCAGCGGCCCAGAAAGCTGTGTCTGCCCTGAAG
GCTAGCGGAGTTCAAGCTCAAATGGCCAAGCAACAAGAACAAGACCCTAC
CAACCTGTATATTTCTAATTTGCCACTGTCCATGGATGAACAAGAGCTTG
AAAACATGCTCAAACCATTTGGACAAGTCATTTCTACAAGGATATTACGT
GACTCCAGTGGTACAAGTCGTGGCGTTGGCTTTGCTAGGATGGAATCAAC
AGAAAAATGCGAAGCCGTTATTGGTCATTTCAATGGAAAATTCATTAAGA
CACCACCAGGAGTTTCTGCTCCTACAGAACCTTTATTGTGTAAGTTTGCC
GATGGAGGACAGAAGAAGAGACAGAACCCGAACAAATACATCCCCAATGG
AAGACCATGGCATAGAGAAGGAGAGGCTGGAATGACACTTACTTACGACC
CAACCACAGCTGCTATACAGAACGGATTTTATCCTTCACCATACAGTATT
GCTACAAACCGAATGATCACTCAAACTTCCATTACACCTTATATTGCATC
TCCTGTATCTGCCTACCAGGTGGCAAAGGAAACGAGAGAAAGCAAGTATA
GGGGCTCTGCGGTTAAGGTGCAAAGTCCTTCTTGGATGCAGCCTCAACCG
TACATCCTACAGCACCCGGGTGCCGTGTTAACTCCCTCAATGGAGCACAC
CATGTCACTACAACCTGCATCTATGATCAGCCCTCTGGCCCAGCAGATGA
GTCATCTGTCACTAGGCAGCACCGGAACATACATGCCTGCAACATCAGCT
ATGCAAGGAGCCTATCTGCCACAGTACGCACACATGCAGACAGCGGCGGT
TCCTGTTGAGGAGGCAAGTGGTCAGCAGCAGGTGACTGTAGAGACGTCTA
ATGACCATTCTCCATATACTTTTCAACCCAATAAG

Alignment

Align specie	Pep length	Pep align begin	Pep align end	Mutaion type and postion
Human	419	25	419	Insert and frame-shift 307-308:Y-R^C

 Instructions:
 *** -> premature termination codon;  # -> frame shift 

 Alignment:
 Human     pep sequence --->
 ||||||||||||||||||||||
 Treeshrew pep sequence --->
 Treeshrew cds sequence --->
  
  LysGlnSerLeuValProAlaHisProMetAlaProProSerProSerThrThrSerS
     |||||||||||||||   |||||||||||||||||||||||||||||||||||||
  GlnGlnSerLeuValProThrHisProMetAlaProProSerProSerThrThrSerS
  CAGCAGTCTCTGGTCCCAACGCACCCCATGGCCCCTCCCAGTCCCAGCACCACCAGCA

  erAsnAsnAsnSerSerSerSerSerAsnSerGlyTrpAspGlnLeuSerLysThrAs
  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  erAsnAsnAsnSerSerSerSerSerAsnSerGlyTrpAspGlnLeuSerLysThrAs
  GTAATAACAACAGTAGCAGCAGCAGCAACTCAGGATGGGATCAGCTAAGCAAAACGAA

  nLeuTyrIleArgGlyLeuProProHisThrThrAspGlnAspLeuValLysLeuCys
  |||||||||||||||||||||||||   ||||||||||||||||||||||||||||||
  nLeuTyrIleArgGlyLeuProProAsnThrThrAspGlnAspLeuValLysLeuCys
  CCTCTACATCCGAGGCCTGCCTCCCAACACCACCGACCAGGACCTGGTGAAACTCTGT

  Gln{Pr}  >>>> Target Intron 1 >>>>  {o}TyrGlyLysIleValSerT
  |||{||}           60637 bp          {|}|||||||||||||||||||
  Gln{Pr}++                         ++{o}TyrGlyLysIleValSerT
  CAA{CC}gt                         ag{A}TATGGGAAAATAGTCTCTA

  hrLysAlaIleLeuAspLysThrThrAsnLysCysLys{G}  >>>> Target Int
  ||||||||||||||||||||||||||||||||||||||{|}           10795 
  hrLysAlaIleLeuAspLysThrThrAsnLysCysLys{G}++               
  CAAAAGCAATTTTGGATAAGACAACAAACAAATGCAAA{G}gt               

  ron 2 >>>>  {ly}TyrGlyPheValAspPheAspSerProAlaAlaAlaGlnLys
  bp          {||}||||||||||||||||||||||||||||||||||||||||||
            ++{ly}TyrGlyPheValAspPheAspSerProAlaAlaAlaGlnLys
            ag{GT}TACGGTTTTGTCGACTTTGACAGTCCTGCAGCGGCCCAGAAA

  AlaValSerAlaLeuLysAlaSerGlyValGlnAlaGlnMetAlaLys  >>>> Tar
  ||||||||||||||||||||||||||||||||||||||||||||||||          
  AlaValSerAlaLeuLysAlaSerGlyValGlnAlaGlnMetAlaLys++        
  GCTGTGTCTGCCCTGAAGGCTAGCGGAGTTCAAGCTCAAATGGCCAAGgt        

  get Intron 3 >>>>  GlnGlnGluGlnAspProThrAsnLeuTyrIleSerAsn
   12957 bp          |||||||||||||||||||||||||||||||||||||||
                   ++GlnGlnGluGlnAspProThrAsnLeuTyrIleSerAsn
                   agCAACAAGAACAAGACCCTACCAACCTGTATATTTCTAAT

  LeuProLeuSerMetAspGluGlnGluLeuGluAsnMetLeuLysProPheGlyGlnV
  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  LeuProLeuSerMetAspGluGlnGluLeuGluAsnMetLeuLysProPheGlyGlnV
  TTGCCACTGTCCATGGATGAACAAGAGCTTGAAAACATGCTCAAACCATTTGGACAAG

  alIleSerThrArgIleLeuArgAspSerSerGlyThrSerArgGlyValGlyPheAl
  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  alIleSerThrArgIleLeuArgAspSerSerGlyThrSerArgGlyValGlyPheAl
  TCATTTCTACAAGGATATTACGTGACTCCAGTGGTACAAGTCGTGGCGTTGGCTTTGC

  a{Ar}  >>>> Target Intron 4 >>>>  {g}MetGluSerThrGluLysCys
  |{||}           2073 bp           {|}|||||||||||||||||||||
  a{Ar}++                         ++{g}MetGluSerThrGluLysCys
  T{AG}gt                         ag{G}ATGGAATCAACAGAAAAATGC

  GluAlaValIleGlyHisPheAsnGlyLysPheIleLysThrProProGlyValSer{
  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||{
  GluAlaValIleGlyHisPheAsnGlyLysPheIleLysThrProProGlyValSer{
  GAAGCCGTTATTGGTCATTTCAATGGAAAATTCATTAAGACACCACCAGGAGTTTCT{

  A}  >>>> Target Intron 5 >>>>  {la}ProThrGluProLeuLeuCysLy
  |}           18382 bp          {||}|||||||||||||||||||||||
  A}++                         ++{la}ProThrGluProLeuLeuCysLy
  G}gt                         ag{CT}CCTACAGAACCTTTATTGTGTAA

  sPheAlaAspGlyGlyGlnLysLysArgGlnAsnProAsnLysTyrIleProAsnGly
  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  sPheAlaAspGlyGlyGlnLysLysArgGlnAsnProAsnLysTyrIleProAsnGly
  GTTTGCCGATGGAGGACAGAAGAAGAGACAGAACCCGAACAAATACATCCCCAATGGA

  ArgProTrpHisArgGluGlyGlu  >>>> Target Intron 6 >>>>  AlaGl
  ||||||||||||||||||||||||           1929 bp           |||||
  ArgProTrpHisArgGluGlyGlu++                         ++AlaGl
  AGACCATGGCATAGAGAAGGAGAGgt                         agGCTGG

  yMetThrLeuThrTyrAspProThrThrAlaAlaIleGlnAsn{Gl}  >>>> Targ
  |||||||||||||||||||||||||||||||||||||||||||{||}           
  yMetThrLeuThrTyrAspProThrThrAlaAlaIleGlnAsn{Gl}++         
  AATGACACTTACTTACGACCCAACCACAGCTGCTATACAGAAC{GG}gt         

  et Intron 7 >>>>  {y}PheTyrProSerProTyrSerIleAlaThrAsnArgM
   124 bp           {|}|||||||||||||||||||||||||||||||||||||
                  ++{y}PheTyrProSerProTyrSerIleAlaThrAsnArgM
                  ag{A}TTTTATCCTTCACCATACAGTATTGCTACAAACCGAA

  etIleThrGlnThrSerIleThrProTyrIleAlaSerProValSerAlaTyrGln  
  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||  
  etIleThrGlnThrSerIleThrProTyrIleAlaSerProValSerAlaTyrGln++
  TGATCACTCAAACTTCCATTACACCTTATATTGCATCTCCTGTATCTGCCTACCAGgt

  >>>> Target Intron 8 >>>>  ValAlaLysGluThrArgGluAsnLysTyr-
           2624 bp           |||||||||||||||||||||   ||||||#
                           ++ValAlaLysGluThrArgGluSerLysTyr#
                           agGTGGCAAAGGAAACGAGAGAAAGCAAGTATC

  ArgGlySerAlaIleLys  >>>> Target Intron 9 >>>>  ValGlnSerPr
  ||||||||||||   |||            885 bp           |||||||||||
  ArgGlySerAlaValLys++                         ++ValGlnSerPr
  AGGGGCTCTGCGGTTAAGgt                         agGTGCAAAGTCC

  oSerTrpMetGlnProGlnProTyrIleLeuGlnHisPro  >>>> Target Intr
  ||||||||||||||||||||||||||||||||||||||||            3056 b
  oSerTrpMetGlnProGlnProTyrIleLeuGlnHisPro++                
  TTCTTGGATGCAGCCTCAACCGTACATCCTACAGCACCCGgt                

  on 10 >>>>  GlyAlaValLeuThrProSerMetGluHisThrMetSerLeuGlnP
  p           ||||||||||||||||||||||||||||||||||||||||||||||
            ++GlyAlaValLeuThrProSerMetGluHisThrMetSerLeuGlnP
            agGGTGCCGTGTTAACTCCCTCAATGGAGCACACCATGTCACTACAAC

  roAlaSerMetIleSerProLeuAlaGlnGlnMetSerHisLeuSerLeuGlySerTh
  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  roAlaSerMetIleSerProLeuAlaGlnGlnMetSerHisLeuSerLeuGlySerTh
  CTGCATCTATGATCAGCCCTCTGGCCCAGCAGATGAGTCATCTGTCACTAGGCAGCAC

  rGlyThr  >>>> Target Intron 11 >>>>  TyrMetProAlaThrSerAla
  |||||||            1253 bp           |||||||||||||||||||||
  rGlyThr++                          ++TyrMetProAlaThrSerAla
  CGGAACAgt                          agTACATGCCTGCAACATCAGCT

  MetGlnGlyAlaTyrLeuProGlnTyrAlaHisMetGlnThrThrAlaValProValG
  ||||||||||||||||||||||||||||||||||||||||||   |||||||||||||
  MetGlnGlyAlaTyrLeuProGlnTyrAlaHisMetGlnThrAlaAlaValProValG
  ATGCAAGGAGCCTATCTGCCACAGTACGCACACATGCAGACAGCGGCGGTTCCTGTTG

  lu  >>>> Target Intron 12 >>>>  GluAlaSerGlyGlnGlnGlnValAl
  ||            2140 bp           ||||||||||||||||||||||||  
  lu++                          ++GluAlaSerGlyGlnGlnGlnValTh
  AGgt                          agGAGGCAAGTGGTCAGCAGCAGGTGAC

  aValGluThrSerAsnAspHisSerProTyrThrPheGlnProAsnLys
   ||||||||||||||||||||||||||||||||||||||||||||||||
  rValGluThrSerAsnAspHisSerProTyrThrPheGlnProAsnLys
  TGTAGAGACGTCTAATGACCATTCTCCATATACTTTTCAACCCAATAAG


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