| Basic information |
| Official Symbol | PSD4 |
| Description | pleckstrin and Sec7 domain containing 4 |
| Other Aliases | EFA6B, TIC |
| Other Description | ADP-ribosylation factor guanine nucleotide-exchange factor 6; PH and SEC7 domain-containing protein 4; SEC7 homolog; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B; exchange factor for ARF6 B; pleckstrin homology and SEC7 domain-containing protein 4; telomeric of interleukin-1 cluster protein |
| Mutation type | Insert and frame-shift 549-550:P-M^CACTA |
| Location | Scaffold000511_1:3070729 3085039 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| PSD4 |
GAACCTCCTGAATCCACCAGACAAGATGCTCCTTTCTGGGATGCTGGTGT GGAGCCTACACACTTGGAAAGCTGCTCTTTCCAGAGGGAGAGCAAGCAGA CAGAAACATCCCAAGGAATGTCTGGAGATAGCTGTCCTGTGGAGAGCCCA AGGCAGAACCAGAGCACATCCACACAGGTGGTGTTCTGGGCAGGCATCCT GCAGGCCCAGATGTGCGTCCTCGACCTGGAGGAGGAGCTGGAGAAGACAG AAGGGCTCAGGGCTGGGCTGAGGCGCTGTGTCCCCACACTCCCAGCAGAC TCCCCTGGGGACGTGGACTTGCACCCCACCCCACCTGCAGAGGCGAACTT GGTGGAAGACAGCAGTGGATCTGAAGGGGAGAACCAAGTATGGCCGAGGG TGGGAACACCAGGCTCTTCTCCAGAGTGGGGTGCTGAGGAAGAGAGTGTG TTCTTCAACAACCCCCTTTTCCTGGAGACTCCTTGCTCAGAGACCAGTGT CCCTGAAGAGTGCTTTTCCTGGGGGTTCCCAGACTCCCATGTGGACATGA GGACTGGGTCTGACAGCCCACACACTCTGGAGCCTTCACTCCCAGAAGAC ACAGTGACATGGGAGCTGGGAAACACACTGGATTTGGGGGACAGCTCTGC TGATTCTGGTGGGTGTACCACCCCCCCATTCCCTGTGCCCACCTACAGAC CACACACCTGCTGGGTCTCAGTGGCTGCTGATGAGGAGGCTCCTGCAGCA CCTTCTCTTCAGGAGGGGAGTGAGGAAGACAGGCTTGGTCCTGCCCCATG TGCAGCCCCCTGTGTGGACAAGGCATTGACCTGGGAAACAGGACACACTG GATCTAACCTCAGTCGTGCTACACATCCTGTGCAACTTTGGGTAAGTCAC TGCCCCTCTCTGGGCTTCACCTTCTCCATCTGTGAAGGAGCCAGCCTCAC TCCACGCTCCTCCTCAGGTGAAGGGGATGCTGGGTGTCCCCAAGAACCTG CTCCCTGCACCCTGGCCTCTGGCCCCTGGGGAAGTCCAGCTTCTTCACCA CAGCCCAGCAGCCCAGAGTCCGAGAGAAGCAGCCTTGGCCCCAAGCCCAG TCCCGCGTCCTCCCAGGAGGGCAGCCCGCAGCTCCGGCGCCACAACTCAG GCATTTCTCCCAAGCTGGCACTAGATGCTCTCTGCTCTTCACTCTTGGAG ACGGATGGAGCAGAGCCAAGTTCTCTGGAGCAAGAGGAGGTCAGAGAGGC CCCAAGCCCAGGGACTGAAGTAAAGAGTGAAGGCCCAGCCAGAGCTGTGG AGGCTGGAGGCATCCAGCCCAGCGTGCACGTGACCTCTACAGAAGGTAGG AATCTGAGGACTCTTATGGACTCTTCTAGGTTTCCTGAGAACCCCATGCC TCAAGCACAGCGCCCCCCAGAAGGCCAGAGGCCACTGCCTGGAGACAAGC TGGCTAATGGCGTCAGGAATGACCAGGTGGCCCGGAACTTGGCGTCACGC CTCTATCATCTGGAGGGCTTCAGAAAGTCCGAAGTGGCTGCCTACCTGCA GAAGAACAACGACTTCAGCAGGGCTGTGGCTCAGGAATATTTGTCATTTT TCCAGTTTGGAGGCCAGAGCCTGGACCGAGCCCTCCGGGGCTTCCTCCAG GCCCTGGTGCTCAGTGGAGAGACCCAGGAGCGGGAGCGAATCCTCTACCA GTTCTCCAGACGTTTCCACCACTGCAACCCTAGGCTCTTCCCCTCCGTAG ATTCTGTCCACACCTTGACCTGCGCAATCATGCTCCTTAACACGGACCTG CACGGACAGAACATTGGGAAGAGCATGAGCTGCCAGGAATTCATAGCCAA CCTGCACGGCCTACGGGACGGTGGGGACTTCCCCAAGGAGCTACTGAAGG CCCTCTACTGGTCTATTCGGAGTGAGAAGCTCGAGTGGGCCATGGATGAA GAAGACCCAGCCAGACCTGAGAAAGCCCAGCCATCTCCCCCCATTGGCAA GATGAGCAACCCCTTACTGCAGCTAGCTCAGGACCCCACAGCACCCACCT ACAAGCAGGGCATCCTGGCTCGGAAGATGCATCACGATGCAGACGGCAAG AAAACGCCCTGGGGCAAGCGCGGCTGGAAGATGTTCCACACCTTACTACG AGGGATGGTTCTCTACTTCCTGAAGCAGGGAGAAGACCAATGCCCCGAGG GGGACCGTTTGCTGGGGCAGATGGTAGATGAGCCCGTGGGGGTGCACCAC TCGCTGGCCACCCCTGCCACTCACTACACCAAGAAGCCACACGTCTTCCA ACTGCGGACTGCGGACTGGCGCCTCTACCTCTTCCAGGCACCCACCGCCA AGGAGATGAATTCCTGGATCGCGCGCATCAACCTGGCGGCTGCCACGCAC TCGGCGCCACCCTTTCCGGCGGCCGTGGGCTCCCAGCGCAAATTCGTGCG ACCCATCCTGCCCATGAGCCCAGCCCAGAGCTCCCTGGAGGAGCAGCATC GATCCCACGAAAACTGCCTGGATGCCGCCTCCGATGACCTGCTGGATCTG CAGAGGAACTTACCGGAGCGGCGGGGCCGCAGCCGGGAGCTGGAGGAATA CCGCTTGCGCAAGGAGTATCTGGAATACGAGAAAAGCCGCTACGAGACAT ATGTACAGCTGCTGGTGGCTCGCCTGCACTGCCCCTGTGACGACCTGGAG CAGTTGGAGGAGCAGCTGGGGAGGGAAGCTGGCAGCACTCAGGAGCCCAA GCCTAGCCTGAAGAAGTCCCACTCAAGCCCATCTCTGCACCAAGATGAGG CCCCTACCACGGCCAAAGTGAAGCGCAACATCTCAGAGCGCAGAACGTAC AGGAAGATCATCCCCAAGCGGAACCGCAATCAGCTG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 1056 | 95 | 1056 | Insert and frame-shift 549-550:P-M^CACTA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
AspProProGluSerThrArgGlnAspAlaProProTrpGlySerGlyValGluLeuThr
|||||||||||||||||||||||||||||| ||| ||||||||| |||
GluProProGluSerThrArgGlnAspAlaProPheTrpAspAlaGlyValGluProThr
GAACCTCCTGAATCCACCAGACAAGATGCTCCTTTCTGGGATGCTGGTGTGGAGCCTACA
HisLeuGlySerProSerAlaGlnArgGluHisArgGlnAsnThrAlaSerProGlySer
|||||| ||| ||| ||||||||| ||| ||| |||
HisLeuGluSerCysSerPheGlnArgGluSerLysGlnThrGluThrSerGlnGlyMet
CACTTGGAAAGCTGCTCTTTCCAGAGGGAGAGCAAGCAGACAGAAACATCCCAAGGAATG
ProValAsnSerHisLeuProGlySerProLysGlnAsnArgSerThrSerThrGlnVal
||| |||||| |||||| ||||||||||||||||||
SerGlyAspSerCysProValGluSerProArgGlnAsnGlnSerThrSerThrGlnVal
TCTGGAGATAGCTGTCCTGTGGAGAGCCCAAGGCAGAACCAGAGCACATCCACACAGGTG
ValPheTrpAlaGlyIleLeuGlnAlaGlnMetCysValLeuAspLeuGluGluGluLeu
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ValPheTrpAlaGlyIleLeuGlnAlaGlnMetCysValLeuAspLeuGluGluGluLeu
GTGTTCTGGGCAGGCATCCTGCAGGCCCAGATGTGCGTCCTCGACCTGGAGGAGGAGCTG
GluLysThrGluGlyLeuLysAlaGlyLeuLysCysCysLeuProThrProProValAsp
|||||||||||||||||| ||||||||| ||| |||||| ||| |||
GluLysThrGluGlyLeuArgAlaGlyLeuArgArgCysValProThrLeuProAlaAsp
GAGAAGACAGAAGGGCTCAGGGCTGGGCTGAGGCGCTGTGTCCCCACACTCCCAGCAGAC
LeuProGlyAspThrGlyLeuHisSerSerProProGluAsnGluAspSerGlyGluAsp
||||||||| |||||| |||||| ||||||
SerProGlyAspValAspLeuHisProThrProProAlaGluAlaAsnLeuValGluAsp
TCCCCTGGGGACGTGGACTTGCACCCCACCCCACCTGCAGAGGCGAACTTGGTGGAAGAC
SerSerGluProGluGlyGluGlyGlnAlaTrpLeuArgGluGlyThrProAspSerSer
|||||| ||||||||| ||| ||| ||| ||||||||| ||||||
SerSerGlySerGluGlyGluAsnGlnValTrpProArgValGlyThrProGlySerSer
AGCAGTGGATCTGAAGGGGAGAACCAAGTATGGCCGAGGGTGGGAACACCAGGCTCTTCT
ProGlnTrpGlyAlaGluGluGluSerMetPhePheSerAsnProLeuPheLeuAlaSer
||| ||||||||||||||||||||| |||||| |||||||||||||||
ProGluTrpGlyAlaGluGluGluSerValPhePheAsnAsnProLeuPheLeuGluThr
CCAGAGTGGGGTGCTGAGGAAGAGAGTGTGTTCTTCAACAACCCCCTTTTCCTGGAGACT
ProCysSerGluAsnSerAlaSerGlyGluCysPheSerTrpGlyAlaSerAspSerHis
|||||||||||| ||| |||||||||||||||||| |||||||||
ProCysSerGluThrSerValProGluGluCysPheSerTrpGlyPheProAspSerHis
CCTTGCTCAGAGACCAGTGTCCCTGAAGAGTGCTTTTCCTGGGGGTTCCCAGACTCCCAT
AlaGlyValArgThrGlyProGluSerProAlaThrLeuGluProProLeuProGluAsp
||||||||| |||||| |||||||||||| ||||||||||||
ValAspMetArgThrGlySerAspSerProHisThrLeuGluProSerLeuProGluAsp
GTGGACATGAGGACTGGGTCTGACAGCCCACACACTCTGGAGCCTTCACTCCCAGAAGAC
ThrValLeuTrpGluLeuGluSerGluProAspLeuGlyAspGlyAlaAlaIleSerGly
|||||| ||||||||| |||||||||||| ||| ||||||
ThrValThrTrpGluLeuGlyAsnThrLeuAspLeuGlyAspSerSerAlaAspSerGly
ACAGTGACATGGGAGCTGGGAAACACACTGGATTTGGGGGACAGCTCTGCTGATTCTGGT
HisCys<->ThrProProPheProValProIleTyrLysProHisSerIleCysTrpAla
||| ||||||||||||||||||||| ||| |||||| ||||||
GlyCysThrThrProProPheProValProThrTyrArgProHisThr---CysTrpVal
GGGTGTACCACCCCCCCATTCCCTGTGCCCACCTACAGACCACACACC---TGCTGGGTC
SerValAlaAlaAlaGluGlyAlaProAlaAlaProProGlyHisGlyGluSerGlu >
|||||||||||| ||| ||||||||||||||| ||||||
SerValAlaAlaAspGluGluAlaProAlaAlaProSerLeuGlnGluGlySerGlu++
TCAGTGGCTGCTGATGAGGAGGCTCCTGCAGCACCTTCTCTTCAGGAGGGGAGTGAGgt
>>> Target Intron 1 >>>> GlyAspArgLeuGlyProAlaProSerAlaAlaP
1004 bp ||||||||||||||||||||| |||||||
-+GluAspArgLeuGlyProAlaProCysAlaAlaP
tgGAAGACAGGCTTGGTCCTGCCCCATGTGCAGCCC
roCysValAspGluAlaLeuThrTrpGluSerGlyCysValGlySerAspLeuGlyProA
||||||||||| ||||||||||||||| ||| |||||| ||| |
roCysValAspLysAlaLeuThrTrpGluThrGlyHisThrGlySerAsnLeuSerArgA
CCTGTGTGGACAAGGCATTGACCTGGGAAACAGGACACACTGGATCTAACCTCAGTCGTG
laAlaHisProValGlnProTrpAlaSerLeuSerProGluGlyTrpGlnArgGlyGlyP
|| |||||||||||| ||| ||| |||
laThrHisProValGlnLeuTrpValSerHisCysProSerLeuGlyPheThrPheSerI
CTACACATCCTGTGCAACTTTGGGTAAGTCACTGCCCCTCTCTGGGCTTCACCTTCTCCA
roPheTrpPro{G} >>>> Target Intron 2 >>>> {ln}ValThrLeuAsnS
{ } 752 bp { }
leCysGluGly{A}+- ++{la}SerLeuThrProA
TCTGTGAAGGA{G}gg ag{CC}AGCCTCACTCCAC
erGlnAspArgAspGluArgGluGlyGlyHisProGlnGluSerLeuProCysThrLeuA
||| ||| ||||||||| |||||||||||||
rgSerSerSerGlyGluGlyAspAlaGlyCysProGlnGluProAlaProCysThrLeuA
GCTCCTCCTCAGGTGAAGGGGATGCTGGGTGTCCCCAAGAACCTGCTCCCTGCACCCTGG
laProCysProTrpArgSerProAlaSerSerProGluProSerSerProGluSerGluS
|| |||||| |||||||||||||||||| |||||||||||||||||||||
laSerGlyProTrpGlySerProAlaSerSerProGlnProSerSerProGluSerGluA
CCTCTGGCCCCTGGGGAAGTCCAGCTTCTTCACCACAGCCCAGCAGCCCAGAGTCCGAGA
erArgGlyProGlyProArgProSerProAlaSerSerGlnGluGlySerProGlnLeuG
|||||| |||||||||||||||||||||||||||||||||||||||
rgSerSerLeuGlyProLysProSerProAlaSerSerGlnGluGlySerProGlnLeuA
GAAGCAGCCTTGGCCCCAAGCCCAGTCCCGCGTCCTCCCAGGAGGGCAGCCCGCAGCTCC
lnHisHisSerSerGlyIleLeuProLysTrpThrLeuAspAlaSerGlnSerSerLeuL
||| ||||||||| |||||| ||||||||| ||||||||||
rgArgHisAsnSerGlyIleSerProLysLeuAlaLeuAspAlaLeuCysSerSerLeuL
GGCGCCACAACTCAGGCATTTCTCCCAAGCTGGCACTAGATGCTCTCTGCTCTTCACTCT
euGluThrAspGlyGluGlnProSerSerLeuLysLysLysGluAlaGlyGluAlaProL
|||||||||||||| |||||||||||| ||| |||||||||
euGluThrAspGlyAlaGluProSerSerLeuGluGlnGluGluValArgGluAlaProS
TGGAGACGGATGGAGCAGAGCCAAGTTCTCTGGAGCAAGAGGAGGTCAGAGAGGCCCCAA
ysProGlyGluGluValLysSerGluGlyThrAlaArgProAlaGluThrGlyAspValG
|||||| |||||||||||||||||| |||||| ||| ||| |
erProGlyThrGluValLysSerGluGlyProAlaArgAlaValGluAlaGlyGlyIleG
GCCCAGGGACTGAAGTAAAGAGTGAAGGCCCAGCCAGAGCTGTGGAGGCTGGAGGCATCC
lnProAspIleHisLeuThrSerAlaGlu{Hi} >>>> Target Intron 3 >>>>
||||| ||| |||||| |||{ } 3068 bp
lnProSerValHisValThrSerThrGlu{Gl}++
AGCCCAGCGTGCACGTGACCTCTACAGAA{GG}gt
{s}GluAsnLeuArgThrPro-----MetAsnSerSerTrpLeuProGlySerProMe
{ } |||||||||||| #####||| |||||| ||| |||||
++{y}ArgAsnLeuArgThrLeu#####MetAspSerSerArgPheProGluAsnProMe
ag{T}AGGAATCTGAGGACTCTTCACTAATGGACTCTTCTAGGTTTCCTGAGAACCCCAT
tProGlnAlaGlnSerProGluGluGlyGlnArgProProAlaGlyAspLysLeuAlaAs
||||||||||||| ||| ||||||||||||||| |||||||||||||||||
tProGlnAlaGlnArgProProGluGlyGlnArgProLeuProGlyAspLysLeuAlaAs
GCCTCAAGCACAGCGCCCCCCAGAAGGCCAGAGGCCACTGCCTGGAGACAAGCTGGCTAA
nGlyValArgAsnAsnLysValAlaTrpAsnLeuAlaSerArgLeuTyrArgLeuGluGl
||||||||||||| |||||| ||||||||||||||||||||| ||||||||
nGlyValArgAsnAspGlnValAlaArgAsnLeuAlaSerArgLeuTyrHisLeuGluGl
TGGCGTCAGGAATGACCAGGTGGCCCGGAACTTGGCGTCACGCCTCTATCATCTGGAGGG
yPheArgLysSerGluValAlaAlaTyrLeuGlnLys{As} >>>> Target Intro
|||||||||||||||||||||||||||||||||||||{||} 405 bp
yPheArgLysSerGluValAlaAlaTyrLeuGlnLys{As}++
CTTCAGAAAGTCCGAAGTGGCTGCCTACCTGCAGAAG{AA}gt
n 4 >>>> {n}AsnAspPheSerArgAlaValAlaGluGluTyrLeuSerPhePheGl
{|}|||||||||||||||||||||||| ||||||||||||||||||||
++{n}AsnAspPheSerArgAlaValAlaGlnGluTyrLeuSerPhePheGl
ag{C}AACGACTTCAGCAGGGCTGTGGCTCAGGAATATTTGTCATTTTTCCA
nPheGlyGlyGlnSerLeuAspArgAlaLeu{Ar} >>>> Target Intron 5 >>
|||||||||||||||||||||||||||||||{||} 148 bp
nPheGlyGlyGlnSerLeuAspArgAlaLeu{Ar}++
GTTTGGAGGCCAGAGCCTGGACCGAGCCCTC{CG}gt
>> {g}SerPheLeuGlnAlaLeuValLeuSerGlyGluThrGlnGluArgGluArgIl
{|} ||||||||||||||||||||||||||||||||||||||||||||||||||
++{g}GlyPheLeuGlnAlaLeuValLeuSerGlyGluThrGlnGluArgGluArgIl
ag{G}GGCTTCCTCCAGGCCCTGGTGCTCAGTGGAGAGACCCAGGAGCGGGAGCGAAT
eLeuTyrGlnPheSerArgArgPheHisHisCysAsnProGlyIlePheProSerVal{A
|||||||||||||||||||||||||||||||||||||||| ||||||||||||{|
eLeuTyrGlnPheSerArgArgPheHisHisCysAsnProArgLeuPheProSerVal{A
CCTCTACCAGTTCTCCAGACGTTTCCACCACTGCAACCCTAGGCTCTTCCCCTCCGTA{G
} >>>> Target Intron 6 >>>> {sp}SerValHisThrLeuThrCysAlaIl
} 202 bp {||}||||||||||||||||||||||||||
}++ ++{sp}SerValHisThrLeuThrCysAlaIl
}gt ag{AT}TCTGTCCACACCTTGACCTGCGCAAT
eMetLeuLeuAsnThrAspLeuHisGlyGln >>>> Target Intron 7 >>>>
||||||||||||||||||||||||||||||| 177 bp
eMetLeuLeuAsnThrAspLeuHisGlyGln++ ++
CATGCTCCTTAACACGGACCTGCACGGACAGgt ag
AsnIleGlyLysSerMetSerCysGlnGluPheIleThrAsnLeuAsnGlyLeuArgAsp
|||||||||||||||||||||||||||||||||||| |||||| ||||||||||||
AsnIleGlyLysSerMetSerCysGlnGluPheIleAlaAsnLeuHisGlyLeuArgAsp
AACATTGGGAAGAGCATGAGCTGCCAGGAATTCATAGCCAACCTGCACGGCCTACGGGAC
GlyGlyAsnPheProLysGluLeuLeuLys >>>> Target Intron 8 >>>> A
|||||| ||||||||||||||||||||| 1347 bp |
GlyGlyAspPheProLysGluLeuLeuLys++ ++A
GGTGGGGACTTCCCCAAGGAGCTACTGAAGgt agG
laLeuTyrTrpSerIleArgSerGluLysLeuGluTrpAla{Va} >>>> Target I
|||||||||||||||||||||||||||||||||||||||||{ } 328
laLeuTyrTrpSerIleArgSerGluLysLeuGluTrpAla{Me}++
CCCTCTACTGGTCTATTCGGAGTGAGAAGCTCGAGTGGGCC{AT}gt
ntron 9 >>>> {l}AspGluGluAspThrAlaArgProGluLysAlaGlnProSerL
bp { }|||||||||||| |||||||||||||||||||||||||||
++{t}AspGluGluAspProAlaArgProGluLysAlaGlnProSerP
ag{G}GATGAAGAAGACCCAGCCAGACCTGAGAAAGCCCAGCCATCTC
euProAlaGlyLysMetSerLysProPheLeuGlnLeuAlaGlnAspProThrValProT
||| |||||||||||| ||| |||||||||||||||||||||||| ||||
roProIleGlyLysMetSerAsnProLeuLeuGlnLeuAlaGlnAspProThrAlaProT
CCCCCATTGGCAAGATGAGCAACCCCTTACTGCAGCTAGCTCAGGACCCCACAGCACCCA
hrTyrLysGlnGlyIleLeuAlaArgLysMetHisGlnAspAlaAspGlyLysLys{T}
||||||||||||||||||||||||||||||||||| ||||||||||||||||||{|}
hrTyrLysGlnGlyIleLeuAlaArgLysMetHisHisAspAlaAspGlyLysLys{T}+
CCTACAAGCAGGGCATCCTGGCTCGGAAGATGCATCACGATGCAGACGGCAAGAAA{A}g
>>>> Target Intron 10 >>>> {hr}ProTrpGlyLysArgGlyTrpLysMet
1298 bp {||}|||||||||||||||||||||||||||
+ ++{hr}ProTrpGlyLysArgGlyTrpLysMet
t ag{CG}CCCTGGGGCAAGCGCGGCTGGAAGATG
PheHisThrLeuLeuArgGlyMetValLeuTyrPheLeuLys >>>> Target Intr
|||||||||||||||||||||||||||||||||||||||||| 100 bp
PheHisThrLeuLeuArgGlyMetValLeuTyrPheLeuLys++
TTCCACACCTTACTACGAGGGATGGTTCTCTACTTCCTGAAGgt
on 11 >>>> GlnGlyGluAspHisCysLeuGluGlyGluSerLeuValGlyGlnMet
|||||||||||| ||| |||||| ||| |||||||||
-+GlnGlyGluAspGlnCysProGluGlyAspArgLeuLeuGlyGlnMet
ggCAGGGAGAAGACCAATGCCCCGAGGGGGACCGTTTGCTGGGGCAGATG
ValAspGluProValGlyValHisHisSerLeuAlaThrProAlaThrHisTyrThrLys
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ValAspGluProValGlyValHisHisSerLeuAlaThrProAlaThrHisTyrThrLys
GTAGATGAGCCCGTGGGGGTGCACCACTCGCTGGCCACCCCTGCCACTCACTACACCAAG
LysProHisValPheGlnLeuArgThrAlaAspTrpArgLeuTyrLeuPheGlnAla{Pr
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||{||
LysProHisValPheGlnLeuArgThrAlaAspTrpArgLeuTyrLeuPheGlnAla{Pr
AAGCCACACGTCTTCCAACTGCGGACTGCGGACTGGCGCCTCTACCTCTTCCAGGCA{CC
} >>>> Target Intron 12 >>>> {o}ThrAlaLysGluMetSerSerTrpIl
} 483 bp {|}||||||||||||||| ||||||||
}++ ++{o}ThrAlaLysGluMetAsnSerTrpIl
}gt ag{C}ACCGCCAAGGAGATGAATTCCTGGAT
eAlaArgIleAsnLeuAlaAlaAlaThrHisSerAlaProProPheProAlaAlaValGl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
eAlaArgIleAsnLeuAlaAlaAlaThrHisSerAlaProProPheProAlaAlaValGl
CGCGCGCATCAACCTGGCGGCTGCCACGCACTCGGCGCCACCCTTTCCGGCGGCCGTGGG
ySerGlnArgArgPheValArgProIleLeuProValGlyProAlaGlnSerSerLeu
|||||||||| ||||||||||||||||||||| ||||||||||||||||||
ySerGlnArgLysPheValArgProIleLeuProMetSerProAlaGlnSerSerLeu++
CTCCCAGCGCAAATTCGTGCGACCCATCCTGCCCATGAGCCCAGCCCAGAGCTCCCTGgt
>>>> Target Intron 13 >>>> GluGluGlnHisArgSerHisGluAsnCysLe
170 bp ||||||||||||||||||||||||||||||||
++GluGluGlnHisArgSerHisGluAsnCysLe
agGAGGAGCAGCATCGATCCCACGAAAACTGCCT
uAspAlaAlaAlaAspAspLeuLeuAspLeuGlnArgAsnLeuProGluArgArgGlyAr
|||||||||| |||||||||||||||||||||||||||||||||||||||||||||||
uAspAlaAlaSerAspAspLeuLeuAspLeuGlnArgAsnLeuProGluArgArgGlyAr
GGATGCCGCCTCCGATGACCTGCTGGATCTGCAGAGGAACTTACCGGAGCGGCGGGGCCG
gGlyArgGluLeuGluGluHisArgLeuArgLysGluTyrLeuGluTyrGlu >>>> T
| ||||||||||||||| ||||||||||||||||||||||||||||||
gSerArgGluLeuGluGluTyrArgLeuArgLysGluTyrLeuGluTyrGlu++
CAGCCGGGAGCTGGAGGAATACCGCTTGCGCAAGGAGTATCTGGAATACGAGgt
arget Intron 14 >>>> LysThrArgTyrGluThrTyrValGlnLeuLeuValAl
1938 bp ||| ||||||||||||||||||||||||||||||||
++LysSerArgTyrGluThrTyrValGlnLeuLeuValAl
agAAAAGCCGCTACGAGACATATGTACAGCTGCTGGTGGC
aArgLeuHisCysProSerAspAlaLeuAspLeuTrpGluGluGlnLeuGlyArgGluAl
|||||||||||||||| ||| ||| |||||||||||||||||||||||
aArgLeuHisCysProCysAspAspLeuGluGlnLeuGluGluGlnLeuGlyArgGluAl
TCGCCTGCACTGCCCCTGTGACGACCTGGAGCAGTTGGAGGAGCAGCTGGGGAGGGAAGC
aGlyGlyThrArgGluProLysLeuSerLeuLysLysSerHisSerSerProSerLeuHi
|||| ||| ||||||||| |||||||||||||||||||||||||||||||||||
aGlySerThrGlnGluProLysProSerLeuLysLysSerHisSerSerProSerLeuHi
TGGCAGCACTCAGGAGCCCAAGCCTAGCCTGAAGAAGTCCCACTCAAGCCCATCTCTGCA
sGlnAspGluAlaProThrThrAlaLysValLysArgAsnIleSerGluArgArgThrTy
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sGlnAspGluAlaProThrThrAlaLysValLysArgAsnIleSerGluArgArgThrTy
CCAAGATGAGGCCCCTACCACGGCCAAAGTGAAGCGCAACATCTCAGAGCGCAGAACGTA
rArgLysIleIleProLysArgAsnArgAsnGlnLeu
|||||||||||||||||||||||||||||||||||||
rArgLysIleIleProLysArgAsnArgAsnGlnLeu
CAGGAAGATCATCCCCAAGCGGAACCGCAATCAGCTG
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