| Basic information |
| Official Symbol | PCSK4 |
| Description | proprotein convertase subtilisin/kexin type 4 |
| Other Aliases | UNQ2757/PRO6496, PC4, SPC5 |
| Other Description | NA |
| Mutation type | premature termination 233:D->TGA |
| Location | Scaffold149964_1:1023768 1018020 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| PCSK4 |
ATGCGGCCCGCCCCGACTTCGCTCTGGCTGCGCCTGACCTTGGCCCTGGG TCTGGCCCTCGTTGGCCTCCTGGCCCCAGGGTGGGCCTCGGCCAGGGCCC CCATCTACGTTAGCAGCTGGGCCGTGCGGGTATCCCTGGGTTACCCGGAG GCCCAGCGCCTAGCACGCAAATTGGGCTTCGTCAACCTAGGGCAGATCTT TCCTGACGGGCAGTATTTCCACCTGCGGCACCGGGGCGTGGCCCCACAGT CCCTGACCCCACACTGGGGCCACTGCCTCCGTCTGAAGAAAGACCCCAAG GTGCAGTGGTTCGAGCAGCAGACTGTGCGGCGACGCAGGAAGCGCTCCCT GGCCGTGCCCTCGGACCCCTGGTTCTCCAAGCAGTGGTATATGAACAGCG AGGTGCAGCCGGACCTGAACATCCTGCAGGCCTGGGGCCAGGGCCTGTCG GGCCAGGGTGTCGTGGTGTCCATCTTGGACGACGGCATCGAGAAGGACCA CCCGGACCTCTGGGCCAACTACGACCCACGGGCCAGCTACGACTTCAACG ACTACGATCCGGACCCCCAGCCTCGATATACGCCCAGCGATGAGAACCGA CACGGGACACGCTGTGCTGGGGAGGTGGCAGCAGTGGCAGACAATGGCTT CTGCGGCACCGGGGTCGCCTTCAACGCCCGCATTGGAGGTACCCGGGCCC TCTGAGGGGCCCCGCAGCGGCAGAGGGTGACGGGCGTGCGGATGCTGGAC GGCCCCATCACGGACGTGGTGGAGGCCCAGTGGGGCCCCGAGGACGACGG CCGTACCGTGGACGGCCCGGGCGTGCTCACCCGCGAGGCCTTCCAGCGCG GCGTGACCCAGGGCCGTGGCGGGCTGGGCACGCTGTTCGTCTGGGCGTCG GGCAACGGCGGCTTGCACTACGACAACTGCAACTGTGACGGCTACACCAA CAGCATCCACACGCTGTCCGTGGGCAGCGTCACCCGGCAGGGCCACGTGC CCTGGTACAGCGAGGCCTGTGCCTCCATGCTCACCACCACCTACAGCAGC GGGGTGGCTGCCGACCCCCAGATCGTCACCACGGACCTGCACCACCAGTG CACGGACAAGCACACGGGCACGTCTGCCTCGGCCCCGCTGGCGGCCGGCA TCATCGCCCTGGCTCTGGAGGCCAACCCGTTCCTGACGTGGAGGGACATG CAGCACCTGGTGGTCCGCGCGTCCAAGCCCGCCCAGCTGCAGGCCGAGGA CTGGAGGACCAACGGCGTGGGGCGCAGAGTGAGCCACCACTACGGCTACC GGCTG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 755 | 1 | 433 | Premature termination 233:D->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetArgProAlaProIleAlaLeuTrpLeuArgLeuValLeuAla<-><->LeuAlaLeu
||||||||||||||| ||||||||||||||| |||||| |||||||||
MetArgProAlaProThrSerLeuTrpLeuArgLeuThrLeuAlaLeuGlyLeuAlaLeu
ATGCGGCCCGCCCCGACTTCGCTCTGGCTGCGCCTGACCTTGGCCCTGGGTCTGGCCCTC
ValArgProArgAlaValGlyTrpAlaProValArgAlaProIleTyrValSerSerTrp
||| ||| ||||||||| |||||||||||||||||||||||||||
ValGlyLeuLeuAlaProGlyTrpAlaSerAlaArgAlaProIleTyrValSerSerTrp
GTTGGCCTCCTGGCCCCAGGGTGGGCCTCGGCCAGGGCCCCCATCTACGTTAGCAGCTGG
AlaValGlnValSerGlnGlyAsnArgGluValGluArgLeuAlaArgLysPheGlyPhe
|||||| |||||| ||| ||| ||||||||||||||| ||||||
AlaValArgValSerLeuGlyTyrProGluAlaGlnArgLeuAlaArgLysLeuGlyPhe
GCCGTGCGGGTATCCCTGGGTTACCCGGAGGCCCAGCGCCTAGCACGCAAATTGGGCTTC
ValAsnLeuGlyPro >>>> Target Intron 1 >>>> IlePheProAspGlyG
|||||||||||| 215 bp ||||||||||||||||
ValAsnLeuGlyGln++ ++IlePheProAspGlyG
GTCAACCTAGGGCAGgt agATCTTTCCTGACGGGC
lnTyrPheHisLeuArgHisArgGlyValValGlnGlnSerLeuThrProHisTrpGlyH
||||||||||||||||||||||||||||| |||||||||||||||||||||||||
lnTyrPheHisLeuArgHisArgGlyValAlaProGlnSerLeuThrProHisTrpGlyH
AGTATTTCCACCTGCGGCACCGGGGCGTGGCCCCACAGTCCCTGACCCCACACTGGGGCC
isArgLeuHisLeuLysLysAsnProLys >>>> Target Intron 2 >>>> Va
|| ||| ||||||||| |||||| 2633 bp ||
isCysLeuArgLeuLysLysAspProLys++ ++Va
ACTGCCTCCGTCTGAAGAAAGACCCCAAGgt agGT
lGlnTrpPheGlnGlnGlnThrLeuGlnArgArgValLysArgSerValValValProTh
|||||||||| ||||||||| |||||| ||||||||| ||||||
lGlnTrpPheGluGlnGlnThrValArgArgArgArgLysArgSerLeuAlaValProSe
GCAGTGGTTCGAGCAGCAGACTGTGCGGCGACGCAGGAAGCGCTCCCTGGCCGTGCCCTC
rAspProTrpPheSerLysGlnTrpTyrMet >>>> Target Intron 3 >>>>
|||||||||||||||||||||||||||||| 68 bp
rAspProTrpPheSerLysGlnTrpTyrMet++ ++
GGACCCCTGGTTCTCCAAGCAGTGGTATATGgt ag
AsnSerGluAlaGlnProAspLeuSerIleLeuGlnAlaTrpSerGlnGlyLeuSerGly
||||||||| |||||||||||| ||||||||||||||| |||||||||||||||
AsnSerGluValGlnProAspLeuAsnIleLeuGlnAlaTrpGlyGlnGlyLeuSerGly
AACAGCGAGGTGCAGCCGGACCTGAACATCCTGCAGGCCTGGGGCCAGGGCCTGTCGGGC
GlnGlyIleValValSerValLeuAspAspGlyIleGluLysAspHisProAspLeuTrp
|||||| ||||||||| |||||||||||||||||||||||||||||||||||||||
GlnGlyValValValSerIleLeuAspAspGlyIleGluLysAspHisProAspLeuTrp
CAGGGTGTCGTGGTGTCCATCTTGGACGACGGCATCGAGAAGGACCACCCGGACCTCTGG
AlaAsnTyr >>>> Target Intron 4 >>>> AspProLeuAlaSerTyrAspP
||||||||| 82 bp |||||| |||||||||||||
AlaAsnTyr++ ++AspProArgAlaSerTyrAspP
GCCAACTACgt agGACCCACGGGCCAGCTACGACT
heAsnAspTyrAspProAspProGlnProArgTyrThrProSerLysGluAsn{Ar} >
|||||||||||||||||||||||||||||||||||||||||||| ||||||{||}
heAsnAspTyrAspProAspProGlnProArgTyrThrProSerAspGluAsn{Ar}++
TCAACGACTACGATCCGGACCCCCAGCCTCGATATACGCCCAGCGATGAGAAC{CG}gt
>>> Target Intron 5 >>>> {g}HisGlyThrArgCysAlaGlyGluValAlaA
90 bp {|}|||||||||||||||||||||||||||||||
++{g}HisGlyThrArgCysAlaGlyGluValAlaA
ag{A}CACGGGACACGCTGTGCTGGGGAGGTGGCAG
laMetAlaAsnAsnGlyPheCysGlyValGlyValAlaPheAsnAlaArgIleGlyGlyV
|| ||| ||||||||||||||| ||||||||||||||||||||||||||||||
laValAlaAspAsnGlyPheCysGlyThrGlyValAlaPheAsnAlaArgIleGlyGlyT
CAGTGGCAGACAATGGCTTCTGCGGCACCGGGGTCGCCTTCAACGCCCGCATTGGAGGTA
alArgMetLeuAspGlyThrIleThrAspValIleGluAla{G} >>>> Target In
||| ||| ||| { } 505
hrArgAlaLeu***GlyAlaProGlnArgGlnArgValThr{G}++
CCCGGGCCCTCTGAGGGGCCCCGCAGCGGCAGAGGGTGACG{G}gt
tron 6 >>>> {ln}SerLeuSerLeuGlnProGlnHisIleHisIleTyrSerAlaS
bp { } ||| |||
++{ly}ValArgMetLeuAspGlyProIleThrAspValValGluAlaG
ag{GC}GTGCGGATGCTGGACGGCCCCATCACGGACGTGGTGGAGGCCC
erTrpGlyProGluAspAspGlyArgThrValAspGlyProGlyIleLeuThrArgGluA
|||||||||||||||||||||||||||||||||||||||||| |||||||||||||
lnTrpGlyProGluAspAspGlyArgThrValAspGlyProGlyValLeuThrArgGluA
AGTGGGGCCCCGAGGACGACGGCCGTACCGTGGACGGCCCGGGCGTGCTCACCCGCGAGG
laPheArgArgGlyValThrLys >>>> Target Intron 7 >>>> GlyArgGl
||||| |||||||||||| 75 bp ||||||||
laPheGlnArgGlyValThrGln++ ++GlyArgGl
CCTTCCAGCGCGGCGTGACCCAGgt agGGCCGTGG
yGlyLeuGlyThrLeuPheIleTrpAlaSerGlyAsnGlyGlyLeuHisTyrAspAsnCy
||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||
yGlyLeuGlyThrLeuPheValTrpAlaSerGlyAsnGlyGlyLeuHisTyrAspAsnCy
CGGGCTGGGCACGCTGTTCGTCTGGGCGTCGGGCAACGGCGGCTTGCACTACGACAACTG
sAsnCysAspGlyTyrThrAsnSerIleHisThrLeuSerValGlySerThrThrGlnGl
||||||||||||||||||||||||||||||||||||||||||||||||| ||| ||
sAsnCysAspGlyTyrThrAsnSerIleHisThrLeuSerValGlySerValThrArgGl
CAACTGTGACGGCTACACCAACAGCATCCACACGCTGTCCGTGGGCAGCGTCACCCGGCA
nGlyArgValProTrpTyrSerGluAlaCysAlaSerThrLeuThrThrThrTyrSerSe
|||| |||||||||||||||||||||||||||||| ||||||||||||||||||||
nGlyHisValProTrpTyrSerGluAlaCysAlaSerMetLeuThrThrThrTyrSerSe
GGGCCACGTGCCCTGGTACAGCGAGGCCTGTGCCTCCATGCTCACCACCACCTACAGCAG
rGlyValAlaThrAspProGlnIle >>>> Target Intron 8 >>>> ValThr
|||||||||| |||||||||||| 533 bp ||||||
rGlyValAlaAlaAspProGlnIle++ ++ValThr
CGGGGTGGCTGCCGACCCCCAGATCgt agGTCACC
ThrAspLeuHisHisGlyCysThrAspGlnHisThrGlyThrSerAlaSerAlaProLeu
||||||||||||||| ||||||||| ||||||||||||||||||||||||||||||
ThrAspLeuHisHisGlnCysThrAspLysHisThrGlyThrSerAlaSerAlaProLeu
ACGGACCTGCACCACCAGTGCACGGACAAGCACACGGGCACGTCTGCCTCGGCCCCGCTG
AlaAlaGlyMetIleAlaLeuAlaLeuGluAla{As} >>>> Target Intron 9
||||||||| |||||||||||||||||||||{||} 72 bp
AlaAlaGlyIleIleAlaLeuAlaLeuGluAla{As}++
GCGGCCGGCATCATCGCCCTGGCTCTGGAGGCC{AA}gt
>>>> {n}ProPheLeuThrTrpArgAspMetGlnHisLeuValValArgAlaSerLys
{|}|||||||||||||||||||||||||||||||||||||||||||||||||||
++{n}ProPheLeuThrTrpArgAspMetGlnHisLeuValValArgAlaSerLys
ag{C}CCGTTCCTGACGTGGAGGGACATGCAGCACCTGGTGGTCCGCGCGTCCAAG
ProAlaHisLeuGlnAlaGluAspTrpArgThrAsnGlyValGlyArgGln{V} >>>>
|||||| ||||||||||||||||||||||||||||||||||||||| {|}
ProAlaGlnLeuGlnAlaGluAspTrpArgThrAsnGlyValGlyArgArg{V}++
CCCGCCCAGCTGCAGGCCGAGGACTGGAGGACCAACGGCGTGGGGCGCAGA{G}gt
Target Intron 10 >>>> {al}SerHisHisTyrGlyTyrGlyLeu
171 bp {||}|||||||||||||||||| |||
++{al}SerHisHisTyrGlyTyrArgLeu
ag{TG}AGCCACCACTACGGCTACCGGCTG
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