| Basic information |
| Official Symbol | OTUB1 |
| Description | OTU domain, ubiquitin aldehyde binding 1 |
| Other Aliases | HSPC263, OTB1, OTU1 |
| Other Description | OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU-domain Ubal-binding 1; deubiquitinating enzyme OTUB1; otubain-1; ubiquitin thioesterase OTUB1; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1 |
| Mutation type | premature termination 30:S->TAG |
| Location | Scaffold000273_1:697814 706549 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| OTUB1 |
TGCTGGGGAGGGGCCAAGAGGAGGGGCTCACTTCCGGGAGGCGTGCCACT AGTAACCCGGAAGCGGTAGGCAGTGCGGCGCTGTTTAAAGATGGCGGCGG AGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCAGCGACTCCGAAGGT GTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAAT TCAGCAAGAGATTGCTGTGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGC TCTCGGTCCTATATAAGGAATATGCTGAGGATGACAATATCTACCAACAG AAGATCAAGGATCTCCACAAAAAGTACTCATACATCCGGAAGACCAGGCC TGATGGCAACTGCTTCTATCGAGCTTTTGGATTCTCTCACTTGGAGGCAC TGCTGGATGATAGCAAGGAACTGCAGCGGTTCAAGGCTGTGTCTGCCAAG AGTAAAGAGGACCTGGTGTCCCAGGGCTTCACCGAGTTCACAATAGAGGA TTTCCATAACACGTTCATGGACCTGATTGAGCAGGTGGAGAAGCAGACCT CAGTAGCCGACCTGCTGGCCTCCTTCAACGACCAGAGCACCTCGGACTAC CTGGTGGTCTACCTGCGGCTGCTCACCTCAGGCTACCTTCAGCGAGAGAG CAAGTTCTTCGAGCACTTCATCGAGGGGGGGCGGACTGTCAAGGAGTTCT GCCAGCAGGAAGTGGAGCCCATGTGCAAGGAGAGCGACCACATCCACATC ATCGCGCTGGCCCAGGCCCTCAGCGTCTCTATCCAGGTGGAGTACATGGA CCGCGGCGAGGGCGGCACCACCAACCCGCACATCTTTCCCGAGGGCTCTG AGCCCAAGGTCTACCTTCTCTACCGGCCCGGACACTACGATATCCTCTAC AAA |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 308 | 8 | 308 | Premature termination 30:S->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
CysGlnGlyGlyAlaThrArgArgGlySerLeuProGlyGlyArgGlnLeuAlaThrArg
||| ||||||||| |||||||||||||||||||||||| ||| ||||||
CysTrpGlyGlyAlaLysArgArgGlySerLeuProGlyGlyValProLeuValThrArg
TGCTGGGGAGGGGCCAAGAGGAGGGGCTCACTTCCGGGAGGCGTGCCACTAGTAACCCGG
LysArgSerValValArgArgCysLeuLysMetAlaAlaGluGluProGlnGlnGlnLys
|||||| ||||||||||||||||||||||||||||||||||||||||||||||||
LysArg***AlaValArgArgCysLeuLysMetAlaAlaGluGluProGlnGlnGlnLys
AAGCGGTAGGCAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAG
GlnGluProLeuGlySerAspSerGlu{G} >>>> Target Intron 1 >>>> {
|||||||||||||||||||||||||||{|} 3412 bp {
GlnGluProLeuGlySerAspSerGlu{G}++ ++{
CAGGAGCCGCTGGGCAGCGACTCCGAA{G}gt ag{
ly}ValAsnCysLeuAlaTyrAspGluAlaIleMetAlaGlnGlnAspArgIleGlnGln
||}|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ly}ValAsnCysLeuAlaTyrAspGluAlaIleMetAlaGlnGlnAspArgIleGlnGln
GT}GTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAA
Glu >>>> Target Intron 2 >>>> IleAlaValGlnAsnProLeuValSerG
||| 258 bp ||||||||||||||||||||||||||||
Glu++ ++IleAlaValGlnAsnProLeuValSerG
GAGgt agATTGCTGTGCAGAACCCTCTGGTGTCAG
luArgLeuGluLeuSerValLeuTyrLysGluTyrAlaGluAspAspAsnIleTyrGlnG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luArgLeuGluLeuSerValLeuTyrLysGluTyrAlaGluAspAspAsnIleTyrGlnG
AGCGGCTGGAGCTCTCGGTCCTATATAAGGAATATGCTGAGGATGACAATATCTACCAAC
lnLysIleLys >>>> Target Intron 3 >>>> AspLeuHisLysLysTyrSe
||||||||||| 3626 bp ||||||||||||||||||||
lnLysIleLys++ ++AspLeuHisLysLysTyrSe
AGAAGATCAAGgt agGATCTCCACAAAAAGTACTC
rTyrIleArgLysThrArgProAspGlyAsnCysPheTyrArgAlaPheGlyPheSerHi
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rTyrIleArgLysThrArgProAspGlyAsnCysPheTyrArgAlaPheGlyPheSerHi
ATACATCCGGAAGACCAGGCCTGATGGCAACTGCTTCTATCGAGCTTTTGGATTCTCTCA
sLeuGluAlaLeuLeuAspAspSerLysGluLeuGln{Ar} >>>> Target Intro
|||||||||||||||||||||||||||||||||||||{||} 269 bp
sLeuGluAlaLeuLeuAspAspSerLysGluLeuGln{Ar}++
CTTGGAGGCACTGCTGGATGATAGCAAGGAACTGCAG{CG}gt
n 4 >>>> {g}PheLysAlaValSerAlaLysSerLysGluAspLeuValSerGlnGl
{|}|||||||||||||||||||||||||||||||||||||||||||||||
++{g}PheLysAlaValSerAlaLysSerLysGluAspLeuValSerGlnGl
ag{G}TTCAAGGCTGTGTCTGCCAAGAGTAAAGAGGACCTGGTGTCCCAGGG
yPheThrGluPheThrIleGluAspPheHisAsnThr >>>> Target Intron 5
||||||||||||||||||||||||||||||||||||| 111 bp
yPheThrGluPheThrIleGluAspPheHisAsnThr++
CTTCACCGAGTTCACAATAGAGGATTTCCATAACACGgt
>>>> PheMetAspLeuIleGluGlnValGluLysGlnThrSerValAlaAspLeuLeu
||||||||||||||||||||||||||||||||||||||||||||||||||||||
++PheMetAspLeuIleGluGlnValGluLysGlnThrSerValAlaAspLeuLeu
agTTCATGGACCTGATTGAGCAGGTGGAGAAGCAGACCTCAGTAGCCGACCTGCTG
AlaSerPheAsnAspGlnSerThrSerAspTyrLeuValValTyrLeuArgLeuLeuThr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AlaSerPheAsnAspGlnSerThrSerAspTyrLeuValValTyrLeuArgLeuLeuThr
GCCTCCTTCAACGACCAGAGCACCTCGGACTACCTGGTGGTCTACCTGCGGCTGCTCACC
SerGlyTyrLeuGlnArgGluSerLysPhePheGluHisPheIleGluGlyGlyArgThr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SerGlyTyrLeuGlnArgGluSerLysPhePheGluHisPheIleGluGlyGlyArgThr
TCAGGCTACCTTCAGCGAGAGAGCAAGTTCTTCGAGCACTTCATCGAGGGGGGGCGGACT
ValLysGluPheCysGlnGln >>>> Target Intron 6 >>>> GluValGluP
||||||||||||||||||||| 157 bp ||||||||||
ValLysGluPheCysGlnGln++ ++GluValGluP
GTCAAGGAGTTCTGCCAGCAGgt agGAAGTGGAGC
roMetCysLysGluSerAspHisIleHisIleIleAlaLeuAlaGlnAlaLeuSerValS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
roMetCysLysGluSerAspHisIleHisIleIleAlaLeuAlaGlnAlaLeuSerValS
CCATGTGCAAGGAGAGCGACCACATCCACATCATCGCGCTGGCCCAGGCCCTCAGCGTCT
erIleGlnValGluTyrMetAspArgGlyGluGlyGlyThrThrAsnProHisIlePheP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
erIleGlnValGluTyrMetAspArgGlyGluGlyGlyThrThrAsnProHisIlePheP
CTATCCAGGTGGAGTACATGGACCGCGGCGAGGGCGGCACCACCAACCCGCACATCTTTC
roGluGlySerGluProLysValTyrLeuLeuTyrArgProGlyHisTyrAspIleLeuT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
roGluGlySerGluProLysValTyrLeuLeuTyrArgProGlyHisTyrAspIleLeuT
CCGAGGGCTCTGAGCCCAAGGTCTACCTTCTCTACCGGCCCGGACACTACGATATCCTCT
yrLys
|||||
yrLys
ACAAA
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