| Basic information |
| Official Symbol | LCK |
| Description | lymphocyte-specific protein tyrosine kinase |
| Other Aliases | RP4-675E8.4, LSK, YT16, p56lck, pp58lck |
| Other Description | T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; tyrosine-protein kinase Lck |
| Mutation type | Insert and frame-shift 338-339:P-W^TC, premature termination 344:Q->TAG |
| Location | Scaffold000573_1:2723206 2714316 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| LCK |
ATGGGCTGTAGCTGCAGCTCAAACCCTGAAGATGACTGGATGGAGAACAT CGACGTGTGTGGGAACTGCCATTACCCCATAGTCCCACTGGACGGCAAGG CCACGCTTCCCATGCGCAATGGCTCTGAGGTGCGGGACCCGCTGGTCACA TACGAGGGCTCCAACCCGCCGGCCTCCCCGCTGCAAGACAACCTGGTTAT TGCCCTGCACAGCTACGAGCCCTCTCACGACGGGGACCTGGGCTTCGTAA AGGGCGAACAGCTCCGCGTCCTGGAGCAGAGCGGCGAGTGGTGGAAGGCG CAGTCCCTGACCACCGGCCAGGAAGGCTTCATCCCTTTCAACTTCGTGGC CAAAGCGAACAGCCTAGAGCCCGAACCCTGGTTCTTCAAGAACCTGAGCC GCAAGGACGCGGAGCGGCAGCTCCTGGCGCCCGGGAACACGCACGGCTCC TTCCTGATCCGGGAGAGTGAGAGCACAGCCGGATCATTTTCACTGTCCGT CCGGGACTTCGACCAGAACCAGGGGGAGGTGGTGAAGCATTACAAGATCC GTAATCTGGACGACGGAGGCTTCTACATCTCCCCCCGCATCACTTTTCCC GGCCTACATGAACTGGTCCGCCATTATACCAACGCTTCGGACGGGCTGTG CACGCGCCTGAGCCGCCCCTGCCAGACCCAGAAGCCCCAGAAGCCGTGGT GGGAGGATGAGTGGGAGGTTCCCAGGGAGACACTGAAGCTGGTGGAGCGG CTGGGGAGCGGCCAGTTCGGGGAGGTGTGGATGGGGTACTACAACGGGCA CACGAAGGTGGCAGTGAAGAGCCTGAAGCAGGGCAGCATGTCCCCCGACG CCTTCCTAGCCGAGGCCAACCTCATGAAGCAGCTGCAGCACCAGCGGCTG GTCCGGCTGTACGCCGTGGTCACCCAGGAGCCGATCTACATTATCACTGA GTACATGGAGAACGACACTGCTTCTAGACCCCCAGTTGGGGACAAGGGTC TTGAGGCTCCCTGGGGCAACTTGAGTTAGCAACTCTCGCTTCTGCCCACA GGGAGCCTGGTGGATTTTCTCAAGACCCCCCCAGGCATCAAGCTGACCAT CAACAAGCTCTTGGACATGGCGGCCCAGATCGCAGAGGGCATGGCATTCA TTGAAGAGCGGAATTACATCCACCGGGACCTGCGGGCTGCCAACATCCTG GTGTCGGACACCCTGAGCTGCAAGATTGCAGACTTCGGCCTGGCTCGTCT CATCGAGGACAACGAGTACACAGCCAGGGAGGGGGCCAAGTTCCCCATTA AGTGGACAGCACCAGAAGCCATCAACTATGGGACGTTCACCATCAAGTCA GACGTGTGGTCTTTTGGGATCCTGCTGACAGAGATCGTCACCCACGGCCG CATCCCTTACCCAGGGATGACCAACCCCGAGGTGATCCAGAACCTGGAAC GAGGCTACCGCATGGTGCGCCCCGACAACTGTCCCGAGGAGCTGTACCAT CTCATGATGCTGTGCTGGAAGGAGCGCCCCGAGGACCGGCCCACCTTTGA CTACCTGCGCAGCGTGCTGGAGGACTTCTTCACAGCCACGGAGGGCCAGT ACCAGCCCCAGCCG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 539 | 1 | 539 | Insert and frame-shift 338-339:P-W^TC, Premature termination 344:Q->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetGlyCysGlyCysSerSerHisProGluAspAspTrpMetGluAsnIleAspValCys
||||||||| ||||||||| ||||||||||||||||||||||||||||||||||||
MetGlyCysSerCysSerSerAsnProGluAspAspTrpMetGluAsnIleAspValCys
ATGGGCTGTAGCTGCAGCTCAAACCCTGAAGATGACTGGATGGAGAACATCGACGTGTGT
GluAsnCysHisTyrProIleValProLeuAspGlyLysGlyThr >>>> Target I
|||||||||||||||||||||||||||||||||||| ||| 1079
GlyAsnCysHisTyrProIleValProLeuAspGlyLysAlaThr++
GGGAACTGCCATTACCCCATAGTCCCACTGGACGGCAAGGCCACGgt
ntron 1 >>>> LeuLeuIleArgAsnGlySerGluValArgAspProLeuValThrT
bp ||| |||||||||||||||||||||||||||||||||||||
++LeuProMetArgAsnGlySerGluValArgAspProLeuValThrT
agCTTCCCATGCGCAATGGCTCTGAGGTGCGGGACCCGCTGGTCACAT
yrGluGlySerAsnProProAlaSerProLeuGln{A} >>>> Target Intron 2
|||||||||||||||||||||||||||||||||||{|} 163 bp
yrGluGlySerAsnProProAlaSerProLeuGln{A}++
ACGAGGGCTCCAACCCGCCGGCCTCCCCGCTGCAA{G}gt
>>>> {sp}AsnLeuValIleAlaLeuHisSerTyrGluProSerHisAspGlyAspL
{||}|||||||||||||||||||||||||||||||||||||||||||||||||
++{sp}AsnLeuValIleAlaLeuHisSerTyrGluProSerHisAspGlyAspL
ag{AC}AACCTGGTTATTGCCCTGCACAGCTACGAGCCCTCTCACGACGGGGACC
euGlyPheGluLysGlyGluGlnLeuArgIleLeuGlu{Gl} >>>> Target Intr
|||||||| |||||||||||||||||| ||||||{||} 219 bp
euGlyPheValLysGlyGluGlnLeuArgValLeuGlu{Gl}++
TGGGCTTCGTAAAGGGCGAACAGCTCCGCGTCCTGGAG{CA}gt
on 3 >>>> {n}SerGlyGluTrpTrpLysAlaGlnSerLeuThrThrGlyGlnGluG
{|}||||||||||||||||||||||||||||||||||||||||||||||
++{n}SerGlyGluTrpTrpLysAlaGlnSerLeuThrThrGlyGlnGluG
ag{G}AGCGGCGAGTGGTGGAAGGCGCAGTCCCTGACCACCGGCCAGGAAG
lyPheIleProPheAsnPheValAlaLysAlaAsnSerLeuGluProGlu{Pr} >>>>
||||||||||||||||||||||||||||||||||||||||||||||||||{||}
lyPheIleProPheAsnPheValAlaLysAlaAsnSerLeuGluProGlu{Pr}++
GCTTCATCCCTTTCAACTTCGTGGCCAAAGCGAACAGCCTAGAGCCCGAA{CC}gt
Target Intron 4 >>>> {o}TrpPhePheLysAsnLeuSerArgLysAspAlaG
95 bp {|}||||||||||||||||||||||||||||||||||
++{o}TrpPhePheLysAsnLeuSerArgLysAspAlaG
ag{C}TGGTTCTTCAAGAACCTGAGCCGCAAGGACGCGG
luArgGlnLeuLeuAlaProGlyAsnThrHisGlySerPheLeuIleArgGluSerGluS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luArgGlnLeuLeuAlaProGlyAsnThrHisGlySerPheLeuIleArgGluSerGluS
AGCGGCAGCTCCTGGCGCCCGGGAACACGCACGGCTCCTTCCTGATCCGGGAGAGTGAGA
erThrAla{G} >>>> Target Intron 5 >>>> {ly}SerPheSerLeuSerV
||||||||{|} 222 bp {||}||||||||||||||||
erThrAla{G}++ ++{ly}SerPheSerLeuSerV
GCACAGCC{G}gt ag{GA}TCATTTTCACTGTCCG
alArgAspPheAspGlnAsnGlnGlyGluValValLysHisTyrLysIleArgAsnLeuA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
alArgAspPheAspGlnAsnGlnGlyGluValValLysHisTyrLysIleArgAsnLeuA
TCCGGGACTTCGACCAGAACCAGGGGGAGGTGGTGAAGCATTACAAGATCCGTAATCTGG
spAsnGlyGlyPheTyrIleSerProArgIleThrPheProGlyLeuHisGluLeuValA
|| |||||||||||||||||||||||||||||||||||||||||||||||||||||||
spAspGlyGlyPheTyrIleSerProArgIleThrPheProGlyLeuHisGluLeuValA
ACGACGGAGGCTTCTACATCTCCCCCCGCATCACTTTTCCCGGCCTACATGAACTGGTCC
rgHisTyrThr{A} >>>> Target Intron 6 >>>> {sn}AlaSerAspGlyL
|||||||||||{|} 260 bp {||}|||||||||||||
rgHisTyrThr{A}++ ++{sn}AlaSerAspGlyL
GCCATTATACC{A}gt ag{AC}GCTTCGGACGGGC
euCysThrArgLeuSerArgProCysGlnThrGlnLysProGlnLysProTrpTrpGluA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euCysThrArgLeuSerArgProCysGlnThrGlnLysProGlnLysProTrpTrpGluA
TGTGCACGCGCCTGAGCCGCCCCTGCCAGACCCAGAAGCCCCAGAAGCCGTGGTGGGAGG
spGluTrpGluValProArgGluThrLeuLysLeuValGluArgLeuGlyAlaGlyGlnP
|||||||||||||||||||||||||||||||||||||||||||||||||| |||||||
spGluTrpGluValProArgGluThrLeuLysLeuValGluArgLeuGlySerGlyGlnP
ATGAGTGGGAGGTTCCCAGGGAGACACTGAAGCTGGTGGAGCGGCTGGGGAGCGGCCAGT
heGlyGluValTrpMet{G} >>>> Target Intron 7 >>>> {ly}TyrTyrA
|||||||||||||||||{|} 132 bp {||}|||||||
heGlyGluValTrpMet{G}++ ++{ly}TyrTyrA
TCGGGGAGGTGTGGATG{G}gt ag{GG}TACTACA
snGlyHisThrLysValAlaValLysSerLeuLysGlnGlySerMetSerProAspAlaP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
snGlyHisThrLysValAlaValLysSerLeuLysGlnGlySerMetSerProAspAlaP
ACGGGCACACGAAGGTGGCAGTGAAGAGCCTGAAGCAGGGCAGCATGTCCCCCGACGCCT
heLeuAlaGluAlaAsnLeuMetLysGlnLeuGlnHisGlnArgLeuValArgLeuTyrA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
heLeuAlaGluAlaAsnLeuMetLysGlnLeuGlnHisGlnArgLeuValArgLeuTyrA
TCCTAGCCGAGGCCAACCTCATGAAGCAGCTGCAGCACCAGCGGCTGGTCCGGCTGTACG
laValValThrGlnGluProIleTyrIleIleThrGluTyrMetGluAsn{A} >>>>
||||||||||||||||||||||||||||||||||||||||||||||||||{|}
laValValThrGlnGluProIleTyrIleIleThrGluTyrMetGluAsn{A}++
CCGTGGTCACCCAGGAGCCGATCTACATTATCACTGAGTACATGGAGAAC{G}gt
Target Intron 8 >>>> {sp}ThrLeuLeuAspSerGlnLeuGluGluLysGlyL
2293 bp {||}||| |||||||
++{sp}ThrAlaSerArgProProValGlyAspLysGlyL
ag{AC}ACTGCTTCTAGACCCCCAGTTGGGGACAAGGGTC
euGlyAlaSerPro--TrpGlyAsnLeuGlyGlnGlnLeuLeuLeuLeuProThrGlySe
|| ||| |||##|||||||||||| |||||| |||||||||||||||||
euGluAla---Pro##TrpGlyAsnLeuSer***GlnLeuSerLeuLeuProThrGlySe
TTGAGGCT---CCCTCTGGGGCAACTTGAGTTAGCAACTCTCGCTTCTGCCCACAGGGAG
rLeuValAspPheLeuLysThrProSerGlyIleLysLeuThrIleAsnLysLeuLeuAs
||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||
rLeuValAspPheLeuLysThrProProGlyIleLysLeuThrIleAsnLysLeuLeuAs
CCTGGTGGATTTTCTCAAGACCCCCCCAGGCATCAAGCTGACCATCAACAAGCTCTTGGA
pMetAlaAlaGln >>>> Target Intron 9 >>>> IleAlaGluGlyMetAla
||||||||||||| 426 bp ||||||||||||||||||
pMetAlaAlaGln++ ++IleAlaGluGlyMetAla
CATGGCGGCCCAGgt agATCGCAGAGGGCATGGCA
PheIleGluGluArgAsnTyrIleHisArgAspLeuArgAlaAlaAsnIleLeuValSer
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PheIleGluGluArgAsnTyrIleHisArgAspLeuArgAlaAlaAsnIleLeuValSer
TTCATTGAAGAGCGGAATTACATCCACCGGGACCTGCGGGCTGCCAACATCCTGGTGTCG
AspThrLeuSerCysLysIleAlaAspPheGlyLeuAlaArgLeuIleGluAspAsnGlu
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AspThrLeuSerCysLysIleAlaAspPheGlyLeuAlaArgLeuIleGluAspAsnGlu
GACACCCTGAGCTGCAAGATTGCAGACTTCGGCCTGGCTCGTCTCATCGAGGACAACGAG
TyrThrAlaArgGlu{G} >>>> Target Intron 10 >>>> {ly}AlaLysPh
|||||||||||||||{|} 145 bp {||}||||||||
TyrThrAlaArgGlu{G}++ ++{ly}AlaLysPh
TACACAGCCAGGGAG{G}gt ag{GG}GCCAAGTT
eProIleLysTrpThrAlaProGluAlaIleAsnTyrGlyThrPheThrIleLysSerAs
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
eProIleLysTrpThrAlaProGluAlaIleAsnTyrGlyThrPheThrIleLysSerAs
CCCCATTAAGTGGACAGCACCAGAAGCCATCAACTATGGGACGTTCACCATCAAGTCAGA
pValTrpSerPheGlyIleLeuLeuThrGluIleValThrHisGlyArgIleProTyrPr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pValTrpSerPheGlyIleLeuLeuThrGluIleValThrHisGlyArgIleProTyrPr
CGTGTGGTCTTTTGGGATCCTGCTGACAGAGATCGTCACCCACGGCCGCATCCCTTACCC
o{G} >>>> Target Intron 11 >>>> {ly}MetThrAsnProGluValIleG
|{|} 2241 bp {||}||||||||||||||||||||||
o{G}++ ++{ly}MetThrAsnProGluValIleG
A{G}gt ag{GG}ATGACCAACCCCGAGGTGATCC
lnAsnLeuGluArgGlyTyrArgMetValArgProAspAsnCysProGluGluLeuTyrG
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnAsnLeuGluArgGlyTyrArgMetValArgProAspAsnCysProGluGluLeuTyrH
AGAACCTGGAACGAGGCTACCGCATGGTGCGCCCCGACAACTGTCCCGAGGAGCTGTACC
lnLeuMetArgLeuCysTrpLysGluArgProGluAspArgProThrPheAspTyrLeuA
|||||| |||||||||||||||||||||||||||||||||||||||||||||||||
isLeuMetMetLeuCysTrpLysGluArgProGluAspArgProThrPheAspTyrLeuA
ATCTCATGATGCTGTGCTGGAAGGAGCGCCCCGAGGACCGGCCCACCTTTGACTACCTGC
rgSerValLeuGluAspPhePheThrAlaThrGluGlyGlnTyrGlnProGlnPro
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rgSerValLeuGluAspPhePheThrAlaThrGluGlyGlnTyrGlnProGlnPro
GCAGCGTGCTGGAGGACTTCTTCACAGCCACGGAGGGCCAGTACCAGCCCCAGCCG
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