| Basic information |
| Official Symbol | KRT4 |
| Description | keratin 4 |
| Other Aliases | CK-4, CK4, CYK4, K4 |
| Other Description | cytokeratin 4; keratin, type II cytoskeletal 4; type-II keratin Kb4 |
| Mutation type | Insert and frame-shift 60-61:G-P^CT |
| Location | Scaffold000059_1:319451 326167 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| KRT4 |
ATGACTTCTGTAGGTGTGTTTAGTGACATGCTGAGCAGGTGCAAGAAAGA TGGGCCTGTGCCAAAGGCCAAGCCCAGAGATGTTTCGGATTTTTCCCTTT ATGCCCCTGCAACCAAGCCCTGCTGCTCCAGCACATATAAGAGACCCAGG TGCAGGGCTCCAGCATTCATTGGCCTTGCCTCCTGCTCCTCTCTGGTAGC TCCGAACTCACTCTCCTCTCTCATCATGATCGCCAGACAGCAGGGTGTCA GGGGTGGCTCTCGGGGCTTCAGCTGTGGCTCGGCCATCGTAGGTGGGGGC AAGAGGGCTGCCTTCAGCTCACTTTCTGTGTCTGGGGGTGCAGGTCGCTG CTCTTCTGGGGGCTTTGGCAGCAGGAGCCTCTACAACCTTGGGGGGAGTA AGAGCATCTGCATGAGTGTGGCTGGGTCTCGGCAAGGCGCTGGCTTTGGG GGTGCTGGTTTCGGCGCTGGCGGCTTTGGTAGTGGATATGGGGGCTCCTT CAATGGCCGGGGTGGTCCTGGCTTCCCAGTATGCCCTGCTGGGGGAATTC AGGAGGTCACGATCAACCAGAGCCTGTTGACCCCACTCCATGTGGAGATT GATCCTGAAATCCAGAAAGTCCGGACTGAGGAGCGGGAGCAGATCAAGAC CCTCAATAACAAGTTCGCCTCCTTCATCGACAAGGTGCGGTTCTTAGAGC AACAGAATAAGGTCCTGGAGACCAAATGGAACCTCCTCCAGCAGCAGACG ACCACCACGTCTGTCAAAAACCTTGAGCCCTTATTTGAGGTCTACTTGAG TGCCTTGAGGAAGCAGCTGGACAGCCTTTCCAATGACAAAGGGCGTCTGC AGTCTGAGCTGAAGACCATGCAGGACAGTGTGGAGGACTTCAAGACCAAG TATGAAGATGAGATCAACAAACGCACAGCTGCTGAGAATGACTTCGTGGT TCTCAAGAAGGATGTGGATGCTGCCTACATGACCAAGGTGGAGCTGGAGG CCAAGGTGGATGGCCTTAATGATGAGATCAGCTTCCTGAAGGCCTTCTAT GATGCGGAGCTGTCCCAGATGCAGACCCATGTCAGTGACACATCCGTGGT CCTCTCTATGGACAACAACCGCAATCTGGACCTGGACAGCATCATCGCGG AGGTCCGTGCCCAGTATGAAGAGATTGCCCAGAGGAGCAAGGCTGAGGCT GAGGCGCTGTACCAGACCAAGGTCCAACAACTCCAGACCTCAGTTGACTT ACATGGTGACAGCCTGAAGAACACCAAGAGTGAGATTGCAGAGCTCAACA GGATGATCCAGAGGCTGAGGGCTGAGATCGAGAATGTCAAGAAGCAGTGC CAGACTCTGCAGGCATCTGTGGCTGATGCTGAGCAGCGTGGGGAGGTGGC CCTCAAAGATGCCTATAACAAGCGCACAGAGCTGGAGGGTGCCCTGCAGA AGGCCAAGGAGGAGCTGGCCAAGATGTTGCGCGAGTACCAGGAGCTGATG AACGTGAAGCTGGCCTTGGACATCGAGATTGCCACCTACCGCAAGCTGCT GGAGGGCGAGGAGTTCAGAATGTCTGGAGAATGCCAGAGTGCCGTGAGCA TCTCCGTGGTCGGCAGTGGGGTCAGTGCTGGAGGAATCGGTGGAGGATTA GGAAGCTCCTCTGGATTTGGCCTAGGTAGTGGCTTCGGCTCTGGCTCTGG AAGTGGCTTCGGGTTTGGCGGCGGCGTCAGTGGAAGTTCCAGCGGCAAGA TCATCACTACC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 594 | 1 | 587 | Insert and frame-shift 60-61:G-P^CT |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetThrSerValGlyValPheSerAspMetLeuAsnGlyCysGlyLysAspGlyLeuVal
||||||||||||||||||||||||||||||||| ||| ||||||||| |||
MetThrSerValGlyValPheSerAspMetLeuSerArgCysLysLysAspGlyProVal
ATGACTTCTGTAGGTGTGTTTAGTGACATGCTGAGCAGGTGCAAGAAAGATGGGCCTGTG
ProArgAlaLysProArgAspValSerAspPheSerLeuTyrAlaProAlaThrLysPro
||| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
ProLysAlaLysProArgAspValSerAspPheSerLeuTyrAlaProAlaThrLysPro
CCAAAGGCCAAGCCCAGAGATGTTTCGGATTTTTCCCTTTATGCCCCTGCAACCAAGCCC
CysCysSerArgThrTyrLysArgArgArgLeuArgAlaProAlaLeuThrGlyLeuGly
||||||||| |||||||||||| ||| |||||||||||| ||||||
CysCysSerSerThrTyrLysArgProArgCysArgAlaProAlaPheIleGlyLeuAla
TGCTGCTCCAGCACATATAAGAGACCCAGGTGCAGGGCTCCAGCATTCATTGGCCTTGCC
--ProValThrSerLeuIleAlaProSerSerLeuSerAla<->AlaMetIleAlaArgG
## |||||| |||||| ||||||||| |||||||||||||
##SerCysSerSerLeuValAlaProAsnSerLeuSerSerLeuIleMetIleAlaArgG
CTTCCTGCTCCTCTCTGGTAGCTCCGAACTCACTCTCCTCTCTCATCATGATCGCCAGAC
lnGlnCysValArgGlyGlyProArgGlyPheSerCysGlySerAlaIleValGlyGlyG
||||| |||||||||||| |||||||||||||||||||||||||||||||||||||
lnGlnGlyValArgGlyGlySerArgGlyPheSerCysGlySerAlaIleValGlyGlyG
AGCAGGGTGTCAGGGGTGGCTCTCGGGGCTTCAGCTGTGGCTCGGCCATCGTAGGTGGGG
lyLysArgGlyAlaPheSerSerValSerMetSerGlyGlyAlaGlyArgCysSerSerG
|||||||| |||||||||||| ||| ||||||||||||||||||||||||||||
lyLysArgAlaAlaPheSerSerLeuSerValSerGlyGlyAlaGlyArgCysSerSerG
GCAAGAGGGCTGCCTTCAGCTCACTTTCTGTGTCTGGGGGTGCAGGTCGCTGCTCTTCTG
lyGlyPheGlySerArgSerLeuTyrAsnLeuArgGlyAsnLysSerIleSerMetSerV
|||||||||||||||||||||||||||||||| ||| ||||||||| |||||||
lyGlyPheGlySerArgSerLeuTyrAsnLeuGlyGlySerLysSerIleCysMetSerV
GGGGCTTTGGCAGCAGGAGCCTCTACAACCTTGGGGGGAGTAAGAGCATCTGCATGAGTG
alAlaGlySerArgGlnGlyAlaCysPheGlyGlyAla{G} >>>> Target Intro
||||||||||||||||||||||| ||||||||||||{|} 30 bp
alAlaGlySerArgGlnGlyAlaGlyPheGlyGlyAla{G}+-
TGGCTGGGTCTCGGCAAGGCGCTGGCTTTGGGGGTGCT{G}ga
n 1 >>>> {ly}GlyPheGlyThrGlyGlyPheGlyGlyGlyPheGlyGlySerPheS
{||} |||||| |||||||||||| ||| ||||||||||||
-+{ly}---PheGlyAlaGlyGlyPheGlySerGlyTyrGlyGlySerPheA
tg{GT}---TTCGGCGCTGGCGGCTTTGGTAGTGGATATGGGGGCTCCTTCA
erGlyLysGlyGlyProGlyPheProValCysProAlaGlyGlyIleGlnGluValThrI
||| ||||||||||||||||||||||||||||||||||||||||||||||||||||
snGlyArgGlyGlyProGlyPheProValCysProAlaGlyGlyIleGlnGluValThrI
ATGGCCGGGGTGGTCCTGGCTTCCCAGTATGCCCTGCTGGGGGAATTCAGGAGGTCACGA
leAsnGlnSerLeuLeuThrProLeuHisValGluIleAspProGluIleGlnLysValA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
leAsnGlnSerLeuLeuThrProLeuHisValGluIleAspProGluIleGlnLysValA
TCAACCAGAGCCTGTTGACCCCACTCCATGTGGAGATTGATCCTGAAATCCAGAAAGTCC
rgThrGluGluArgGluGlnIleLysLeuLeuAsnAsnLysPheAlaSerPheIleAspL
|||||||||||||||||||||||||| |||||||||||||||||||||||||||||||
rgThrGluGluArgGluGlnIleLysThrLeuAsnAsnLysPheAlaSerPheIleAspL
GGACTGAGGAGCGGGAGCAGATCAAGACCCTCAATAACAAGTTCGCCTCCTTCATCGACA
ys >>>> Target Intron 2 >>>> ValGlnPheLeuGluGlnGlnAsnLysVa
|| 2084 bp ||| |||||||||||||||||||||||
ys++ ++ValArgPheLeuGluGlnGlnAsnLysVa
AGgt agGTGCGGTTCTTAGAGCAACAGAATAAGGT
lLeuGluThrLysTrpAsnLeuLeuGlnGlnGlnThrThrThrThrSerSerLysAsnLe
||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||
lLeuGluThrLysTrpAsnLeuLeuGlnGlnGlnThrThrThrThrSerValLysAsnLe
CCTGGAGACCAAATGGAACCTCCTCCAGCAGCAGACGACCACCACGTCTGTCAAAAACCT
uGluProLeuPheGluThrTyrLeuSerValLeuArgLysGlnLeuAspThrLeuGlyAs
|||||||||||||||| ||||||||| |||||||||||||||||| ||| ||
uGluProLeuPheGluValTyrLeuSerAlaLeuArgLysGlnLeuAspSerLeuSerAs
TGAGCCCTTATTTGAGGTCTACTTGAGTGCCTTGAGGAAGCAGCTGGACAGCCTTTCCAA
nAspLysGlyArgLeuGlnSerGluLeuLysThrMetGlnAspSerValGluAspPheLy
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nAspLysGlyArgLeuGlnSerGluLeuLysThrMetGlnAspSerValGluAspPheLy
TGACAAAGGGCGTCTGCAGTCTGAGCTGAAGACCATGCAGGACAGTGTGGAGGACTTCAA
sThr{Ly} >>>> Target Intron 3 >>>> {s}TyrGluGluGluIleAsnLy
||||{||} 913 bp {|}|||||| |||||||||||
sThr{Ly}++ ++{s}TyrGluAspGluIleAsnLy
GACC{AA}gt ag{G}TATGAAGATGAGATCAACAA
sArgThrAlaAlaGluAsnAspPheValValLeuLysLys >>>> Target Intron
|||||||||||||||||||||||||||||||||||||||| 398 bp
sArgThrAlaAlaGluAsnAspPheValValLeuLysLys++
ACGCACAGCTGCTGAGAATGACTTCGTGGTTCTCAAGAAGgt
4 >>>> AspValAspAlaAlaTyrLeuAsnLysValGluLeuGluAlaLysValAsp
|||||||||||||||||| |||||||||||||||||||||||||||
++AspValAspAlaAlaTyrMetThrLysValGluLeuGluAlaLysValAsp
agGATGTGGATGCTGCCTACATGACCAAGGTGGAGCTGGAGGCCAAGGTGGAT
SerLeuAsnAspGluIleAsnPheLeuLysValLeuTyrAspAla >>>> Target I
||||||||||||||| ||||||||| ||||||||| 550
GlyLeuAsnAspGluIleSerPheLeuLysAlaPheTyrAspAla++
GGCCTTAATGATGAGATCAGCTTCCTGAAGGCCTTCTATGATGCGgt
ntron 5 >>>> GluLeuSerGlnMetGlnThrHisValSerAspThrSerValValL
bp ||||||||||||||||||||||||||||||||||||||||||||||
++GluLeuSerGlnMetGlnThrHisValSerAspThrSerValValL
agGAGCTGTCCCAGATGCAGACCCATGTCAGTGACACATCCGTGGTCC
euSerMetAspAsnAsnArgAsnLeuAspLeuAspSerIleIleAlaGluValArgAlaG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euSerMetAspAsnAsnArgAsnLeuAspLeuAspSerIleIleAlaGluValArgAlaG
TCTCTATGGACAACAACCGCAATCTGGACCTGGACAGCATCATCGCGGAGGTCCGTGCCC
lnTyrGluGluIleAlaGlnArgSerLysAlaGluAlaGluAlaLeuTyrGlnThrLys
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnTyrGluGluIleAlaGlnArgSerLysAlaGluAlaGluAlaLeuTyrGlnThrLys+
AGTATGAAGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAGGCGCTGTACCAGACCAAGg
>>>> Target Intron 6 >>>> ValGlnGlnLeuGlnIleSerValAspGlnHi
251 bp ||||||||||||||| ||||||||| ||
+ ++ValGlnGlnLeuGlnThrSerValAspLeuHi
t agGTCCAACAACTCCAGACCTCAGTTGACTTACA
sGlyAspAsnLeuLysAsnThrLysSerGluIleAlaGluLeuAsnArgMetIleGlnAr
||||||| ||||||||||||||||||||||||||||||||||||||||||||||||||
sGlyAspSerLeuLysAsnThrLysSerGluIleAlaGluLeuAsnArgMetIleGlnAr
TGGTGACAGCCTGAAGAACACCAAGAGTGAGATTGCAGAGCTCAACAGGATGATCCAGAG
gLeuArgAlaGluIleGluAsnIleLysLysGln >>>> Target Intron 7 >>>
|||||||||||||||||||||| ||||||||| 398 bp
gLeuArgAlaGluIleGluAsnValLysLysGln++
GCTGAGGGCTGAGATCGAGAATGTCAAGAAGCAGgt
> CysGlnThrLeuGlnValSerValAlaAspAlaGluGlnArgGlyGluAsnAlaLeu
||||||||||||||| |||||||||||||||||||||||||||||| ||||||
++CysGlnThrLeuGlnAlaSerValAlaAspAlaGluGlnArgGlyGluValAlaLeu
agTGCCAGACTCTGCAGGCATCTGTGGCTGATGCTGAGCAGCGTGGGGAGGTGGCCCTC
LysAspAlaHisSerLysArgValGluLeuGluAlaAlaLeuGlnGlnAlaLysGluGlu
||||||||| |||||| ||||||||| ||||||||| ||||||||||||
LysAspAlaTyrAsnLysArgThrGluLeuGluGlyAlaLeuGlnLysAlaLysGluGlu
AAAGATGCCTATAACAAGCGCACAGAGCTGGAGGGTGCCCTGCAGAAGGCCAAGGAGGAG
LeuAlaArgMetLeuArgGluTyrGlnGluLeuMetSerValLysLeuAlaLeuAspIle
|||||| ||||||||||||||||||||||||||| |||||||||||||||||||||
LeuAlaLysMetLeuArgGluTyrGlnGluLeuMetAsnValLysLeuAlaLeuAspIle
CTGGCCAAGATGTTGCGCGAGTACCAGGAGCTGATGAACGTGAAGCTGGCCTTGGACATC
GluIleAlaThrTyrArgLysLeuLeuGluGlyGluGluTyr{Ar} >>>> Target
||||||||||||||||||||||||||||||||||||||| {||} 22
GluIleAlaThrTyrArgLysLeuLeuGluGlyGluGluPhe{Ar}++
GAGATTGCCACCTACCGCAAGCTGCTGGAGGGCGAGGAGTTC{AG}gt
Intron 8 >>>> {g}MetSerGlyGluCysGlnSerAlaValSerIle{S} >>>>
1 bp {|}|||||||||||||||||||||||||||||||||{|}
++{g}MetSerGlyGluCysGlnSerAlaValSerIle{S}++
ag{A}ATGTCTGGAGAATGCCAGAGTGCCGTGAGCATC{T}gt
Target Intron 9 >>>> {er}ValValSerGlySerThrSerThrGlyGlyIle
109 bp {||}|||||| ||| |||||||||
++{er}ValValGlySerGlyValSerAlaGlyGlyIle
ag{CC}GTGGTCGGCAGTGGGGTCAGTGCTGGAGGAATC
SerGlyGlyLeuGlySerGlySerGlyPheGlyLeuSerSerGlyPheGlySerGlySer
||||||||||||||| ||||||||||||||| |||||||||||||||||||||
GlyGlyGlyLeuGlySerSerSerGlyPheGlyLeuGlySerGlyPheGlySerGlySer
GGTGGAGGATTAGGAAGCTCCTCTGGATTTGGCCTAGGTAGTGGCTTCGGCTCTGGCTCT
GlySerGlyPheGlyPheGlyGlySerValSerGlySerSerSerSerLysIleIleSer
|||||||||||||||||||||||| |||||||||||||||||| |||||||||
GlySerGlyPheGlyPheGlyGlyGlyValSerGlySerSerSerGlyLysIleIleThr
GGAAGTGGCTTCGGGTTTGGCGGCGGCGTCAGTGGAAGTTCCAGCGGCAAGATCATCACT
Thr
|||
Thr
ACC
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