| Basic information |
| Official Symbol | KMO |
| Description | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| Other Aliases | RP1-317G22.1, dJ317G22.1 |
| Other Description | kynurenine 3-hydroxylase; kynurenine 3-monooxygenase |
| Mutation type | Insert and frame-shift 466-467:T-T^GG, premature termination 18:L->TAG |
| Location | Scaffold000074_1:8840132 8872614 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| KMO |
GGTTCCTAGGTTGGATCACTACATGCATGCTTCCTTGCAAAAAGGAATTT CCAAGTTGATGTATATGAAGCTAGGGAAGATATTCGAGTGGCTGAATTCG CACGTGGAAGAAGCATTAACTTGGCCCTTTCTTATAGAGGACGGCAAGCC TTGAAAGCCATTGGCCTAGAAGATCAGATTGTATCCCAAGGTATTCCCAT GAGAGCAAGAATGATTCACTCTCTTTCAGGAAAAAAGTCTGCCATTCCCT ACGGGACAAAGTCTCAGTATATTCTTTCCATAAGCAGAGAAAATTTAAAC AAGGATCTTCTGACTGCTGTTGAAAAATACCCCAATGCGAAAGTGCACTT TGGCCACAGGCTGTTGAAATGTTTTCTTGAAGAAGGAAAAATCACAGTGC TTGGATCTGACAAAGTTTCAAAAGATGCCACTTATGACCTCATTGTAGGA TGTGATGGAGCCTATTCAACTGTCAGAGCTCACCTCATGAAGAAGCCTCG CTTTGATTATAGTCAGCAATACATTCCTCATGGGTACATGGAGCTGACTA TTCCACCTAAGAATGGAGATTATGCCATGGAACCCAATTATCTACATATT TGGCCCAGAAATACCTTCATGATGATTGCACTTCCTAATACGAACAAATC TTTCACATGCACTTTGTTCATGCCCTTCGAAGAGTTCGACAAACTTCTAA CCAGTAGCGATGTGCTGAATTTCTTCCAGAAGTACTTCCCAGACGCCATC CCTCTAATTGGAAAGCAAACCCTGGCAAATGATTTCTTTCTATTGCCTGC TCAGCCCATGATATCTGTAAAGTGCTCTTCTTTTCACTTTAAGTCACATT GTGTACTAATGGGAGATGCGGCTCATGCCATAGTGCCATTCTTTGGGCAA GGAATGAATGCGGGATTTGAAGACTGCTTAGTATTTGATGAGTTAATGGA TAAATTTAATAATAATCTTTGTTTATGTCTTCCTGAATTCTCAAGACTTA GAATTCCAGATGACCATGCAGTTTCAGATCTATCCATGTACAATTATATA GAGATGCGAGCACACGTCAACTCAAGGTGGTTCATTTTTCAAAAGAATGT GGAGAGATTTCTTCATGCTATTATGCCATCTACATTTATCCCTCTCTATA CCATGGTCACCTTTTCTAGAATAAGATACCATGAGGCAGCACTGCGTTGG CACTGGCAAAAAAAGGTAATAAACAAAGGACTCTTTTTCTTTGGTTCACT GATAGCCATCGGTAGTACCTACCTACTTATGCGCTATATGTCCCAAGGAC CTCTGGACTACTTGAGAAGACCAGGGCACTGGATTGCTCACTTCCGGAAT ACAACATGCTTCCCTACAAACTCCATGGAGCCACTA |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 486 | 16 | 477 | Insert and frame-shift 466-467:T-T^GG, Premature termination 18:L->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
GlyGlyLeuValGlySerLeuGlnAlaCysPheLeuAlaLysArgAsnPheGlnIleAsp
||| |||||||||||| |||||||||||||||||||||||||||||| |||
GlySer***ValGlySerLeuHisAlaCysPheLeuAlaLysArgAsnPheGlnValAsp
GGTTCCTAGGTTGGATCACTACATGCATGCTTCCTTGCAAAAAGGAATTTCCAAGTTGAT
ValTyrGluAlaArgGlu{A} >>>> Target Intron 1 >>>> {sp}ThrArg
||||||||||||||||||{|} 928 bp {||} |||
ValTyrGluAlaArgGlu{A}++ ++{sp}IleArg
GTATATGAAGCTAGGGAA{G}gt ag{AT}ATTCGA
ValAlaThrPheThrArgGlyArgSerIleAsnLeuAlaLeuSerHisArgGlyArgGln
|||||| ||| |||||||||||||||||||||||||||||| ||||||||||||
ValAlaGluPheAlaArgGlyArgSerIleAsnLeuAlaLeuSerTyrArgGlyArgGln
GTGGCTGAATTCGCACGTGGAAGAAGCATTAACTTGGCCCTTTCTTATAGAGGACGGCAA
AlaLeuLysAlaValGlyLeuGluAspGln >>>> Target Intron 2 >>>> I
|||||||||||| ||||||||||||||| 1839 bp |
AlaLeuLysAlaIleGlyLeuGluAspGln++ ++I
GCCTTGAAAGCCATTGGCCTAGAAGATCAGgt agA
leValSerGlnGlyIleProMetArgAlaArgMetIleHisSerLeuSerGlyLysLysS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
leValSerGlnGlyIleProMetArgAlaArgMetIleHisSerLeuSerGlyLysLysS
TTGTATCCCAAGGTATTCCCATGAGAGCAAGAATGATTCACTCTCTTTCAGGAAAAAAGT
erAlaIleProTyrGlyThrLysSerGln >>>> Target Intron 3 >>>> Ty
||||||||||||||||||||||||||||| 5096 bp ||
erAlaIleProTyrGlyThrLysSerGln++ ++Ty
CTGCCATTCCCTACGGGACAAAGTCTCAGgt agTA
rIleLeuSerValSerArgGluAsnLeuAsnLysAspLeuLeuThr{A} >>>> Targ
|||||||||| |||||||||||||||||||||||||||||||||{|}
rIleLeuSerIleSerArgGluAsnLeuAsnLysAspLeuLeuThr{A}++
TATTCTTTCCATAAGCAGAGAAAATTTAAACAAGGATCTTCTGACT{G}gt
et Intron 4 >>>> {la}AlaGluLysTyrProAsnValLysMetHisPheAsnHi
7776 bp {||} ||||||||||||||| ||| |||||| ||
++{la}ValGluLysTyrProAsnAlaLysValHisPheGlyHi
ag{CT}GTTGAAAAATACCCCAATGCGAAAGTGCACTTTGGCCA
sArgLeuLeuLysCysAsnProGluGluGlyMetIleThrValLeu{Gl} >>>> Tar
|||||||||||||||| ||||||||| ||||||||||||{||}
sArgLeuLeuLysCysPheLeuGluGluGlyLysIleThrValLeu{Gl}++
CAGGCTGTTGAAATGTTTTCTTGAAGAAGGAAAAATCACAGTGCTT{GG}gt
get Intron 5 >>>> {y}SerAspLysValProLysAspValThrCysAspLeuIl
2523 bp {|}|||||||||||| |||||| ||| ||||||||
++{y}SerAspLysValSerLysAspAlaThrTyrAspLeuIl
ag{A}TCTGACAAAGTTTCAAAAGATGCCACTTATGACCTCAT
eValGlyCysAspGlyAlaTyrSerThrValArgSerHisLeuMetLysLysProArgPh
|||||||||||||||||||||||||||||||||| |||||||||||||||||||||||
eValGlyCysAspGlyAlaTyrSerThrValArgAlaHisLeuMetLysLysProArgPh
TGTAGGATGTGATGGAGCCTATTCAACTGTCAGAGCTCACCTCATGAAGAAGCCTCGCTT
eAspTyrSerGlnGlnTyrIleProHisGlyTyrMetGluLeuThrIleProProLysAs
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
eAspTyrSerGlnGlnTyrIleProHisGlyTyrMetGluLeuThrIleProProLysAs
TGATTATAGTCAGCAATACATTCCTCATGGGTACATGGAGCTGACTATTCCACCTAAGAA
nGlyAsp >>>> Target Intron 6 >>>> TyrAlaMetGluProAsnTyrLeu
||||||| 3581 bp ||||||||||||||||||||||||
nGlyAsp++ ++TyrAlaMetGluProAsnTyrLeu
TGGAGATgt agTATGCCATGGAACCCAATTATCTA
HisIleTrpProArgAsnThrPheMetMetIleAlaLeuProAsnMet >>>> Targe
||||||||||||||||||||||||||||||||||||||||||||| 1
HisIleTrpProArgAsnThrPheMetMetIleAlaLeuProAsnThr++
CATATTTGGCCCAGAAATACCTTCATGATGATTGCACTTCCTAATACGgt
t Intron 7 >>>> AsnLysSerPheThrCysThrLeuPheMetProPheGluGluP
134 bp |||||||||||||||||||||||||||||||||||||||||||
++AsnLysSerPheThrCysThrLeuPheMetProPheGluGluP
agAACAAATCTTTCACATGCACTTTGTTCATGCCCTTCGAAGAGT
heGluLysLeuLeuThrSerAsnAspValValAspPhePheGlnLysTyrPheProAspA
|| ||||||||||||||| |||||| |||||||||||||||||||||||||
heAspLysLeuLeuThrSerSerAspValLeuAsnPhePheGlnLysTyrPheProAspA
TCGACAAACTTCTAACCAGTAGCGATGTGCTGAATTTCTTCCAGAAGTACTTCCCAGACG
laIleProLeuIleGly{Gl} >>>> Target Intron 8 >>>> {u}LysLeuL
|||||||||||||||||{ } 2094 bp { } |
laIleProLeuIleGly{Ly}++ ++{s}GlnThrL
CCATCCCTCTAATTGGA{AA}gt ag{G}CAAACCC
euValGlnAspPhePheLeuLeuProAlaGlnProMetIleSerValLysCysSerSerP
|| ||||||||||||||||||||||||||||||||||||||||||||||||||||
euAlaAsnAspPhePheLeuLeuProAlaGlnProMetIleSerValLysCysSerSerP
TGGCAAATGATTTCTTTCTATTGCCTGCTCAGCCCATGATATCTGTAAAGTGCTCTTCTT
heHisPheLysSerHisCysValLeuLeuGlyAspAlaAlaHisAlaIleValProPheP
|||||||||||||||||||||||||| |||||||||||||||||||||||||||||||
heHisPheLysSerHisCysValLeuMetGlyAspAlaAlaHisAlaIleValProPheP
TTCACTTTAAGTCACATTGTGTACTAATGGGAGATGCGGCTCATGCCATAGTGCCATTCT
heGlyGlnGlyMetAsnAla >>>> Target Intron 9 >>>> GlyPheGluAs
|||||||||||||||||||| 1614 bp |||||||||||
heGlyGlnGlyMetAsnAla++ ++GlyPheGluAs
TTGGGCAAGGAATGAATGCGgt agGGATTTGAAGA
pCysLeuValPheAspGluLeuMetAspLysPheSerAsnAspLeu{S} >>>> Targ
|||||||||||||||||||||||||||||||||| ||| |||{ }
pCysLeuValPheAspGluLeuMetAspLysPheAsnAsnAsnLeu{C}++
CTGCTTAGTATTTGATGAGTTAATGGATAAATTTAATAATAATCTT{T}gt
et Intron 10 >>>> {er}LeuCysLeuProValPheSerArgLeuArgIleProA
2462 bp { }|||||||||||| ||||||||||||||||||||||
++{ys}LeuCysLeuProGluPheSerArgLeuArgIleProA
ag{GT}TTATGTCTTCCTGAATTCTCAAGACTTAGAATTCCAG
spAspHisAlaIleSerAspLeuSerMetTyrAsnTyrIleGlu >>>> Target In
||||||||||| |||||||||||||||||||||||||||||| 235
spAspHisAlaValSerAspLeuSerMetTyrAsnTyrIleGlu++
ATGACCATGCAGTTTCAGATCTATCCATGTACAATTATATAGAGgt
tron 11 >>>> MetArgAlaHisValAsnSerSerTrpPheIlePheGlnLysAsnM
bp ||||||||||||||||||||| |||||||||||||||||||||
++MetArgAlaHisValAsnSerArgTrpPheIlePheGlnLysAsnV
agATGCGAGCACACGTCAACTCAAGGTGGTTCATTTTTCAAAAGAATG
etGluArgPheLeuHisAlaIleMetProSerThrPheIleProLeuTyrThrMet >>
||||||||||||||||||||||||||||||||||||||||||||||||||||||
alGluArgPheLeuHisAlaIleMetProSerThrPheIleProLeuTyrThrMet++
TGGAGAGATTTCTTCATGCTATTATGCCATCTACATTTATCCCTCTCTATACCATGgt
>> Target Intron 12 >>>> ValThrPheSerArgIleArgTyrHisGluAlaV
89 bp |||||||||||||||||||||||||||||||||
++ValThrPheSerArgIleArgTyrHisGluAlaA
agGTCACCTTTTCTAGAATAAGATACCATGAGGCAG
alGlnArgTrpHisTrpGlnLysLys >>>> Target Intron 13 >>>> ValI
||||||||||||||||||||| 1724 bp ||||
laLeuArgTrpHisTrpGlnLysLys++ ++ValI
CACTGCGTTGGCACTGGCAAAAAAAGgt agGTAA
leAsnLysGlyLeuPhePheLeuGlySerLeuIleAlaIleSerSerThrTyrLeuLeuI
|||||||||||||||||||| |||||||||||||||||| |||||||||||||||
leAsnLysGlyLeuPhePhePheGlySerLeuIleAlaIleGlySerThrTyrLeuLeuM
TAAACAAAGGACTCTTTTTCTTTGGTTCACTGATAGCCATCGGTAGTACCTACCTACTTA
leHisTyrMetSerProArgSerPheLeuArgLeuArgArgProTrpAsnTrpIleAlaH
||||||||| |||||||||||| ||||||||||
etArgTyrMetSerGlnGlyProLeuAspTyrLeuArgArgProGlyHisTrpIleAlaH
TGCGCTATATGTCCCAAGGACCTCTGGACTACTTGAGAAGACCAGGGCACTGGATTGCTC
isPheArgAsnThr--ThrCysPheProAlaLysAlaValAspSerLeu
||||||||||||||##|||||||||||| |||
isPheArgAsnThr##ThrCysPheProThrAsnSerMetGluProLeu
ACTTCCGGAATACAGGACATGCTTCCCTACAAACTCCATGGAGCCACTA
//
|