| Basic information |
| Official Symbol | KIF12 |
| Description | kinesin family member 12 |
| Other Aliases | RP11-56P10.3 |
| Other Description | kinesin-like protein KIF12 |
| Mutation type | Insert and frame-shift 632-633:C-S^CC, premature termination 464:L->TGA |
| Location | Scaffold000081_1:5191663 5184356 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| KIF12 |
ATGGAGGAACGAGGGTCTCCGGATGGGGACCCCGCGCGGAACCTGGAGCA GGGGCCGGAAGGACCGGAAACGCCCATCCAGGTGGTGCTCAGGGTGCGAC CTATGAGCGCAGCCGAGCTGCGTCGAGGGGAACAGAGCGTTCTGCATTGC TCAGGGACCCGGACTCTGCAGGGGGGCCCCGACGTGGCGTTCCGCTTCGG CGTGGTGCTGGACGCGACGCGCACGCAGGAGGACGTGTTCCAGGCGTGCG GCGTGCGGCGCCTGGGAGAGCTTGCGCTGCGGGGTTTCTCCTGCACCGTC TTCACCTTTGGTCAGACTGGTTCCGGCAAGACTTACACCCTGACCGGACC CCCTCCCCAGGGGGAGGGGGTGCCAGTGCCCCCCAGCCTGGCTGGCATCA TGCAGAGGACCTTCGCCTGGCTGTTAGACCGCGTGCAGCGCCTGGGCTCC CAGGTCACCCTTCGCGCCTCCTATCTGGAGATCTACAATGAGCAGGTTCG GGACTTACTGAGCCTGGGGTCTTCCCGGCCCCTCCCAGTTCGCTGGAACA AGACCCGGGGCTTCTACGTGGAGCAGCTCCGGGAGGTGGAGTTCGGGAGC CTGGAGGCCTTGATGGAACTGCTGCAGAAGGGTCTTAGCCGGCGGCGGAG CTCCGCCCACTCCCTGAACCAGGCGTCCAGCCGAAGCCACGCCCTGCTCA CGCTCCACATCTGCCGCCCGGTTTCCCCGCAGCTGCCTCCTGCAGACGCT GGGGAGCCCCCTGCTGGTGGGAAGCTGTGCTTTGTAGACCTGGCTGGCAG CGAGAAGGTGACAGCCACGGGATCCCGCGGGGAGCTGATGCTTGAGGCCA ACAGCATCAACCGCAGCCTGCTGGCCCTGGGTCACTGCATCTCCCTGCTG CTGGACCCTCAGCGGAAGCAAAGTCACATCCCTTTCCGAGACAGCAAGCT CACCAAGCTGTTGGCAGACTCCCTGGGGGGCCGTGGGGTCACCCTCATGG TGGCCTGCGTGTCCCCCTCAGCCCAGTGCCTTCCCGAGACACTCAGCACC CTGCGCTATGCAAGCCGGGCTCAGCGGGTCACCACCCGGCCACAGGCCCC CAAGTCCCCTGTGGCAAAGCAGCCTCAGCGTTTGGAGACCGAGGTGCTGC AGCTCCAGGAGGAGAACCGTCGCCTTCGGTTCCAGCTGGACCAAATGGAT CCCAAGGGTTCAGGGCCCAGCGGGGCCCGAGTGGCCTGGGCCCAGCGGAA CCTCTATGGGATGCTACAGGAGTTCATGCTGGAAAATGAAAGGCTCAGAA AAGAAAAGAGCCAGCTGCAGAGAAGCCGAGACCTGGCCCGGAATGAGCAG CGCATCCTGGCTCAGCAGGTGCATGAGCTGGAGAGGTGAGTGTCACCGCC CGGTCACCAGCCTTGGACACTCTCCATCTGTCACCTTCGCCACTCGGGCC CTGGCCCAGCCCCACCGTGCGCCGCACTACCACCCCTCTGCTCCTGCCCC TGCTGCCACCTCTGCCCTCTGGCCCACTGGGCCTGCCCACGGAGGGAGCA CCATCTGCAGCAGGTGCCGAGCCCCGAGCCCCCCGGCGGCCTGCCCCTGT CTGCCCGACCCCCACCCTGCGTACCCCCATGTGGCTCTGGCTCTGGCTCT GGCTCTGCCAAGTGCCCAAGAGAGAGGAGTCACCGTGACTCGTGGATGCA GACCAGGGCCCTGGCAGAGATGCTGACGGAGGAGGAGGTGGTACCCTCTG CACCGCCCCTGCCTGTGGGGCCCCCGGACACGTCGCCTGTGCTGAGAGGT GGGGCTGGGGTTCCGAACCTGGCCCGGAGGCTAGAGGCCCTCAGAGACCA GACTGGCGGCTCCTTACTCCATGGCCAGAGCCAACCTCCCAGCGAGGGTG CACAGAGCCCAGGCCACGTCCTCCCTCCCCAC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 646 | 1 | 646 | Insert and frame-shift 632-633:C-S^CC, Premature termination 464:L->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetGluGluArgGlySerProAsp{Gl} >>>> Target Intron 1 >>>> {y}
||||||||||||||||||||||||{||} 85 bp {|}
MetGluGluArgGlySerProAsp{Gl}++ ++{y}
ATGGAGGAACGAGGGTCTCCGGAT{GG}gt ag{G}
AspLeuAlaArgSerLeuGluGlnGlyProGluGlyProGluThrProIleGlnValVal
||| |||||| |||||||||||||||||||||||||||||||||||||||||||||
AspProAlaArgAsnLeuGluGlnGlyProGluGlyProGluThrProIleGlnValVal
GACCCCGCGCGGAACCTGGAGCAGGGGCCGGAAGGACCGGAAACGCCCATCCAGGTGGTG
Leu{Ar} >>>> Target Intron 2 >>>> {g}ValArgProMetSerAlaAla
|||{||} 88 bp {|}|||||||||||||||||||||
Leu{Ar}++ ++{g}ValArgProMetSerAlaAla
CTC{AG}gt ag{G}GTGCGACCTATGAGCGCAGCC
GluLeuArgArgGlyGlnGlnSerValLeuHisCysSerGlyThrArgThrLeuGln >
||||||||||||||| |||||||||||||||||||||||||||||||||||||||
GluLeuArgArgGlyGluGlnSerValLeuHisCysSerGlyThrArgThrLeuGln++
GAGCTGCGTCGAGGGGAACAGAGCGTTCTGCATTGCTCAGGGACCCGGACTCTGCAGgt
>>> Target Intron 3 >>>> GlyGlyProGluValAlaPheArgPheGlyAlaV
157 bp ||||||||| |||||||||||||||||| |
--GlyGlyProAspValAlaPheArgPheGlyValV
gcGGGGGCCCCGACGTGGCGTTCCGCTTCGGCGTGG
alLeuAspAlaAlaArgThrGlnGluAspValPheArgAlaCysGlyValArgArgLeuG
||||||||||| ||||||||||||||||||||| ||||||||||||||||||||||
alLeuAspAlaThrArgThrGlnGluAspValPheGlnAlaCysGlyValArgArgLeuG
TGCTGGACGCGACGCGCACGCAGGAGGACGTGTTCCAGGCGTGCGGCGTGCGGCGCCTGG
lyGluLeuAlaLeuArg{Gl} >>>> Target Intron 4 >>>> {y}PheSerC
|||||||||||||||||{||} 419 bp {|}|||||||
lyGluLeuAlaLeuArg{Gl}++ ++{y}PheSerC
GAGAGCTTGCGCTGCGG{GG}gt ag{T}TTCTCCT
ysThrValPheThrPheGlyGlnThrGlySerGlyLysThrTyrThrLeuThrGlyProP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ysThrValPheThrPheGlyGlnThrGlySerGlyLysThrTyrThrLeuThrGlyProP
GCACCGTCTTCACCTTTGGTCAGACTGGTTCCGGCAAGACTTACACCCTGACCGGACCCC
roProGln >>>> Target Intron 5 >>>> GlyGluGlyValProValProPr
|||||||| 454 bp |||||||||||||||||||||||
roProGln++ ++GlyGluGlyValProValProPr
CTCCCCAGgt agGGGGAGGGGGTGCCAGTGCCCCC
oSerLeuAlaGlyIleMetGlnArgThrPheAlaTrpLeuLeuAspArgValGlnHisLe
||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||
oSerLeuAlaGlyIleMetGlnArgThrPheAlaTrpLeuLeuAspArgValGlnArgLe
CAGCCTGGCTGGCATCATGCAGAGGACCTTCGCCTGGCTGTTAGACCGCGTGCAGCGCCT
uGlyAlaProValThrLeuArgAlaSerTyrLeuGluIleTyrAsnGluGln >>>> T
|||| ||||||||||||||||||||||||||||||||||||||||||
uGlySerGlnValThrLeuArgAlaSerTyrLeuGluIleTyrAsnGluGln++
GGGCTCCCAGGTCACCCTTCGCGCCTCCTATCTGGAGATCTACAATGAGCAGgt
arget Intron 6 >>>> ValArgAspLeuLeuSerLeuGlySerProArgProLeu
125 bp ||||||||||||||||||||||||||| |||||||||
++ValArgAspLeuLeuSerLeuGlySerSerArgProLeu
agGTTCGGGACTTACTGAGCCTGGGGTCTTCCCGGCCCCTC
ProValArgTrpAsnLysThrArgGlyPheTyrValGluGlnLeuArgValValGluPhe
|||||||||||||||||||||||||||||||||||||||||||||||| |||||||||
ProValArgTrpAsnLysThrArgGlyPheTyrValGluGlnLeuArgGluValGluPhe
CCAGTTCGCTGGAACAAGACCCGGGGCTTCTACGTGGAGCAGCTCCGGGAGGTGGAGTTC
GlySerLeuGluAlaLeuMetGluLeuLeuGlnThr{G} >>>> Target Intron
||||||||||||||||||||||||||||||||| {|} 650 bp
GlySerLeuGluAlaLeuMetGluLeuLeuGlnLys{G}++
GGGAGCCTGGAGGCCTTGATGGAACTGCTGCAGAAG{G}gt
7 >>>> {ly}LeuSerArgArgArgAsnSerAlaHisThrLeuAsnGlnAlaSerSer
{||}||||||||||||||| ||||||||| ||||||||||||||||||
++{ly}LeuSerArgArgArgSerSerAlaHisSerLeuAsnGlnAlaSerSer
ag{GT}CTTAGCCGGCGGCGGAGCTCCGCCCACTCCCTGAACCAGGCGTCCAGC
ArgSerHisAlaLeuLeuThrLeuTyrIleSerArgGlnThr >>>> Target Intr
|||||||||||||||||||||||| ||| ||| 154 bp
ArgSerHisAlaLeuLeuThrLeuHisIleCysArgProVal++
CGAAGCCACGCCCTGCTCACGCTCCACATCTGCCGCCCGGTTgt
on 8 >>>> AlaGlnGlnMetProSerValAspProGlyGluProProValGlyGlyL
||| ||| ||| |||||||||||| |||||||
++SerProGlnLeuProProAlaAspAlaGlyGluProProAlaGlyGlyL
agTCCCCGCAGCTGCCTCCTGCAGACGCTGGGGAGCCCCCTGCTGGTGGGA
ysLeuCysPheValAspLeuAlaGlySerGluLysValAlaAlaThrGlySerArgGlyG
|||||||||||||||||||||||||||||||||||||| |||||||||||||||||||
ysLeuCysPheValAspLeuAlaGlySerGluLysValThrAlaThrGlySerArgGlyG
AGCTGTGCTTTGTAGACCTGGCTGGCAGCGAGAAGGTGACAGCCACGGGATCCCGCGGGG
luLeuMetLeuGluAlaAsnSerIleAsnArgSerLeuLeuAlaLeu{G} >>>> Tar
|||||||||||||||||||||||||||||||||||||||||||||||{|}
luLeuMetLeuGluAlaAsnSerIleAsnArgSerLeuLeuAlaLeu{G}++
AGCTGATGCTTGAGGCCAACAGCATCAACCGCAGCCTGCTGGCCCTG{G}gt
get Intron 9 >>>> {ly}HisCysIleSerLeuLeuLeuAspProGlnArgLysG
553 bp {||}|||||||||||||||||||||||||||||||||||||
++{ly}HisCysIleSerLeuLeuLeuAspProGlnArgLysG
ag{GT}CACTGCATCTCCCTGCTGCTGGACCCTCAGCGGAAGC
lnSerHisIleProPheArgAspSerLysLeuThrLysLeuLeuAlaAspSerLeuGlyG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnSerHisIleProPheArgAspSerLysLeuThrLysLeuLeuAlaAspSerLeuGlyG
AAAGTCACATCCCTTTCCGAGACAGCAAGCTCACCAAGCTGTTGGCAGACTCCCTGGGGG
lyArgGlyValThrLeuMet >>>> Target Intron 10 >>>> ValAlaCysV
|||||||||||||||||||| 70 bp ||||||||||
lyArgGlyValThrLeuMet++ ++ValAlaCysV
GCCGTGGGGTCACCCTCATGgt agGTGGCCTGCG
alSerProSerAlaGlnCysLeuProGluThrLeuSerThrLeuArgTyrAlaSerArgA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
alSerProSerAlaGlnCysLeuProGluThrLeuSerThrLeuArgTyrAlaSerArgA
TGTCCCCCTCAGCCCAGTGCCTTCCCGAGACACTCAGCACCCTGCGCTATGCAAGCCGGG
laGlnArgValThrThrArgProGlnAlaProLys >>>> Target Intron 11 >
||||||||||||||||||||||||||||||||||| 852 bp
laGlnArgValThrThrArgProGlnAlaProLys++
CTCAGCGGGTCACCACCCGGCCACAGGCCCCCAAGgt
>>> SerProValAlaLysGlnProGlnArgLeuGluThrGluMetLeuGlnLeuGlnG
||||||||||||||||||||||||||||||||||||||| |||||||||||||
++SerProValAlaLysGlnProGlnArgLeuGluThrGluValLeuGlnLeuGlnG
agTCCCCTGTGGCAAAGCAGCCTCAGCGTTTGGAGACCGAGGTGCTGCAGCTCCAGG
luGluAsnArgArgLeuGlnPheGlnLeuAspGlnMetAspCysLys{A} >>>> Tar
||||||||||||||||| ||||||||||||||||||||| |||{ }
luGluAsnArgArgLeuArgPheGlnLeuAspGlnMetAspProLys{G}++
AGGAGAACCGTCGCCTTCGGTTCCAGCTGGACCAAATGGATCCCAAG{G}gt
get Intron 12 >>>> {la}SerGlyLeuSerGlyAlaArgValAlaTrpAlaGln
92 bp { }|||||| |||||||||||||||||||||||||||
--{ly}SerGlyProSerGlyAlaArgValAlaTrpAlaGln
ca{GT}TCAGGGCCCAGCGGGGCCCGAGTGGCCTGGGCCCAG
ArgAsnLeuTyrGlyMetLeuGlnGluPheMetLeuGluAsnGluArgLeu{Ar} >>>
|||||||||||||||||||||||||||||||||||||||||||||||||||{||}
ArgAsnLeuTyrGlyMetLeuGlnGluPheMetLeuGluAsnGluArgLeu{Ar}++
CGGAACCTCTATGGGATGCTACAGGAGTTCATGCTGGAAAATGAAAGGCTC{AG}gt
> Target Intron 13 >>>> {g}LysGluLysSerGlnLeuGlnAsnSerArgAs
121 bp {|}||||||||||||||||||||| ||||||||
++{g}LysGluLysSerGlnLeuGlnArgSerArgAs
ag{A}AAAGAAAAGAGCCAGCTGCAGAGAAGCCGAGA
pLeuAlaGlnAsnGluGlnArgIleLeuAlaGlnGlnValHisAlaLeuGluArgArgLe
||||||| ||||||||||||||||||||||||||||||||| |||||| |||
pLeuAlaArgAsnGluGlnArgIleLeuAlaGlnGlnValHisGluLeuGlu---Arg**
CCTGGCCCGGAATGAGCAGCGCATCCTGGCTCAGCAGGTGCATGAGCTGGAG---AGGTG
uLeuSerAlaCysTyrHisHisGlnGlnGly >>>> Target Intron 14 >>>>
||| ||| 344 bp
*ValSerProProGlyHisGlnProTrpThr+- -
AGTGTCACCGCCCGGTCACCAGCCTTGGACAga t
ProGlyLeuThrProProCysProCysLeuMetAlaProAlaProProCysHis >>>
|||||||||||||||
-LeuSerIleCysHisLeuArgHisSerGlyProGlyProAlaProProCysAla--
cCTCTCCATCTGTCACCTTCGCCACTCGGGCCCTGGCCCAGCCCCACCGTGCGCCtg
> Target Intron 15 >>>> AlaLeuProProLeuTyrSerCysProCysCysHi
101 bp ||||||||||||||| |||||||||||||||||
++AlaLeuProProLeuCysSerCysProCysCysHi
agGCACTACCACCCCTCTGCTCCTGCCCCTGCTGCCA
sIleCysProLeuCysArgValProLeuAlaHisTrpAlaCysLeuProGlyGluHisHi
| ||| ||||||||||||||||||||| ||||||||
sLeuCys---------------ProLeuAlaHisTrpAlaCysProArgArgGluHisHi
CCTCTGC---------------CCTCTGGCCCACTGGGCCTGCCCACGGAGGGAGCACCA
sLeuProGln >>>> Target Intron 16 >>>> ValLeuAspProGluAlaSe
|||| ||| 714 bp ||| ||||||
sLeuGlnGln++ ++ValProSerProGluProPr
TCTGCAGCAGgt agGTGCCGAGCCCCGAGCCCCC
rGlyGlyArgProProSerAlaArgProProProTrpAlaProProCys<-><-><-><-
|||||| ||| |||||||||||||||||| |||||||||
oGlyGlyLeuProLeuSerAlaArgProProProCysValProProCysGlySerGlySe
CGGCGGCCTGCCCCTGTCTGCCCGACCCCCACCCTGCGTACCCCCATGTGGCTCTGGCTC
>SerProGlySerAlaLysCysProArgGlu{Ar} >>>> Target Intron 17 >
||||||||||||||||||||||||{||} 88 bp
rGlySerGlySerAlaLysCysProArgGlu{Ar}++
TGGCTCTGGCTCTGCCAAGTGCCCAAGAGAG{AG}gt
>>> {g}SerHisSerAsp<->TrpThrGlnThrArgValLeuAlaGluMetLeuThrG
{|}|||||| ||| ||| ||||||||| |||||||||||||||||||
++{g}SerHisArgAspSerTrpMetGlnThrArgAlaLeuAlaGluMetLeuThrG
ag{G}AGTCACCGTGACTCGTGGATGCAGACCAGGGCCCTGGCAGAGATGCTGACGG
luGluGluValValProSerAlaProProLeuProValArgProProLysThrSerProG
|||||||||||||||||||||||||||||||||||||| |||||| |||||||||
luGluGluValValProSerAlaProProLeuProValGlyProProAspThrSerProV
AGGAGGAGGTGGTACCCTCTGCACCGCCCCTGCCTGTGGGGCCCCCGGACACGTCGCCTG
lyLeuArg{G} >>>> Target Intron 18 >>>> {ly}GlyAlaGlyValPro
||||||{|} 307 bp {||}|||||||||||||||
alLeuArg{G}++ ++{ly}GlyAlaGlyValPro
TGCTGAGA{G}gt ag{GT}GGGGCTGGGGTTCCG
AsnLeuAlaGlnArgLeuGluAlaLeuArgAspGlnIleGlySerSerLeuArgArgGly
||||||||| |||||||||||||||||||||||| ||| |||||| |||
AsnLeuAlaArgArgLeuGluAlaLeuArgAspGlnThrGlyGlySerLeuLeuHisGly
AACCTGGCCCGGAGGCTAGAGGCCCTCAGAGACCAGACTGGCGGCTCCTTACTCCATGGC
ArgSerGlnProProCys--SerGluGlyAlaArgSerProGlyGlnValLeuProProH
|||||||||||| ##|||||||||||| ||||||||| |||||||||||||
GlnSerGlnProPro---##SerGluGlyAlaGlnSerProGlyHisValLeuProProH
CAGAGCCAACCTCCC---CCAGCGAGGGTGCACAGAGCCCAGGCCACGTCCTCCCTCCCC
is
||
is
AC
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