| Basic information |
| Official Symbol | KIAA0586 |
| Description | KIAA0586 |
| Other Aliases | Talpid3 |
| Other Description | ortholog of chicken talpid{3}; uncharacterized protein KIAA0586 |
| Mutation type | premature termination 517:L->TGA, premature termination 522:Q->TAG |
| Location | Scaffold000133_1:2187492 2067700 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| KIAA0586 |
TCCTTTTTTATGTACAGAGCTCAAAGCATGCCTGTTTTTAAAGAAGTAAA GGTACACCTTTTAGAAGATGCAGGAACAGAAAAGGACGCTGTCACTCAGG AGGCCAGAATTTCACCCAGTGGAATTGACTCAGCTACCACTGTGGCTGCA GCTACTGCTGCTGCCATCGCCACAGCAGCTCCACTCATAAAAGTGCAGAG TGATTTGGAAGCGAAAGTCAATTCTGTTGCAGAATTACTTAATAAGTTAC AGGAGACCGATAAACACTTACAACGAGTTACAGAGCAGCAAACAAGCATT CAGAATAAGCATGAGAAACTACATTGTCATGATCATGAAAAACAAATGAA TGTGTTTATGGAGCAGCATATTAGGCATCTTGAAAAATTACAGCAACAAC AAATAGATATTCAGACTCATTTTATTAGTGCTGCACTCAAGACTAGCAGT TTTCAGCCTGCTCGTGAGCCCTCTTTAAGAGCAGTGGAAAAGTATTCTGT AAAACCAGAGCATCCTAATCTTGGTAACAGTAATCTGTCTTCACATAACA CATTCGCCTCCAAACAAGGTACAATATNNNNNNNNNNNNNTATGGACTTT GATAAACAGAAATCTTTGGAAACACCAGCACCTCGCAGGTTTGCTCCTAT ACCTGTTTCAAGGGATGCTGAAATATTTAAGAGGGAGAATACTATGGAAG AAAAAGAAAATATGCAAATTTCAGGTCATAGAGGAAATGTAAGACTGTTG GAACAAATTTTAAATAACAATGACTCTTCGACAAGAAAAAGTGAATCATC AGACAAAACCTCACTAACTAAGTCAAAAATAGGGTGGAGTCTTGAGAAAA GAGACAGATTTCCTTCCTATGAAGAGCTTGGAACAGCCACCAAGATTATG GAGAGGTCTGATGATGTTCTTCATGATCTTGGTCAAAAGAGGAAAGAAAC AAATGGCATGTTCCAGGTAAAACAGGCATGGTGTGAAAATGGATGACTAG ATCTTCCATAGAATTCCAAGCTTCAGACAGCCAATACAAGATCCATATTG AAAGATGCTGAGAAGATTTTGAGAGGAGTACAAAACAATAAGAAAGTACT TGAAGAAAACTTGGAAGCTATTATTCGTGCAAAGGATGGAGCTGCCATGT ACTCGTTTATCAATGCTCTGTCTACCAACAGAGAGATGTCAGAGAAGATT AGGATCAGAAAGACAGTAGATGAGTGGATTAAAACTATTTCTGCAGAAAT TCAGGATGAACTGACAAAAGATTATGAACAAAAAAGATTTGATCAGAAGA GTCAAAAGACCAAGAAAGCTCAGAATCTAAATAAAGATATTAAAACCAAC ACACAAGACAAAACTGTAAACAAATTTGTTGTTCCAAGAAAACCTTCTCA AAAACAAGAAGGACATTGTAGAAATCCACCTGTGAGGAGCATGCCTGCTT CAAGTTTACAGAAAGAGAGAAAAGAAGGACTTTTGAAAGCAACCACAGTG ATACAAGATGAGGATTTTATGTTACAAATATATGGAAAACCAGTTTACCA GGGCCATCGGAGCACTCTTAAAAAAGGACCGTACCTCAGATTTAATTCTC CATCTCCCAAGTCCAAACCACACAGACCAAAAGTAATAGAGCAAGTTAAA GGCACTAAAGTCAAGTCAATAAGAACACAGACTGACTTTTATGCAACAAA ACCTACGAAGATGCACTCTAAAGTACAGCATTCCGCTACTGCACTGCCTC ATGGTGATAAGCAGTATTTGTTTAGTCCAAGCAGAGAAATGGCTACTCTT TCAGGCACACTGGAAGGTCATCTAATTCCTATGGCGATTCTTTTAGGACA AACCCAAAGTAATAGTGAGTCCATGCCCCCTGCTGGAGTGATTATAAACA AGCCACATCCAATCACCGTGACTACTTCTATTCCTCCATCACCTCGGAAA ATAGAAACTGCGGTAAAGAAACCTAACATAGCAGTTGTAGAAATGAAGTC AGAAAAGAAGGATCCTCCTCGGCTTACTGTACAGGTGTTGCCAAATGTAG ACATTGACAGCATTTCAAATGGTAGTGCTGACATCAGTCCACCTCTGCTT AGTCCCAAAGAAGCAGCTCTTCCTCCTCTGAAAAACTGGATTCAGACTCC AGAATTTATGAATATAGATGAAGAAGAGGTGAAGTTTCCAGGAACTAACT TCGATGAAGTAGTTGATATCATACAGGAAGAGGAAAAGTGTGATGAAATC CCAGAATCCTCTGAACCAGTTTTGGAGTTTAACAGAAATATCGAAGTTGT TCCTACAAAATATAATGGTCCTCCATTTCCACCAGTTGCTTCTTCCTTTC AACCCACTACTGATATTCTTGACAAAGTAATCAAGAGAAAAGAAACATTG GAAAATAGCTTAATTCAATGGGTAGAACAAGAAATAATGTCAAGAATTAT TTCTGGACTCTTTCCAGTCCAACAACAGGCTATAACGAATGTCAGTGTTT CAGTCAGCGAGGCAAGTGAACCATTGACTTCAGATGTTGTGGAAGGAACA AGTGCTCGTGCCCTCAAGCTTTTTGTTGATGCTGGAGTTCCTGTGAATTC CGACATGATTAGCCATTTCGTGAATGAAGCTCTTGCTGAAACCATTGAGG TTATGTTGGGTGACGGAGAGGTGAAGAAACAAGTTCCTGTTGTTACAGAT GTTTCAACAAATGAAACATTCTTGCCGGCAAGAATGTGTACCCCAGTGAC CACTCCACAGCCTACTCCTCCTCTCTCACCTCTGTCGCCTCTTAAGGAGC ATATATTGGTAAAAACTCCAAATTCTTCTCCCTCTGATTCAGATCACGAT GTGGCTCTCCCTGTGAAAGAAATACTTGCTGAAAAAGGAAATGATATGCC CACCATCATGCTTGTTAATACTCCAACAGTTACTCCTGTTACTACACCTC CTCCGGCAGTGGCTCTTACACCAACTTTATCAGAGATTTCCATGGATAAA TTGAAAATATCCAGCCCAGGGGTTCCTAAGCCATGGGAGGATGGAGACCT GCCCCTGGAAGAAGAGAATCCTAATTCTCCTCCTCAAGAAGAGCTGCTTC ACCCGAGAGCTATAGTCATGTCTGTGGCTAAGGATGAAGAACCTGAGAGT TTGGATTTCCCTGTTCAACCAGCACCTCCAGAACAAGTTCCCGATATGCC TCTTCCTGCTACCACCAAAGTTGCCTCCCCCTTACAGATGCCAAGTTCAG AGTCATCCACACTGGAGAGCACCTCAAACACTACTGTCACTGATACGGAA ACACTAGATCGGCCCATCTCTGAAGGGGAGGTTTTATTTAGCGGTCAAAA ATCGGTTCCCAAGATTTTAGGAGGTGGAGGACTATGTCTTACAAACCTAA ATGATAGCTTATCCAGCACTCTGCACGATGCCCTTGACATGGAAGATGAT CCTCTCAGTGAAGGACAAGTGATTAGGATGCCCTGTAAGAAATTTCATAC AGATGCAATTCTTTCTCTTCTTGCTAAACAAAACCAGGAATTACTGGTTT CACAGGAGGCAGTCTATCATTCAGAGGATTTGGAAAACAGCGTGGGTGAA CTTAGCGAAGGACAAAGGCCCAGGCTGAAGGCGGCAGCAGAGAACATCTT AGTGGGATGTTCTCTCTCTACGCAGCAGCGAATGGTCACTGCCGAGTCTT TGGCTCAACATTGTGATCCTAATCTGTCACCTCCGCACGTTGACACAGTT TCAGGTGGTATTTATGAAGATTCATGTGCTAGTCATGGTCCAATGAGTTT AGGAGAATTGGAGTTGCTTTCAAATTCTAACCTTGGTTTTCCTTCAACAC TTGGGACATCAGAAGAAAATGATGTTAATTTACCAGTAACAGCTGGAGCT ATTTCTCAGTGCCAGCAAAAGCAAGGCCAGGATGTTGAGCAGGTTGAACA CAAGCCAGTACAAAGTCGTCTCATATGTGTAAGAAGTAAACCAGACGTTT CACTTTTTTTCAGTGTAACTTCGCCAGGTGATGTGGATCAGACACAAATT GAACCCAGTCTGTGCTTTGCATCTATATTTAGC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 1644 | 185 | 1551 | Premature termination 517:L->TGA, Premature termination 522:Q->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
SerSerTrpAspTyrArgAlaGlnSerMetProValPheLysGluValLysValHisL
||| ||||||||||||||||||||||||||||||||||||||||||||||
SerPhePheMetTyrArgAlaGlnSerMetProValPheLysGluValLysValHisL
TCCTTTTTTATGTACAGAGCTCAAAGCATGCCTGTTTTTAAAGAAGTAAAGGTACACC
euLeuGluAspAlaGlyIleGluLysAspAlaValThrGlnGluThrArgIleSerPr
||||||||||||||||| |||||||||||||||||||||||| |||||||||||
euLeuGluAspAlaGlyThrGluLysAspAlaValThrGlnGluAlaArgIleSerPr
TTTTAGAAGATGCAGGAACAGAAAAGGACGCTGTCACTCAGGAGGCCAGAATTTCACC
oSerGlyIleAspSerAlaThrThrValAlaAlaAlaThrAlaAlaAlaIleAlaThr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
oSerGlyIleAspSerAlaThrThrValAlaAlaAlaThrAlaAlaAlaIleAlaThr
CAGTGGAATTGACTCAGCTACCACTGTGGCTGCAGCTACTGCTGCTGCCATCGCCACA
AlaAlaProLeuIleLys >>>> Target Intron 1 >>>> ValGlnSerAs
|||||||||||||||||| 996 bp |||||||||||
AlaAlaProLeuIleLys++ ++ValGlnSerAs
GCAGCTCCACTCATAAAAgt agGTGCAGAGTGA
pLeuGluAlaLysValAsnSerValThrGluLeuLeuSerLysLeuGlnGluThrAsp
||||||||||||||||||||||||| ||||||||| ||||||||||||||||||
pLeuGluAlaLysValAsnSerValAlaGluLeuLeuAsnLysLeuGlnGluThrAsp
TTTGGAAGCGAAAGTCAATTCTGTTGCAGAATTACTTAATAAGTTACAGGAGACCGAT
LysHisLeuGlnArgValThrGluGlnGlnThrSerIleGlnArgLysGlnGluLysL
|||||||||||||||||||||||||||||||||||||||||| ||| |||||||
LysHisLeuGlnArgValThrGluGlnGlnThrSerIleGlnAsnLysHisGluLysL
AAACACTTACAACGAGTTACAGAGCAGCAAACAAGCATTCAGAATAAGCATGAGAAAC
euHisCysHisAspHisGluLysGlnMetAsnValPheMetGluGlnHisIleArgHi
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euHisCysHisAspHisGluLysGlnMetAsnValPheMetGluGlnHisIleArgHi
TACATTGTCATGATCATGAAAAACAAATGAATGTGTTTATGGAGCAGCATATTAGGCA
sLeuGluLysLeuGlnGlnGlnGlnIleAspIleGln >>>> Target Intron
||||||||||||||||||||||||||||||||||||| 3115 bp
sLeuGluLysLeuGlnGlnGlnGlnIleAspIleGln++
TCTTGAAAAATTACAGCAACAACAAATAGATATTCAGgt
2 >>>> ThrHisPheIleSerAlaAlaLeuLysThrSerSerPheGlnProValSe
|||||||||||||||||||||||||||||||||||||||||||||
++ThrHisPheIleSerAlaAlaLeuLysThrSerSerPheGlnProAlaAr
agACTCATTTTATTAGTGCTGCACTCAAGACTAGCAGTTTTCAGCCTGCTCG
rMetProSerSerArgAlaValGluLysTyrSerValLysProGluHisProAsnLeu
|||||| |||||||||||||||||||||||||||||||||||||||||||||
gGluProSerLeuArgAlaValGluLysTyrSerValLysProGluHisProAsnLeu
TGAGCCCTCTTTAAGAGCAGTGGAAAAGTATTCTGTAAAACCAGAGCATCCTAATCTT
GlySerCysAsnProSerLeuTyrAsnThrPheAlaSerLysGlnAlaProLeu{L}
||| ||| ||| ||||||||||||||||||||| { }
GlyAsnSerAsnLeuSerSerHisAsnThrPheAlaSerLysGlnGlyThrIle{U}+
GGTAACAGTAATCTGTCTTCACATAACACATTCGCCTCCAAACAAGGTACAATA{T}g
>>>> Target Intron 3 >>>> {ys}GluValGluAspThrSerPheAspLy
3632 bp { } ||||||||
+ --{nk}UnkUnkUnkUnkMetAspPheAspLy
t nn{NN}NNNNNNNNNNNTATGGACTTTGATAA
sGlnLysSerProLeuGluThrProAlaProArgArgPheAlaProValProValSer
|||||||||| ||||||||||||||||||||||||||||||||| |||||||||
sGlnLysSer---LeuGluThrProAlaProArgArgPheAlaProIleProValSer
ACAGAAATCT---TTGGAAACACCAGCACCTCGCAGGTTTGCTCCTATACCTGTTTCA
ArgAspAspGluLeuSerLysArgGluAsnLeuLeuGluGluLysGluAsnMetGluV
|||||| ||| |||||||||||| ||||||||||||||||||
ArgAspAlaGluIlePheLysArgGluAsnThrMetGluGluLysGluAsnMetGlnI
AGGGATGCTGAAATATTTAAGAGGGAGAATACTATGGAAGAAAAAGAAAATATGCAAA
alSerCysHisArg{G} >>>> Target Intron 4 >>>> {ly}AsnValAr
||| ||||||{|} 1199 bp {||}||||||||
leSerGlyHisArg{G}++ ++{ly}AsnValAr
TTTCAGGTCATAGA{G}gt ag{GA}AATGTAAG
gLeuLeuGluGlnIleLeuAsnAsnAsnAspSerLeuThrArgLysSerGluSerSer
|||||||||||||||||||||||||||||||||| |||||||||||||||||||||
gLeuLeuGluGlnIleLeuAsnAsnAsnAspSerSerThrArgLysSerGluSerSer
ACTGTTGGAACAAATTTTAAATAACAATGACTCTTCGACAAGAAAAAGTGAATCATCA
AsnThrThrSerLeuThrArgSerLysIleGlyTrpThrProGluLysThrAsn{Ar}
|||||||||||| ||||||||||||||| |||||| {||}
AspLysThrSerLeuThrLysSerLysIleGlyTrpSerLeuGluLysArgAsp{Ar}
GACAAAACCTCACTAACTAAGTCAAAAATAGGGTGGAGTCTTGAGAAAAGAGAC{AG}
>>>> Target Intron 5 >>>> {g}PheProSerCysGluGluLeuGluTh
6194 bp {|}||||||||| ||||||||| ||
++ --{g}PheProSerTyrGluGluLeuGlyTh
gt ca{A}TTTCCTTCCTATGAAGAGCTTGGAAC
rThrLysValThrMetGlnLysSerAspAspValLeuHisAspLeuGlyGlnLysGlu
| ||| |||||||||||||||||||||||||||||||||
rAlaThrLysIleMetGluArgSerAspAspValLeuHisAspLeuGlyGlnLysArg
AGCCACCAAGATTATGGAGAGGTCTGATGATGTTCTTCATGATCTTGGTCAAAAGAGG
LysGluThrAsnSerMetValGlnProLysGluSerLeuSerMetLeuLysLeuPro
|||||||||||| ||| ||| |||
LysGluThrAsnGlyMetPheGlnValLysGlnAlaTrpCysGluAsnGly***Leu+
AAAGAAACAAATGGCATGTTCCAGGTAAAACAGGCATGGTGTGAAAATGGATGACTAg
>>>> Target Intron 6 >>>> AspLeuProGlnAsnSerValLysLeuGln
646 bp ||||||||| |||||| |||||||||
+ --AspLeuPro***AsnSer---LysLeuGln
t gtGATCTTCCATAGAATTCC---AAGCTTCAG
ThrThrAsnThrThrArgSerValLeuLysAspAlaGluLysIleLeuArgGlyValG
||| ||| ||||||||| ||||||||||||||||||||||||||||||||||
ThrAlaAsn---ThrArgSerIleLeuLysAspAlaGluLysIleLeuArgGlyValG
ACAGCCAAT---ACAAGATCCATATTGAAAGATGCTGAGAAGATTTTGAGAGGAGTAC
lnAsnAsnLysLysValLeuGluGluAsnLeuGluAlaIleIleArgAlaLysAspGl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnAsnAsnLysLysValLeuGluGluAsnLeuGluAlaIleIleArgAlaLysAspGl
AAAACAATAAGAAAGTACTTGAAGAAAACTTGGAAGCTATTATTCGTGCAAAGGATGG
yAlaAlaMetTyrSerLeuIleAsnAlaLeuSerThrAsn{Ar} >>>> Target
|||||||||||||||| |||||||||||||||||||||{||} 31
yAlaAlaMetTyrSerPheIleAsnAlaLeuSerThrAsn{Ar}++
AGCTGCCATGTACTCGTTTATCAATGCTCTGTCTACCAAC{AG}gt
Intron 7 >>>> {g}GluMetSerGluLysIleArgIleArgLysThrValAspG
5 bp {|}||||||||||||||||||||||||||||||||||||||||
++{g}GluMetSerGluLysIleArgIleArgLysThrValAspG
ag{A}GAGATGTCAGAGAAGATTAGGATCAGAAAGACAGTAGATG
luTrpIleLysThrIleSerAlaGluIleGln >>>> Target Intron 8 >>>
|||||||||||||||||||||||||||||||| 2060 bp
luTrpIleLysThrIleSerAlaGluIleGln++
AGTGGATTAAAACTATTTCTGCAGAAATTCAGgt
> AspGluLeuSerArgThrAspTyrGluGlnLysArgPheAspGlnLysAsnGlnA
||||||||| |||||||||||||||||||||||||||||| |||
++AspGluLeuThrLys---AspTyrGluGlnLysArgPheAspGlnLysSerGlnL
agGATGAACTGACAAAA---GATTATGAACAAAAAAGATTTGATCAGAAGAGTCAAA
rgThrLysLysGlyGlnAsnMetThrLysAspIleArgThrAsnThrGlnAspLysTh
||||||||| |||||| ||||||||| ||||||||||||||||||||
ysThrLysLysAlaGlnAsnLeuAsnLysAspIleLysThrAsnThrGlnAspLysTh
AGACCAAGAAAGCTCAGAATCTAAATAAAGATATTAAAACCAACACACAAGACAAAAC
rValAsnLysSerValIleProArgLysHisSerGlnLysGlnIleGluGluHisPhe
|||||||||| ||| ||||||||| |||||||||||| ||| |||
rValAsnLysPheValValProArgLysProSerGlnLysGln---GluGlyHisCys
TGTAAACAAATTTGTTGTTCCAAGAAAACCTTCTCAAAAACAA---GAAGGACATTGT
ArgAsnLeuProMetArgGlyMetProAlaSerSerLeuGlnLysGluArgLysGlu
|||||| ||| ||| ||||||||||||||||||||||||||||||||||||
ArgAsnProProValArgSerMetProAlaSerSerLeuGlnLysGluArgLysGlu+
AGAAATCCACCTGTGAGGAGCATGCCTGCTTCAAGTTTACAGAAAGAGAGAAAAGAAg
>>>> Target Intron 9 >>>> GlyLeuLeuLysAlaThrThrValIleGln
1219 bp ||||||||||||||||||||||||||||||
+ ++GlyLeuLeuLysAlaThrThrValIleGln
t agGGACTTTTGAAAGCAACCACAGTGATACAA
AspGluAspTyrMetLeuGlnValTyrGlyLysProValTyrGlnGlyHisArgSerT
||||||||| ||||||||| ||||||||||||||||||||||||||||||||||
AspGluAspPheMetLeuGlnIleTyrGlyLysProValTyrGlnGlyHisArgSerT
GATGAGGATTTTATGTTACAAATATATGGAAAACCAGTTTACCAGGGCCATCGGAGCA
hrLeuLysLysGlyProTyrLeuArgPheAsnSerProSerProLysSerArgProGl
|||||||||||||||||||||||||||||||||||||||||||||||||| |||
hrLeuLysLysGlyProTyrLeuArgPheAsnSerProSerProLysSerLysProHi
CTCTTAAAAAAGGACCGTACCTCAGATTTAATTCTCCATCTCCCAAGTCCAAACCACA
nArgProLysValIleGluArgValLys{G} >>>> Target Intron 10 >>>
|||||||||||||||||| ||||||{|} 4001 bp
sArgProLysValIleGluGlnValLys{G}++
CAGACCAAAAGTAATAGAGCAAGTTAAA{G}gt
> {ly}ThrLysValLysSerIleArgThrGlnThrAspPheTyrAlaThrLysPro
{||}|||||||||||||||||||||||||||||||||||||||||||||||||||
++{ly}ThrLysValLysSerIleArgThrGlnThrAspPheTyrAlaThrLysPro
ag{GC}ACTAAAGTCAAGTCAATAAGAACACAGACTGACTTTTATGCAACAAAACCT
LysLysMetAspSerLysMetLysHisSerValProValLeuProHisGlyAspGlnG
|||||| |||||| |||||| ||||||||||||||| |
ThrLysMetHisSerLysValGlnHisSerAlaThrAlaLeuProHisGlyAspLysG
ACGAAGATGCACTCTAAAGTACAGCATTCCGCTACTGCACTGCCTCATGGTGATAAGC
lnTyrLeuPheSerProSerArgGluMetProThrPheSerGlyThrLeuGluGlyHi
||||||||||||||||||||||||||||| ||| ||||||||||||||||||||
lnTyrLeuPheSerProSerArgGluMetAlaThrLeuSerGlyThrLeuGluGlyHi
AGTATTTGTTTAGTCCAAGCAGAGAAATGGCTACTCTTTCAGGCACACTGGAAGGTCA
sLeuIleProMetAlaIleLeuLeu{G} >>>> Target Intron 11 >>>>
|||||||||||||||||||||||||{|} 1837 bp
sLeuIleProMetAlaIleLeuLeu{G}++ ++
TCTAATTCCTATGGCGATTCTTTTA{G}gt ag
{ly}GlnThrGlnSerAsnSerAspThrMetProProAlaGlyValIleValSerLys
{||}|||||||||||||||||| ||||||||||||||||||||| |||
{ly}GlnThrGlnSerAsnSerGluSerMetProProAlaGlyValIleIleAsnLys
{GA}CAAACCCAAAGTAATAGTGAGTCCATGCCCCCTGCTGGAGTGATTATAAACAAG
ProHisProValThrValThrThrSerIleProProSerSerArgLysValGluThrG
||||||||| ||||||||||||||||||||||||||| |||||| ||||||
ProHisProIleThrValThrThrSerIleProProSerProArgLysIleGluThrA
CCACATCCAATCACCGTGACTACTTCTATTCCTCCATCACCTCGGAAAATAGAAACTG
lyValLysLysProAsnIleAlaIleValGluMetLysSerGluLysLysAspProPr
||||||||||||||||||||| ||||||||||||||||||||||||||||||||
laValLysLysProAsnIleAlaValValGluMetLysSerGluLysLysAspProPr
CGGTAAAGAAACCTAACATAGCAGTTGTAGAAATGAAGTCAGAAAAGAAGGATCCTCC
oGlnLeuThrValGln >>>> Target Intron 12 >>>> ValLeuProSer
| |||||||||||| 673 bp |||||||||
oArgLeuThrValGln++ ++ValLeuProAsn
TCGGCTTACTGTACAGgt agGTGTTGCCAAAT
ValAspIleAspSerIleSerAsnSerSerAlaAspValLeuSerProLeuSerSerP
|||||||||||||||||||||||| ||||||||| |||||| ||||
ValAspIleAspSerIleSerAsnGlySerAlaAspIleSerProProLeuLeuSerP
GTAGACATTGACAGCATTTCAAATGGTAGTGCTGACATCAGTCCACCTCTGCTTAGTC
roLysGluAlaSerLeuProProValGlnThrTrpIleLys >>>> Target Int
||||||||||| ||||||||| |||||| 2329
roLysGluAlaAlaLeuProProLeuLysAsnTrpIleGln++
CCAAAGAAGCAGCTCTTCCTCCTCTGAAAAACTGGATTCAGgt
ron 13 >>>> ThrProGluIleMetLysValAspGluGluGluValLysPhePro
bp ||||||||| ||| ||||||||||||||||||||||||
++ThrProGluPheMetAsnIleAspGluGluGluValLysPhePro
agACTCCAGAATTTATGAATATAGATGAAGAAGAGGTGAAGTTTCCA
GlyThrAsnPheAspGluIleIleAspValIleGln >>>> Target Intron 1
|||||||||||||||||| ||| |||||| 1185 bp
GlyThrAsnPheAspGluValValAspIleIleGln++
GGAACTAACTTCGATGAAGTAGTTGATATCATACAGgt
4 >>>> GluGluGluLysCysAspGluIleProAsp<->SerGluProIleLeuGl
||||||||||||||||||||||||||| ||||||||| |||||
++GluGluGluLysCysAspGluIleProGluSerSerGluProValLeuGl
agGAAGAGGAAAAGTGTGATGAAATCCCAGAATCCTCTGAACCAGTTTTGGA
uPheAsnArgSerValLysAlaAspSerThrLysTyrAsnGlyProProPheProPro
|||||||||| ||||||||||||||||||||||||||||||
uPheAsnArgAsnIleGluValValProThrLysTyrAsnGlyProProPheProPro
GTTTAACAGAAATATCGAAGTTGTTCCTACAAAATATAATGGTCCTCCATTTCCACCA
ValAlaSerThrPheGlnProThrAlaAspIleLeuAspLysValIleGluArgLysG
||||||||| |||||||||||| ||||||||||||||||||||| |||||||
ValAlaSerSerPheGlnProThrThrAspIleLeuAspLysValIleLysArgLysG
GTTGCTTCTTCCTTTCAACCCACTACTGATATTCTTGACAAAGTAATCAAGAGAAAAG
luThrLeuGluAsnSerLeuIleGln{Tr} >>>> Target Intron 15 >>>>
||||||||||||||||||||||||||{||} 2903 bp
luThrLeuGluAsnSerLeuIleGln{Tr}++
AAACATTGGAAAATAGCTTAATTCAA{TG}gt
{p}ValGluGlnGluIleMetSerArgIleIleSerGlyLeuPheProValGlnGl
{|}|||||||||||||||||||||||||||||||||||||||||||||||||||||
++{p}ValGluGlnGluIleMetSerArgIleIleSerGlyLeuPheProValGlnGl
ag{G}GTAGAACAAGAAATAATGTCAAGAATTATTTCTGGACTCTTTCCAGTCCAACA
nGlnIleAlaProSerIleSerValSerValSerGluThrSerGluProLeuThrSer
|||| |||||||||||||||||| ||||||||||||||||||
nGlnAlaIleThrAsnValSerValSerValSerGluAlaSerGluProLeuThrSer
ACAGGCTATAACGAATGTCAGTGTTTCAGTCAGCGAGGCAAGTGAACCATTGACTTCA
AspIle{V} >>>> Target Intron 16 >>>> {al}GluGlyThrSerSer
||| {|} 2770 bp {||}||||||||||||
AspVal{V}++ ++{al}GluGlyThrSerAla
GATGTT{G}gt ag{TG}GAAGGAACAAGTGCT
GlyAlaLeuGlnLeuPheValAspAlaGlyValProValAsnSerAsnValIleLysH
|||||| ||||||||||||||||||||||||||||||||| ||| |
ArgAlaLeuLysLeuPheValAspAlaGlyValProValAsnSerAspMetIleSerH
CGTGCCCTCAAGCTTTTTGTTGATGCTGGAGTTCCTGTGAATTCCGACATGATTAGCC
isPheValAsnGluAlaLeuAlaGluThrIleAlaValMetLeuGlyAspArgGluAl
|||||||||||||||||||||||||||||||| ||||||||||||||| |||
isPheValAsnGluAlaLeuAlaGluThrIleGluValMetLeuGlyAspGlyGluVa
ATTTCGTGAATGAAGCTCTTGCTGAAACCATTGAGGTTATGTTGGGTGACGGAGAGGT
aLysLysGlnGlyProValAlaThrGlyValSerGlyAspAlaSerThrAsnGluThr
||||||||| |||||| ||| ||| |||||||||||||||
lLysLysGlnValProValValThr------------AspValSerThrAsnGluThr
GAAGAAACAAGTTCCTGTTGTTACA------------GATGTTTCAACAAATGAAACA
TyrLeuPro >>>> Target Intron 17 >>>> AlaArgValCysThrProL
|||||| 2398 bp |||||| |||||||||
PheLeuPro++ ++AlaArgMetCysThrProV
TTCTTGCCGgt agGCAAGAATGTGTACCCCAG
euProThrProGlnProThrProProCysSerProSerSerProAlaLysGluCysVa
||||||||||||||||||||| |||||| |||||| ||||||
alThrThrProGlnProThrProProLeuSerProLeuSerProLeuLysGluHisIl
TGACCACTCCACAGCCTACTCCTCCTCTCTCACCTCTGTCGCCTCTTAAGGAGCATAT
lLeuValLysThrProAspSerSerProCysAspSerAspHisAspMetAlaPhePro
||||||||||||||| ||||||||| ||||||||||||||| ||| |||
eLeuValLysThrProAsnSerSerProSerAspSerAspHisAspValAlaLeuPro
ATTGGTAAAAACTCCAAATTCTTCTCCCTCTGATTCAGATCACGATGTGGCTCTCCCT
ValLysGluIleCysAlaGluLys{G} >>>> Target Intron 18 >>>> {
|||||||||||| |||||||||{|} 1974 bp {
ValLysGluIleLeuAlaGluLys{G}++ ++{
GTGAAAGAAATACTTGCTGAAAAA{G}gt ag{
ly}AspAspMetProAlaIleMetLeuValAsnThrProThrValThrProThrThrT
||} ||||||||| ||||||||||||||||||||||||||||||||| ||||
ly}AsnAspMetProThrIleMetLeuValAsnThrProThrValThrProValThrT
GA}AATGATATGCCCACCATCATGCTTGTTAATACTCCAACAGTTACTCCTGTTACTA
hrProProProAlaAlaAlaValPheThrProThrLeuSerAspIleSerIleAspLy
|||||||||||||| ||| ||||||||||||||| |||||| |||||
hrProProProAlaValAlaLeu---ThrProThrLeuSerGluIleSerMetAspLy
CACCTCCTCCGGCAGTGGCTCTT---ACACCAACTTTATCAGAGATTTCCATGGATAA
sLeuLysValSerSerProGluLeuProLysProTrpGlyAspGlyAspLeuProLeu
||||||| ||||||||| |||||||||||| ||||||||||||||||||
sLeuLysIleSerSerProGlyValProLysProTrpGluAspGlyAspLeuProLeu
ATTGAAAATATCCAGCCCAGGGGTTCCTAAGCCATGGGAGGATGGAGACCTGCCCCTG
GluGluGluAsnProAsnSerProGlnGluGlu<-><->LeuHisProArgAla{Il}
|||||||||||||||||||||||| ||| |||||||||||||||{||}
GluGluGluAsnProAsnSerProProGlnGluGluLeuLeuHisProArgAla{Il}
GAAGAAGAGAATCCTAATTCTCCTCCTCAAGAAGAGCTGCTTCACCCGAGAGCT{AT}
>>>> Target Intron 19 >>>> {e}ValMetSerValAlaLysAspGluG
1315 bp {|}|||||||||||||||||||||||||
++ ++{e}ValMetSerValAlaLysAspGluG
gt ag{A}GTCATGTCTGTGGCTAAGGATGAAG
luProGluSerMetAspPheProAlaGlnProProProProGluProValProPheMe
||||||||||| ||||||||| |||||| ||||||||| |||||| ||
luProGluSerLeuAspPheProValGlnProAlaProProGluGlnValProAspMe
AACCTGAGAGTTTGGATTTCCCTGTTCAACCAGCACCTCCAGAACAAGTTCCCGATAT
tProPheProAlaGlyThrLysAlaProSerProSerGlnMetProGlySerAspSer
|||| |||||| |||||| |||||| ||||||||| ||| |||
tProLeuProAlaThrThrLysValAlaSerProLeuGlnMetProSerSerGluSer
GCCTCTTCCTGCTACCACCAAAGTTGCCTCCCCCTTACAGATGCCAAGTTCAGAGTCA
SerThrLeuGluSerThrLeuSerValThrValThrGluThrGluThrLeuAspLysP
|||||||||||||||||| ||||||||| ||||||||||||||| |
SerThrLeuGluSerThrSerAsnThrThrValThrAspThrGluThrLeuAspArgP
TCCACACTGGAGAGCACCTCAAACACTACTGTCACTGATACGGAAACACTAGATCGGC
roIleSerGluGlyGluIleLeuPheSerCysGlyGlnLysLeuAlaProLys{I}
||||||||||||||||| ||||||||| ||||||||| ||||||{|}
roIleSerGluGlyGluValLeuPheSer---GlyGlnLysSerValProLys{I}++
CCATCTCTGAAGGGGAGGTTTTATTTAGC---GGTCAAAAATCGGTTCCCAAG{A}gt
>>>> Target Intron 20 >>>> {le}LeuGluAspIleGlyLeuTyrLeuTh
2397 bp {||}||| |||||| |||||
++{le}LeuGlyGlyGlyGlyLeuCysLeuTh
ag{TT}TTAGGAGGTGGAGGACTATGTCTTAC
rAsnLeuAsnAspSerLeuSerSerThrLeuHisAspAlaValGluMet >>>> Ta
|||||||||||||||||||||||||||||||||||||||| |||
rAsnLeuAsnAspSerLeuSerSerThrLeuHisAspAlaLeuAspMet++
AAACCTAAATGATAGCTTATCCAGCACTCTGCACGATGCCCTTGACATGgt
rget Intron 21 >>>> GluAspAspProProSerGluGlyGlnValIleArgM
4207 bp |||||||||||| ||||||||||||||||||||||
++GluAspAspProLeuSerGluGlyGlnValIleArgM
agGAAGATGATCCTCTCAGTGAAGGACAAGTGATTAGGA
etSerHisLysLysPheHisAlaAspAlaIleLeuSer<->PheAlaLysGlnAsnGl
|| |||||||||||| ||||||||||||||| ||||||||||||||
etProCysLysLysPheHisThrAspAlaIleLeuSerLeuLeuAlaLysGlnAsnGl
TGCCCTGTAAGAAATTTCATACAGATGCAATTCTTTCTCTTCTTGCTAAACAAAACCA
nGluSerAlaValSerGlnGlnAlaValTyrHisSerGlu >>>> Target Intr
|||| ||||||||| |||||||||||||||||| 5209 b
nGluLeuLeuValSerGlnGluAlaValTyrHisSerGlu++
GGAATTACTGGTTTCACAGGAGGCAGTCTATCATTCAGAGgt
on 22 >>>> AspLeuGluAsnSerValGlyGluLeuSerGluGlyGlnArgProG
p |||||||||||||||||||||||||||||||||||||||||||||
++AspLeuGluAsnSerValGlyGluLeuSerGluGlyGlnArgProA
agGATTTGGAAAACAGCGTGGGTGAACTTAGCGAAGGACAAAGGCCCA
lnLeuThrAlaAlaAlaGluAsnIleLeuMetGlyHisSerLeuTyrMetGlnProPr
||| ||||||||||||||||||||| ||| |||||| |||
rgLeuLysAlaAlaAlaGluAsnIleLeuValGlyCysSerLeuSerThrGlnGlnAr
GGCTGAAGGCGGCAGCAGAGAACATCTTAGTGGGATGTTCTCTCTCTACGCAGCAGCG
oValThrAsnThrGlnSerLeuAspGlnGlnCysAspProLysProLeuSerArgGln
|||||| ||| |||||||||
gMetValThrAlaGluSerLeuAlaGlnHisCysAspProAsnLeuSerProProHis
AATGGTCACTGCCGAGTCTTTGGCTCAACATTGTGATCCTAATCTGTCACCTCCGCAC
PheAspThrValSer{G} >>>> Target Intron 23 >>>> {ly}SerIle
||||||||||||{|} 9637 bp {||} |||
ValAspThrValSer{G}++ ++{ly}GlyIle
GTTGACACAGTTTCA{G}gt ag{GT}GGTATT
TyrGluAspSerCysAlaSerHisGlyProMetSerLeuGlyGluLeuGluLeuGluP
||||||||||||||||||||||||||||||||||||||||||||||||||||||
TyrGluAspSerCysAlaSerHisGlyProMetSerLeuGlyGluLeuGluLeuLeuS
TATGAAGATTCATGTGCTAGTCATGGTCCAATGAGTTTAGGAGAATTGGAGTTGCTTT
roAsnSerLysLeuValLeuProThrThrLeuLeuThrAlaGlnGluAsnAspValAs
|||||| ||| ||| |||||| ||| ||||||||||||||
erAsnSerAsnLeuGlyPheProSerThrLeuGlyThrSerGluGluAsnAspValAs
CAAATTCTAACCTTGGTTTTCCTTCAACACTTGGGACATCAGAAGAAAATGATGTTAA
nLeuProValAlaAlaGluAspPheSerGln >>>> Target Intron 24 >>>
|||||||||| ||| |||||| 17252 bp
nLeuProValThrAlaGlyAlaIleSerGln++
TTTACCAGTAACAGCTGGAGCTATTTCTCAGgt
> TyrGlnLeuLysGlnAsnGlnAspValLysGlnValGluHisLysProSerGlnS
||| |||||| ||||||||| |||||||||||||||||| ||||
++CysGlnGlnLysGlnGlyGlnAspValGluGlnValGluHisLysProValGlnS
agTGCCAGCAAAAGCAAGGCCAGGATGTTGAGCAGGTTGAACACAAGCCAGTACAAA
erTyrLeu<->ArgValArgAsnLysSerAspIleAla{Pr} >>>> Target In
|| ||| |||||| ||| ||| { } 36247
erArgLeuIleCysValArgSerLysProAspValSer{Le}-+
GTCGTCTCATATGTGTAAGAAGTAAACCAGACGTTTCA{CT}tt
tron 25 >>>> {o}SerGlnGlnGlnValSerProGlyAspMetAspArgThrGl
bp { } |||||||||||| ||| |||||
++{u}PhePheSerValThrSerProGlyAspValAspGlnThrGl
ag{T}TTTTTCAGTGTAACTTCGCCAGGTGATGTGGATCAGACACA
nIleGluLeuAsnProTyrLeuThrCysValPheSer
||||||| ||||||
nIleGluProSerLeuCysPheAlaSerIlePheSer
AATTGAACCCAGTCTGTGCTTTGCATCTATATTTAGC
//
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