| Basic information |
| Official Symbol | HTR3A |
| Description | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
| Other Aliases | 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 |
| Other Description | 5-HT3-A; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT3 serotonin receptor; serotonin receptor 3A; serotonin-gated ion channel receptor |
| Mutation type | Insert and frame-shift 343-344:T-G^CA, premature termination 319:R->TGA |
| Location | Scaffold000311_2:8548423 8562809 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| HTR3A |
GCCATGCCACAGTGGGTCCGGCAGGCACTGCTGGCCTTACTCCTCCCCAC GCTCCTGGCACAGGGCGAAGGTAAGGGGGCCCGGAACAGCAGCAGACCTG CGCTCATAAGGCTGTCGGACTACCTTCTGGCCAACTACGAGAAGGGCGTG CGGCCTGTGCGTGACTGGAGGAAGCCAACCACCGTCTCCATTGATGTCAT GGTCTATGCCATACTCAACGTGGATGAGAAGAACCAGGTACTGACCACCT ACATCTGGTACCGGCAGTACTGGACTGACGAGTTTCTCCAGTGGAACCCC AAGGACTTTGACAACATCACCAAGTTGTCCATCCCCACGGACAGCATCTG GGTCCCCGACATTCTCATCAACGAGTTTGTGGACGTGGGGAAGTCTCCGA ATATCCCGTATGTGTATGTTCGGCATCATGGCGAGGTTCAGAACTACAAG CCCCTCCAGGTGGTGACCGCCTGCAGCCTGGACATCTACAACTTCCCCTT CGATGTACAGAACTGCTCGCTGACCTTCACCAGCTGGCTGCACACCATCC AGGACATCAACATCTCCCTGTGGCGTTTGCCAGAAAAGGTGAAGTTTGAC AAGAGCGTCTTCATGAACCAGGGCGAGTGGGAGCTGCTGGGGGTGCTGAC CCAGTTCCGGGAGTTCAGCATCGAAAGCAGCAACCACTATGCAGAAATGA AGTTCTATGTGGTCATCCGCCGGCGGCCCCTGTTCTATGCCGTCAGCCTG CTGCTGCCCAGTATCTTCCTCATGGTCATGGACATCGTGGGCTTCTACCT GCCCCCGGACAGCGGCGAGAGGGTCTCCTTCAAGATCACCCTCCTCCTGG GCTACTCGGTCTTCCTGATCATCGTGTCCGACACGCTGCCAGCCACTGCC ATCGGCACTCCCCTCATCGGTAAGACCTCCTGGGGATGAGCTCATCCCCA AGAGGAACTGGCCCCCTCTCACCTCCTGTGTGTTGTTCTCCACCCCTGCC GCGGCACGGGTGTCTACTTCGTGGTGTGCATGGCTCTGCTGGTGATCAGC TTGGCCGAGACCATCCTCATCGTGCGGCTGGTGCACAAGCAAGACCTGCA GCAGCCCGTGCCCGCCTGGCTGCGGCGCTTGGTTCTAGAGCAACTCTCCT GGCTGCTTTGTCTTGGCGAGCAGCCAACCTCCCATAGGCCCCCGGCCAAC TCCCAAGCCACCAAGACTGATGACTGCTCAGCCATGGGGAACCACTGCGA CCATTTGGGAGGACCCCAGGACTTGGAGAAGATCCCGAGGGGCAGAGGCA GCCCTCCCCCTCCGCCGCGGGAGGCCTCGCTTGCAGTGCGAGGGCTGCTG CAGGAGCTGTCGTCCATCCGGCGCTTTCTGGAGAAGCGGGATGAGATCCG GGAGGTGGCCCGGGACTGGCTGCGCGTGGGCTCTGTGCTGGACAGGCTGC TCTTCCGCATCTACCTGCTGGCTGTGCTGGCCTACAGTGCCACCCTGGTC ACACTCTGGTCCATCTGGCAGTATTCT |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 516 | 6 | 516 | Insert and frame-shift 343-344:T-G^CA, Premature termination 319:R->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
AlaMetLeuLeuTrpValGlnGlnAlaLeuLeuAlaLeuLeuLeuProThrLeuLeuAla
|||||| |||||| |||||||||||||||||||||||||||||||||||||||
AlaMetProGlnTrpValArgGlnAlaLeuLeuAlaLeuLeuLeuProThrLeuLeuAla
GCCATGCCACAGTGGGTCCGGCAGGCACTGCTGGCCTTACTCCTCCCCACGCTCCTGGCA
GlnGlyGluAlaArgArg >>>> Target Intron 1 >>>> SerArgAsnThrT
||||||||| 2259 bp ||||||
GlnGlyGluGlyLysGly-+ ++AlaArgAsnSerS
CAGGGCGAAGGTAAGGGGct agGCCCGGAACAGCA
hrArgProAlaLeuLeuArgLeuSerAspTyrLeuLeuThrAsnTyrArgLysGlyValA
|||||||||||| ||||||||||||||||||||| |||||| ||||||||||
erArgProAlaLeuIleArgLeuSerAspTyrLeuLeuAlaAsnTyrGluLysGlyValA
GCAGACCTGCGCTCATAAGGCTGTCGGACTACCTTCTGGCCAACTACGAGAAGGGCGTGC
rgProValArgAspTrpArgLysProThrThrValSerIleAspValIleValTyrAlaI
||||||||||||||||||||||||||||||||||||||||||||||| ||||||||||
rgProValArgAspTrpArgLysProThrThrValSerIleAspValMetValTyrAlaI
GGCCTGTGCGTGACTGGAGGAAGCCAACCACCGTCTCCATTGATGTCATGGTCTATGCCA
leLeuAsnVal >>>> Target Intron 2 >>>> AspGluLysAsnGlnValLe
||||||||||| 941 bp ||||||||||||||||||||
leLeuAsnVal++ ++AspGluLysAsnGlnValLe
TACTCAACGTGgt agGATGAGAAGAACCAGGTACT
uThrThrTyrIleTrpTyrArgGln >>>> Target Intron 3 >>>> TyrTrp
||||||||||||||||||||||||| 1836 bp ||||||
uThrThrTyrIleTrpTyrArgGln+- ++TyrTrp
GACCACCTACATCTGGTACCGGCAGgg agTACTGG
ThrAspGluPheLeuGlnTrpAsnProGluAspPheAspAsnIleThrLysLeuSerIle
||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||
ThrAspGluPheLeuGlnTrpAsnProLysAspPheAspAsnIleThrLysLeuSerIle
ACTGACGAGTTTCTCCAGTGGAACCCCAAGGACTTTGACAACATCACCAAGTTGTCCATC
ProThrAspSerIleTrpValProAspIleLeuIleAsnGlu{Ph} >>>> Target
||||||||||||||||||||||||||||||||||||||||||{||} 133
ProThrAspSerIleTrpValProAspIleLeuIleAsnGlu{Ph}++
CCCACGGACAGCATCTGGGTCCCCGACATTCTCATCAACGAG{TT}gt
Intron 4 >>>> {e}ValAspValGlyLysSerProAsnIleProTyrValTyrIle
8 bp {|}|||||||||||||||||||||||||||||||||||||||
++{e}ValAspValGlyLysSerProAsnIleProTyrValTyrVal
ag{T}GTGGACGTGGGGAAGTCTCCGAATATCCCGTATGTGTATGTT
ArgHisGlnGlyGluValGlnAsnTyrLysProLeuGlnValValThrAlaCysSerLeu
|||||| |||||||||||||||||||||||||||||||||||||||||||||||||||
ArgHisHisGlyGluValGlnAsnTyrLysProLeuGlnValValThrAlaCysSerLeu
CGGCATCATGGCGAGGTTCAGAACTACAAGCCCCTCCAGGTGGTGACCGCCTGCAGCCTG
AspIleTyrAsnPheProPheAspValGlnAsnCysSerLeuThrPheThrSerTrpLeu
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AspIleTyrAsnPheProPheAspValGlnAsnCysSerLeuThrPheThrSerTrpLeu
GACATCTACAACTTCCCCTTCGATGTACAGAACTGCTCGCTGACCTTCACCAGCTGGCTG
HisThr{I} >>>> Target Intron 5 >>>> {le}GlnAspIleAsnIleSer
||||||{|} 1578 bp {||}||||||||||||||||||
HisThr{I}++ ++{le}GlnAspIleAsnIleSer
CACACC{A}gt ag{TC}CAGGACATCAACATCTCC
LeuTrpArgLeuProGluLysValLysSerAspArgSerValPheMetAsnGlnGlyGlu
||||||||||||||||||||||||||| ||| ||||||||||||||||||||||||
LeuTrpArgLeuProGluLysValLysPheAspLysSerValPheMetAsnGlnGlyGlu
CTGTGGCGTTTGCCAGAAAAGGTGAAGTTTGACAAGAGCGTCTTCATGAACCAGGGCGAG
TrpGluLeuLeuGlyValLeuProTyrPheArgGluPheSerMetGluSerSerAsnTyr
||||||||||||||||||||| ||||||||||||||| ||||||||||||
TrpGluLeuLeuGlyValLeuThrGlnPheArgGluPheSerIleGluSerSerAsnHis
TGGGAGCTGCTGGGGGTGCTGACCCAGTTCCGGGAGTTCAGCATCGAAAGCAGCAACCAC
TyrAlaGluMetLysPheTyr >>>> Target Intron 6 >>>> ValValIleA
||||||||||||||||||||| 295 bp ||||||||||
TyrAlaGluMetLysPheTyr++ ++ValValIleA
TATGCAGAAATGAAGTTCTATgt agGTGGTCATCC
rgArgArgProLeuPheTyrValValSerLeuLeuLeuProSerIlePheLeuMetValM
|||||||||||||||||||| |||||||||||||||||||||||||||||||||||||
rgArgArgProLeuPheTyrAlaValSerLeuLeuLeuProSerIlePheLeuMetValM
GCCGGCGGCCCCTGTTCTATGCCGTCAGCCTGCTGCTGCCCAGTATCTTCCTCATGGTCA
etAspIleValGlyPheTyrLeuProProAsnSerGlyGluArgValSerPheLysIleT
||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||
etAspIleValGlyPheTyrLeuProProAspSerGlyGluArgValSerPheLysIleT
TGGACATCGTGGGCTTCTACCTGCCCCCGGACAGCGGCGAGAGGGTCTCCTTCAAGATCA
hrLeuLeuLeuGlyTyrSerValPheLeuIleIleValSerAspThrLeuProAlaThrA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
hrLeuLeuLeuGlyTyrSerValPheLeuIleIleValSerAspThrLeuProAlaThrA
CCCTCCTCCTGGGCTACTCGGTCTTCCTGATCATCGTGTCCGACACGCTGCCAGCCACTG
laIleGlyThrProLeuIleGlyLysAlaProProGlySerArgAlaGlnSerGlyGluL
|||||||||||||||||||||||||| ||| ||| |||
laIleGlyThrProLeuIleGlyLysThrSerTrpGly---***AlaHisProGlnGluG
CCATCGGCACTCCCCTCATCGGTAAGACCTCCTGGGGA---TGAGCTCATCCCCAAGAGG
ysProAlaProSerHisLeuLeuHisValSerLeuAlaSerAlaLeuGlyCysThr--Gl
|||||||||||||||||| ||| ||| ||| |||##||
luLeuAlaProSerHisLeuLeuCysValValLeuHisProCysArgGly---Thr##Gl
AACTGGCCCCCTCTCACCTCCTGTGTGTTGTTCTCCACCCCTGCCGCGGC---ACGCAGG
yValTyrPheValValCysMetAlaLeuLeuValIleSerLeuAlaGluThrIlePheIl
||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||
yValTyrPheValValCysMetAlaLeuLeuValIleSerLeuAlaGluThrIleLeuIl
TGTCTACTTCGTGGTGTGCATGGCTCTGCTGGTGATCAGCTTGGCCGAGACCATCCTCAT
eValArgLeuValHisLysGlnAspLeuGlnGlnProValProAlaTrpLeuArgHisLe
||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||
eValArgLeuValHisLysGlnAspLeuGlnGlnProValProAlaTrpLeuArgArgLe
CGTGCGGCTGGTGCACAAGCAAGACCTGCAGCAGCCCGTGCCCGCCTGGCTGCGGCGCTT
uValLeuGluArgIleAlaTrpLeuLeuCysLeuArgGluGlnSerThrSerGlnArgPr
|||||||||| ||||||||||||||| |||||| |||||| |||||
uValLeuGluGlnLeuSerTrpLeuLeuCysLeuGlyGluGlnProThrSerHisArgPr
GGTTCTAGAGCAACTCTCCTGGCTGCTTTGTCTTGGCGAGCAGCCAACCTCCCATAGGCC
oProAlaThrSerGlnAlaThrLysThrAspAspCysSer{A} >>>> Target Int
||||||| ||||||||||||||||||||||||||||||{|} 4611 b
oProAlaAsnSerGlnAlaThrLysThrAspAspCysSer{A}++
CCCGGCCAACTCCCAAGCCACCAAGACTGATGACTGCTCA{G}gt
ron 7 >>>> {la}MetGlyAsnHisCysSerHisMetGlyGlyProGlnAspPheGl
p {||}||||||||||||||| ||| ||||||||||||||| ||
++{la}MetGlyAsnHisCysAspHisLeuGlyGlyProGlnAspLeuGl
ag{CC}ATGGGGAACCACTGCGACCATTTGGGAGGACCCCAGGACTTGGA
uLysSerProArgAspArgCysSerProProProProProArgGluAlaSerLeuAlaVa
|||| |||||| ||| ||||||||||||||||||||||||||||||||||||||
uLysIleProArgGlyArgGlySerProProProProProArgGluAlaSerLeuAlaVa
GAAGATCCCGAGGGGCAGAGGCAGCCCTCCCCCTCCGCCGCGGGAGGCCTCGCTTGCAGT
lCysGlyLeuLeuGlnGluLeuSerSerIleArgGlnPheLeuGluLysArgAspGluIl
| |||||||||||||||||||||||||||||| |||||||||||||||||||||||
lArgGlyLeuLeuGlnGluLeuSerSerIleArgArgPheLeuGluLysArgAspGluIl
GCGAGGGCTGCTGCAGGAGCTGTCGTCCATCCGGCGCTTTCTGGAGAAGCGGGATGAGAT
eArgGluValAlaArgAspTrpLeuArgValGlySerValLeuAspLysLeuLeuPheHi
|||||||||||||||||||||||||||||||||||||||||||||| |||||||||
eArgGluValAlaArgAspTrpLeuArgValGlySerValLeuAspArgLeuLeuPheAr
CCGGGAGGTGGCCCGGGACTGGCTGCGCGTGGGCTCTGTGCTGGACAGGCTGCTCTTCCG
sIleTyrLeuLeuAlaValLeuAlaTyrSerIleThrLeuValMetLeuTrpSerIleTr
|||||||||||||||||||||||||||||| ||||||||| ||||||||||||||
gIleTyrLeuLeuAlaValLeuAlaTyrSerAlaThrLeuValThrLeuTrpSerIleTr
CATCTACCTGCTGGCTGTGCTGGCCTACAGTGCCACCCTGGTCACACTCTGGTCCATCTG
pGlnTyrAla
|||||||
pGlnTyrSer
GCAGTATTCT
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