| Basic information |
| Official Symbol | HLA-DRB1 |
| Description | major histocompatibility complex, class II, DR beta 1 |
| Other Aliases | XXbac-BPG161M6.1, DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1 |
| Other Description | DW2.2/DR2.2; HLA class II histocompatibility antigen, DR-1 beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class II antigen; human leucocyte antigen DRB1; lymphocyte antigen DRB1 |
| Mutation type | premature termination 96:I->TAG |
| Location | Scaffold144459_1:55693 49793 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| HLA-DRB1 |
CGTTTCATGGAGCAGCTTAAGTTTGACTGCCATTTCTCCAACGGGACCCA GCGGGTGCGGTTCCTGGAGCAATACATCTATAATCCGGAGGAGTTCGTGC ACTTTGACAGCGACGTGGGCGAGTACCTGGCGGTGACTGAGCTGGGGCGG CGGGACGCTGAGCTCTGGAACAGCCAGAAGGACTAGATGGAGGAACGGCG GGCCATGGTGGACACCTTCTGCAGATACAACTACTGGAGTGGCGAGATCT TCATGGTGCAGAGGCGAGCTCAGCCCAAGGTGACCGTGTATCCTACAAGG ACCCAGCCCCTGCAGCACCACAGCCTCCTGGTCTGCTCTGTGAACGGTTT CTACCCAGGCAACGTTGAAGTCAGATGGTTCCGGAATGGCCAGGAAGAGA AGGCTGGGGTTGTCTCCACAGGCCTGATCCGTAATGGAGACTGGACCTTC CAGATCCTGGTGATGCTGGAAACAGTTCCTCAGAGTGGAGAGGTTTACAC TTGCCAAGTGGAACACCCAAGCCTGACGGACCCTGTCAGGGTGGAATGGA AGGCACAATCTGAATCTGCACGGGGCAAGATGCTGAGTGGAATTGGGGGC TCTGTTCTGGGCCTGCTTTTCCTTGGGGTGGGGCCATTCATCCACTTCAG GAATCAGAAAGGT |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 266 | 35 | 255 | Premature termination 96:I->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
ArgPheLeuTrpGlnProLysArgGluCysHisPhePheAsnGlyThrGluArgValArgPh
|||||| ||| ||| ||||||||| ||||||||| |||||||||||
ArgPheMetGluGlnLeuLysPheAspCysHisPheSerAsnGlyThrGlnArgValArgPh
CGTTTCATGGAGCAGCTTAAGTTTGACTGCCATTTCTCCAACGGGACCCAGCGGGTGCGGTT
eLeuAspArgTyrPheTyrAsnGlnGluGluSerValArgPheAspSerAspValGlyGluP
|||| ||| |||||| |||||| ||| |||||||||||||||||||||
eLeuGluGlnTyrIleTyrAsnProGluGluPheValHisPheAspSerAspValGlyGluT
CCTGGAGCAATACATCTATAATCCGGAGGAGTTCGTGCACTTTGACAGCGACGTGGGCGAGT
heArgAlaValThrGluLeuGlyArgProAspAlaGluTyrTrpAsnSerGlnLysAspIle
||||||||||||||||||||| ||||||||| ||||||||||||||||||
yrLeuAlaValThrGluLeuGlyArgArgAspAlaGluLeuTrpAsnSerGlnLysAsp***
ACCTGGCGGTGACTGAGCTGGGGCGGCGGGACGCTGAGCTCTGGAACAGCCAGAAGGACTAG
LeuGluGlnAlaArgAlaAlaValAspThrTyrCysArgHisAsnTyrGlyValValGluSe
||| |||||| ||||||||| |||||| |||||| |||
MetGluGluArgArgAlaMetValAspThrPheCysArgTyrAsnTyrTrpSerGlyGluIl
ATGGAGGAACGGCGGGCCATGGTGGACACCTTCTGCAGATACAACTACTGGAGTGGCGAGAT
rPheThrValGlnArgArg{V} >>>> Target Intron 1 >>>> {al}GlnProL
||| ||||||||||||{ } 4312 bp { }|||||||
ePheMetValGlnArgArg{A}++ ++{la}GlnProL
CTTCATGGTGCAGAGGCGA{G}gt ag{CT}CAGCCCA
ysValThrValTyrProSerLysThrGlnProLeuGlnHisHisAsnLeuLeuValCysSer
||||||||||||||||| ||||||||||||||||||||| |||||||||||||||
ysValThrValTyrProThrArgThrGlnProLeuGlnHisHisSerLeuLeuValCysSer
AGGTGACCGTGTATCCTACAAGGACCCAGCCCCTGCAGCACCACAGCCTCCTGGTCTGCTCT
ValSerGlyPheTyrProGlySerIleGluValArgTrpPheLeuAsnGlyGlnGluGluLy
||| ||||||||||||||| ||||||||||||||| |||||||||||||||||
ValAsnGlyPheTyrProGlyAsnValGluValArgTrpPheArgAsnGlyGlnGluGluLy
GTGAACGGTTTCTACCCAGGCAACGTTGAAGTCAGATGGTTCCGGAATGGCCAGGAAGAGAA
sAlaGlyMetValSerThrGlyLeuIleGlnAsnGlyAspTrpThrPheGlnThrLeuValM
||||||| |||||||||||||||||| ||||||||||||||||||||| |||||||
sAlaGlyValValSerThrGlyLeuIleArgAsnGlyAspTrpThrPheGlnIleLeuValM
GGCTGGGGTTGTCTCCACAGGCCTGATCCGTAATGGAGACTGGACCTTCCAGATCCTGGTGA
etLeuGluThrValProArgSerGlyGluValTyrThrCysGlnValGluHisProSerVal
||||||||||||||||| |||||||||||||||||||||||||||||||||||||||
etLeuGluThrValProGlnSerGlyGluValTyrThrCysGlnValGluHisProSerLeu
TGCTGGAAACAGTTCCTCAGAGTGGAGAGGTTTACACTTGCCAAGTGGAACACCCAAGCCTG
ThrSerProLeuThrValGluTrp{A} >>>> Target Intron 2 >>>> {rg}Al
||| ||| |||||||||{ } 926 bp { }||
ThrAspProValArgValGluTrp{L}++ ++{ys}Al
ACGGACCCTGTCAGGGTGGAATGG{A}gt ag{AG}GC
aArgSerGluSerAlaGlnSerLysMetLeuSerGlyValGlyGlyPheValLeuGlyLeuL
| |||||||||||| ||||||||||||||| |||||| |||||||||||||
aGlnSerGluSerAlaArgGlyLysMetLeuSerGlyIleGlyGlySerValLeuGlyLeuL
ACAATCTGAATCTGCACGGGGCAAGATGCTGAGTGGAATTGGGGGCTCTGTTCTGGGCCTGC
euPheLeuGlyAlaGlyLeuPheIleTyrPheArgAsnGlnLysGly
||||||||||| ||| |||||| ||||||||||||||||||
euPheLeuGlyValGlyProPheIleHisPheArgAsnGlnLysGly
TTTTCCTTGGGGTGGGGCCATTCATCCACTTCAGGAATCAGAAAGGT
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