| Basic information |
| Official Symbol | FASTKD2 |
| Description | FAST kinase domains 2 |
| Other Aliases | KIAA0971 |
| Other Description | FAST kinase domain-containing protein 2 |
| Mutation type | Delete and frame-shift 10:S->A |
| Location | Scaffold000076_1:1647063 1670648 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| FASTKD2 |
ATCTTGACAACATTCAAGCCATTTGGAAATTTTAGTGGACAACAAAATGAATAACAAAGC AGGTTCCTTTCTATGGAACCTCAGACAATTCAGTACTTTGGTTCCAACCAGCCGAACTAT GAGGCTATTTTCTTTGGGACTTTGCAAAACAAAAGTGGTTCATTCAGGCTGGAACCTCAA CAGCCTAAGTGACTTCCATAGCAGAATGCAATTATCTATTAGATATCTCTTTCAGGGTAC ATTCTTTTTAAAAACAGGAGCTGGCTGCTTTCAAACAAAGGGCATAAGCACTGTAGCAGC CATTAAAAGTGACAGACTACTTGGTCCTAGAAAGCTGTCCCTTGACTCAAAACATTCTCT TGTCCCTGTTGGTACTGCTGATAATGGAAATGAACAAAGTACGCTTTCATCAGGAGGTCC CCAATGAAGATATTGTCAGCAAGGAAATAAAACCAACCCCTATCACTTATAAAAAGCTGG CCCAGGAGTGTAATTCCCTAAGTGATGTGTTAGATACGTTTTCAAAAGCTCCTACATTTC CTAGTAGTAACTATTTCTCAGCAATGTGGACAATTGCCAAAAGGATGTCTGAGGACCAGA AGCGCTTTGAAAAACAACTGATGTTTAACCATCCTGCATTTAACCAGCTGTGTGAACATA TGTTGAGAGAAGTCAAGTTTTTGCACTATGACCAGTTGCTCTTCAGTCTTCATGCAATGG TGAAGCTTGGAATCCCTCAGAACACTCTTCTGATACAGACTTTGCTGAGGGTGATCCAGG AACGAATCAATGAGTGTGACGAGAAATGCCTTTCAGTTTTGTCAAATATTATAGAGGCGA TGGAGCCATGCAAGAATGTGCAAGTTCTGCGAGCGGGATTGTTACTAGTTGATCAGCAAG TTTGGAAGATAGAACGTGTCTTCACCTTGCAAACTGTGATGAAATGTATTGGAAAAGATG CACCACATGCTCTTAAAAGGAAACTAGAGATGAAAGCTTTGAGGGAATTAGACAAATTTT CTGTTCTGAATAGCCAGCGTATGTTCGAGGTGCTAGCTGCCATGAATCACCATTCTGCTG TTCTCCTGAATGAATGCAGTAAAACATTCATAAATATCCATGGGTGTCCTTTTAAAATAT TGATCAACATACTGCAGTCCTGCAAAGACCTCCGATACTTTAATATAGATCTCTACAAGG GAATAGCAGATTATGTGACTACAACTTTTGACATGTGGAAGTTTAAACAAGTTCTTTTTC TCCTTATTTTGTTTGAAGACCTTTGTTTCCGACCTGTTGATTTGATGGATTTGTTTATGA AAAAAGTAGAAGAAGAACCTGAATCCCTAACGGTGAAAAACATTGTTTCTATTCTTCACG TGTATTCTTCTCTGAATCACTTCTATAAGTGCCAGAACAAAGAATTCCTAGAAGTTATGG CTAGTGCTCTGACTGGTTGTCTTCACAACATCTCTTCTGAAAACCTGTTGCATGCTGTAT ACTCATTTGGTCTGATGAATTACTTCCCCCTGGCTCCTGTTAATCAGCTTCTCCAAAAGG ATATCGTCACTGAGTTGCTGACATCAATAGAGAGGAATGTTTACAAGCTCCATGTATTGG ATACTTGTCTAAAGCTCGATGATACACCTTATCAGAGGGCCGTGGGCCTGTCACTGCCAC AGCCACCCTTGACACCACCGTATCCAAATGCCAAGGTGGCAGAGGTGCTCAGTAGCCTTC TAGGAGGTGAAGGGTACTTCTCAAAAAATGTGCAGTTGCCACATAATTATCATATCTTTG AAATCAGAATGGATACTAATAGGAGTCAAGTGCTTCCGTTTTCTGATGTGGATGTAACTT CTACAGATATGCAAGTAGCTGTGCTGTGTGTGCCTAGATCTGCTTATTGTTTGGATCTAA GCCACCCCAGAGGATCCCTTGCTATGAAAATGCGGCATTTGAATGTGATGGGTTTTCATG TGATCTTGGTCAATAACTGGGAGATGAAAAAACAAGAGAGGGAAGATGCCATCACATTTT TGAAGAATAAAATTTATTCAGTCGAAGCCCTTCCTACTGCTGATGTAAATTTGCAAAGCA CG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 710 | 1 | 709 | Delete and frame-shift 10:S->A |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetLeuThrThrLeuLysProPheGlySerValSerValGluSerLysMetAsn
||||||||| |||||||||||||## ||| |||||||||
IleLeuThrThrPheLysProPheGly---IleLeuValAspAsnLysMetAsn
ATCTTGACAACATTCAAGCCATTTGGAA##ATTTTAGTGGACAACAAAATGAAT
AsnLysAlaGlySerPhePheTrpAsnLeuArgGlnPheSerThrLeuValSer
|||||||||||||||||| ||||||||||||||||||||||||||||||
AsnLysAlaGlySerPheLeuTrpAsnLeuArgGlnPheSerThrLeuValPro
AACAAAGCAGGTTCCTTTCTATGGAACCTCAGACAATTCAGTACTTTGGTTCCA
ThrSerArgThrMetArgLeuCysCysLeuGlyLeuCysLysProLysIleVal
||||||||||||||||||||| ||||||||||||||| ||| |||
ThrSerArgThrMetArgLeuPheSerLeuGlyLeuCysLysThrLysValVal
ACCAGCCGAACTATGAGGCTATTTTCTTTGGGACTTTGCAAAACAAAAGTGGTT
HisSerAsnTrpAsnIleLeuAsnAsnPheHisAsnArgMetGlnSerThrAsp
|||||| ||||||
HisSerGlyTrpAsnLeuAsnSerLeuSerAspPheHisSerArgMetGlnLeu
CATTCAGGCTGGAACCTCAACAGCCTAAGTGACTTCCATAGCAGAATGCAATTA
IleIleArgTyrLeuPheGlnAspAlaPheIlePheLysSerAspValGly<->
|||||||||||||||||| ||| ||| |||
SerIleArgTyrLeuPheGlnGlyThrPhePheLeuLysThrGlyAlaGlyCys
TCTATTAGATATCTCTTTCAGGGTACATTCTTTTTAAAAACAGGAGCTGGCTGC
PheGlnThrLysGlyIleSerThrLeuThrAlaLeuArgIleGluArgLeuLeuTyr
|||||||||||||||||||||||| ||| |||||||||
PheGlnThrLysGlyIleSerThrValAlaAlaIleLysSerAspArgLeuLeuGly
TTTCAAACAAAGGGCATAAGCACTGTAGCAGCCATTAAAAGTGACAGACTACTTGGT
AlaLysArgLeuPhePheAspSerLysGlnSerLeuValProValAspLysSerAspAsp
||| ||||||||| ||||||||||||||| |||
ProArgLysLeuSerLeuAspSerLysHisSerLeuValProValGlyThrAlaAspAsn
CCTAGAAAGCTGTCCCTTGACTCAAAACATTCTCTTGTCCCTGTTGGTACTGCTGATAAT
GluLeuLysLysValAsnLeuAsnHisGluValSerAsnGluAspValLeuThrLysGlu
||| |||||| |||||| ||||||||| ||||||
GluMetAsnLysValArgPheHisGlnGluValProAsnGluAspIleValSerLysGlu
GAAATGAACAAAGTACGCTTTCATCAGGAGGTCCCCAATGAAGATATTGTCAGCAAGGAA
ThrLysProAsnArgIleSerSerArgLysLeuSerGluGluCysAsnSerLeuSerAsp
|||||| ||| |||||| |||||||||||||||||||||
IleLysProThrProIleThrTyrLysLysLeuAlaGlnGluCysAsnSerLeuSerAsp
ATAAAACCAACCCCTATCACTTATAAAAAGCTGGCCCAGGAGTGTAATTCCCTAAGTGAT
ValLeuAspAlaPheSerLysAlaProThrPheProSerSerAsnTyrPheThrAlaMet
||||||||| ||||||||||||||||||||||||||||||||||||||| ||||||
ValLeuAspThrPheSerLysAlaProThrPheProSerSerAsnTyrPheSerAlaMet
GTGTTAGATACGTTTTCAAAAGCTCCTACATTTCCTAGTAGTAACTATTTCTCAGCAATG
TrpThrIleAlaLysArgLeuSerAspAspGlnLysArgPheGluLysArgLeuMetPhe
|||||||||||||||||| ||| ||||||||||||||||||||| |||||||||
TrpThrIleAlaLysArgMetSerGluAspGlnLysArgPheGluLysGlnLeuMetPhe
TGGACAATTGCCAAAAGGATGTCTGAGGACCAGAAGCGCTTTGAAAAACAACTGATGTTT
SerHisProAlaPheAsnGlnLeuCysGluHisMetMetArgGluAlaLysIleMetGln
||||||||||||||||||||||||||||||||| |||||| |||
AsnHisProAlaPheAsnGlnLeuCysGluHisMetLeuArgGluValLysPheLeuHis
AACCATCCTGCATTTAACCAGCTGTGTGAACATATGTTGAGAGAAGTCAAGTTTTTGCAC
TyrLysTyrLeuLeuPheSerLeuHisAlaIleValLysLeuGlyIleProGlnAsnThr
||| ||||||||||||||||||||| |||||||||||||||||||||||||||
TyrAspGlnLeuLeuPheSerLeuHisAlaMetValLysLeuGlyIleProGlnAsnThr
TATGACCAGTTGCTCTTCAGTCTTCATGCAATGGTGAAGCTTGGAATCCCTCAGAACACT
IleLeuValGlnThrLeuLeuArgValThrGln >>>> Target Intron 1 >>>>
||| |||||||||||||||||| ||| 3362 bp
LeuLeuIleGlnThrLeuLeuArgValIleGln++
CTTCTGATACAGACTTTGCTGAGGGTGATCCAGgt
GluArgIleAsnGluCysAspGluIleCysLeuSerValLeuSerThrValLeuGluA
|||||||||||||||||||||||| |||||||||||||||||| ||||
++GluArgIleAsnGluCysAspGluLysCysLeuSerValLeuSerAsnIleIleGluA
agGAACGAATCAATGAGTGTGACGAGAAATGCCTTTCAGTTTTGTCAAATATTATAGAGG
laMetGluProCysLysAsnValHisValLeuArgThrGlyPhe{Ar} >>>> Targe
||||||||||||||||||||||| ||||||||| ||| {||} 1
laMetGluProCysLysAsnValGlnValLeuArgAlaGlyLeu{Ar}++
CGATGGAGCCATGCAAGAATGTGCAAGTTCTGCGAGCGGGATTG{AG}gt
t Intron 2 >>>> {g}IleLeuValAspGlnGlnValTrpLysIleGluAspValP
157 bp {|} |||||||||||||||||||||||||||||| ||||
++{g}LeuLeuValAspGlnGlnValTrpLysIleGluArgValP
ag{A}TTACTAGTTGATCAGCAAGTTTGGAAGATAGAACGTGTCT
heThrLeuGlnValValMetLysCysIleGlyLysAspAlaProIleAlaLeuLysArgL
||||||||||| |||||||||||||||||||||||||||||| |||||||||||||
heThrLeuGlnThrValMetLysCysIleGlyLysAspAlaProHisAlaLeuLysArgL
TCACCTTGCAAACTGTGATGAAATGTATTGGAAAAGATGCACCACATGCTCTTAAAAGGA
ysLeuGlu >>>> Target Intron 3 >>>> MetLysAlaLeuArgGluLeuAs
|||||||| 2657 bp |||||||||||||||||||||||
ysLeuGlu++ ++MetLysAlaLeuArgGluLeuAs
AACTAGAGgt agATGAAAGCTTTGAGGGAATTAGA
pArgPheSerValLeuAsnSerGlnHisMetPheGluValLeuAlaAlaMetAsnHisAr
| ||||||||||||||||||||| ||||||||||||||||||||||||||||||
pLysPheSerValLeuAsnSerGlnArgMetPheGluValLeuAlaAlaMetAsnHisHi
CAAATTTTCTGTTCTGAATAGCCAGCGTATGTTCGAGGTGCTAGCTGCCATGAATCACCA
gSerLeuIleLeuLeuAspGluCysSerLysValValLeu{A} >>>> Target Int
||| |||||| |||||||||||| {|} 244 b
sSerAlaValLeuLeuAsnGluCysSerLysThrPheIle{A}++
TTCTGCTGTTCTCCTGAATGAATGCAGTAAAACATTCATA{G}gt
ron 4 >>>> {sp}AsnIleHisGlyCysProLeuArgIleMetIleAsnIleLeuGl
p {||}|||||||||||||||||| ||| ||||||||||||||
++{sp}AsnIleHisGlyCysProPheLysIleLeuIleAsnIleLeuGl
ag{AT}AATATCCATGGGTGTCCTTTTAAAATATTGATCAACATACTGCA
nSerCysLysAspLeuGlnTyrHisAsnLeuAspLeuPheLysGlyLeuAlaAspTyrVa
|||||||||||||||| ||| ||| |||||| |||||| |||||||||||
nSerCysLysAspLeuArgTyrPheAsnIleAspLeuTyrLysGlyIleAlaAspTyrVa
GTCCTGCAAAGACCTCCGATACTTTAATATAGATCTCTACAAGGGAATAGCAGATTATGT
lAlaAlaThrPheAspIleTrpLysPheArgLys >>>> Target Intron 5 >>>
| ||||||||| ||||||||| 1405 bp
lThrThrThrPheAspMetTrpLysPheLysGln++
GACTACAACTTTTGACATGTGGAAGTTTAAACAAgt
> ValLeuPheIleLeuIleLeuPheGluAsnLeuGlyPheArgProValGlyLeuMet
||||||||| ||||||||||||||| ||| |||||||||||| ||||||
++ValLeuPheLeuLeuIleLeuPheGluAspLeuCysPheArgProValAspLeuMet
agGTTCTTTTTCTCCTTATTTTGTTTGAAGACCTTTGTTTCCGACCTGTTGATTTGATG
AspLeuPheMetLysArgIleValGluAspProGluSerLeuAsnMetLysAsnIleLeu
||||||||||||||| ||| |||||||||||| |||||||||
AspLeuPheMetLysLysValGluGluGluProGluSerLeuThrValLysAsnIleVal
GATTTGTTTATGAAAAAAGTAGAAGAAGAACCTGAATCCCTAACGGTGAAAAACATTGTT
SerIleLeuHisThrTyrSerSerLeuAsnHisValTyrLysCysGlnAsnLys{Gl}
|||||||||||| |||||||||||||||||| ||||||||||||||||||{||}
SerIleLeuHisValTyrSerSerLeuAsnHisPheTyrLysCysGlnAsnLys{Gl}++
TCTATTCTTCACGTGTATTCTTCTCTGAATCACTTCTATAAGTGCCAGAACAAA{GA}gt
>>>> Target Intron 6 >>>> {u}GlnPheValGluValMetAlaSerAlaLeu
4450 bp {|} ||| |||||||||||||||||||||
++{u}GluPheLeuGluValMetAlaSerAlaLeu
ag{A}GAATTCCTAGAAGTTATGGCTAGTGCTCTG
ThrGlyTyrLeuHisThrIleSerSerGluAsnLeuLeuAspAlaValTyrSerPheCys
|||||| |||||| ||||||||||||||||||||| |||||||||||||||
ThrGlyCysLeuHisAsnIleSerSerGluAsnLeuLeuHisAlaValTyrSerPheGly
ACTGGTTGTCTTCACAACATCTCTTCTGAAAACCTGTTGCATGCTGTATACTCATTTGGT
LeuMetAsnTyrPheProLeuAlaProPheAsnGlnLeuLeuGlnLysAspIleIleSer
||||||||||||||||||||||||||| ||||||||||||||||||||||||
LeuMetAsnTyrPheProLeuAlaProValAsnGlnLeuLeuGlnLysAspIleValThr
CTGATGAATTACTTCCCCCTGGCTCCTGTTAATCAGCTTCTCCAAAAGGATATCGTCACT
GluLeuLeuThrSer{A} >>>> Target Intron 7 >>>> {sp}AspMetLys
|||||||||||||||{|} 3082 bp {||}
GluLeuLeuThrSer{A}++ -+{sp}IleGluArg
GAGTTGCTGACATCA{G}gt tg{AC}ATAGAGAGG
AsnAlaTyrLysLeuHisThrLeuAspThrCysLeuLysLeuAspAspThrValTyrLeu
||| |||||||||||| |||||||||||||||||||||||||||||| |||
AsnValTyrLysLeuHisValLeuAspThrCysLeuLysLeuAspAspThrProTyrGln
AATGTTTACAAGCTCCATGTATTGGATACTTGTCTAAAGCTCGATGATACACCTTATCAG
ArgAspIleAlaLeuSerLeuProGlnLeuProArgGluLeuProSerSerHisThrAsn
||| ||||||||||||||| ||| ||| |||
ArgAlaValGlyLeuSerLeuProGlnProPro------LeuThrProProTyrProAsn
AGGGCCGTGGGCCTGTCACTGCCACAGCCACCC------TTGACACCACCGTATCCAAAT
AlaLysValAlaGluValLeuSerSerLeuLeuGlyGlyGluGlyHisPheSerLysAsp
||||||||||||||||||||||||||||||||||||||||||||| |||||||||
AlaLysValAlaGluValLeuSerSerLeuLeuGlyGlyGluGlyTyrPheSerLysAsn
GCCAAGGTGGCAGAGGTGCTCAGTAGCCTTCTAGGAGGTGAAGGGTACTTCTCAAAAAAT
ValHisLeuProHisAsnTyrHisIle{A} >>>> Target Intron 8 >>>> {
||| |||||||||||||||||||||{|} 393 bp {
ValGlnLeuProHisAsnTyrHisIle{A}++ ++{
GTGCAGTTGCCACATAATTATCATATC{G}gt ag{
sp}PheGluIleArgMetAspThrAsnArgAsnGlnValLeuProLeuSerAspValAsp
||}||||||||||||||||||||||||||| |||||||||||| ||||||||||||
sp}PheGluIleArgMetAspThrAsnArgSerGlnValLeuProPheSerAspValAsp
AT}TTTGAAATCAGAATGGATACTAATAGGAGTCAAGTGCTTCCGTTTTCTGATGTGGAT
ThrThrSerAlaThrAspIleGln{Ar} >>>> Target Intron 9 >>>> {g}
|||||| |||||| |||{||} 3019 bp {|}
ValThrSer---ThrAspMetGln{Ar}++ ++{g}
GTAACTTCT---ACAGATATGCAA{AG}gt ag{A}
ValAlaValLeuCysValSerArgSerAlaTyrCysLeuGlySerSerHisProArgGly
|||||||||||||||||| |||||||||||||||||| |||||||||||||||
ValAlaValLeuCysValProArgSerAlaTyrCysLeuAspLeuSerHisProArgGly
GTAGCTGTGCTGTGTGTGCCTAGATCTGCTTATTGTTTGGATCTAAGCCACCCCAGAGGA
PheLeuAlaMetLysMetArgHisLeuAsnAlaMetGlyPheHisValIleLeu >>>>
||||||||||||||||||||||||||| |||||||||||||||||||||
SerLeuAlaMetLysMetArgHisLeuAsnValMetGlyPheHisValIleLeu++
TCCCTTGCTATGAAAATGCGGCATTTGAATGTGATGGGTTTTCATGTGATCTTGgt
Target Intron 10 >>>> ValAsnAsnTrpGluMetAspLysLeuGluMetGlu
1698 bp |||||||||||||||||| ||| ||| |||
++ValAsnAsnTrpGluMetLysLysGlnGluArgGlu
agGTCAATAACTGGGAGATGAAAAAACAAGAGAGGGAA
AspAlaValThrPheLeuLysThrLysIleTyrSerValGluAlaLeuProValAlaAla
|||||| |||||||||||| ||||||||||||||||||||||||||| |||
AspAlaIleThrPheLeuLysAsnLysIleTyrSerValGluAlaLeuProThrAlaAsp
GATGCCATCACATTTTTGAAGAATAAAATTTATTCAGTCGAAGCCCTTCCTACTGCTGAT
ValAsnValGlnSerThr
|||||| |||||||||
ValAsnLeuGlnSerThr
GTAAATTTGCAAAGCACG
//
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