| Basic information |
| Official Symbol | DNHD1 |
| Description | dynein heavy chain domain 1 |
| Other Aliases | UNQ5781/PRO12970, C11orf47, CCDC35, DHCD1, DNHD1L |
| Other Description | DNHD1 variant protein; coiled-coil domain containing 35; dynein heavy chain domain 1-like protein; dynein heavy chain domain-containing protein 1 |
| Mutation type | Insert and frame-shift 2428-2429:R-G^GA |
| Location | Scaffold139491_1:1106780 1128789 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| DNHD1 |
ACCCAAAGTTTCAAGTCTTTGAAAAGCAGCTCTCGATCCCAGGCTGACCA CAACGATGTGCCGAGTAGGTGCAGGGAGCACTTGTTGGCTGTCAGCAGTT TTCTTTTTGCCTTGATCTGGGGCTTTGGAGCTCACCTTCCCTCCAGGTTC TGGCCTCTCTTTGATACCTTCATAAGGAGTTCTATTAACTGCCTCTCCAA CTACCCCGAGCTACCACCATCCACCTTCGTGTTTGATCTGCATGTAAGCC CTGAAGATGGGACGCTGGTCCCCTTCACTGGCCAATTCCTGAATAGCCAC ATCAAAGGAACTCTGGGCACCTTCTACCCTTCTGCACAGACTGAACGGCT TTTGTATGTGGTGGACCTACTTCTGTCAGGGGGACAGCCAGTGCTCTTGG CTGGAGAGGCAGCAGCGGGGAAGTCAACCTTCGTGGAGGTGCTAGTGGAG CCTAGTCACCCTTACATATACAGCCCCATCCACCCTGCCTTCAGTTCCAA CCACCTTCGCCTCCTGGGAGTCCAGGGCCAAGCACAGTCTAGCGTGTGGT CTGGATACCAACAGGATTCTAAAGGCTCCCTCCTCTTCCTGCTGGAGGAT CTGCACCTGGCCGCCTCTGACCCGGAGAAGAGCTGCCAGCCAGTGTGGGA GACTCTGCGCCAGGCTATAGATGGCACCGTGTATGCCCATAACACCTTGG AATTGCAGACGCTGCAACCTACAGTCAACTTCCTTGCCACAGCCACAGTG CCAGGCTGCTATGAACGCCCACTGTGCCCACGTCTCTTTCGACTATTCAC AGTGCTGGCCCTGGACACCGTAACCCAGGCCACCCTGCTGAGCAGGCACG TGCCCAGCATTCAGGCGTGGCTTGAGCGCTTCCCCTCTGTGGAGAGGGAG GGTGTTCTGGCAAGAGCCCTGGTCCGAGCCTCGGTGGAGGCTCTGGAGGC TGTGTGCAAGTGCTTCATGCCATCACCCCTCCACCCACACTACCGCTTCT CCTTGCACTCTGTGAGCCACCTCCTGGGCAGCCTGCAGCTGCTGCCCACC AGAATGGGCTCCCGAGGATTTCTGGACTGCCCCAATCACCTGGAGCACTT GCGCAGGGTGTCAGGCTTGCGCGGCACTCGCCTTACTTTTATGATAGCCA CGCGCAACATGGTGCGCCTTTGGTTGCACGAGGCCCAGAGGACTTTTTGT GACCGACTAGACAGCTCCAGGGAGCGCTCCTACTGTGCCAAACTGCTCCT AGAAGTGGCTCAGAATGTCTTCTGCTGCGGGCCAGAGCCCCAGCATCTGG GCAAGGACCTGGAGGAGGAAGAAGAGGAGGAGCGAGTGCCTGAAGTGGAA TCTGAAGGGGAGCTGGCTCGGTGGGAGGATTTAAACAACAGTGACAGTGA GACAGAAGAGGAAGAGAATCCCTGTGGCCTTCAGGTCACCACAGGCTCAC AGTCTAGCGATCCAAGTCTAGAACCATCCCTGAGAGCAATAAGCAGGGAG ACCACAGAGAACATAAATTACAAGATAAGGCAAGAGGAGAGCACAAAGGC TTCTAGCTACAAGATCCAGGCAAAGAAATCCAGGAGTGGGTGGCAGAAGA CAACGCAGGTGGACCTGGTCTCACCTCTGTTGCTTCCAGTGCTCTTACTT CGTCCCCAGGAAAAACCCTCAGACCTGGTCTTTAGTCAGGAACTGATACT GGCTTCCAGCTCTGAGAGCACCAACTTGTACCTGGAACGGCAATGGGAAA ACCTGGAAAAGCAGCTGGCCACCTCAGCCGCTCAGCTGAAACTGAACCCC CACCTGGCCCAGTGTCATTCTATGGCTCAGCACGTAGCTCGCCTCGTCCG GGTGCTGTCCAGGCCCCGGCAGCATGGCCTACTGCTCTCAGGGTTTCCAG GTACTGGGCGCCAGACTGCCATCACTCTGGCTGCTGGCATTTCTCCAACT CGCCTCTTCCATTTGCCATCTGGGCCAAAGGAGGCCATTCTCCAGTGTCT ACGAGATGCCAGCTGGCATGCTGGCATTTTAAGCCAGACAGTGGCCCTTC TGGTACCCCAGGGCGTGGATGTCACTACCCTTCATTGCCTCCTGGGCTTA GCAACCTCAGGCAGTTGCCCTAACCTGTATACAGAGGCAGATCTCGACAG AATTGAAGAAGACCTCCCTAGAGAGACCCCTGGTATCAAACAGAACATCA GGAAAGAAATGGTGTTGCAGAGGTTCTATCAACAAGTTTGCGGCCACTTG CACATGTTCTTCCTGATTGGAGATGACCAGGCCCGCAAGCAGCTGCCTTC CACCCTTCTCCTGAGACTCCTTCAACTAACCACTGCCAGCATTGACCACT ATGAACCCTGGGAACAAGCTGACCTGGTCAAGGTGGCCCAGCACCACCTG GAAGGTGCTCAGAGACTACCTTGTGATGATGGCTTCTGGAAGTGCCCAGA CCTCCAGACCTCAGTTTCCAGCGTGGCCAAAGCCATGGCGCTCATCCATC TTTCGGCTGCTGATTACCATGAGCACCTGTGCCCCATGTTGCCACTCGTC ACCCCCAAGACCTTTCTGGACTTTATGGACACCTTTCTACTGCTGCAGCA GCAGATGACCCAGCAGATAAGGAGCAAGGCCTGGCGGATCCAGAATGCCC TGGAGAATCTGAGAATGCTGATCGAGCAGCACAACACTCACACCAACCTG GTCTTCACCTTGGAACAGCAGCTGAAGGGCTCCCGCAAGAGCCTCAGCAT ATTTCAGCAGCAGCTGGAGCAGAGCAAGCACCTGTACAAACGGCAGCTGG CAGAGTGTGAGCACCAGGAGAGCCTTGTTGAGAACCTGGCAAAGCAGCGG GATTCCCTACAGACACAGCAGGAGGCTTTCCTGGAGCAGATGGGCAAGGC ATTTCTGGGGCCTCTGAGCCAGCTGCAGGTGGCGGATTTTGAGGAAATCC GGAGCTATCGCACACCACCGGAATCTGTGGTCCGGGTAACCAATGCACTG TGTGACCTGTTCCACCATGAAGCAGGTTGGGCCAGTGCAAAGCAGCTGTT ATGCACTGAAGACTTTTATCAGGAGCTGGTGTTCTTCCCCAAGGAGAAGA TGACAGACTCAGAGCTGATCAAGTTAAATCTGGCTCTGAAGGCTCCAGGT TTAAGTGATGAAGCCCTGAGGGCCGTTAGCATCCCTGCAGCAAACCTGGC AGCCTGGCTCTGGGCCGTTTTGCGGTATGGGCTGGCACAGCGCCGGGGAC TGCCCACGGGCCTGCTGCTGCGGCAGGTGGAGGCAGCACTGGCTCGCGAG CAGAGCCGCCTGGGCTACTACCAGTTTCGGACCCAGGAGACCCTGGAGCA TACTTTGACACTGTCTAAGAAGCTGGAGAATGCCCGAGACTCCTACAGCC ATGTGGCAGAGAGCCTTAGTCAGGCGCGGTGTGGCCGATATCACAAATGG CACGTAAAGGCTGCATTGCTCACACCCATGCACTCCTGGACTACACAGCT CCAGCAACTGAAGGGACACTTCATGACTGTGTTTGGAGATGCCCTCTTGT GTTCAGCTGCCATCACCTACCTGGGTCCCTTTCCACCAGTGCGGCGCCAG GAGCTACTGGACAAGTGGTTGGCTCTGTGTAGGGGCTTTCAGCAGCCCCT GGGCCCAGATGATGTAGTGCAGGCAATGAAGCAGAAGCAGAAATCTGTCA TCATGCCAAAGACGCCCCTGCTGTCCACGCGTTCTCCCTTCAGTATTCCA TCCTTGCTGAGCTCTGAATCAGAACAGAACCAGTGGGATCGAGACCAGAA GCCCCAGGCAAAGTCAGCCCGCCTGGTGGGCCTGCTTCTGCGAAGTCAGA GCCACTACCGCAGCTGCCGCTGGCCTCTGCTGCTTGACCCCAGCAACCAG GCACTCATCTGGTTGAAACCGCTGCCTCGGGAAGAGAATAGAAGCTTGGC ACCAGCCTCACCTGAGGATAGTGGGAGAGGCCTCAAGAGAAATCAAAACA GAAGGAATAAAGAGAACACAGAGAAGGAAGATGTTGACAGTGAAGAAGAT GAGTCTAAGGACCAGGAAGAAGAGAGGAAAGCAGAGGAGGAGAAGAACAA AGAGGAGAATGGAGAAGGAGAAGAGGAAGAGGAGGAGAGTGAGACAGAGA GAAAGGGGTCAAAGCCAGCCTCCGAAGCTCAGTCTCCACCTCTTCCCAAT CTCACTGTGCTCTCAGGTGCTGACCCAGAGCTGGGTCCTCAGCTCCAGAG GGCAGCTGCTGGTGGCCTGCCTGTGCTACTGACCAACATGGAACTGGGCC TAGAATGCCAAGAACTACATTGGTTGCTGCAGCGGGAGCAGCTGAGCCCA CCCCAAGTGCAGCCTGGCTTCTGTCTTTATCTGAGCACTACCCTCCCCCT CCATGCCTTGGAAAAAGTGCTAGGTTGTAAACTTCTAAAAGGGCTGAATG TGCTGGATCTGGGCCTGAACATGAAAATACTAGAAGAGCAGATGCTGCAT GAAATTGTGTACCGAGAGAGACCTGGACTTGAGACCCGCTGGCAGGACCT GAAGATCGGAACTATAGATACCTGTGAAGCCATGGAGATTGCGGAGGAAC GACTGCTCACGATGCTGCTGTTCAAGAACCAAAAGCAACTGCAACCATCC AAGTTTCTGCGGCACCTGGTGAGGGCCCAGGCGGGGCTGTGTCAACTGCG TGCCCATTTCGAGGAGCTAGAGGAGCAGAGGCTGCAGGAAGTGGCATTGT GGGAACCCTATCAGTGTGTGGTTCAGCACGGAATGGCCATGATAAAGGCC CTAAGCCCCCTGCAGAACCTGCTGCCCTTTTTCCGTATGGGCCCAGAGAA CTGGCTGACAGCCACCAAGCAGGCCCTGGACAGCATGAACCCAAATGAGA TGCAGCATGGGGAGGACCTGGCCAGCCATCTGCTGCAGTTGAGAACACAC CTGACCCGCCAGCTACTGGGCAGTGCTGTGGCCATGGTGGGCCTGACCCA CGTACGCTTGGTGGGTGCTTTGGGAGCTTTGGCTCTGCTGCAAGTGACGA AAAAGGCATCAGAGCTGGAGATTCTGGCCTTCTGGCCTGGACTGGCAGCC TCTCCCAGCATAGGTCATGGCAAACTAGTTCCAGATGTGGCCCGACCAGC CTGGCTAGGGCCGAGAGCTTGGCACGAGTGTGGGTTGTTAGAGCTGCTGC CCCCATTTGCTGGGCTGCGTGCATCCCTGGCAGGCCATTCCAGTGTTTGG CAGGCTTACCTGTCACTGTCATCCACAGTGCTGGGTCCTGCACCTGGGCC AGGACCTGGGCCACTCAGTCTCCTTCAGAAGCTGATCCTCTGGCGTGTGC TCCGACCTGAGTGCCTAGCAGGAGCCCTAGCAGACTTCACCACCAGCCTC CTGGGCCGGCCCCTAGAGGAAAACCTGGGCGCCCACACCATCCCCTTTGA ACATAGTCAGGCTATTCGGCCCATGCTGATCTTATTGCCACCAGCTGGTC ACCCCACGGCCATCCTGCATCCGCTGACTGTCATCCAGAAACTGGCTGCC ACACATGAGCAGGGGCAGAAGCATCTGCAGGTGATAGCCCTGGGTTCTGA AGCCTGGGACCCGGTCTCAGCTGTGGTCAGCAGGCTACACCAGGCTATGC ACAAGGGGCACTGGCTTGTGCTGGATAACTGTCATCTGATGCCCCATTGG CCTAAAGAGCTGCTACAGCCCTTGCTGGGGCTGTCAGATGGAGCTCAGGT GATCTCAGACCTGGAATTGGAGCTGCTTTCAGTCCAACCTGAAAGGAATA GGATCACTGTCCACAGAGATTTCCGACTTTGGCTTATCGTGTCTGCAGAG GCCAGTGCTTCCTTGCCAGCTGTGCTGACTCAGCGAGCCATGCCGGTTTT CTGGGACCAGTCTCTGGACCTGGGCCATGTCTTGATCGACAGTGTGGAGC TAGCGCAGCAAGGACTCCACATGCAACCCTCGACCCAGACTTTGCCTCTG GTCCTGTTACACAGCCTCCTGCTACACCGGCAGCTCTATGGAATCCGGCT GCAGGCACACAGGGGGCGCTGGAGTCAAGCAACCCTGACCCAGGTGCTTC AGACCCAAGGTCAGCTGTGGGCCAGCCTCAGCAATCCCAGTGTTGCCATG CAGGAGCTGACTGCCTCAGTTTTCTATGGGGCTCCAGTGGGGGACGTCAA CGACAGGGAGGCTCTGATTAGCCTCGTGAAAGCCTGCCTGAGCCCCAGGA GTGGGAGCGGGGTCCAACCACACACACCCCGGCATCTGCTGGCCACGCTG ATGCCCAGCCCAGAGCTCGGGGAGCCGGATGCGATCGCCGAGTGCAAGGC CCAGATGCGCCTACTGCCCACGCCATCAGAGCCTCGGATGTGCGGACTGA GCGAGGGCCCCCAGACCTGGCTGTTGAGACTCCAGAGCCGCGCTCTCCTG AGTGCGCTGCAGCGCAGCTTGCCCAGGTGGGTTCCGGCTGCTCGCGAAGC GGAGCGACGCACAGAAAAGCGGCTGCGGCAACGCCTAGCGCAAGCCTTGC GAAGGCTGGAGTCGCTGCAGGCTCTACTGACCGACGCTACTCGCCAGGAG GAGTATACAACCCCTGCCCAACCCGCGGCGCTGGGGCCGCATACCCGGCG ACCTCTGGAGGCCTTCCTGGAGAGCGAGGCGCTGGAACTGAGACAGCTGG TAGGCTTGCTACAGCGCGACCTGCGCTGCCTGTGGCAGCAGCTGAAGGGC GGCCCCCCGTGCGCCTCCCGGCGCTGTGTCGCGGTGGCCCACGCTCTCTG GACTGGCCTCCTACCCCCACCTTGGCGACTCCATGCGCCCGCCAGTCTGC AGCCGCCCTGGCACTGGCTGGGGCAGCTGTCGCGCCGGGGCCAGTTGCTG GTTCGCTACTTGGCGGTGGGCGTGGACGCCCGCACAAACGCACCCGAACG CGTCTTTCACCTGTCAGCCTTTTGCCACCCGCGCCGCCTGCTGCTGGCAC TGCGTTGGGAGGCTGCCCTGCACCAGTACGTGCCCAGCCCGAATGTCTCA GGTAGCCGAGGCCTCGGCTCCAGCCAACTCCCGCATAAACGTCAGGAGCT GAACGGCAGCCCTCTGCACCTTCGGGTGGAGAATGACCCAAATCCCACGA TCCCAGAGATGGGGCTGCTGCTGATCGGGCTACAGGTCCTGCACGCAGAA TGGGACCCGATCGCTGGGGCCCTGCAGGACAATCCTTCCAGCCAGCCCAG CCCACTGCCTCCAGTCAGCGTCAGTGCCCGGGCCCCAGTTGCCAGTGACT TGCCACATTCTGCGGGACTGGCTGTGTACTCCTGCCCTGTGTACATGGCA GGACCTCTTGGCACCACGAAGCTGCACAGCAGGAACATCTTAATGCACCT GCCCCTGCCCACGAAGCTCAGCCCAGCCACCTGTGTCCAACGCAGAGTCC ATGTGTGCAGTCCACCCCTG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 4753 | 2252 | 4752 | Insert and frame-shift 2428-2429:R-G^GA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
AlaGlnSerPheArgSerSerLysSerSerPheLeuAsnArgSerGlnValAspSerAsp
||||||||| ||| ||||||||| ||||||||| |||
ThrGlnSerPheLysSerLeuLysSerSer------SerArgSerGlnAlaAspHisAsn
ACCCAAAGTTTCAAGTCTTTGAAAAGCAGC------TCTCGATCCCAGGCTGACCACAAC
AspValProAspLysCysArgGluHisLeuLeuAlaValSerSerPheLeuPheAlaLeu
||||||||| |||||||||||||||||||||||||||||||||||||||||||||
AspValProSerArgCysArgGluHisLeuLeuAlaValSerSerPheLeuPheAlaLeu
GATGTGCCGAGTAGGTGCAGGGAGCACTTGTTGGCTGTCAGCAGTTTTCTTTTTGCCTTG
IleTrpGlyPheGlyAlaHisLeuProSer{Ar} >>>> Target Intron 1 >>>
||||||||||||||||||||||||||||||{||} 158 bp
IleTrpGlyPheGlyAlaHisLeuProSer{Ar}++
ATCTGGGGCTTTGGAGCTCACCTTCCCTCC{AG}gt
> {g}PheTrpProIlePheAspThrPheIleArgAspSerIleSerArgLeuSerAsn
{|}||||||||| |||||||||||||||||| |||||| |||||||||
++{g}PheTrpProLeuPheAspThrPheIleArgSerSerIleAsnCysLeuSerAsn
ag{G}TTCTGGCCTCTCTTTGATACCTTCATAAGGAGTTCTATTAACTGCCTCTCCAAC
TyrProGluProProProSerAlaLeuValPheAspLeuHisValSerProGluAspGly
||||||||| ||||||||| |||||||||||||||||||||||||||||||||
TyrProGluLeuProProSerThrPheValPheAspLeuHisValSerProGluAspGly
TACCCCGAGCTACCACCATCCACCTTCGTGTTTGATCTGCATGTAAGCCCTGAAGATGGG
ThrLeuValProPheThrGlyGlnTyrLeuSerSerHisIleLysGlyThrLeuGlyThr
|||||||||||||||||||||||| ||| |||||||||||||||||||||||||||
ThrLeuValProPheThrGlyGlnPheLeuAsnSerHisIleLysGlyThrLeuGlyThr
ACGCTGGTCCCCTTCACTGGCCAATTCCTGAATAGCCACATCAAAGGAACTCTGGGCACC
PheHisProSerIleGln >>>> Target Intron 2 >>>> ThrGluArgLeuL
||| |||||| ||| 347 bp |||||||||||||
PheTyrProSerAlaGln++ ++ThrGluArgLeuL
TTCTACCCTTCTGCACAGgt agACTGAACGGCTTT
euTyrValValAspLeuLeuLeuSerGlyGlyGlnProValLeuLeuAlaGlyGluAlaA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euTyrValValAspLeuLeuLeuSerGlyGlyGlnProValLeuLeuAlaGlyGluAlaA
TGTATGTGGTGGACCTACTTCTGTCAGGGGGACAGCCAGTGCTCTTGGCTGGAGAGGCAG
laThrGlyLysSerAlaPheValGluValLeuValGluProHisHisProTyrIleTyrS
|| ||||||||| |||||||||||||||||||||||| ||||||||||||||||
laAlaGlyLysSerThrPheValGluValLeuValGluProSerHisProTyrIleTyrS
CAGCGGGGAAGTCAACCTTCGTGGAGGTGCTAGTGGAGCCTAGTCACCCTTACATATACA
erProIleHisProAlaPheSerSerSerHisLeuArgLeuLeuLeuSerArg--GlyIl
|||||||||||||||||||||||||| ||||||||||||||| ##|||
erProIleHisProAlaPheSerSerAsnHisLeuArgLeuLeu---------##GlyVa
GCCCCATCCACCCTGCCTTCAGTTCCAACCACCTTCGCCTCCTG---------GAGGAGT
eGlnGlyGlnThrGlnAlaSerProGlnProGlyHisHisGlnAspSerLysProSerLe
||||||||| ||| ||| ||| |||||||||||| |||||
lGlnGlyGlnAlaGlnSerSerValTrpSerGlyTyrGlnGlnAspSerLysGlySerLe
CCAGGGCCAAGCACAGTCTAGCGTGTGGTCTGGATACCAACAGGATTCTAAAGGCTCCCT
uLeuPheLeuLeuGluAspLeuHisLeuAlaThrSer{A} >>>> Target Intron
||||||||||||||||||||||||||||||| |||{|} 3498 bp
uLeuPheLeuLeuGluAspLeuHisLeuAlaAlaSer{A}++
CCTCTTCCTGCTGGAGGATCTGCACCTGGCCGCCTCT{G}gt
3 >>>> {sp}ProGluLysSerCysGlnProValLeuGluThrLeuArgGlnAlaMe
{||}|||||||||||||||||||||||| ||||||||||||||||||
++{sp}ProGluLysSerCysGlnProValTrpGluThrLeuArgGlnAlaIl
ag{AC}CCGGAGAAGAGCTGCCAGCCAGTGTGGGAGACTCTGCGCCAGGCTAT
tAspGlyThrValTyrAlaHisSerThrLeuGluLeuGlnThrLeuGlnProThrValAs
||||||||||||||||||||| |||||||||||||||||||||||||||||||||||
eAspGlyThrValTyrAlaHisAsnThrLeuGluLeuGlnThrLeuGlnProThrValAs
AGATGGCACCGTGTATGCCCATAACACCTTGGAATTGCAGACGCTGCAACCTACAGTCAA
nPheLeuAlaThrValThrValProGlyTyrCysGluArgProLeuCysProArgLeuPh
||||||||||||| |||||||||||| ||||||||||||||||||||||||||
nPheLeuAlaThrAlaThrValProGlyCysTyrGluArgProLeuCysProArgLeuPh
CTTCCTTGCCACAGCCACAGTGCCAGGCTGCTATGAACGCCCACTGTGCCCACGTCTCTT
eArgLeuPheThrValLeuAlaLeuGluSerMetThrGlnAlaThrLeuLeuGluArgHi
||||||||||||||||||||||||| |||||||||||||||||| |||||
eArgLeuPheThrValLeuAlaLeuAspThrValThrGlnAlaThrLeuLeuSerArgHi
TCGACTATTCACAGTGCTGGCCCTGGACACCGTAACCCAGGCCACCCTGCTGAGCAGGCA
sValProIleIleGlnAlaTrpLeuGluArgPheProSerValGluArgGluArgAlaLe
||||||| |||||||||||||||||||||||||||||||||||||||||| ||
sValProSerIleGlnAlaTrpLeuGluArgPheProSerValGluArgGluGlyValLe
CGTGCCCAGCATTCAGGCGTGGCTTGAGCGCTTCCCCTCTGTGGAGAGGGAGGGTGTTCT
uAlaArgGlyLeuValArgAlaSerValGluAlaTrpGluAlaValCysAsnCysPheMe
||||||| |||||||||||||||||||||||| |||||||||||| ||||||||
uAlaArgAlaLeuValArgAlaSerValGluAlaLeuGluAlaValCysLysCysPheMe
GGCAAGAGCCCTGGTCCGAGCCTCGGTGGAGGCTCTGGAGGCTGTGTGCAAGTGCTTCAT
tProSerProLeuHisProHisTyrHisPheSerLeuHisSerValSerHisLeuLeuSe
||||||||||||||||||||||||| ||||||||||||||||||||||||||||||
tProSerProLeuHisProHisTyrArgPheSerLeuHisSerValSerHisLeuLeuGl
GCCATCACCCCTCCACCCACACTACCGCTTCTCCTTGCACTCTGTGAGCCACCTCCTGGG
rSerLeuGlnLeuLeuProAsnArgThrGlySerArgGlyPheValAspTyrProAsnHi
|||||||||||||||||| ||| ||||||||||||||| ||| ||||||||
ySerLeuGlnLeuLeuProThrArgMetGlySerArgGlyPheLeuAspCysProAsnHi
CAGCCTGCAGCTGCTGCCCACCAGAATGGGCTCCCGAGGATTTCTGGACTGCCCCAATCA
sGlnGluHisLeuArgArgValSerGlyLeuArgGlyThrCysLeuThrValMetMetAl
| |||||||||||||||||||||||||||||||||||| |||||| ||| ||
sLeuGluHisLeuArgArgValSerGlyLeuArgGlyThrArgLeuThrPheMetIleAl
CCTGGAGCACTTGCGCAGGGTGTCAGGCTTGCGCGGCACTCGCCTTACTTTTATGATAGC
aThrArgAsnValValArgLeuTrpLeuHisGluAlaGlnArgThrPheCysAspArgLe
|||||||||| |||||||||||||||||||||||||||||||||||||||||||||||
aThrArgAsnMetValArgLeuTrpLeuHisGluAlaGlnArgThrPheCysAspArgLe
CACGCGCAACATGGTGCGCCTTTGGTTGCACGAGGCCCAGAGGACTTTTTGTGACCGACT
uAspSerProArgGluArgSerTyrCysAlaLysLeuLeuLeuValValAlaGlnSerVa
||||||| ||||||||||||||||||||||||||||||||| ||||||||| ||
uAspSerSerArgGluArgSerTyrCysAlaLysLeuLeuLeuGluValAlaGlnAsnVa
AGACAGCTCCAGGGAGCGCTCCTACTGTGCCAAACTGCTCCTAGAAGTGGCTCAGAATGT
lPheCysCysGlyProGlyProGlnHisLeuGlyLysAspHisGlnGluSerGluGluGl
|||||||||||||||| ||||||||||||||||||||| ||||||||
lPheCysCysGlyProGluProGlnHisLeuGlyLysAsp---------LeuGluGluGl
CTTCTGCTGCGGGCCAGAGCCCCAGCATCTGGGCAAGGAC---------CTGGAGGAGGA
uGluGluGluGluArgValProGluValGluSerGluGlyGluLeuAlaGlnTrpGluAs
||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||
uGluGluGluGluArgValProGluValGluSerGluGlyGluLeuAlaArgTrpGluAs
AGAAGAGGAGGAGCGAGTGCCTGAAGTGGAATCTGAAGGGGAGCTGGCTCGGTGGGAGGA
pPheSerAsnSerAsnSerGluThrGluGluGluGluGluProTyrGlyLeuGlnValAl
| |||||| ||||||||||||||||||||| ||| ||||||||||||
pLeuAsnAsnSerAspSerGluThrGluGluGluGluAsnProCysGlyLeuGlnValTh
TTTAAACAACAGTGACAGTGAGACAGAAGAGGAAGAGAATCCCTGTGGCCTTCAGGTCAC
aArgValSerAsnSerArgAspProSerLeuThrProSerIleGlyProValSerArgGl
||| ||| |||||||||||| |||||| ||||||
rThrGlySerGlnSerSerAspProSerLeuGluProSerLeuArgAlaIleSerArgGl
CACAGGCTCACAGTCTAGCGATCCAAGTCTAGAACCATCCCTGAGAGCAATAAGCAGGGA
yMetLysGluSerIleSerHisLysIleArgGlnGluLysGlyThrArgAlaSerAsnTy
||| ||| ||||||||||||||| ||| |||||| ||
uThrThrGluAsnIleAsnTyrLysIleArgGlnGluGluSerThrLysAlaSerSerTy
GACCACAGAGAACATAAATTACAAGATAAGGCAAGAGGAGAGCACAAAGGCTTCTAGCTA
rArgLeuGlnValArgArgSerPheLysThrTrpTrpGlnLysLysProGlnMetAspLe
| ||| ||| ||||||||| ||| |||||
rLysIleGlnAlaLysLysSer---ArgSerGlyTrpGlnLysThrThrGlnValAspLe
CAAGATCCAGGCAAAGAAATCC---AGGAGTGGGTGGCAGAAGACAACGCAGGTGGACCT
uIleSerProLeuLeuLeuProValLeuLeuLeuHisProGlnGluLysProSerAspLe
| |||||||||||||||||||||||||||||| |||||||||||||||||||||||
uValSerProLeuLeuLeuProValLeuLeuLeuArgProGlnGluLysProSerAspLe
GGTCTCACCTCTGTTGCTTCCAGTGCTCTTACTTCGTCCCCAGGAAAAACCCTCAGACCT
uValPheSerGlnGluLeuIleLeuGlyProAsnSerGluThrProAsnLeuTyrLeuGl
||||||||||||||||||||||||| |||||| ||||||||||||||
uValPheSerGlnGluLeuIleLeuAlaSerSerSerGluSerThrAsnLeuTyrLeuGl
GGTCTTTAGTCAGGAACTGATACTGGCTTCCAGCTCTGAGAGCACCAACTTGTACCTGGA
uArgGlnTrpGluLysLeuGluGluGlnLeuAlaThrSerAlaAlaGlnLeuLysLeuSe
||||||||||||| |||||| |||||||||||||||||||||||||||||||||
uArgGlnTrpGluAsnLeuGluLysGlnLeuAlaThrSerAlaAlaGlnLeuLysLeuAs
ACGGCAATGGGAAAACCTGGAAAAGCAGCTGGCCACCTCAGCCGCTCAGCTGAAACTGAA
rProHisLeuAlaArgCysHisSerMetAlaGlnHisValAlaArgLeuValArgValLe
|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||
nProHisLeuAlaGlnCysHisSerMetAlaGlnHisValAlaArgLeuValArgValLe
CCCCCACCTGGCCCAGTGTCATTCTATGGCTCAGCACGTAGCTCGCCTCGTCCGGGTGCT
uAlaArgProArgGlnHisGlyLeuLeuLeuSerGlyAlaLeuGlyThrGlyArgHisTh
| ||||||||||||||||||||||||||||||||| |||||||||||| ||
uSerArgProArgGlnHisGlyLeuLeuLeuSerGlyPheProGlyThrGlyArgGlnTh
GTCCAGGCCCCGGCAGCATGGCCTACTGCTCTCAGGGTTTCCAGGTACTGGGCGCCAGAC
rAlaIleThrLeuAlaSerSerIleCysGlnAlaHisPhePheHisLeuProSerGlySe
|||||||||||||||| ||| ||||||||||||||||||
rAlaIleThrLeuAlaAlaGlyIleSerProThrArgLeuPheHisLeuProSerGlyPr
TGCCATCACTCTGGCTGCTGGCATTTCTCCAACTCGCCTCTTCCATTTGCCATCTGGGCC
rGluGluAlaIleLeuGlnCysLeuArgAspAlaSerTrpHisAlaGlyMetLeuSerGl
||||||||||||||||||||||||||||||||||||||||||||| ||||||||
oLysGluAlaIleLeuGlnCysLeuArgAspAlaSerTrpHisAlaGlyIleLeuSerGl
AAAGGAGGCCATTCTCCAGTGTCTACGAGATGCCAGCTGGCATGCTGGCATTTTAAGCCA
nProValAlaLeuLeuValProSerGlyValAspLeuThrThrLeuHisArgLeuLeuAl
| |||||||||||||||||| ||||||||| |||||||||||| ||||||
nThrValAlaLeuLeuValProGlnGlyValAspValThrThrLeuHisCysLeuLeuGl
GACAGTGGCCCTTCTGGTACCCCAGGGCGTGGATGTCACTACCCTTCATTGCCTCCTGGG
aLeuAlaThrSerGlySerPheProGlyGlnTyrThrGluAlaAspLeuAspArgIleGl
|||||||||||||||||| ||| |||||||||||||||||||||||||||
yLeuAlaThrSerGlySerCysProAsnLeuTyrThrGluAlaAspLeuAspArgIleGl
CTTAGCAACCTCAGGCAGTTGCCCTAACCTGTATACAGAGGCAGATCTCGACAGAATTGA
yGluHisLeuProArgGluAsnLeuGlyValLysGlnAsnIleLysLysGluMetValLe
||| |||||||||||| ||| |||||||||||| ||||||||||||||
uGluAspLeuProArgGluThrProGlyIleLysGlnAsnIleArgLysGluMetValLe
AGAAGACCTCCCTAGAGAGACCCCTGGTATCAAACAGAACATCAGGAAAGAAATGGTGTT
uGln{Ar} >>>> Target Intron 4 >>>> {g}PheHisGlnGlnValCysSe
||||{||} 180 bp {|}||| ||||||||||||
uGln{Ar}++ ++{g}PheTyrGlnGlnValCysGl
GCAG{AG}gt ag{G}TTCTATCAACAAGTTTGCGG
rHisLeuHisLeuPhePheLeuIleGlyAspLysGlnAlaHisLysGlnLeuProSerTh
||||||||| |||||||||||||||||| |||||| |||||||||||||||||
yHisLeuHisMetPhePheLeuIleGlyAspAspGlnAlaArgLysGlnLeuProSerTh
CCACTTGCACATGTTCTTCCTGATTGGAGATGACCAGGCCCGCAAGCAGCTGCCTTCCAC
rLeuPheLeuArgLeuLeuGlnLeuAlaThrAlaSerIleAspArgTyrGluProTrpAs
|||| |||||||||||||||||| ||||||||||||||| ||||||||||||
rLeuLeuLeuArgLeuLeuGlnLeuThrThrAlaSerIleAspHisTyrGluProTrpGl
CCTTCTCCTGAGACTCCTTCAACTAACCACTGCCAGCATTGACCACTATGAACCCTGGGA
pGlnAlaAlaLeuAlaLysValAlaGlnHisHisLeuGluGlyAlaGlnSerValProLe
|||||| ||| ||||||||||||||||||||||||||||||||| |||
uGlnAlaAspLeuValLysValAlaGlnHisHisLeuGluGlyAlaGlnArgLeuProCy
ACAAGCTGACCTGGTCAAGGTGGCCCAGCACCACCTGGAAGGTGCTCAGAGACTACCTTG
uAspAsp{G} >>>> Target Intron 5 >>>> {ly}SerTrpLysTyrProAs
||||||{|} 216 bp {||} |||||| |||||
sAspAsp{G}++ ++{ly}PheTrpLysCysProAs
TGATGAT{G}gt ag{GC}TTCTGGAAGTGCCCAGA
pLeuGlnAlaSerIleProSerValAlaLysAlaMetAlaLeuIleHisLeuSerAlaTh
||||||| ||| |||||||||||||||||||||||||||||||||||||||
pLeuGlnThrSerValSerSerValAlaLysAlaMetAlaLeuIleHisLeuSerAlaAl
CCTCCAGACCTCAGTTTCCAGCGTGGCCAAAGCCATGGCGCTCATCCATCTTTCGGCTGC
rHisTyrHisGluHisLeuCysProAlaLeuProLeuValThrProLysThrPheLeuAs
||||||||||||||||||||| ||||||||||||||||||||||||||||||||
aAspTyrHisGluHisLeuCysProMetLeuProLeuValThrProLysThrPheLeuAs
TGATTACCATGAGCACCTGTGCCCCATGTTGCCACTCGTCACCCCCAAGACCTTTCTGGA
pPheLeuAspThrPheLeuMetLeuGlnGlnGlnThrIleLeuLysIleLysAsnLysAl
|||| |||||||||||| |||||||||||| ||| |||||
pPheMetAspThrPheLeuLeuLeuGlnGlnGlnMetThrGlnGlnIleArgSerLysAl
CTTTATGGACACCTTTCTACTGCTGCAGCAGCAGATGACCCAGCAGATAAGGAGCAAGGC
aGln{Ar} >>>> Target Intron 6 >>>> {g}ValGlnAsnAlaLeuGluAs
| {||} 75 bp {|} |||||||||||||||||
aTrp{Ar}++ ++{g}IleGlnAsnAlaLeuGluAs
CTGG{CG}gt ag{G}ATCCAGAATGCCCTGGAGAA
nLeuArgMetLeuIleLysGluHisGlyThrHisAlaAsnLeuIlePheAspLeuGluGl
|||||||||||||||| ||| |||||| |||||| ||| ||||||||
nLeuArgMetLeuIleGluGlnHisAsnThrHisThrAsnLeuValPheThrLeuGluGl
TCTGAGAATGCTGATCGAGCAGCACAACACTCACACCAACCTGGTCTTCACCTTGGAACA
nGlnLeuLysAspSerGlyLys >>>> Target Intron 7 >>>> SerLeuSer
|||||||||| ||| ||| 3919 bp |||||||||
nGlnLeuLysGlySerArgLys++ ++SerLeuSer
GCAGCTGAAGGGCTCCCGCAAGgt agAGCCTCAGC
MetPheGlnGlnGlnLeuGluGlnSerLysLeuLeuTyrLysGlnGlnLeuGluGluCys
||||||||||||||||||||||||||| ||||||||| |||||| ||||||
IlePheGlnGlnGlnLeuGluGlnSerLysHisLeuTyrLysArgGlnLeuAlaGluCys
ATATTTCAGCAGCAGCTGGAGCAGAGCAAGCACCTGTACAAACGGCAGCTGGCAGAGTGT
ArgHisGlnGluAsnLeuIleGluAsnLeuAlaArgGlnArgAspAlaLeuGlnAlaGln
||||||||| ||| |||||||||||| ||||||||| |||||| |||
GluHisGlnGluSerLeuValGluAsnLeuAlaLysGlnArgAspSerLeuGlnThrGln
GAGCACCAGGAGAGCCTTGTTGAGAACCTGGCAAAGCAGCGGGATTCCCTACAGACACAG
ArgGluAlaPheLeuGluGln >>>> Target Intron 8 >>>> MetSerLysA
|||||||||||||||||| 251 bp ||| ||||
GlnGluAlaPheLeuGluGln++ ++MetGlyLysA
CAGGAGGCTTTCCTGGAGCAGgt agATGGGCAAGG
laPheLeuGluProLeuSerGlnLeuGlnValAlaAspPheGluGluIleArgSerTyrA
|||||||| |||||||||||||||||||||||||||||||||||||||||||||||||
laPheLeuGlyProLeuSerGlnLeuGlnValAlaAspPheGluGluIleArgSerTyrA
CATTTCTGGGGCCTCTGAGCCAGCTGCAGGTGGCGGATTTTGAGGAAATCCGGAGCTATC
rgAlaProProGluSerValValArgValThrAspAlaMetCysAspLeuPheHisHisG
|| ||||||||||||||||||||||||||| ||| |||||||||||||||||||
rgThrProProGluSerValValArgValThrAsnAlaLeuCysAspLeuPheHisHisG
GCACACCACCGGAATCTGTGGTCCGGGTAACCAATGCACTGTGTGACCTGTTCCACCATG
luThrGlyTrpAlaSerAlaLysGlnLeuLeuCysThrGluAspPheTyrGln >>>>
|| ||||||||||||||||||||||||||||||||||||||||||||||||
luAlaGlyTrpAlaSerAlaLysGlnLeuLeuCysThrGluAspPheTyrGln++
AAGCAGGTTGGGCCAGTGCAAAGCAGCTGTTATGCACTGAAGACTTTTATCAGgt
Target Intron 9 >>>> GluLeuValPhePheProLysGluLysIleThrAspSe
112 bp ||||||||||||||||||||||||||| ||||||||
++GluLeuValPhePheProLysGluLysMetThrAspSe
agGAGCTGGTGTTCTTCCCCAAGGAGAAGATGACAGACTC
rGluLeuIleLysLeuHisLeuIleLeuLysAlaProGlyMetAspAspAlaAlaLeuAr
|||||||||||||||| ||| ||||||||||||||| ||| ||||||||
rGluLeuIleLysLeuAsnLeuAlaLeuLysAlaProGlyLeuSerAspGluAlaLeuAr
AGAGCTGATCAAGTTAAATCTGGCTCTGAAGGCTCCAGGTTTAAGTGATGAAGCCCTGAG
gAlaValSerArgProAlaAlaSerLeuAlaAlaTrpLeuTrpAlaValLeuHisTyrGl
|||||||||| ||||||||| ||||||||||||||||||||||||||| |||||
gAlaValSerIleProAlaAlaAsnLeuAlaAlaTrpLeuTrpAlaValLeuArgTyrGl
GGCCGTTAGCATCCCTGCAGCAAACCTGGCAGCCTGGCTCTGGGCCGTTTTGCGGTATGG
yLeuAlaHisCysArgGlyLeuProThrAspLeuLeuLeuGlnGlnValGluAlaThrLe
||||||| ||||||||||||||| ||||||||| |||||||||||| ||
yLeuAlaGlnArgArgGlyLeuProThrGlyLeuLeuLeuArgGlnValGluAlaAlaLe
GCTGGCACAGCGCCGGGGACTGCCCACGGGCCTGCTGCTGCGGCAGGTGGAGGCAGCACT
uThrArgGluGlnAlaArgLeuGlyTyrTyrGlnPheGlnAlaGlnGluThrLeuGluHi
| ||||||||| ||||||||||||||||||||| |||||||||||||||||
uAlaArgGluGlnSerArgLeuGlyTyrTyrGlnPheArgThrGlnGluThrLeuGluHi
GGCTCGCGAGCAGAGCCGCCTGGGCTACTACCAGTTTCGGACCCAGGAGACCCTGGAGCA
sAsnLeuAlaLeuAlaLysMetValGluAspAlaGlnAlaSerHisAsnCysValAlaLy
| ||| ||| ||| ||| ||| ||| ||||||
sThrLeuThrLeuSerLysLysLeuGluAsnAlaArgAspSerTyrSerHisValAlaGl
TACTTTGACACTGTCTAAGAAGCTGGAGAATGCCCGAGACTCCTACAGCCATGTGGCAGA
sThrLeuSerGlnAlaGlnCysGlyGlnTyrHisLysTrpProMetLysAlaAlaLeuLe
|||||||||||| |||||| |||||||||||| ||||||||||||||
uSerLeuSerGlnAlaArgCysGlyArgTyrHisLysTrpHisValLysAlaAlaLeuLe
GAGCCTTAGTCAGGCGCGGTGTGGCCGATATCACAAATGGCACGTAAAGGCTGCATTGCT
uThrProMetArgAlaTrpThrThrGlnLeuGln >>>> Target Intron 10 >>
|||||||||| |||||||||||||||||| 198 bp
uThrProMetHisSerTrpThrThrGlnLeuGln++
CACACCCATGCACTCCTGGACTACACAGCTCCAGgt
>> LysLeuLysGlyArgCysMetThrValPheGlyAspThrLeuLeuCysSerAlaAl
||||||||| |||||||||||||||||| |||||||||||||||||
++GlnLeuLysGlyHisPheMetThrValPheGlyAspAlaLeuLeuCysSerAlaAl
agCAACTGAAGGGACACTTCATGACTGTGTTTGGAGATGCCCTCTTGTGTTCAGCTGC
aIleIleTyrLeuGlyProPheProProLeuArgArgGlnGluLeuLeuAspGluTrpLe
|||| ||||||||||||||||||||| ||||||||||||||||||||| |||||
aIleThrTyrLeuGlyProPheProProValArgArgGlnGluLeuLeuAspLysTrpLe
CATCACCTACCTGGGTCCCTTTCCACCAGTGCGGCGCCAGGAGCTACTGGACAAGTGGTT
uAlaLeuCysArgGlyPheGlnGluAlaLeuGlyProAspAspValAlaGlnAlaLeuLy
|||||||||||||||||||||| |||||||||||||||||| |||||| ||
uAlaLeuCysArgGlyPheGlnGlnProLeuGlyProAspAspValValGlnAlaMetLy
GGCTCTGTGTAGGGGCTTTCAGCAGCCCCTGGGCCCAGATGATGTAGTGCAGGCAATGAA
sArgLysGlnLysSerValSerIleProProLysAsnProLeuLeuAlaThrHisSerPr
| ||||||||||||||| ||| |||||| ||||||||| ||| |||||
sGlnLysGlnLysSerVal---IleMetProLysThrProLeuLeuSerThrArgSerPr
GCAGAAGCAGAAATCTGTC---ATCATGCCAAAGACGCCCCTGCTGTCCACGCGTTCTCC
oPheSerIleLeuSerLeuLeuSerSerGluSerGluGlnTyrGlnTrpAspGlyAsnLe
|||||||||| ||||||||||||||||||||||||||| |||||||||
oPheSerIleProSerLeuLeuSerSerGluSerGluGlnAsnGlnTrpAspArgAspGl
CTTCAGTATTCCATCCTTGCTGAGCTCTGAATCAGAACAGAACCAGTGGGATCGAGACCA
uLysProGlnAlaLysSerAlaHisLeuAlaGlyLeuLeuLeuArgSerProThrHisTy
||||||||||||||||||||| ||| |||||||||||||||||| |||||
nLysProGlnAlaLysSerAlaArgLeuValGlyLeuLeuLeuArgSerGlnSerHisTy
GAAGCCCCAGGCAAAGTCAGCCCGCCTGGTGGGCCTGCTTCTGCGAAGTCAGAGCCACTA
rSerSerCysArgTrpProLeuLeuLeuAspProSerAsnGluAlaLeuIleTrpLeuAs
| |||||||||||||||||||||||||||||||||||| |||||||||||||||
rArgSerCysArgTrpProLeuLeuLeuAspProSerAsnGlnAlaLeuIleTrpLeuLy
CCGCAGCTGCCGCTGGCCTCTGCTGCTTGACCCCAGCAACCAGGCACTCATCTGGTTGAA
pProLeuProLeuGluGluAsnArgSerPheAlaProAlaLeuThrGluGlyArg{G}
||||||||| ||||||||||||||| ||||||||| ||| {|}
sProLeuProArgGluGluAsnArgSerLeuAlaProAlaSerProGluAspSer{G}++
ACCGCTGCCTCGGGAAGAGAATAGAAGCTTGGCACCAGCCTCACCTGAGGATAGT{G}gt
>>>> Target Intron 11 >>>> {ly}LysGlyLeuMetArgAsnGlnLysArgG
3283 bp {||} |||||| ||||||||| |||
++{ly}ArgGlyLeuLysArgAsnGlnAsnArgA
ag{GG}AGAGGCCTCAAGAGAAATCAAAACAGAA
luSerLysThrAspMetLysGluGluAspAspGluSerGluGluSerAsnGluAlaGluA
||| ||| ||| ||| ||| |
rgAsnLys---GluAsnThrGluLysGluAspValAspSerGluGluAspGluSerLysA
GGAATAAA---GAGAACACAGAGAAGGAAGATGTTGACAGTGAAGAAGATGAGTCTAAGG
spGlnThrLysGluGlnLysAlaGluGluArgLysAsnGluGlnGlu >>>> Target
||||| ||| |||||||||||| |||||| |||
spGlnGluGluGluArgLysAlaGluGluGluLysAsnLysGluGlu-+
ACCAGGAAGAAGAGAGGAAAGCAGAGGAGGAGAAGAACAAAGAGGAGat
Intron 12 >>>> LysGluGlnGluGluAsnGluGluLysGluGluGluLysThrG
30 bp ||| |||||| |||||| ||||
++AsnGlyGluGlyGlu---GluGluGluGluGluSerGluThrG
agAATGGAGAAGGAGAA---GAGGAAGAGGAGGAGAGTGAGACAG
luSerGlnGlySerLysProAlaTyrGluThrGlnLeuProSerLeuProTyrLeuSerV
|| ||||||||||||||| ||| ||| ||| |||||| ||| |
luArgLysGlySerLysProAlaSerGluAlaGlnSerProProLeuProAsnLeuThrV
AGAGAAAGGGGTCAAAGCCAGCCTCCGAAGCTCAGTCTCCACCTCTTCCCAATCTCACTG
alLeuSerGlyAlaAspProGluLeuGlySerGlnLeuGlnGluAlaAlaAlaCys{G}
||||||||||||||||||||||||||||| ||||||||| ||||||||| {|}
alLeuSerGlyAlaAspProGluLeuGlyProGlnLeuGlnArgAlaAlaAlaGly{G}+
TGCTCTCAGGTGCTGACCCAGAGCTGGGTCCTCAGCTCCAGAGGGCAGCTGCTGGT{G}g
>>>> Target Intron 13 >>>> {ly}LeuProValLeuLeuThrAsnValGlu
264 bp {||}||||||||||||||||||||| |||
+ ++{ly}LeuProValLeuLeuThrAsnMetGlu
t ag{GC}CTGCCTGTGCTACTGACCAACATGGAA
LeuGlyLeuGlyCysGluGluLeuGlnTrpLeuLeuGlnArgGluGlnLeuSerProPro
||||||||| ||| |||||| |||||||||||||||||||||||||||||||||
LeuGlyLeuGluCysGlnGluLeuHisTrpLeuLeuGlnArgGluGlnLeuSerProPro
CTGGGCCTAGAATGCCAAGAACTACATTGGTTGCTGCAGCGGGAGCAGCTGAGCCCACCC
GlnValGlnProGlyPheCysLeuTyrLeuSerThrThrLeuSerLeuCysAlaMetGlu
|||||||||||||||||||||||||||||||||||||||||| ||| ||| |||
GlnValGlnProGlyPheCysLeuTyrLeuSerThrThrLeuProLeuHisAlaLeuGlu
CAAGTGCAGCCTGGCTTCTGTCTTTATCTGAGCACTACCCTCCCCCTCCATGCCTTGGAA
Lys{V} >>>> Target Intron 14 >>>> {al}LeuGlyCysGluLeuLeuLy
|||{|} 107 bp {||}||||||||| ||||||||
Lys{V}++ ++{al}LeuGlyCysLysLeuLeuLy
AAA{G}gt ag{TG}CTAGGTTGTAAACTTCTAAA
sGlyLeuAsnValLeuAspLeuGlyLeuAsnMetGluIleLeuGluGluGlnMetLeuHi
|||||||||||||||||||||||||||||||||| |||||||||||||||||||||||
sGlyLeuAsnValLeuAspLeuGlyLeuAsnMetLysIleLeuGluGluGlnMetLeuHi
AGGGCTGAATGTGCTGGATCTGGGCCTGAACATGAAAATACTAGAAGAGCAGATGCTGCA
sGluIleLeuCysArgGluTyrProGluLeuGluThrArgTrpGlnAspLeuLysIleAr
||||||| |||||| ||| ||||||||||||||||||||||||||||||
sGluIleValTyrArgGluArgProGlyLeuGluThrArgTrpGlnAspLeuLysIleGl
TGAAATTGTGTACCGAGAGAGACCTGGACTTGAGACCCGCTGGCAGGACCTGAAGATCGG
gAlaLeuAspThrCysLysAlaValGluAlaAlaGlu >>>> Target Intron 15
||||||||| ||| ||| |||||| 128 bp
yThrIleAspThrCysGluAlaMetGluIleAlaGlu++
AACTATAGATACCTGTGAAGCCATGGAGATTGCGGAGgt
>>>> GluArgLeuLeuThrMetLeuLeuPheGlnAsnProLysArgGlnLysProAl
||||||||||||||||||||||||||| ||| ||| |||
++GluArgLeuLeuThrMetLeuLeuPheLysAsnGlnLysGlnLeuGlnProSe
agGAACGACTGCTCACGATGCTGCTGTTCAAGAACCAAAAGCAACTGCAACCATC
aLysPheLeuArgAsnIleValArgAlaGlnGlyLysLeuCysGlnLeuArgAlaHisCy
|||||||||||| |||||||||||| |||||||||||||||||||||
rLysPheLeuArgHisLeuValArgAlaGlnAlaGlyLeuCysGlnLeuArgAlaHisPh
CAAGTTTCTGCGGCACCTGGTGAGGGCCCAGGCGGGGCTGTGTCAACTGCGTGCCCATTT
sGluGluLeuGluGlyGlnLysLeuGlnGluMetValLeuTrpAlaProTyrArgProVa
|||||||||||| ||| ||||||||| |||||| |||||| ||
eGluGluLeuGluGluGlnArgLeuGlnGluValAlaLeuTrpGluProTyrGlnCysVa
CGAGGAGCTAGAGGAGCAGAGGCTGCAGGAAGTGGCATTGTGGGAACCCTATCAGTGTGT
lValTrpHisGlyMetAlaMetValLysAlaLeuSerGlnLeuGlnAsnLeuLeuProLe
|||| ||||||||||||||| |||||||||||| ||||||||||||||||||
lValGlnHisGlyMetAlaMetIleLysAlaLeuSerProLeuGlnAsnLeuLeuProPh
GGTTCAGCACGGAATGGCCATGATAAAGGCCCTAAGCCCCCTGCAGAACCTGCTGCCCTT
uPheCysMetSerProGluAsnTrpLeuAlaValThrLysGlnAlaLeuAspSerMetLy
||| ||| ||||||||||||||| ||||||||||||||||||||||||
ePheArgMetGlyProGluAsnTrpLeuThrAlaThrLysGlnAlaLeuAspSerMetAs
TTTCCGTATGGGCCCAGAGAACTGGCTGACAGCCACCAAGCAGGCCCTGGACAGCATGAA
sProArgGluIleAsnHisGlyGluAspLeuAlaSerHisLeuLeuGlnLeuArgAlaHi
||| ||| ||||||||||||||||||||||||||||||||||||||| ||
nProAsnGluMetGlnHisGlyGluAspLeuAlaSerHisLeuLeuGlnLeuArgThrHi
CCCAAATGAGATGCAGCATGGGGAGGACCTGGCCAGCCATCTGCTGCAGTTGAGAACACA
sLeuThrArgGlnLeuLeuGlySerThrValThrAlaLeuGlyLeuThrGlnValProLe
||||||||||||||||||||||||| ||| ||||||||| ||| ||
sLeuThrArgGlnLeuLeuGlySerAlaValAlaMetValGlyLeuThrHisValArgLe
CCTGACCCGCCAGCTACTGGGCAGTGCTGTGGCCATGGTGGGCCTGACCCACGTACGCTT
uValGlyAlaLeuGlyAlaLeuAlaLeuLeuGlnAlaThrGlyLysAlaSerGluLeuGl
|||||||||||||||||||||||||||||||||| ||| |||||||||||||||||
uValGlyAlaLeuGlyAlaLeuAlaLeuLeuGlnValThrLysLysAlaSerGluLeuGl
GGTGGGTGCTTTGGGAGCTTTGGCTCTGCTGCAAGTGACGAAAAAGGCATCAGAGCTGGA
uArgLeuAlaLeuTrpProGlyLeuAlaAlaSerProSerThrValHisSerLysProVa
| |||||| ||||||||||||||||||||||||||| ||| ||| ||
uIleLeuAlaPheTrpProGlyLeuAlaAlaSerProSerIleGlyHisGlyLysLeuVa
GATTCTGGCCTTCTGGCCTGGACTGGCAGCCTCTCCCAGCATAGGTCATGGCAAACTAGT
lSerAspValAlaArgProAlaTrpLeuGlyProLysAlaTrpHisGluCysGluMetLe
| |||||||||||||||||||||||||||||| ||||||||||||||| ||
lProAspValAlaArgProAlaTrpLeuGlyProArgAlaTrpHisGluCysGlyLeuLe
TCCAGATGTGGCCCGACCAGCCTGGCTAGGGCCGAGAGCTTGGCACGAGTGTGGGTTGTT
uGluLeuLeuProProPheValGlyLeuCysAlaSerLeuAlaGlyHisSerSerAlaTr
||||||||||||||||||| |||||| |||||||||||||||||||||||| ||
uGluLeuLeuProProPheAlaGlyLeuArgAlaSerLeuAlaGlyHisSerSerValTr
AGAGCTGCTGCCCCCATTTGCTGGGCTGCGTGCATCCCTGGCAGGCCATTCCAGTGTTTG
pGlnAlaTyrLeuSerLeuSerSerThrValLeuGlyProAlaProGlyProGlyProGl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pGlnAlaTyrLeuSerLeuSerSerThrValLeuGlyProAlaProGlyProGlyProGl
GCAGGCTTACCTGTCACTGTCATCCACAGTGCTGGGTCCTGCACCTGGGCCAGGACCTGG
uProLeuSerLeuLeuGlnLysLeuIleLeuTrpArgValLeuArgProGluCysLeuAl
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
yProLeuSerLeuLeuGlnLysLeuIleLeuTrpArgValLeuArgProGluCysLeuAl
GCCACTCAGTCTCCTTCAGAAGCTGATCCTCTGGCGTGTGCTCCGACCTGAGTGCCTAGC
aGlyAlaLeuAlaAspPheThrThrSerLeuLeuGlyArgProLeuAspGluAsnThrTy
|||||||||||||||||||||||||||||||||||||||||||||| ||||||
aGlyAlaLeuAlaAspPheThrThrSerLeuLeuGlyArgProLeuGluGluAsnLeuGl
AGGAGCCCTAGCAGACTTCACCACCAGCCTCCTGGGCCGGCCCCTAGAGGAAAACCTGGG
rAlaProThrMetProPheLysHisSerGlnAlaThrGlnProMetLeuIleLeuLeuPr
||| ||| |||||| |||||||||||| ||||||||||||||||||||
yAlaHisThrIleProPheGluHisSerGlnAlaIleArgProMetLeuIleLeuLeuPr
CGCCCACACCATCCCCTTTGAACATAGTCAGGCTATTCGGCCCATGCTGATCTTATTGCC
oProProGlyHisProSerAlaThrLeuHisProLeuThrValIleGlnLysLeuAlaAl
|||| ||||||||| ||| |||||||||||||||||||||||||||||||||||
oProAlaGlyHisProThrAlaIleLeuHisProLeuThrValIleGlnLysLeuAlaAl
ACCAGCTGGTCACCCCACGGCCATCCTGCATCCGCTGACTGTCATCCAGAAACTGGCTGC
aLysTyrGlnGln >>>> Target Intron 16 >>>> GlyGlnLysGlnLeuGl
| ||| 191 bp ||||||||| |||||
aThrHisGluGln++ ++GlyGlnLysHisLeuGl
CACACATGAGCAGgt agGGGCAGAAGCATCTGCA
nValIleAlaLeuGlySerGluAlaTrpAspProValSerValValValSerThrLeuSe
|||||||||||||||||||||||||||||||||||||||| ||||||||| |||
nValIleAlaLeuGlySerGluAlaTrpAspProValSerAlaValValSerArgLeuHi
GGTGATAGCCCTGGGTTCTGAAGCCTGGGACCCGGTCTCAGCTGTGGTCAGCAGGCTACA
rGlnAlaMetTyrGluGlyHisTrpLeuValLeuAspAsnCysHisLeuMetProHisTr
||||||||| ||||||||||||||||||||||||||||||||||||||||||||
sGlnAlaMetHisLysGlyHisTrpLeuValLeuAspAsnCysHisLeuMetProHisTr
CCAGGCTATGCACAAGGGGCACTGGCTTGTGCTGGATAACTGTCATCTGATGCCCCATTG
pProLysGluLeuLeuGlnLeuLeuLeuGluLeuLeuGlyArgAlaLys{V} >>>> T
||||||||||||||||||| |||||| ||| ||| {|}
pProLysGluLeuLeuGlnProLeuLeuGlyLeuSerAspGlyAlaGln{V}++
GCCTAAAGAGCTGCTACAGCCCTTGCTGGGGCTGTCAGATGGAGCTCAG{G}gt
arget Intron 17 >>>> {al}ValAlaAspLeuGluSerGluGlnLeuLeuAspG
208 bp {||} ||||||||| ||| ||| |
+-{al}IleSerAspLeuGluLeuGluLeuLeuSerValG
ac{TG}ATCTCAGACCTGGAATTGGAGCTGCTTTCAGTCC
lnProGluSerArgAsnValSerThrValHisArgAspPheArgLeuTrpLeuIleValP
|||||||| |||||| ||||||||||||||||||||||||||||||||||||
lnProGlu---ArgAsnArgIleThrValHisArgAspPheArgLeuTrpLeuIleValS
AACCTGAA---AGGAATAGGATCACTGTCCACAGAGATTTCCGACTTTGGCTTATCGTGT
roAlaGluSerSerAlaSerLeuPro{A} >>>> Target Intron 18 >>>> {
|||||| |||||||||||||||{|} 87 bp {
erAlaGluAlaSerAlaSerLeuPro{A}++ ++{
CTGCAGAGGCCAGTGCTTCCTTGCCA{G}gt ag{
la}ValLeuThrGlnHisSerMetProValPheTrpAsnGlnSerLeuGluLeuGlyHis
||}|||||||||||| ||||||||||||||| ||||||||| |||||||||
la}ValLeuThrGlnArgAlaMetProValPheTrpAspGlnSerLeuAspLeuGlyHis
CT}GTGCTGACTCAGCGAGCCATGCCGGTTTTCTGGGACCAGTCTCTGGACCTGGGCCAT
ValLeuIleAspSerValGluLeuAlaGlnGlnValLeuTyrMetGlnProProThrGln
||||||||||||||||||||||||||||||||| ||| ||||||||| ||||||
ValLeuIleAspSerValGluLeuAlaGlnGlnGlyLeuHisMetGlnProSerThrGln
GTCTTGATCGACAGTGTGGAGCTAGCGCAGCAAGGACTCCACATGCAACCCTCGACCCAG
AlaLeuProLeuLeuLeuLeuHisGlyLeuLeuLeuHisArgGlnLeuTyrGlyThrArg
||||||||| ||||||||| ||||||||||||||||||||||||||| |||
ThrLeuProLeuValLeuLeuHisSerLeuLeuLeuHisArgGlnLeuTyrGlyIleArg
ACTTTGCCTCTGGTCCTGTTACACAGCCTCCTGCTACACCGGCAGCTCTATGGAATCCGG
LeuGlnAlaHisArgGlyArg{Tr} >>>> Target Intron 19 >>>> {p}Se
|||||||||||||||||||||{||} 714 bp {|}||
LeuGlnAlaHisArgGlyArg{Tr}++ ++{p}Se
CTGCAGGCACACAGGGGGCGC{TG}gt ag{G}AG
rGlnValThrLeuThrGlnValLeuGlnThrGlnAspGlnLeuTrpAlaSerLeuSerAs
|||| ||||||||||||||||||||||||||| |||||||||||||||||||||||
rGlnAlaThrLeuThrGlnValLeuGlnThrGlnGlyGlnLeuTrpAlaSerLeuSerAs
TCAAGCAACCCTGACCCAGGTGCTTCAGACCCAAGGTCAGCTGTGGGCCAGCCTCAGCAA
nProArgAlaAlaMetGlnGluLeuAla{A} >>>> Target Intron 20 >>>>
|||| ||||||||||||||| {|} 147 bp
nProSerValAlaMetGlnGluLeuThr{A}++ +
TCCCAGTGTTGCCATGCAGGAGCTGACT{G}gt a
{la}SerValPheTyrGlyGlyProLeuGlyAspThrGluAspArgGluAlaLeuIleS
{||}||||||||||||||| ||| |||||| |||||||||||||||||||
+{la}SerValPheTyrGlyAlaProValGlyAspValAsnAspArgGluAlaLeuIleS
g{CC}TCAGTTTTCTATGGGGCTCCAGTGGGGGACGTCAACGACAGGGAGGCTCTGATTA
erLeuThrGlnAlaCysLeuSerProSerSerGlySerTrpValGlnProHisThrProG
||||| ||||||||||||||| ||||||||| ||||||||||||||||||
erLeuValLysAlaCysLeuSerProArgSerGlySerGlyValGlnProHisThrProA
GCCTCGTGAAAGCCTGCCTGAGCCCCAGGAGTGGGAGCGGGGTCCAACCACACACACCCC
lnSerLeuLeuAlaThrLeuMetProLeuPro{G} >>>> Target Intron 21 >
||||||||||||||||||||| |||{|} 219 bp
rgHisLeuLeuAlaThrLeuMetProSerPro{G}++
GGCATCTGCTGGCCACGCTGATGCCCAGCCCA{G}gt
>>> {lu}LeuArgGluLeuAspAlaMetAlaGluCysLysAlaGlnMetHisLeuLeu
{||}||| ||| |||||| ||||||||||||||||||||| ||||||
++{lu}LeuGlyGluProAspAlaIleAlaGluCysLysAlaGlnMetArgLeuLeu
ag{AG}CTCGGGGAGCCGGATGCGATCGCCGAGTGCAAGGCCCAGATGCGCCTACTG
ProSerProProGluProArgLeuCysGlyLeuSerGluGlyProGlnAlaTrpLeuLeu
||| ||| ||||||||| |||||||||||||||||||||||| |||||||||
ProThrProSerGluProArgMetCysGlyLeuSerGluGlyProGlnThrTrpLeuLeu
CCCACGCCATCAGAGCCTCGGATGTGCGGACTGAGCGAGGGCCCCCAGACCTGGCTGTTG
ArgArgGlnSerArgAlaLeuLeuSerAlaLeuGlnArgSerSerProValTrpValPro
||| |||||||||||||||||||||||||||||||||||| ||| |||||||||
ArgLeuGlnSerArgAlaLeuLeuSerAlaLeuGlnArgSerLeuProArgTrpValPro
AGACTCCAGAGCCGCGCTCTCCTGAGTGCGCTGCAGCGCAGCTTGCCCAGGTGGGTTCCG
GluSerArgArgGlyAlaGlnLeuAlaGluArgArgLeuArgGlnArgLeuValGlnVal
||| ||| |||||||||||||||||| |||
AlaAlaArgGluAlaGluArgArgThrGluLysArgLeuArgGlnArgLeuAlaGlnAla
GCTGCTCGCGAAGCGGAGCGACGCACAGAAAAGCGGCTGCGGCAACGCCTAGCGCAAGCC
AsnArgArgLeuGluSerLeuGlnAspLeuLeuThrHisValIleArgGlnAspGluSer
||||||||||||||||||||| ||||||||| |||||| |||
LeuArgArgLeuGluSerLeuGlnAlaLeuLeuThrAspAlaThrArgGlnGluGluTyr
TTGCGAAGGCTGGAGTCGCTGCAGGCTCTACTGACCGACGCTACTCGCCAGGAGGAGTAT
AspAlaProTrp<-><->SerValLeuGlyProAsnAlaArgArgProLeuGluGlyVal
||| ||||||||| |||||||||||||||
ThrThrProAlaGlnProAlaAlaLeuGlyProHisThrArgArgProLeuGluAlaPhe
ACAACCCCTGCCCAACCCGCGGCGCTGGGGCCGCATACCCGGCGACCTCTGGAGGCCTTC
LeuGluThrGluAlaLeuGluLeuSerGlnLeuValGlyThrLeuGlnArgAspLeuAsp
|||||| ||||||||||||||| |||||||||||| |||||||||||||||
LeuGluSerGluAlaLeuGluLeuArgGlnLeuValGlyLeuLeuGlnArgAspLeuArg
CTGGAGAGCGAGGCGCTGGAACTGAGACAGCTGGTAGGCTTGCTACAGCGCGACCTGCGC
CysLeuLeuGlnGlnLeuLysGlyAlaProProCysProSerArgArgCysAlaAlaVal
|||||| ||||||||||||||| ||||||||| |||||||||||| ||||||
CysLeuTrpGlnGlnLeuLysGlyGlyProProCysAlaSerArgArgCysValAlaVal
TGCCTGTGGCAGCAGCTGAAGGGCGGCCCCCCGTGCGCCTCCCGGCGCTGTGTCGCGGTG
AlaHisAlaLeuTrpThrGlyArgLeuProLeuProTrpArgProHisAlaProAlaGly
||||||||||||||||||||| |||||| ||||||||| ||||||||||||
AlaHisAlaLeuTrpThrGlyLeuLeuProProProTrpArgLeuHisAlaProAlaSer
GCCCACGCTCTCTGGACTGGCCTCCTACCCCCACCTTGGCGACTCCATGCGCCCGCCAGT
ProGlnProProTrpHisTrpLeuArgGlnLeuSerArgArgGlyGlnLeuLeuValArg
||||||||||||||||||||| |||||||||||||||||||||||||||||||||
LeuGlnProProTrpHisTrpLeuGlyGlnLeuSerArgArgGlyGlnLeuLeuValArg
CTGCAGCCGCCCTGGCACTGGCTGGGGCAGCTGTCGCGCCGGGGCCAGTTGCTGGTTCGC
TyrLeuGlyValGlyAlaAspAlaSerSerAspValProGluArgValPheHisLeuSer
|||||| |||||| |||||| ||||||||||||||||||||||||
TyrLeuAlaValGlyValAspAlaArgThrAsnAlaProGluArgValPheHisLeuSer
TACTTGGCGGTGGGCGTGGACGCCCGCACAAACGCACCCGAACGCGTCTTTCACCTGTCA
AlaPheArgHisProArgArgLeuLeuLeuAlaLeuArgGlyGluAlaAlaLeuAspGln
|||||| |||||||||||||||||||||||||||||| |||||||||||| |||
AlaPheCysHisProArgArgLeuLeuLeuAlaLeuArgTrpGluAlaAlaLeuHisGln
GCCTTTTGCCACCCGCGCCGCCTGCTGCTGGCACTGCGTTGGGAGGCTGCCCTGCACCAG
AsnValProSerSerAsnPheProGlySerArgGlySerValSerSerGlnLeuGlnTyr
||||||||| ||| |||||||||||| ||||||||||||
TyrValProSerProAsnValSerGlySerArgGlyLeuGlySerSerGlnLeuProHis
TACGTGCCCAGCCCGAATGTCTCAGGTAGCCGAGGCCTCGGCTCCAGCCAACTCCCGCAT
LysArgLeuGluMetAsnSerAsnProLeuHisPheArg >>>> Target Intron
|||||| ||| ||| ||||||||| ||| 206 bp
LysArgGlnGluLeuAsnGlySerProLeuHisLeuArg++
AAACGTCAGGAGCTGAACGGCAGCCCTCTGCACCTTCGGgt
22 >>>> ValGluAsnGlyProAsnProThrValProGluArgGlyLeuLeuLeuIle
||||||||| |||||||||||| |||||| |||||||||||||||
++ValGluAsnAspProAsnProThrIleProGluMetGlyLeuLeuLeuIle
agGTGGAGAATGACCCAAATCCCACGATCCCAGAGATGGGGCTGCTGCTGATC
GlyLeuGlnValLeuHisAlaGluTrpAspProIleAlaGlyAlaLeuGlnAspSerPro
|||||||||||||||||||||||||||||||||||||||||||||||||||||| |||
GlyLeuGlnValLeuHisAlaGluTrpAspProIleAlaGlyAlaLeuGlnAspAsnPro
GGGCTACAGGTCCTGCACGCAGAATGGGACCCGATCGCTGGGGCCCTGCAGGACAATCCT
SerSerGlnProSerProLeuProProValSerIleSerThrGlnAlaProGlyThrSer
||||||||||||||||||||||||||||||||| ||| |||||| |||
SerSerGlnProSerProLeuProProValSerValSerAlaArgAlaProValAlaSer
TCCAGCCAGCCCAGCCCACTGCCTCCAGTCAGCGTCAGTGCCCGGGCCCCAGTTGCCAGT
AspLeuProAlaProAlaAspLeuThrValTyrSerCysProValTyrMetGlyGlyPro
||||||||| ||| ||| |||||||||||||||||||||||| ||||||
AspLeuProHisSerAlaGlyLeuAlaValTyrSerCysProValTyrMetAlaGlyPro
GACTTGCCACATTCTGCGGGACTGGCTGTGTACTCCTGCCCTGTGTACATGGCAGGACCT
LeuGlyThrAlaLysLeuGlnSerArgAsnIleValMetHisLeuProLeuProThrLys
||||||||| |||||| |||||||||||| ||||||||||||||||||||||||
LeuGlyThrThrLysLeuHisSerArgAsnIleLeuMetHisLeuProLeuProThrLys
CTTGGCACCACGAAGCTGCACAGCAGGAACATCTTAATGCACCTGCCCCTGCCCACGAAG
LeuThrProAsnThrCysValGlnArgArgValHisValCysSerProProLeu
||| ||| ||||||||||||||||||||||||||||||||||||||||||
LeuSerProAlaThrCysValGlnArgArgValHisValCysSerProProLeu
CTCAGCCCAGCCACCTGTGTCCAACGCAGAGTCCATGTGTGCAGTCCACCCCTG
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