| Basic information |
| Official Symbol | DNALI1 |
| Description | dynein, axonemal, light intermediate chain 1 |
| Other Aliases | P28, dJ423B22.5, hp28 |
| Other Description | axonemal dynein light intermediate polypeptide 1; dJ423B22.5 (axonemal dynein light chain (hp28)); dynein, axonemal, light intermediate polypeptide 1; inner dynein arm light chain, axonemal; inner dynein arm, homolog of clamydomonas |
| Mutation type | Insert and frame-shift 11-12:Q-G^A |
| Location | Scaffold000604_1:1241123 1248770 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| DNALI1 |
ATGGTGACGGCAAACAAGGCTCACACTGAGGGCAGCTGCTCTGCTGCTAC CCACGCCGTCGCCATGATCCCGCCCGCCGACTCTCTACTTAAATACGACA CCCCGGTGTTGGTGAGCCGGAACACGGAGAAACGGAGTCCCAAGGCTCGG CCACTGAAAGTCAGCCCCCAGCAGCCTGGGCCCTCAGGTCCAGTCCCACA GCCACCCAAGACCAAGCTCCCCTCAACTTCCTGTGTCCCAGACCCTACAA AGCAGGCAGAAGAAATCCTGAATGCCATCCTGCCCCCCAGGGAGTGGGTA GAAGACACGCAGCTATGGATCCAGCAGGTATCCAGCACGCCCAGCACCAG GATGGACGTGGTGCACCTGCAGGAGCAGCTGGACCTGAAGCTGCAGCAGC GGCAAGCCAGGGAGACGGGCATCTGCCCGGTCCGCAGGGAGCTCTACTCC CAGTGCTTCGATGAGCTGATCCGGGAAGTCACCATCAACTGCGCAGAGAG GGGGCTGCTGCTGCTGCGAGTCCGGGATGAGATCCGCATGACCATTGCCG CCTACCAGACCCTGTATGAGAGCAGCGTGGCGTTTGGCATGAGGAAGGCC CTGCAGGCCGAACAGGGGAAGTCAGACATGGAGAGGAAAATTGCAGAGTT GGAGACGGAGAAGAGAGATCTGGAGAGGCAAGTGAACGAGCAGAAGGCCA AGTGCGAGGCCACCGAGAAGCGCGAGACCGAGAGGCGGCAGGTGGAGGAG AAGAAGCACAACGAGGAGATTCAGTTCCTGAAGCGGACCAATCAGCAGCT GAAGGCCCAACTGGAAGGCATCATTGCACCGAAGAAG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 280 | 1 | 280 | Insert and frame-shift 11-12:Q-G^A |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetValThrAlaAsnLysAlaHisThrGlyGln-GlySerCysTrpValAlaThrLeuAl
||||||||||||||||||||||||||| #||||||||| |||||| ||
MetValThrAlaAsnLysAlaHisThr---Glu#GlySerCysSerAlaAlaThrHisAl
ATGGTGACGGCAAACAAGGCTCACACT---GAGAGGCAGCTGCTCTGCTGCTACCCACGC
aSerAlaMetIleProProAlaAspSerLeuLeuLysTyrAspThrProValLeuValSe
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
aValAlaMetIleProProAlaAspSerLeuLeuLysTyrAspThrProValLeuValSe
CGTCGCCATGATCCCGCCCGCCGACTCTCTACTTAAATACGACACCCCGGTGTTGGTGAG
rArgAsnThrGluLysArgSerProLys >>>> Target Intron 1 >>>> Ala
|||||||||||||||||||||||||||| 470 bp |||
rArgAsnThrGluLysArgSerProLys++ ++Ala
CCGGAACACGGAGAAACGGAGTCCCAAGgt agGCT
ArgLeuLeuLysValSerProGlnGlnProGlyProSerGlySerAlaProGlnProPro
||| |||||||||||||||||||||||||||||||||||| ||||||||||||
ArgProLeuLysValSerProGlnGlnProGlyProSerGlyProValProGlnProPro
CGGCCACTGAAAGTCAGCCCCCAGCAGCCTGGGCCCTCAGGTCCAGTCCCACAGCCACCC
LysThrLysLeuProSerThrProCysValProAspProThrLysGlnAlaGluGluIle
||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||
LysThrLysLeuProSerThrSerCysValProAspProThrLysGlnAlaGluGluIle
AAGACCAAGCTCCCCTCAACTTCCTGTGTCCCAGACCCTACAAAGCAGGCAGAAGAAATC
LeuAsnAlaIleLeuProPro{Ar} >>>> Target Intron 2 >>>> {g}Glu
|||||||||||||||||||||{||} 2252 bp {|}|||
LeuAsnAlaIleLeuProPro{Ar}++ ++{g}Glu
CTGAATGCCATCCTGCCCCCC{AG}gt ag{G}GAG
TrpValGluAspThrGlnLeuTrpIleGlnGlnValSerSerThrProSerThrArgMet
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TrpValGluAspThrGlnLeuTrpIleGlnGlnValSerSerThrProSerThrArgMet
TGGGTAGAAGACACGCAGCTATGGATCCAGCAGGTATCCAGCACGCCCAGCACCAGGATG
AspValValHisLeuGlnGluGlnLeuAspLeuLysLeuGlnGlnArgGlnAlaArgGlu
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AspValValHisLeuGlnGluGlnLeuAspLeuLysLeuGlnGlnArgGlnAlaArgGlu
GACGTGGTGCACCTGCAGGAGCAGCTGGACCTGAAGCTGCAGCAGCGGCAAGCCAGGGAG
ThrGlyIleCysProValArgArgGluLeuTyrSerGlnCysPhe{A} >>>> Targe
|||||||||||||||||||||||||||||||||||||||||||||{|} 1
ThrGlyIleCysProValArgArgGluLeuTyrSerGlnCysPhe{A}++
ACGGGCATCTGCCCGGTCCGCAGGGAGCTCTACTCCCAGTGCTTC{G}gt
t Intron 3 >>>> {sp}GluLeuIleArgGluValThrIleAsnCysAlaGluArg
143 bp {||}|||||||||||||||||||||||||||||||||||||||
++{sp}GluLeuIleArgGluValThrIleAsnCysAlaGluArg
ag{AT}GAGCTGATCCGGGAAGTCACCATCAACTGCGCAGAGAGG
GlyLeuLeuLeuLeuArgValArgAspGluIleArgMetThrIleAlaAlaTyrGlnThr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GlyLeuLeuLeuLeuArgValArgAspGluIleArgMetThrIleAlaAlaTyrGlnThr
GGGCTGCTGCTGCTGCGAGTCCGGGATGAGATCCGCATGACCATTGCCGCCTACCAGACC
LeuTyrGluSerSerValAlaPheGlyMetArgLysAlaLeuGlnAlaGluGlnGlyLys
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuTyrGluSerSerValAlaPheGlyMetArgLysAlaLeuGlnAlaGluGlnGlyLys
CTGTATGAGAGCAGCGTGGCGTTTGGCATGAGGAAGGCCCTGCAGGCCGAACAGGGGAAG
SerAspMetGluArgLys >>>> Target Intron 4 >>>> IleAlaGluLeuG
|||||||||||||||||| 347 bp |||||||||||||
SerAspMetGluArgLys++ ++IleAlaGluLeuG
TCAGACATGGAGAGGAAAgt agATTGCAGAGTTGG
luThrGluLysArgAspLeuGluArgGlnValAsnGluGlnLysAlaLysCysGluAlaT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luThrGluLysArgAspLeuGluArgGlnValAsnGluGlnLysAlaLysCysGluAlaT
AGACGGAGAAGAGAGATCTGGAGAGGCAAGTGAACGAGCAGAAGGCCAAGTGCGAGGCCA
hrGluLysArgGluSerGluArgArgGlnValGluGluLysLysHisAsnGluGluIleG
|||||||||||||| |||||||||||||||||||||||||||||||||||||||||||
hrGluLysArgGluThrGluArgArgGlnValGluGluLysLysHisAsnGluGluIleG
CCGAGAAGCGCGAGACCGAGAGGCGGCAGGTGGAGGAGAAGAAGCACAACGAGGAGATTC
lnPheLeuLysArgThrAsnGlnGlnLeuLys >>>> Target Intron 5 >>>>
|||||||||||||||||||||||||||||||| 2598 bp
lnPheLeuLysArgThrAsnGlnGlnLeuLys++ +
AGTTCCTGAAGCGGACCAATCAGCAGCTGAAGgt a
AlaGlnLeuGluGlyIleIleAlaProLysLys
|||||||||||||||||||||||||||||||||
+AlaGlnLeuGluGlyIleIleAlaProLysLys
gGCCCAACTGGAAGGCATCATTGCACCGAAGAAG
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