| Basic information |
| Official Symbol | DMBT1 |
| Description | deleted in malignant brain tumors 1 |
| Other Aliases | RP11-481L19.1, GP340, muclin |
| Other Description | SAG; deleted in malignant brain tumors 1 protein; glycoprotein 340; gp-340; hensin; salivary agglutinin; surfactant pulmonary-associated D-binding protein |
| Mutation type | Insert and frame-shift 1202-1203:P-H^CC, Insert and frame-shift 555-556:P-I^CA, Insert and frame-shift 663-664:P-I^CA, premature termination 1134:R->TGA, premature termination 1176:R->TGA, premature termination 120:R->TGA, premature termination 1206:W->TGA, premature termination 1236:P->TGA, premature termination 219:I->TGA, premature termination 338:S->TGA, premature termination 348:P->TGA, premature termination 467:S->TGA, premature termination 470:T->TGA, premature termination 479:I->TGA, premature termination 718:I->TGA, premature termination 847:P->TGA, premature termination 966:S->TGA, premature termination 978:I->TGA |
| Location | Scaffold000113_1:4756098 4647947 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| DMBT1 |
GGGTCTGACTCAGGTTTGGCCCTGAGACTGGTGAATGGAGGTGACCATTG TCAGGGCCAAGTAGAAGTCCTGTACTGAGGCTCCTGGGGTACCATGTGTG ATGACAGCTGGGACACTGGTGATGCCCATATGGTGTGCAGGCAGCTGGGC TGTGGCTGGGCCACATCAGCTCCAGGATATGCCCAGTTCGGTCAGGGCTC AGGTCCGATTGTCGTTGATGACATGCGCTGCTCAGGACACGAGTCCTACC TGTGGAACTGCCCCCACAATGACTGGCTCTCTCATAACTGTAACCATGGT GAAGATGCTGGTGTCATGTGCTCAGGTGGGCATCGAAGACCCTCAGACTC CAATTTCCAGGAATAAGTGAGTTGAGTAATAACTGTGTCCTTTCTAGGAA CTGATGCAGGTTTGGCCCTGAGGCTGGTGAATGGAAGTGACCAATGTCAA GGCCGGGTGGAGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATGA CAACTGGGACATCAATGATGCCAACGTGGTGTGCAGGCAGCTGGGCTGTG GCTGGGCCAAATCTGCTCCAGGATATGCCCAGTTCGGTCAAGGCTCAGGT CCGATTGTCCTTGATGACATGCGCTGCTCAGGACACGAGTCCTACCTGTG GAACTGCCCCCACAATGACTGGCTCTCTCATAACTGTAACCATGGTGAAG ATGCTGGTGTCATGTGCTCAGGTGGGCATTGAAGACCCTCACTATTACCA AAAATGCAATGAGAAGTAACTGGGTGCTCTCTAGGAACTGATGCAGGTTT GGCCCTGAGGCTGGTGAATGGAAGTAACCAATGTCAAGGCCGGGTGGAGG TCCTGTACCGAGGCTCCTGTGGGACCGTGTGTGATGACAGCTGGGACATC AATGATGCCAACGTGGTGTGCAGGCAGCTGGGCTGTGGCTGGGCCAAATC TGCTCCAGGATATGCCCAGTTCGGTCAGGGCTCAGGTCCGATTGTCCTTG ATGACATGCGCTGCTCAGGACATGAGTCCTACCTGTGGAACTGCCCCCAC AATGGCTGGCTCTCTCATAACTGTAACCATGGTGAAGATGCTGGTGTCCT GTGCTCAGGTGCGCATTGAAGACCCTGAGACCCCAATTTCCAGAAAATGC AATGAGAATTAACTGGGTGCTCTCTAGGAACTGATGCAAGTTTGGCCCTG AGGCTGGTGAATGGAGGTGATCAATGTCAAGGCCGGGTGGAAGTCCTGTA CCGAGGCTCCTGGGGCACCATGTGTGATGATAGCTGGGACACCAATGATG CCAATGTGGTGTGCAGGCAGCTGGGCTGTGGTTGGGCTATGTCTGCCCCA GGATATGCCCAGTTTGTTCAGGGCTCAGGTATTGTCCTTAATGACATGCG CTGCTCAGGACACGAGTCCTCCCTGTGGAACTGTCCCCACAATGGCTGGC TCTCTCCTAACTGTAACCACGGGGAAGATGCTGGTGTTATCTGCTCACGA ACTGATGCAGGTTTGGCCCTGAGGCTGGTGAATGGAAGTAACCAATGTCA AGGCCGGGTGGAGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATG ACAGCTGGGACACCAATGATGCCAATGTGGTGTGCAGGCAGCTGGGCTGT GGTTGGGCTATGTCTGCCCCAGGATATGCCCAGTTTGTTCAGGGCTCAGG TATTGTCCTTAATGACATGCGCTGCTCAGGACACGAGTCCTCCCTGTGGA ACTGTCCCCACAATGGCTGGCTCTCTCCTAACTGTAACCACGGGGAAGAT GCTGGTGTCATCTGCTCAGGTGGGCATCGAAGANNNNNNNNNNNNAAATT ATCAGAAGTGCGTTGAGTAATAACTGTGTCCTTTCTAGGAACTGATGCAG GTTTTGCCCTGAGGCTGGTGAACGGAAGTGACCAATGTCAAGGCCGGGTG GAGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATGACAACTGGGA CATCAATGATGCCAACGTGGTGTGCAGGCAGCTGGGCTGTGGCTGGGCCA AATCTGCTCCAGGATATGCCCAGTTCGGTCAAGGCTCAGGTCCGATTGTC CTTGATGACATGCGCTGCTCAGGACACGAGTCCTACCTGTGGAATTGCCC CCACAATGGCTGGCTCTCTCATAACTGTAACCATGGTGAAGATGCTGGTG TCATGTGCTCAGGTGGGCATCGAAGACCCTCAAAATTACCAAAAATGAAT TGAGAAATATCTGTGTCCTCTTTAGGAACTGTTGCTGGTTTGGCCCTGAG GCTGGTGAACGGACGTAACCAATGTCAAGGCCGGGTGGAGGTCTTATACC AAGGCTCCTGGGGCACTGTGTGTGATGACAGCTGGGACATCAATGATGCC AATGTGGTCTGCAGGCAGGTGGGATGTGGTTGGGCCACATCTGCCCCAGG ATATGCCCAGTTTGGTCAGGGCTCAGGTCCAATTGTCCTTGATGATGTGC GCTGCTCAGGACGTGAGTCCTACCTGTGGCATTGCCCCCACAATGGCTGG CTCTCTAATAACTGTAACCACGGAGAAGATGCTGGTGTCATCTGCTCAGG TAGGCATTGACGACCCTTGGTCTCCAATCTTCAGAAAATGCATTGAGAAA TAACTGTGTGCTCTCTAGGAACTGATGCAGGTTTGGCCCTGAGGCTGGTG AATGGAGGGGACCGATGTCAAGGCCGGGTGGAGGTCCTGTACCGAGGCTC CTGGGGCACTGTGTGTGATGACAGCTGGGACACCAATGATGCCAATGTGG TCTGCAGGCAGCTGGGCTGTGGCTGGGCTACCTCTGCACCAGGTTATGCT CGGTTCGGTCAGGGCTCAGGCCCGATTGTCCTTGATGATGTGCGCTGCTC AGGACACGAGTCTTACCTGTGGAACTGTCCTCACAATGGCTGGCTCTCTC ATAACTGTAACCACGGTGAAGATGCTGGTGTCATCTGCTCAGGTGGGTTT CCAAGATCATTGCCATTTATAGACACGTGGCCTACCTCATCCTCACCTAC TGCAGGAAATGATTCTAGTTTGGCCCTGAGGCTAATTAATGAAGGTGACC GGTGTCAGGGTTGAGTGGAGGTCCTGTACCAAGGCTTCTGGGGCATCATG TGTGATGACAGCTGGGACACCAATGATGCTGATGTGCTCTGCAGAGAGCT GAGCTGTGGCTGGGCTACCTCTGCCCCAGGAAATGGCTGATTTAGACAAG GCTCAGGCCAAATTGTCCTTGATGATGTGCGCTGCTCAGGACATGAGTCC TACCTGGGAAACTGCCACAATGGCTGACTCTCTCATAACTGTGGCTATGG GGAAGATGCTGGTGTAATCTGCTCAGACATTGGGGCTTTCTTCTTCATGT GTAGTCTAATGAAATGAGAAATAATTGTGTCTGCTGCAGGAAGTGATTCA AGTTTGGCCCTGAGGCTGGTGAATGGAGGTGACCGATGTCAAGGCCGGGT GGAGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATGACGATTGGG ACACCAATGATGCCAACGTGGTCTGCAGGCAGCTGGGCTGTGGTTGGGCT ACCGCTGCCCCAGGAAATGCCCGGTTCGGACAGGGCTCAGGCCAAATTGT CCTGGATAATGTGCGTTGCTCAGGACACGAGTCCTACCTGTGGAACTGCC CCCACAACGGCTGGCTCTCTCATAACTGTAACCACGGGGAAGATGCTGGT GTCATCTGCTCAGGTGGGACCCAGGATCTTCTTGTGCACAGAATGAAATG GGAAATAATTGTGTCTCCTGCAGGAAGTGATTCCAATTTGGCCCTGAGGC TGGTGAATGGAGGTGACCGATGTCAAGGCCGGGTGGAGGTCCTGTACCGA GGCTCCTGGGGCACCGTGTGTGATGACGATTGGGACACCAATGATGCCAA CGTGGTCTGTAGGCAGCTGGGCTGTGGTTGGGCTACCGCTGCCCCAGGAA ATGCCCGGTTCGGACAGGGCTCAGGCCAAATTGTCCTGGATAATGTGCGT TGCTCAGGACACGAGTCCTACCTGTGGAACTGCCCCCACAACGGCTGGCT CTCTCATAACTGTAACCACGGGGAAGATGCTGGTGTCATCTGCTCAGGTG GGACCCAGGATCTTCTTGTGCACAGAATGAAATGGGAAATAATTGTGTCT CCTGCAGGAAGTGATTCCAATTTGGCCCTGAGGCTGGTGAATGGAGGTGA CCGATGTCAAGGCCGGGTGGAGGTCCTGTACCGAGGCTCCTGGGGCACCG TGTGTGATGACGATTGGGACACCAATGATGCCAACGTGGTCTGTAGGCAG CTGGGCTGTGGTTGGGCTACCGCTGCCCCAGGAAATGCCCGGTTCGGACA GGGCTCAGGCCAAATTGTCCTGGATAATGTGCGTTGCTCAGGACACGAGT CCTACCTGTGGAACTGCCCCCACAACGGCTGGCTCTCTCATAACTGTAAC CACGGGGAAGATGCTGGTGTCATCTGCTCAGGTGGGACCCAGGATCTTCT TGTGCACAGAATGAAATGGGAAATAATTGTGTCTCCTGCAGGAAGTGATT CCAATTTGGCCCTGAGGCTGGTGAATGGAGGTGACCGATGTCAAGGCCGG GTGGAGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATGACGATTG GGACACCAATGATGCCAACGTGGTCTGTAGGCAGCTGGGCTGTGGTTGGG CTACCGCTGCCCCAGGAAATGCCCGGTTCGGACAGGGCTCAGGCCAAATT GTCCTGGATAATGTGCGTTGCTCAGGACACGAGTCCTACCTGTGGAACTG CCCCCACAACGGCTGGCTCTCTCATAACTGTAACCACGGGGAAGATGCTG GTGTCATCTGCTCAGGTGGGACCCAGGATCTTCTTGTGGTGGGGTTTCTT TAAATGAAATGGAAAATAATTGTGTCTCCTGCAGGAAGTGATTCCAGTTT GGCCCTGAGGCTGGTGAATGGAGGTGACCGATGTCAAGGCCGAGTGGAGG TCCTATACAGAGGCTCCTGGGGCACCGTGTGTGATGACGATTGGGACACC AATGATGCCAACGTGGTCTGCAGGCAGCTGGACTGTGGTTGGGCTACCTC TGCTCCAGGAAATGCCTGGTTTGGACAAGGCTCAGGTCAAATTGTCCTGG ACAATGTGCGTTGCTCAGGACACGAGTCCTACCTGTGGAACTGTCCCCAC AATGGCTGGCTCTCTCATAACTGTAACCACGGGGAAGATGCTGGTGTCAT CTGCTCAGGTGGGACCCAAGATCTTCTTGTGGTGGATTGGTGGTATCCAA CAAGTACAACCACCTCAAGACCTTCTTTAAACTGTGGTGGCTTCTTATTC AATGCCAGTGGGACATTTTCCAGTCCATCATATCCTGGATACTACCCCAA CAATGCGTACTGTGTCTGGGAAATAGAAGTGAGTTCCGGTTATCGCATCA ACCTCGGCTTCAGAAACTTGCAGTTGGAGGTGAACAGTAGATGCAGTTTT GATTATGTTGAAATCTTTGATGGACCATCAAGTAGTAGTAATTTGATGGG GAAAATCTGTAATGACACCAGGCAAATATTCACATCTTCTTACAACCGAA TGACGGTTCGATTCCGAAGTGATGTCAGTTTCCAAAATACTGGCTTTTTG GCTTGGTATAACTCCTTTCCAAGAGATGCCAGGTTGAGATTGGTCAATTC AGGCTCCTCTTATGGTGCATGTGCTGGACGTGTGGAAATTTACCATAGTG GCAAGTGGGGGACAGTTTGTGATGATTCCTGGAACATTTGGAATGCCCAA GTGGTCTGCAGACAGGTGGGGTGTGGAAATGCAGTATCAGCTGTGGGAAA TGCCTTTTTTGGCTCCGGCTCTGGCCCCATCACCCTGGATGATGTGTACT GTGTAGGAACAGAATCTACTCTCTGGCAGTGCCAGAACCGAGGCTGGTTC TCCCACAATTGTGGCCACCATGAAGATGCAGGTGTCATTTGCTCAGGTAA GGCACGATGTCATGGATGGCCCATCATTTTTTGTTTTGTTCTGACAGCAA ATTATTCCTGTGGAGGTTTCCTGTCCCAGCCATCAGGGCTCTTTTCCAGT CCATCTTATCCTGGGAACTATCCAAACAATGCCAACTGTGTGTGGGACAT TGAAGTCCAGAACAACTACCGCGTGACTATTATCTTCAGAGATGTTCAGC TTGAAGGTGGCTGCAACTATGATTTTATTGACGTTTTTGATGGTCCCTAC CACAGTTCCCCTCTCATTGCTCGGGTTTGTGATGGAGCTAGGGGCTCCTT CACTTCATCATCAAACTTCATGTCAATTCGCTTCATCAGTGATAGCAGCA TCTCGAGAAGAGGGTTCCAGGCGGAGTACTACTCGACCCCCTCCAATGAC AGCACCAACCTACTTTGTCTGCCAAATCACATGCAAGCCAGTGTGAGCAA GAGCTACCTTCATTCCCTGGGCTATTCTGCCACGGACCTTGTCATTGCCA GCTGGAATGAGAACTACCCATGTCAACCTGAGATAACACTGAGCCAGGTG ATATTCTCAATTCCCTATTTAGGCTGTGGCACCATCAAGAAGGTAGACAA CGACACCATCATCTATTCCAACTTCCTCAAAGCAGCTGTTTCAAGTGGCA TCATCAAAAGGAAGAAAGATCTCCACATTCATGTCAGCTGTAAGATGCTC CAGGATACCTGGGTTGACATGATGTACATTGCTAATGACACCATTGAGCT CAAAGAAGTCCAGTACAGCAATTTTGATGTGAACATTTCCTTTTATACAT CCTCTTCATTCGTATATCCCGTGACCAGCATCCCATACTACGTGGACCTG AACCAGAATTTGTACCTTCAGGCCGAAATTCTCAATTCTGATGATAATCT GGCATTATTTGTGGACACTTGTGTTGCATCACCATACTTCAGTGACTTTA CATCTTTGACTTATGATCTAATCCGGAGTGGG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 2542 | 95 | 2451 | Insert and frame-shift 1202-1203:P-H^CC, Insert and frame-shift 555-556:P-I^CA, Insert and frame-shift 663-664:P-I^CA, Premature termination 1134:R->TGA, Premature termination 1176:R->TGA, Premature termination 120:R->TGA, Premature termination 1206:W->TGA, Premature termination 1236:P->TGA, Premature termination 219:I->TGA, Premature termination 338:S->TGA, Premature termination 348:P->TGA, Premature termination 467:S->TGA, Premature termination 470:T->TGA, Premature termination 479:I->TGA, Premature termination 718:I->TGA, Premature termination 847:P->TGA, Premature termination 966:S->TGA, Premature termination 978:I->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
GlySerAspSerGlyLeuAlaLeuArgLeuValAsnGlyAspGlyArgCysGlnGlyA
||||||||||||||||||||||||||||||||||||||| |||||||||
GlySerAspSerGlyLeuAlaLeuArgLeuValAsnGlyGlyAspHisCysGlnGlyG
GGGTCTGACTCAGGTTTGGCCCTGAGACTGGTGAATGGAGGTGACCATTGTCAGGGCC
rgValGluIleLeuTyrArgGlySerTrpGlyThrValCysAspAspSerTrpAspTh
|||||| |||||| ||||||||||||||| ||||||||||||||||||||
lnValGluValLeuTyr***GlySerTrpGlyThrMetCysAspAspSerTrpAspTh
AAGTAGAAGTCCTGTACTGAGGCTCCTGGGGTACCATGTGTGATGACAGCTGGGACAC
rAsnAspAlaAsnValValCysArgGln >>>> Target Intron 1 >>>> L
| |||||| |||||||||||| 3316 bp |
rGlyAspAlaHisMetValCysArgGln-+ ++L
TGGTGATGCCCATATGGTGTGCAGGCAGct agC
euGlyCysGlyTrpAlaMetSerAlaProGlyAsnAlaTrpPheGlyGlnGlySerGl
||||||||||||||||| |||||||||||| ||| |||||||||||||||||
euGlyCysGlyTrpAlaThrSerAlaProGlyTyrAlaGlnPheGlyGlnGlySerGl
TGGGCTGTGGCTGGGCCACATCAGCTCCAGGATATGCCCAGTTCGGTCAGGGCTCAGG
yProIleAlaLeuAspAspValArgCysSerGlyHisGluSerTyrLeuTrpSerCys
||||||| |||||| |||||||||||||||||||||||||||||| |||
yProIleValValAspAspMetArgCysSerGlyHisGluSerTyrLeuTrpAsnCys
TCCGATTGTCGTTGATGACATGCGCTGCTCAGGACACGAGTCCTACCTGTGGAACTGC
ProHisAsnGlyTrpLeuSerHisAsnCysGlyHisGlyGluAspAlaGlyValIleC
||||||||| |||||||||||||||||| ||||||||||||||||||||| |
ProHisAsnAspTrpLeuSerHisAsnCysAsnHisGlyGluAspAlaGlyValMetC
CCCCACAATGACTGGCTCTCTCATAACTGTAACCATGGTGAAGATGCTGGTGTCATGT
ysSerAlaAlaGlnProGlnSerThrLeuArgProGluSerTrp{P} >>>> Targ
||||| { }
ysSerGlyGlyHisArgArgProSerAspSerAsnPheGlnGlu{*}+-
GCTCAGGTGGGCATCGAAGACCCTCAGACTCCAATTTCCAGGAA{T}gc
et Intron 2 >>>> {ro}ValArgIleSerProProValProThrGluGlySer
11236 bp { }||| ||| |||
++{**}ValSer***ValIleThrValSerPheLeuGlyThr
ag{AA}GTGAGTTGAGTAATAACTGTGTCCTTTCTAGGAACT
GluSerSerLeuAlaLeuArgLeuValAsnGlyGlyAspArgCysArgGlyArgValG
|||||||||||||||||||||||| ||| ||| ||||||||||
AspAlaGlyLeuAlaLeuArgLeuValAsnGlySerAspGlnCysGlnGlyArgValG
GATGCAGGTTTGGCCCTGAGGCTGGTGAATGGAAGTGACCAATGTCAAGGCCGGGTGG
luValLeuTyrArgGlySerTrpGlyThrValCysAspAspTyrTrpAspThrAsnAs
||||||||||||||||||||||||||||||||||||||||| |||||| |||||
luValLeuTyrArgGlySerTrpGlyThrValCysAspAspAsnTrpAspIleAsnAs
AGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATGACAACTGGGACATCAATGA
pAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaMetSerAlaProGlyAsn
|||||||||||||||||||||||||||||||||||||||| ||||||||||||
pAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaLysSerAlaProGlyTyr
TGCCAACGTGGTGTGCAGGCAGCTGGGCTGTGGCTGGGCCAAATCTGCTCCAGGATAT
AlaGlnPheGlyGlnGlySerGlyProIleValLeuAspAspValArgCysSerGlyH
|||||||||||||||||||||||||||||||||||||||||| |||||||||||||
AlaGlnPheGlyGlnGlySerGlyProIleValLeuAspAspMetArgCysSerGlyH
GCCCAGTTCGGTCAAGGCTCAGGTCCGATTGTCCTTGATGACATGCGCTGCTCAGGAC
isGluSerTyrLeuTrpSerCysProHisAsnGlyTrpLeuThrHisAsnCysGlyHi
||||||||||||||||| |||||||||||| |||||| ||||||||| ||
isGluSerTyrLeuTrpAsnCysProHisAsnAspTrpLeuSerHisAsnCysAsnHi
ACGAGTCCTACCTGTGGAACTGCCCCCACAATGACTGGCTCTCTCATAACTGTAACCA
sSerGluAspAlaGlyValIleCysSerAlaProGlnSerArgProThr{Pr} >>>
| ||||||||||||||| |||||| |||||| { }
sGlyGluAspAlaGlyValMetCysSerGlyGlyHis***ArgProSer{Le}--
TGGTGAAGATGCTGGTGTCATGTGCTCAGGTGGGCATTGAAGACCCTCA{CT}cc
> Target Intron 3 >>>> {o}SerProAspThrTrpProThrSerHisAlaS
5506 bp { } |||
+-{u}LeuProLysMetGln***GluValThrGlyC
aa{A}TTACCAAAAATGCAATGAGAAGTAACTGGGT
erThrAlaGlyProGluSerSerLeuAlaLeuArgLeuValAsnGlyGlyAspArgCy
||| |||||||||||||||||||||||| ||
ysSerLeuGlyThrAspAlaGlyLeuAlaLeuArgLeuValAsnGlySerAsnGlnCy
GCTCTCTAGGAACTGATGCAGGTTTGGCCCTGAGGCTGGTGAATGGAAGTAACCAATG
sGlnGlyArgValGluValLeuTyrArgGlySerTrpGlyThrValCysAspAspSer
|||||||||||||||||||||||||||||||||| |||||||||||||||||||||
sGlnGlyArgValGluValLeuTyrArgGlySerCysGlyThrValCysAspAspSer
TCAAGGCCGGGTGGAGGTCCTGTACCGAGGCTCCTGTGGGACCGTGTGTGATGACAGC
TrpAspThrSerAspAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaThrS
|||||| |||||||||||||||||||||||||||||||||||||||||| |
TrpAspIleAsnAspAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaLysS
TGGGACATCAATGATGCCAACGTGGTGTGCAGGCAGCTGGGCTGTGGCTGGGCCAAAT
erAlaProGlyAsnAlaArgPheGlyGlnGlySerGlyProIleValLeuAspAspVa
||||||||||| ||| ||||||||||||||||||||||||||||||||||||
erAlaProGlyTyrAlaGlnPheGlyGlnGlySerGlyProIleValLeuAspAspMe
CTGCTCCAGGATATGCCCAGTTCGGTCAGGGCTCAGGTCCGATTGTCCTTGATGACAT
lArgCysSerGlyTyrGluSerTyrLeuTrpSerCysProHisAsnGlyTrpLeuSer
|||||||||||| ||||||||||||||| ||||||||||||||||||||||||
tArgCysSerGlyHisGluSerTyrLeuTrpAsnCysProHisAsnGlyTrpLeuSer
GCGCTGCTCAGGACATGAGTCCTACCTGTGGAACTGCCCCCACAATGGCTGGCTCTCT
HisAsnCysGlnHisSerGluAspAlaGlyValIleCysSerAlaAlaHisSerTrpS
||||||||| ||| ||||||||||||||| |||||| ||||||
HisAsnCysAsnHisGlyGluAspAlaGlyValLeuCysSerGlyAlaHis***ArgP
CATAACTGTAACCATGGTGAAGATGCTGGTGTCCTGTGCTCAGGTGCGCATTGAAGAC
erThrProSerProAspThr >>>> Target Intron 4 >>>> LeuProThr
5586 bp
ro***AspProAsnPheGln+- --LysMetGln
CCTGAGACCCCAATTTCCAGga caAAAATGCAA
IleThrLeuProAlaSerThrValGlySerGluSerSerLeuAlaLeuArgLeuValA
||| ||| ||||||||||||||||||||||
***GluLeuThrGlyCysSerLeuGlyThrAspAlaSerLeuAlaLeuArgLeuValA
TGAGAATTAACTGGGTGCTCTCTAGGAACTGATGCAAGTTTGGCCCTGAGGCTGGTGA
snGlyGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGlySerTrpGlyTh
||||||||||| ||||||||||||||||||||||||||||||||||||||||||||
snGlyGlyAspGlnCysGlnGlyArgValGluValLeuTyrArgGlySerTrpGlyTh
ATGGAGGTGATCAATGTCAAGGCCGGGTGGAAGTCCTGTACCGAGGCTCCTGGGGCAC
rValCysAspAspSerTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuGly
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
rMetCysAspAspSerTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuGly
CATGTGTGATGATAGCTGGGACACCAATGATGCCAATGTGGTGTGCAGGCAGCTGGGC
CysGlyTrpAlaMetLeuAlaProGlyAsnAlaArgPheGlyGlnGlySerGlyPro-
||||||||||||||| ||||||||| ||| ||| |||||||||||| #
CysGlyTrpAlaMetSerAlaProGlyTyrAlaGlnPheValGlnGlySerGly---#
TGTGGTTGGGCTATGTCTGCCCCAGGATATGCCCAGTTTGTTCAGGGCTCAGGT---C
-IleValLeuAspAspValArgCysSerGlyAsnGluSerTyrLeuTrpSerCysPro
#||||||||| ||| |||||||||||| |||||| |||||| ||||||
#IleValLeuAsnAspMetArgCysSerGlyHisGluSerSerLeuTrpAsnCysPro
AATTGTCCTTAATGACATGCGCTGCTCAGGACACGAGTCCTCCCTGTGGAACTGTCCC
HisAsnGlyTrpLeuSerHisAsnCysGlyHisSerGluAspAlaGlyValIleCysS
|||||||||||||||||| |||||| ||| ||||||||||||||||||||||
HisAsnGlyTrpLeuSerProAsnCysAsnHisGlyGluAspAlaGlyValIleCysS
CACAATGGCTGGCTCTCTCCTAACTGTAACCACGGGGAAGATGCTGGTGTTATCTGCT
er{G} >>>> Target Intron 5 >>>> {ly}ProGluSerSerLeuAlaLe
||{ } 6548 bp { } ||||||||
er{A}++ ++{rg}ThrAspAlaGlyLeuAlaLe
CA{C}gt ag{GA}ACTGATGCAGGTTTGGCCCT
uArgLeuValAsnGlyGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGly
|||||||||||||||| |||||||||||||||||||||||||||||||||
uArgLeuValAsnGlySerAsnGlnCysGlnGlyArgValGluValLeuTyrArgGly
GAGGCTGGTGAATGGAAGTAACCAATGTCAAGGCCGGGTGGAGGTCCTGTACCGAGGC
SerTrpGlyThrValCysAspAspSerTrpAspThrAsnAspAlaAsnValValCysA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SerTrpGlyThrValCysAspAspSerTrpAspThrAsnAspAlaAsnValValCysA
TCCTGGGGCACCGTGTGTGATGACAGCTGGGACACCAATGATGCCAATGTGGTGTGCA
rgGlnLeuGlyCysGlyTrpAlaThrSerAlaProGlyAsnAlaArgPheGlyGlnGl
||||||||||||||||||||||| |||||||||||| ||| ||| |||||
rgGlnLeuGlyCysGlyTrpAlaMetSerAlaProGlyTyrAlaGlnPheValGlnGl
GGCAGCTGGGCTGTGGTTGGGCTATGTCTGCCCCAGGATATGCCCAGTTTGTTCAGGG
ySerGlyPro--IleValLeuAspAspValArgCysSerGlyHisGluSerTyrLeuT
||||||| ##||||||||| ||| ||||||||||||||||||||| ||||
ySerGly---##IleValLeuAsnAspMetArgCysSerGlyHisGluSerSerLeuT
CTCAGGT---CAATTGTCCTTAATGACATGCGCTGCTCAGGACACGAGTCCTCCCTGT
rpSerCysProAsnAsnGlyTrpLeuSerHisAsnCysGlyHisHisGluAspAlaGl
|| |||||| ||||||||||||||| |||||| ||| |||||||||||
rpAsnCysProHisAsnGlyTrpLeuSerProAsnCysAsnHisGlyGluAspAlaGl
GGAACTGTCCCCACAATGGCTGGCTCTCTCCTAACTGTAACCACGGGGAAGATGCTGG
yValIleCysSerAlaAlaGlnSerArgSerThrProArg >>>> Target Intr
||||||||||||| ||| 3448 bp
yValIleCysSerGlyGlyHisArgArgUnkUnkUnkUnk--
TGTCATCTGCTCAGGTGGGCATCGAAGANNNNNNNNNNNNnn
on 6 >>>> ProAspThrLeuSerThrIleThrLeuProProSerThrValGlySe
||| |||
-+LysLeuSerGluValArg***ValIleThrValSerPheLeuGlyTh
tgAAATTATCAGAAGTGCGTTGAGTAATAACTGTGTCCTTTCTAGGAAC
rGluSerSerLeuThrLeuArgLeuValAsnGlySerAspArgCysGlnGlyArgVal
|||||||||||||||||||||||| |||||||||||||||
rAspAlaGlyPheAlaLeuArgLeuValAsnGlySerAspGlnCysGlnGlyArgVal
TGATGCAGGTTTTGCCCTGAGGCTGGTGAACGGAAGTGACCAATGTCAAGGCCGGGTG
GluValLeuTyrArgGlySerTrpGlyThrValCysAspAspSerTrpAspThrAsnA
|||||||||||||||||||||||||||||||||||||||||| |||||| ||||
GluValLeuTyrArgGlySerTrpGlyThrValCysAspAspAsnTrpAspIleAsnA
GAGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATGACAACTGGGACATCAATG
spAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaThrSerAlaProGlyAs
||||||||||||||||||||||||||||||||||||||||| ||||||||||||
spAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaLysSerAlaProGlyTy
ATGCCAACGTGGTGTGCAGGCAGCTGGGCTGTGGCTGGGCCAAATCTGCTCCAGGATA
nAlaArgPheGlyGlnGlySerGlyProIleValLeuAspAspValArgCysSerGly
||| |||||||||||||||||||||||||||||||||||| ||||||||||||
rAlaGlnPheGlyGlnGlySerGlyProIleValLeuAspAspMetArgCysSerGly
TGCCCAGTTCGGTCAAGGCTCAGGTCCGATTGTCCTTGATGACATGCGCTGCTCAGGA
HisGluSerTyrLeuTrpSerCysProHisAsnGlyTrpLeuSerHisAsnCysGlyH
|||||||||||||||||| ||||||||||||||||||||||||||||||||| |
HisGluSerTyrLeuTrpAsnCysProHisAsnGlyTrpLeuSerHisAsnCysAsnH
CACGAGTCCTACCTGTGGAATTGCCCCCACAATGGCTGGCTCTCTCATAACTGTAACC
isHisGluAspAlaGlyValIleCysSerValSerGlnSerArgProThr >>>> T
|| ||||||||||||||| |||||| ||||||
isGlyGluAspAlaGlyValMetCysSerGlyGlyHisArgArgProSer+-
ATGGTGAAGATGCTGGTGTCATGTGCTCAGGTGGGCATCGAAGACCCTCAga
arget Intron 7 >>>> ProSerProAspThrTrpProThrSerHisAlaSerT
4666 bp ||| |||
-+LysLeuProLysMetAsn***GluIleSerValSerS
tgAAATTACCAAAAATGAATTGAGAAATATCTGTGTCCT
hrAlaGlyProGluSerSerLeuAlaLeuArgLeuValAsnGlyGlyAspArgCysGl
||| |||||||||||||||||||||||| |||||
erLeuGlyThrValAlaGlyLeuAlaLeuArgLeuValAsnGlyArgAsnGlnCysGl
CTTTAGGAACTGTTGCTGGTTTGGCCCTGAGGCTGGTGAACGGACGTAACCAATGTCA
nGlyArgValGluValLeuTyrArgGlySerTrpGlyThrValCysAspAspSerTrp
|||||||||||||||||||||| |||||||||||||||||||||||||||||||||
nGlyArgValGluValLeuTyrGlnGlySerTrpGlyThrValCysAspAspSerTrp
AGGCCGGGTGGAGGTCTTATACCAAGGCTCCTGGGGCACTGTGTGTGATGACAGCTGG
AspThrSerAspAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaThrSerA
||| |||||||||||||||||||||||| ||||||||||||||||||||||
AspIleAsnAspAlaAsnValValCysArgGlnValGlyCysGlyTrpAlaThrSerA
GACATCAATGATGCCAATGTGGTCTGCAGGCAGGTGGGATGTGGTTGGGCCACATCTG
laProGlyAsnAlaArgPheGlyGlnGlySerGlyProIleValLeuAspAspValAr
|||||||| ||| |||||||||||||||||||||||||||||||||||||||||
laProGlyTyrAlaGlnPheGlyGlnGlySerGlyProIleValLeuAspAspValAr
CCCCAGGATATGCCCAGTTTGGTCAGGGCTCAGGTCCAATTGTCCTTGATGATGTGCG
gCysSerGlyTyrGluSerTyrLeuTrpSerCysProHisAsnGlyTrpLeuSerHis
|||||||||| ||||||||||||||| ||||||||||||||||||||||||
gCysSerGlyArgGluSerTyrLeuTrpHisCysProHisAsnGlyTrpLeuSerAsn
CTGCTCAGGACGTGAGTCCTACCTGTGGCATTGCCCCCACAATGGCTGGCTCTCTAAT
AsnCysGlnHisSerGluAspAlaGlyValIleCysSerAlaAlaHisSerTrpSerT
|||||| ||| |||||||||||||||||||||||| |||
AsnCysAsnHisGlyGluAspAlaGlyValIleCysSerGlyArgHis***ArgProL
AACTGTAACCACGGAGAAGATGCTGGTGTCATCTGCTCAGGTAGGCATTGACGACCCT
hrProSerProAspThr >>>> Target Intron 8 >>>> LeuProThrIle
||| 3760 bp
euValSerAsnLeuGln+- --LysMetHis***
TGGTCTCCAATCTTCAGga caAAAATGCATTGA
ThrLeuProAlaSerThrValGlySerGluSerSerLeuAlaLeuArgLeuValAsnG
||| ||||||||||||||||||||||
GluIleThrValCysSerLeuGlyThrAspAlaGlyLeuAlaLeuArgLeuValAsnG
GAAATAACTGTGTGCTCTCTAGGAACTGATGCAGGTTTGGCCCTGAGGCTGGTGAATG
lyGlyAspArgCysGlnGlyArgValGluValLeuTyrGlnGlySerTrpGlyThrVa
|||||||||||||||||||||||||||||||||||||| |||||||||||||||||
lyGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGlySerTrpGlyThrVa
GAGGGGACCGATGTCAAGGCCGGGTGGAGGTCCTGTACCGAGGCTCCTGGGGCACTGT
lCysAspAspSerTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuGlyCys
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lCysAspAspSerTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuGlyCys
GTGTGATGACAGCTGGGACACCAATGATGCCAATGTGGTCTGCAGGCAGCTGGGCTGT
GlyTrpAlaMetSerAlaProGlyAsnAlaArgPheGlyGlnGlySerGlyProIleV
||||||||| |||||||||||| |||||||||||||||||||||||||||||||
GlyTrpAlaThrSerAlaProGlyTyrAlaArgPheGlyGlnGlySerGlyProIleV
GGCTGGGCTACCTCTGCACCAGGTTATGCTCGGTTCGGTCAGGGCTCAGGCCCGATTG
alLeuAspAspValArgCysSerGlyHisGluSerTyrLeuTrpSerCysProHisAs
|||||||||||||||||||||||||||||||||||||||||||| |||||||||||
alLeuAspAspValArgCysSerGlyHisGluSerTyrLeuTrpAsnCysProHisAs
TCCTTGATGATGTGCGCTGCTCAGGACACGAGTCTTACCTGTGGAACTGTCCTCACAA
nGlyTrpLeuSerHisAsnCysGlyHisSerGluAspAlaGlyValIleCysSerAla
|||||||||||||||||||||| ||| ||||||||||||||||||||||||
nGlyTrpLeuSerHisAsnCysAsnHisGlyGluAspAlaGlyValIleCysSerGly
TGGCTGGCTCTCTCATAACTGTAACCACGGTGAAGATGCTGGTGTCATCTGCTCAGGT
SerGlnSerArgPro{T} >>>> Target Intron 9 >>>> {hr}ProSerP
||| { } 1766 bp { }|||
GlyPheProArgSer{L}-+ --{eu}ProPheI
GGGTTTCCAAGATCA{T}tt gt{TG}CCATTTA
roAspThrTrpProThrSerHisAlaSerThr >>>> Target Intron 10 >>
|||||||||||||||||| ||| 1100 bp
leAspThrTrpProThrSerSerSerProThr--
TAGACACGTGGCCTACCTCATCCTCACCTACTac
>> AlaGlySerGluSerSerLeuAlaLeuArgLeuValAsnGlyGlyAspArgCys
|||||| ||||||||||||||||||||| ||| ||||||||||||
-+AlaGlyAsnAspSerSerLeuAlaLeuArgLeuIleAsnGluGlyAspArgCys
tgGCAGGAAATGATTCTAGTTTGGCCCTGAGGCTAATTAATGAAGGTGACCGGTGT
GlnGlyArgValGluValLeuTyrArgGlySerTrpGlyThrValCysAspAspTyrT
|||||| ||||||||||||||| ||| |||||| ||||||||| |
GlnGly***ValGluValLeuTyrGlnGlyPheTrpGlyIleMetCysAspAspSerT
CAGGGTTGAGTGGAGGTCCTGTACCAAGGCTTCTGGGGCATCATGTGTGATGACAGCT
rpAspThrAsnAspAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaMetSe
||||||||||||||||| ||| |||||| ||| |||||||||||| ||
rpAspThrAsnAspAlaAspValLeuCysArgGluLeuSerCysGlyTrpAlaThrSe
GGGACACCAATGATGCTGATGTGCTCTGCAGAGAGCTGAGCTGTGGCTGGGCTACCTC
rAlaProGlyAsnAlaArgPheGlyGlnGlySerGlyProIleValLeuAspAspVal
||||||||||||| ||| |||||||||||| ||||||||||||||||||
rAlaProGlyAsnGly***PheArgGlnGlySerGlyGlnIleValLeuAspAspVal
TGCCCCAGGAAATGGCTGATTTAGACAAGGCTCAGGCCAAATTGTCCTTGATGATGTG
ArgCysSerGlyHisGluSerTyrLeuTrpSerCysPro--HisAsnGlyTrpLeuSe
||||||||||||||||||||||||||| ||| ##||||||||| |||||
ArgCysSerGlyHisGluSerTyrLeuGlyAsnCys---##HisAsnGly***LeuSe
CGCTGCTCAGGACATGAGTCCTACCTGGGAAACTGC---CCCACAATGGCTGACTCTC
rHisAsnCysGlyHisHisGluAspAlaGlyValIleCysSerAlaSerGlnSerGln
||||||||||||| ||||||||||||||||||||||||
rHisAsnCysGlyTyrGlyGluAspAlaGlyValIleCysSerAspIleGlyAlaPhe
TCATAACTGTGGCTATGGGGAAGATGCTGGTGTAATCTGCTCAGACATTGGGGCTTTC
ProThrProSerPro{As} >>>> Target Intron 11 >>>> {p}ThrTrp
{ } 11085 bp { }
PhePheMetCysSer{Le}++ -+{u}MetLys
TTCTTCATGTGTAGT{CT}gt tg{A}ATGAAA
ProThrSerHisAlaSerThrAlaGlySerGluSerSerLeuAlaLeuArgLeuValA
||| ||||||||| |||||||||||||||||||||||||
***GluIleIleValSerAlaAlaGlySerAspSerSerLeuAlaLeuArgLeuValA
TGAGAAATAATTGTGTCTGCTGCAGGAAGTGATTCAAGTTTGGCCCTGAGGCTGGTGA
snGlyGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGlySerTrpGlyTh
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
snGlyGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGlySerTrpGlyTh
ATGGAGGTGACCGATGTCAAGGCCGGGTGGAGGTCCTGTACCGAGGCTCCTGGGGCAC
rValCysAspAspTyrTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuGly
||||||||||||| ||||||||||||||||||||||||||||||||||||||||||
rValCysAspAspAspTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuGly
CGTGTGTGATGACGATTGGGACACCAATGATGCCAACGTGGTCTGCAGGCAGCTGGGC
CysGlyTrpAlaThrSerAlaProGlyAsnAlaArgPheGlyGlnGlySerGlyProI
||||||||||||||| |||||||||||||||||||||||||||||||||||| |
CysGlyTrpAlaThrAlaAlaProGlyAsnAlaArgPheGlyGlnGlySerGlyGlnI
TGTGGTTGGGCTACCGCTGCCCCAGGAAATGCCCGGTTCGGACAGGGCTCAGGCCAAA
leValLeuAspAspValArgCysSerGlyHisGluSerTyrLeuTrpSerCysProHi
||||||||||| ||||||||||||||||||||||||||||||||| ||||||||
leValLeuAspAsnValArgCysSerGlyHisGluSerTyrLeuTrpAsnCysProHi
TTGTCCTGGATAATGTGCGTTGCTCAGGACACGAGTCCTACCTGTGGAACTGCCCCCA
sAsnGlyTrpLeuSerHisAsnCysGlyHisHisGluAspAlaGlyValIleCysSer
||||||||||||||||||||||||| ||| ||||||||||||||||||||||||
sAsnGlyTrpLeuSerHisAsnCysAsnHisGlyGluAspAlaGlyValIleCysSer
CAACGGCTGGCTCTCTCATAACTGTAACCACGGGGAAGATGCTGGTGTCATCTGCTCA
AlaSerGlnSerGlnProThrPro >>>> Target Intron 12 >>>> SerP
5581 bp
GlyGlyThrGlnAspLeuLeuVal++ +-HisA
GGTGGGACCCAGGATCTTCTTGTGgt aaCACA
roAspThrTrpProThrSerHisAlaSerThrAlaGlySerGluSerSerLeuAlaLe
||| ||| ||||||||| ||| ||||||||
rgMetLysTrpGluIleIle---ValSerProAlaGlySerAspSerAsnLeuAlaLe
GAATGAAATGGGAAATAATT---GTGTCTCCTGCAGGAAGTGATTCCAATTTGGCCCT
uArgLeuValAsnGlyGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGly
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
uArgLeuValAsnGlyGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGly
GAGGCTGGTGAATGGAGGTGACCGATGTCAAGGCCGGGTGGAGGTCCTGTACCGAGGC
SerTrpGlyThrValCysAspAspTyrTrpAspThrAsnAspAlaAsnValValCysA
|||||||||||||||||||||||| |||||||||||||||||||||||||||||||
SerTrpGlyThrValCysAspAspAspTrpAspThrAsnAspAlaAsnValValCysA
TCCTGGGGCACCGTGTGTGATGACGATTGGGACACCAATGATGCCAACGTGGTCTGTA
rgGlnLeuGlyCysGlyTrpAlaThrSerAlaProGlyAsnAlaArgPheGlyGlnGl
|||||||||||||||||||||||||| |||||||||||||||||||||||||||||
rgGlnLeuGlyCysGlyTrpAlaThrAlaAlaProGlyAsnAlaArgPheGlyGlnGl
GGCAGCTGGGCTGTGGTTGGGCTACCGCTGCCCCAGGAAATGCCCGGTTCGGACAGGG
ySerGlyProIleValLeuAspAspValArgCysSerGlyHisGluSerTyrLeuTrp
||||||| |||||||||||| |||||||||||||||||||||||||||||||||
ySerGlyGlnIleValLeuAspAsnValArgCysSerGlyHisGluSerTyrLeuTrp
CTCAGGCCAAATTGTCCTGGATAATGTGCGTTGCTCAGGACACGAGTCCTACCTGTGG
SerCysProHisAsnGlyTrpLeuSerHisAsnCysGlyHisHisGluAspAlaGlyV
||||||||||||||||||||||||||||||||| ||| |||||||||||||
AsnCysProHisAsnGlyTrpLeuSerHisAsnCysAsnHisGlyGluAspAlaGlyV
AACTGCCCCCACAACGGCTGGCTCTCTCATAACTGTAACCACGGGGAAGATGCTGGTG
alIleCysSerAlaSerGlnSerGlnProThrPro >>>> Target Intron 13
||||||||||| 3931 bp
alIleCysSerGlyGlyThrGlnAspLeuLeuVal++
TCATCTGCTCAGGTGGGACCCAGGATCTTCTTGTGgt
>>>> SerProAspThrTrpProThrSerHisAlaSerThrAlaGlySerGluSer
||| ||| ||||||||| |||
+-HisArgMetLysTrpGluIleIle---ValSerProAlaGlySerAspSer
aaCACAGAATGAAATGGGAAATAATT---GTGTCTCCTGCAGGAAGTGATTCC
SerLeuAlaLeuArgLeuValAsnGlyGlyAspArgCysGlnGlyArgValGluValL
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
AsnLeuAlaLeuArgLeuValAsnGlyGlyAspArgCysGlnGlyArgValGluValL
AATTTGGCCCTGAGGCTGGTGAATGGAGGTGACCGATGTCAAGGCCGGGTGGAGGTCC
euTyrArgGlySerTrpGlyThrValCysAspAspTyrTrpAspThrAsnAspAlaAs
||||||||||||||||||||||||||||||||||| ||||||||||||||||||||
euTyrArgGlySerTrpGlyThrValCysAspAspAspTrpAspThrAsnAspAlaAs
TGTACCGAGGCTCCTGGGGCACCGTGTGTGATGACGATTGGGACACCAATGATGCCAA
nValValCysArgGlnLeuGlyCysGlyTrpAlaThrSerAlaProGlyAsnAlaArg
||||||||||||||||||||||||||||||||||||| ||||||||||||||||||
nValValCysArgGlnLeuGlyCysGlyTrpAlaThrAlaAlaProGlyAsnAlaArg
CGTGGTCTGTAGGCAGCTGGGCTGTGGTTGGGCTACCGCTGCCCCAGGAAATGCCCGG
PheGlyGlnGlySerGlyProIleValLeuAspAspValArgCysSerGlyHisGluS
|||||||||||||||||| |||||||||||| ||||||||||||||||||||||
PheGlyGlnGlySerGlyGlnIleValLeuAspAsnValArgCysSerGlyHisGluS
TTCGGACAGGGCTCAGGCCAAATTGTCCTGGATAATGTGCGTTGCTCAGGACACGAGT
erTyrLeuTrpSerCysProHisAsnGlyTrpLeuSerHisAsnCysGlyHisHisGl
||||||||||| ||||||||||||||||||||||||||||||||| ||| ||
erTyrLeuTrpAsnCysProHisAsnGlyTrpLeuSerHisAsnCysAsnHisGlyGl
CCTACCTGTGGAACTGCCCCCACAACGGCTGGCTCTCTCATAACTGTAACCACGGGGA
uAspAlaGlyValIleCysSerAlaSerGlnSerGlnProThrPro >>>> Targe
||||||||||||||||||||||
uAspAlaGlyValIleCysSerGlyGlyThrGlnAspLeuLeuVal++
AGATGCTGGTGTCATCTGCTCAGGTGGGACCCAGGATCTTCTTGTGgt
t Intron 14 >>>> SerProAspThrTrpProThrSerArgAlaSerThrAlaG
5582 bp ||| ||| ||||
+-HisArgMetLysTrpGluIleIle---ValSerProAlaG
aaCACAGAATGAAATGGGAAATAATT---GTGTCTCCTGCAG
lySerGluSerThrLeuAlaLeuArgLeuValAsnGlyGlyAspArgCysArgGlyAr
||||| ||| |||||||||||||||||||||||||||||||||||| |||||
lySerAspSerAsnLeuAlaLeuArgLeuValAsnGlyGlyAspArgCysGlnGlyAr
GAAGTGATTCCAATTTGGCCCTGAGGCTGGTGAATGGAGGTGACCGATGTCAAGGCCG
gValGluValLeuTyrGlnGlySerTrpGlyThrValCysAspAspTyrTrpAspThr
|||||||||||||||| ||||||||||||||||||||||||||| |||||||||
gValGluValLeuTyrArgGlySerTrpGlyThrValCysAspAspAspTrpAspThr
GGTGGAGGTCCTGTACCGAGGCTCCTGGGGCACCGTGTGTGATGACGATTGGGACACC
AsnAspAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaMetSerAlaProG
||||||||||||||||||||||||||||||||||||||||||||| |||||||
AsnAspAlaAsnValValCysArgGlnLeuGlyCysGlyTrpAlaThrAlaAlaProG
AATGATGCCAACGTGGTCTGTAGGCAGCTGGGCTGTGGTTGGGCTACCGCTGCCCCAG
lyAsnAlaGlnPheGlyGlnGlySerGlyProIleValLeuAspAspValArgCysSe
|||||||| |||||||||||||||||| |||||||||||| |||||||||||
lyAsnAlaArgPheGlyGlnGlySerGlyGlnIleValLeuAspAsnValArgCysSe
GAAATGCCCGGTTCGGACAGGGCTCAGGCCAAATTGTCCTGGATAATGTGCGTTGCTC
rGlyHisGluSerTyrLeuTrpSerCysProHisAsnGlyTrpLeuSerHisAsnCys
|||||||||||||||||||||| |||||||||||||||||||||||||||||||||
rGlyHisGluSerTyrLeuTrpAsnCysProHisAsnGlyTrpLeuSerHisAsnCys
AGGACACGAGTCCTACCTGTGGAACTGCCCCCACAACGGCTGGCTCTCTCATAACTGT
GlyHisHisGluAspAlaGlyValIleCysSerAlaAlaGlnSerGlnSerThrProA
||| ||||||||||||||||||||||||
AsnHisGlyGluAspAlaGlyValIleCysSerGlyGlyThrGlnAspLeuLeuValV
AACCACGGGGAAGATGCTGGTGTCATCTGCTCAGGTGGGACCCAGGATCTTCTTGTGG
rgProAspThr{Tr} >>>> Target Intron 15 >>>> {p}LeuThrThrA
{ } 5477 bp { }
alGlyPheLeu{**}+- ++{*}MetLysTrpL
TGGGGTTTCTT{TA}gg ag{A}ATGAAATGGA
snLeuProAlaLeuThrValGlySerGluSerSerLeuAlaLeuArgLeuValAsnGl
|||||| |||||||||||||||||||||||||||||
ysIleIleValSerProAlaGlySerAspSerSerLeuAlaLeuArgLeuValAsnGl
AAATAATTGTGTCTCCTGCAGGAAGTGATTCCAGTTTGGCCCTGAGGCTGGTGAATGG
yGlyAspArgCysArgGlyArgValGluValLeuTyrArgGlySerTrpGlyThrVal
||||||||||||| ||||||||||||||||||||||||||||||||||||||||||
yGlyAspArgCysGlnGlyArgValGluValLeuTyrArgGlySerTrpGlyThrVal
AGGTGACCGATGTCAAGGCCGAGTGGAGGTCCTATACAGAGGCTCCTGGGGCACCGTG
CysAspAspSerTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuGlyCysG
||||||||| ||||||||||||||||||||||||||||||||||||||| ||||
CysAspAspAspTrpAspThrAsnAspAlaAsnValValCysArgGlnLeuAspCysG
TGTGATGACGATTGGGACACCAATGATGCCAACGTGGTCTGCAGGCAGCTGGACTGTG
lyTrpAlaMetSerAlaProGlyAsnAlaArgPheGlyGlnGlySerGlyProIleVa
|||||||| |||||||||||||||||| |||||||||||||||||| |||||
lyTrpAlaThrSerAlaProGlyAsnAlaTrpPheGlyGlnGlySerGlyGlnIleVa
GTTGGGCTACCTCTGCTCCAGGAAATGCCTGGTTTGGACAAGGCTCAGGTCAAATTGT
lLeuAspAspValArgCysSerGlyAsnGluSerTyrLeuTrpSerCysProHisLys
||||||| ||||||||||||||| ||||||||||||||| |||||||||
lLeuAspAsnValArgCysSerGlyHisGluSerTyrLeuTrpAsnCysProHisAsn
CCTGGACAATGTGCGTTGCTCAGGACACGAGTCCTACCTGTGGAACTGTCCCCACAAT
GlyTrpLeuThrHisAsnCysGlyHisHisGluAspAlaGlyValIleCysSerAlaT
||||||||| ||||||||| ||| ||||||||||||||||||||||||
GlyTrpLeuSerHisAsnCysAsnHisGlyGluAspAlaGlyValIleCysSerGlyG
GGCTGGCTCTCTCATAACTGTAACCACGGGGAAGATGCTGGTGTCATCTGCTCAGGTG
hrGlnIleAsnSerThrThrThr{As} >>>> Target Intron 16 >>>> {
{||} 6807 bp {
lyThrGlnAspLeuLeuValVal{As}++ -+{
GGACCCAAGATCTTCTTGTGGTG{GA}gt gg{
p}TrpTrpHisProThrThrThrThrThrAla{A} >>>> Target Intron 17
|}|||||| |||||| ||||||||| {|} 3825 bp
p}TrpTrpTyrProThrSerThrThrThrSer{A}++
T}TGGTGGTATCCAACAAGTACAACCACCTCA{A}gt
>>>> {rg}ProSerSerAsnCysGlyGlyPheLeuPheTyrAlaSerGlyThrPh
{||}|||||| ||||||||||||||||||||| ||||||||||||||
++{rg}ProSerLeuAsnCysGlyGlyPheLeuPheAsnAlaSerGlyThrPh
ag{GA}CCTTCTTTAAACTGTGGTGGCTTCTTATTCAATGCCAGTGGGACATT
eSerSerProSerTyrProAlaTyrTyrProAsnAsnAlaLysCysValTrpGluIle
||||||||||||||||||| |||||||||||||||||| |||||||||||||||
eSerSerProSerTyrProGlyTyrTyrProAsnAsnAlaTyrCysValTrpGluIle
TTCCAGTCCATCATATCCTGGATACTACCCCAACAATGCGTACTGTGTCTGGGAAATA
GluValAsnSerGlyTyrArgIleAsnLeuGlyPheSerAsnLeu{Ly} >>>> Ta
|||||| ||||||||||||||||||||||||||| ||||||{ }
GluValSerSerGlyTyrArgIleAsnLeuGlyPheArgAsnLeu{Gl}++
GAAGTGAGTTCCGGTTATCGCATCAACCTCGGCTTCAGAAACTTG{CA}gt
rget Intron 18 >>>> {s}LeuGluAlaHisHisAsnCysSerPheAspTyrV
938 bp { }|||||| ||||||||||||||||
++{n}LeuGluValAsnSerArgCysSerPheAspTyrV
ag{G}TTGGAGGTGAACAGTAGATGCAGTTTTGATTATG
alGluIlePheAspGlySerLeuAsnSerSerLeuLeuLeuGlyLysIleCysAsnAs
||||||||||||||||| |||||| ||| |||||||||||||||||
alGluIlePheAspGlyProSerSerSerSerAsnLeuMetGlyLysIleCysAsnAs
TTGAAATCTTTGATGGACCATCAAGTAGTAGTAATTTGATGGGGAAAATCTGTAATGA
pThrArgGlnIlePheThrSerSerTyrAsnArgMetThrIleHisPheArgSerAsp
|||||||||||||||||||||||||||||||||||||||| ||||||||||||
pThrArgGlnIlePheThrSerSerTyrAsnArgMetThrValArgPheArgSerAsp
CACCAGGCAAATATTCACATCTTCTTACAACCGAATGACGGTTCGATTCCGAAGTGAT
IleSerPheGlnAsnThrGlyPheLeuAlaTrpTyrAsnSerPheProSer{A} >>
||||||||||||||||||||||||||||||||||||||||||||| {|}
ValSerPheGlnAsnThrGlyPheLeuAlaTrpTyrAsnSerPheProArg{A}++
GTCAGTTTCCAAAATACTGGCTTTTTGGCTTGGTATAACTCCTTTCCAAGA{G}gt
>> Target Intron 19 >>>> {sp}AlaThrLeuArgLeuValAsnLeuAsnS
459 bp {||}||| ||||||||||||||| |
++{sp}AlaArgLeuArgLeuValAsnSerGlyS
ag{AT}GCCAGGTTGAGATTGGTCAATTCAGGCT
erSerTyrGlyLeuCysAlaGlyArgValGluIleTyrHisGlyGlyThrTrpGlyTh
||||||||||| ||||||||||||||||||||||||||| ||| ||||||||
erSerTyrGlyAlaCysAlaGlyArgValGluIleTyrHisSerGlyLysTrpGlyTh
CCTCTTATGGTGCATGTGCTGGACGTGTGGAAATTTACCATAGTGGCAAGTGGGGGAC
rValCysAspAspSerTrpThrIleGlnGluAlaGluValValCysArgGlnLeuGly
||||||||||||||||||| ||| ||| ||||||||||||||| |||
rValCysAspAspSerTrpAsnIleTrpAsnAlaGlnValValCysArgGlnValGly
AGTTTGTGATGATTCCTGGAACATTTGGAATGCCCAAGTGGTCTGCAGACAGGTGGGG
CysGlyArgAlaValSerAlaLeuGlyAsnAlaTyrPheGlySerGlySerGlyProI
|||||| |||||||||||| ||||||||| ||||||||||||||||||||||
CysGlyAsnAlaValSerAlaValGlyAsnAlaPhePheGlySerGlySerGlyProI
TGTGGAAATGCAGTATCAGCTGTGGGAAATGCCTTTTTTGGCTCCGGCTCTGGCCCCA
leThrLeuAspAspValGluCysSerGlyThrGluSerThrLeuTrpGlnCysArgAs
||||||||||||||||| ||| ||||||||||||||||||||||||||| ||
leThrLeuAspAspValTyrCysValGlyThrGluSerThrLeuTrpGlnCysGlnAs
TCACCCTGGATGATGTGTACTGTGTAGGAACAGAATCTACTCTCTGGCAGTGCCAGAA
nArgGlyTrpPheSerHisAsnCysAsnHisArgGluAspAlaGlyValIleCysSer
||||||||||||||||||||||||| ||| ||||||||||||||||||||||||
nArgGlyTrpPheSerHisAsnCysGlyHisHisGluAspAlaGlyValIleCysSer
CCGAGGCTGGTTCTCCCACAATTGTGGCCACCATGAAGATGCAGGTGTCATTTGCTCA
GlyAsnHisLeuSerThrProAlaPro{Ph} >>>> Target Intron 20 >>>
||| |||{ } 2126 bp
GlyLysAlaArgCysHisGlyTrpPro{Il}-+
GGTAAGGCACGATGTCATGGATGGCCC{AT}tt
> {e}LeuAsnIleThrArgProAsnThrAspTyrSerCysGlyGlyPheLeuSerG
{ } |||||||||||||||||||||||||
+-{e}IlePheCysPheValLeuThrAlaAsnTyrSerCysGlyGlyPheLeuSerG
ac{C}ATTTTTTGTTTTGTTCTGACAGCAAATTATTCCTGTGGAGGTTTCCTGTCCC
lnProSerGlyAspPheSerSerProPheTyrProGlyAsnTyrProAsnAsnAlaLy
||||||||||| |||||||||||| |||||||||||||||||||||||||||
lnProSerGlyLeuPheSerSerProSerTyrProGlyAsnTyrProAsnAsnAlaAs
AGCCATCAGGGCTCTTTTCCAGTCCATCTTATCCTGGGAACTATCCAAACAATGCCAA
sCysValTrpAspIleGluValGlnAsnAsnTyrArgValThrValIlePheArgAsp
|||||||||||||||||||||||||||||||||||||||||| ||||||||||||
nCysValTrpAspIleGluValGlnAsnAsnTyrArgValThrIleIlePheArgAsp
CTGTGTGTGGGACATTGAAGTCCAGAACAACTACCGCGTGACTATTATCTTCAGAGAT
Val{Gl} >>>> Target Intron 21 >>>> {n}LeuGluGlyGlyCysAsn
|||{||} 2779 bp {|}||||||||||||||||||
Val{Gl}++ ++{n}LeuGluGlyGlyCysAsn
GTT{CA}gt ag{G}CTTGAAGGTGGCTGCAAC
TyrAspTyrIleGluValPheAspGlyProTyrArgSerSerProLeuIleAlaArgV
|||||| ||| |||||||||||||||||| ||||||||||||||||||||||
TyrAspPheIleAspValPheAspGlyProTyrHisSerSerProLeuIleAlaArgV
TATGATTTTATTGACGTTTTTGATGGTCCCTACCACAGTTCCCCTCTCATTGCTCGGG
alCysAspGlyAlaArgGlySerPheThrSerSerSerAsnPheMetSerIleArgPh
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
alCysAspGlyAlaArgGlySerPheThrSerSerSerAsnPheMetSerIleArgPh
TTTGTGATGGAGCTAGGGGCTCCTTCACTTCATCATCAAACTTCATGTCAATTCGCTT
eIleSerAspHisSerIleThrArgArgGlyPheArgAlaGluTyrTyrSerSerPro
|||||||||| |||||| |||||||||||| ||||||||||||||| |||
eIleSerAspSerSerIleSerArgArgGlyPheGlnAlaGluTyrTyrSerThrPro
CATCAGTGATAGCAGCATCTCGAGAAGAGGGTTCCAGGCGGAGTACTACTCGACCCCC
SerAsnAspSerThr{A} >>>> Target Intron 22 >>>> {sn}LeuLeu
|||||||||||||||{|} 1160 bp {||}||||||
SerAsnAspSerThr{A}++ ++{sn}LeuLeu
TCCAATGACAGCACC{A}gt ag{AC}CTACTT
CysLeuProAsnHisMetGlnAlaSerValSerArgSerTyrLeuGlnSerLeuGlyP
||||||||||||||||||||||||||||||||| ||||||||| |||||||||
CysLeuProAsnHisMetGlnAlaSerValSerLysSerTyrLeuHisSerLeuGlyT
TGTCTGCCAAATCACATGCAAGCCAGTGTGAGCAAGAGCTACCTTCATTCCCTGGGCT
heSerAlaSerAspLeuValIleSerThrTrpAsnGlyTyrTyrGluCysArgProGl
|||||| |||||||||||| |||||| ||| ||| |||
yrSerAlaThrAspLeuValIleAlaSerTrpAsnGluAsnTyrProCysGlnProGl
ATTCTGCCACGGACCTTGTCATTGCCAGCTGGAATGAGAACTACCCATGTCAACCTGA
nIleThrProAsnLeuValIlePheThrIleProTyrSerGlyCysGlyThrPheLys
|||||| ||||||||| ||||||||| |||||||||||| |||
uIleThrLeuSerGlnValIlePheSerIleProTyrLeuGlyCysGlyThrIleLys
GATAACACTGAGCCAGGTGATATTCTCAATTCCCTATTTAGGCTGTGGCACCATCAAG
Gln >>>> Target Intron 23 >>>> AlaAspAsnAspThrIleAspTyrS
4432 bp ||||||||||||||| ||||
Lys++ ++ValAspAsnAspThrIleIleTyrS
AAGgt agGTAGACAACGACACCATCATCTATT
erAsnPheLeuThrAlaAlaValSerGlyGlyIleIleLysArgArgThrAspLeuAr
||||||||||| |||||||||||| ||||||||||||||| ||||||
erAsnPheLeuLysAlaAlaValSerSerGlyIleIleLysArgLysLysAspLeuHi
CCAACTTCCTCAAAGCAGCTGTTTCAAGTGGCATCATCAAAAGGAAGAAAGATCTCCA
gIleHisValSerCysArgMetLeuGlnAsnThrTrpValAspThrMetTyrIleAla
||||||||||||||| ||||||||| |||||||||||| ||||||||||||
sIleHisValSerCysLysMetLeuGlnAspThrTrpValAspMetMetTyrIleAla
CATTCATGTCAGCTGTAAGATGCTCCAGGATACCTGGGTTGACATGATGTACATTGCT
AsnAspThrIleHisValAlaAsnAsnThrIleGlnValGluGluValGlnTyrGlyA
|||||| |||||| |||||||||||| |
AsnAsp---------------------ThrIleGluLeuLysGluValGlnTyrSerA
AATGAC---------------------ACCATTGAGCTCAAAGAAGTCCAGTACAGCA
snPheAspValAsnIleSerPheTyrThrSerSerSerPheLeuTyrProValThrSe
||||||||||||||||||||||||||||||||||||||||| ||||||||||||||
snPheAspValAsnIleSerPheTyrThrSerSerSerPheValTyrProValThrSe
ATTTTGATGTGAACATTTCCTTTTATACATCCTCTTCATTCGTATATCCCGTGACCAG
rArgProTyrTyrValAspLeuAsnGlnAspLeuTyrValGlnAlaGluIleLeuHis
| |||||||||||||||||||||||| |||||| |||||||||||||||
rIleProTyrTyrValAspLeuAsnGlnAsnLeuTyrLeuGlnAlaGluIleLeuAsn
CATCCCATACTACGTGGACCTGAACCAGAATTTGTACCTTCAGGCCGAAATTCTCAAT
SerAspAlaValLeuThrLeuPheValAspThrCysValAlaSerProTyrSerAsnA
|||||| ||| ||||||||||||||||||||||||||||||||| |
SerAspAspAsnLeuAlaLeuPheValAspThrCysValAlaSerProTyrPheSerA
TCTGATGATAATCTGGCATTATTTGTGGACACTTGTGTTGCATCACCATACTTCAGTG
spPheThrSerLeuThrTyrAspLeuIleArgSerGly
||||||||||||||||||||||||||||||||||||||
spPheThrSerLeuThrTyrAspLeuIleArgSerGly
ACTTTACATCTTTGACTTATGATCTAATCCGGAGTGGG
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