| Basic information |
| Official Symbol | DCDC5 |
| Description | doublecortin domain containing 5 |
| Other Aliases | hCG_1990724 |
| Other Description | doublecortin domain-containing protein 5 |
| Mutation type | premature termination 186:R->TGA |
| Location | Scaffold000037_9:1367027 1326715 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| DCDC5 |
GTCCCCGTGAGACTCCGCGTGGTGCGGAACGGCGACCTGAAGGGAAACAC GGCCCTGGTTGTGACTGGCCTCGAAGTGCCGTCGGCTGGGAACATGCAGT GCACTGAAGTTTTAAATTTACCTACTGCAGCTCAGAGATTGTTCAGTGAG AGGGGGAAGGAAATCTTTTCCCTGGAAGACCTGCAAAGAGAGGAGCTGGT GTATGTTTCCTGTGGGGAGCACTGGGTCAGTCCTGAGCAGTCCGTCGTTC AGCAACAGAAGCAGCTGTTCCTGCGGCACCTGGCCTCGGACGTTGGCAAG ATCCAGGCCTTCTGCAGCGCCCGGAAGCTTGAGGGTCTTGTTTTGGAAGT CCAAGGTGACATTGTTTCTGGAGCAAAGCTTGCTGTGCATAAACTTAGAG CCGTTTTTGGAGAGGAGAAGCAAATTATAGAAGCAGAGGAAAAGCAAATG CAAAAAAGTGCTTTAACAACAGAAAATGCTTCCAGTGAAATTCGAGACGC GCACGCGAGAGCCCACCTCTGAGCGGGGCCTGTCCCACGTCACTCAGGTA CGCCTGGCGGGAAACGGCATGACCGTGGTGTGGATGGCAGTCTCCCCAAG ACAGTGGAAGGAAGGCTCTTCGAAAATGTGGAGCCACAGAAGAAATATAG CCTTTCACTGAAGTGTAACAAATTGCAAAAGCTTGGCCGTCAGCAATTTG AATACAGAGATGGGCAGATTATCAGCCATGCTGTTCCTCAGCTGGTCTTG GGGGTACAAGGCCCCATCCTCCGCTCGGGCGTGGAGGTGGTTCTGGTGGA GAGGAGCTCTGACGGCAGTCACCAGCACTGGGTGCACCGGGACGACAGCA GGACCTTCCACCTGGTGAGCAGCCCAGACCTCGTGCTGGCGGTGTCTCTG ACCAAGACTGAAGAGGGCGTCTGTGGCTGCCCCGTTATCGTTCAGAAATA TAAGCCTTACACCAATGGGACTGCCAATCAGAAGTGGTGTTACATGGAAA AAAACAAGGTGTTCATGGCCTTTTGTAGCACTGTCCTGGATAAGGAAATC ACATCAGCAAATTACGCTGGCGTTTGTACGTCTTCTGTGATTAAAGAAGG AAGCGTTGATCAACCAGGATACTATTACCTCTCACCTGATGGAAAGAGAA AGACTATGCTCTGCTCAGCTTGCGGACGGTCCATGAGAGCGGAGAGGGAA CTGAAGCAGATGCTTCCAGGGGTTCCTTTCCTCTGTGCATCAGGCTCCAC CACCCAGCTCTTCTCACGAGGGCCTTTCAAGGTCATCCGTGTGGCCAAGG CTGATTTATCATCTCACGACAAAGCTGAAAAAACCCTAAGCCACTACAAA GAACGTCTGCTGTCTCTCCGGATGGAGACCTGCCTGCACGCTGTGCCTCA CTGGGCTCCGGCCGCTGCTCGCCAGAAGGCAGTGAAAGTAATCGCACACA AAAACGGGGCTGGCTTTGGTGATGGGAAGTTCATCGTGGCCCGAACATTC CCCATGCTTCTTACAGAGTGCACAGAACAACTCGGGCTGGCCAGAGCGGC CTCCACAGTGTACACGAGAGATGGGACCGCAGTCCATTCCTTGCGTGATT TGGTTCTATGGGCTCTGGAGGAGTCCTGTATCCAGACTGATGCTGAGGGA CAGAGGACAGAGGCAGCTCCTGCTGGAAGAGAAGAGAGAACTGTGCAAAA AAACCTGAGGATAAAAGTGGAAAGCAAGTTCCTTCCAGACTCCGTGGGGC CGGATAGTTTGGATGGTATAGATAAGTCTTTGCTCGCCCTCGTCCTCAGA AATCCTGTTGCCATCTGGGTATCTTGCGGTGAACCATTTCTTCCTCCAAA TGAAAGAAGCAAAGACAGAGAAACAGAACTGGCTAAAAAAGGACAAAATT TTGGC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 648 | 13 | 648 | Premature termination 186:R->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
AlaProValArgLeuArgValLeuGlnAsnGlyGluLysAsnLysAsnArgSerValThr
|||||||||||||||||| |||||| |||
ValProValArgLeuArgValValArgAsnGlyAspLeuLysGlyAsnThrAlaLeuVal
GTCCCCGTGAGACTCCGCGTGGTGCGGAACGGCGACCTGAAGGGAAACACGGCCCTGGTT
IleLeuGlyProAspIleSerProGlyArgLysThr{Gl} >>>> Target Intron
||| {||} 4498 bp
ValThrGlyLeuGluValProSerAlaGlyAsnMet{Gl}++
GTGACTGGCCTCGAAGTGCCGTCGGCTGGGAACATG{CA}gt
1 >>>> {n}CysThrGluIleLeuAsnLeuProSerAlaAlaArgArgLeuTyrAsn
{|}||||||||| |||||||||||| |||||| ||||||
++{n}CysThrGluValLeuAsnLeuProThrAlaAlaGlnArgLeuPheSer
ag{G}TGCACTGAAGTTTTAAATTTACCTACTGCAGCTCAGAGATTGTTCAGT
GluLysGlyLysGluIlePheAlaLeuLysAspLeuGlnArgAspGluLeu >>>> Ta
||| ||||||||||||||| ||| |||||||||||| ||||||
GluArgGlyLysGluIlePheSerLeuGluAspLeuGlnArgGluGluLeu++
GAGAGGGGGAAGGAAATCTTTTCCCTGGAAGACCTGCAAAGAGAGGAGCTGgt
rget Intron 2 >>>> ValTyrValSerCysGlyGluLeuTrpIleAsnProAspL
2667 bp ||||||||||||||||||||| ||| |||
++ValTyrValSerCysGlyGluHisTrpValSerProGluG
agGTGTATGTTTCCTGTGGGGAGCACTGGGTCAGTCCTGAGC
euSerIleAlaGlnGlnLysLysGlnIlePheLeuArgAsnLeuGluSerAspIleAlaL
||| |||||| |||||| ||||||||| ||| |||||| |
lnSerValValGlnGlnGlnLysGlnLeuPheLeuArgHisLeuAlaSerAspValGlyL
AGTCCGTCGTTCAGCAACAGAAGCAGCTGTTCCTGCGGCACCTGGCCTCGGACGTTGGCA
ysIleGlnIlePheCysSerThrHisLysIleGlu{A} >>>> Target Intron 3
|||||||| ||||||||| ||| |||{ } 1485 bp
ysIleGlnAlaPheCysSerAlaArgLysLeuGlu{G}++
AGATCCAGGCCTTCTGCAGCGCCCGGAAGCTTGAG{G}gt
>>>> {la}LeuValLeuGluValGlnSerAspIleValSerGlySerLysLeuAlaV
{ }|||||||||||||||||| ||||||||||||||| ||||||||||
++{ly}LeuValLeuGluValGlnGlyAspIleValSerGlyAlaLysLeuAlaV
ag{GT}CTTGTTTTGGAAGTCCAAGGTGACATTGTTTCTGGAGCAAAGCTTGCTG
alHisLysProValAlaIlePheGlyGluGluLysGlnValThrGluProGluGluLysG
|||||||| ||| |||||||||||||||||| ||| ||||||||||
alHisLysLeuArgAlaValPheGlyGluGluLysGlnIleIleGluAlaGluGluLysG
TGCATAAACTTAGAGCCGTTTTTGGAGAGGAGAAGCAAATTATAGAAGCAGAGGAAAAGC
lnMetGlnGluAspProLeuThrThrGluAsnAlaSerSerGluIle{Le} >>>> Ta
|||||||| ||||||||||||||||||||||||||||||{ }
lnMetGlnLysSerAlaLeuThrThrGluAsnAlaSerSerGluIle{Ar}++
AAATGCAAAAAAGTGCTTTAACAACAGAAAATGCTTCCAGTGAAATT{CG}gt
rget Intron 4 >>>> {u}AspSerHisValArgAlaHisLeuArgMetLysAlaC
4657 bp { }||| ||| ||||||||||||
++{g}AspAlaHisAlaArgAlaHisLeu***AlaGlyProV
ag{A}GACGCGCACGCGAGAGCCCACCTCTGAGCGGGGCCTG
ysHisThrLeuProArgTyrAlaTrpGlnGluThrSerHisAspPheAspGluAspAspS
|||||| ||| |
alProArgHisSerGlyThrProGlyGlyLys---ArgHisAspArgGlyValAspGlyS
TCCCACGTCACTCAGGTACGCCTGGCGGGAAA---CGGCATGACCGTGGTGTGGATGGCA
erLeuProLysLysThrGluLysGlyLeuPheGluAsnValGluProGlnLysLysHis{
||||||||||| ||| |||||||||||||||||||||||||||||| {
erLeuProLysThrValGluGlyArgLeuPheGluAsnValGluProGlnLysLysTyr{
GTCTCCCCAAGACAGTGGAAGGAAGGCTCTTCGAAAATGTGGAGCCACAGAAGAAATAT{
Se} >>>> Target Intron 5 >>>> {r}CysSerProLysHisSerLysLeuH
||} 1143 bp {|} ||| ||| ||||||
Se}++ ++{r}LeuSerLeuLysCysAsnLysLeuG
AG}gt ag{C}CTTTCACTGAAGTGTAACAAATTGC
isLysHisCysHisGlnGlnPheGluTyrArgAspGlyGlnIleIleSerHisAlaAlaP
||| |||||||||||||||||||||||||||||||||||||||||| |
lnLysLeuGlyArgGlnGlnPheGluTyrArgAspGlyGlnIleIleSerHisAlaValP
AAAAGCTTGGCCGTCAGCAATTTGAATACAGAGATGGGCAGATTATCAGCCATGCTGTTC
roGlnLeuValLeuGlyValGlnGlyProAsnLeuArgSerGlyMetGluValValLeuV
||||||||||||||||||||||||||||| |||||||||||| |||||||||||||
roGlnLeuValLeuGlyValGlnGlyProIleLeuArgSerGlyValGluValValLeuV
CTCAGCTGGTCTTGGGGGTACAAGGCCCCATCCTCCGCTCGGGCGTGGAGGTGGTTCTGG
alGluLysLysSerAspGlySerHisGlnArgTrpIleHisGlnGluAspSer{Ar} >
||||| |||||||||||||||||| ||| ||| ||||||{||}
alGluArgSerSerAspGlySerHisGlnHisTrpValHisArgAspAspSer{Ar}+-
TGGAGAGGAGCTCTGACGGCAGTCACCAGCACTGGGTGCACCGGGACGACAGC{AG}gc
>>> Target Intron 6 >>>> {g}ThrPheHisLeuValSerAsnProAspLeuV
6883 bp {|}|||||||||||||||||| ||||||||||
++{g}ThrPheHisLeuValSerSerProAspLeuV
ag{G}ACCTTCCACCTGGTGAGCAGCCCAGACCTCG
alLeuAlaValSerMetThrLysThrArgAsnGluValCysGlyTyrProValIleValG
|||||||||||||| ||||||||| ||||||||| |||||||||||||
alLeuAlaValSerLeuThrLysThrGluGluGlyValCysGlyCysProValIleValG
TGCTGGCGGTGTCTCTGACCAAGACTGAAGAGGGCGTCTGTGGCTGCCCCGTTATCGTTC
ln >>>> Target Intron 7 >>>> LysTyrLysProTyrAsnAsnGlyAlaAl
|| 2425 bp ||||||||||||||| |||||| ||
ln++ ++LysTyrLysProTyrThrAsnGlyThrAl
AGgt agAAATATAAGCCTTACACCAATGGGACTGC
aAsnGlnLysTrpHisTyrMetLysAsnIleLysAlaLeuValAlaPheHisSerThrAl
||||||||||||| |||||| ||| |||||| ||||||
aAsnGlnLysTrpCysTyrMetGluLysAsnLysValPheMetAlaPheCysSerThrVa
CAATCAGAAGTGGTGTTACATGGAAAAAAACAAGGTGTTCATGGCCTTTTGTAGCACTGT
aLeuAspLysGluIleThrSerAlaAsnTyrAlaGlyValCysThrSerSerValIleLy
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lLeuAspLysGluIleThrSerAlaAsnTyrAlaGlyValCysThrSerSerValIleLy
CCTGGATAAGGAAATCACATCAGCAAATTACGCTGGCGTTTGTACGTCTTCTGTGATTAA
sGluGluAsnIleAspGlnPro >>>> Target Intron 8 >>>> GlyTyrCys
|||| ||||||||| 3407 bp ||||||
sGluGlySerValAspGlnPro++ ++GlyTyrTyr
AGAAGGAAGCGTTGATCAACCAgt agGGATACTAT
TyrLeuSerProAspGlyLysArgLysThrMetLeuCysLeuAlaCysGlyGlnSerMet
||||||||||||||||||||||||||||||||||||||| ||||||||| ||||||
TyrLeuSerProAspGlyLysArgLysThrMetLeuCysSerAlaCysGlyArgSerMet
TACCTCTCACCTGATGGAAAGAGAAAGACTATGCTCTGCTCAGCTTGCGGACGGTCCATG
ArgThrGluLysGlyLeuLysGlnLeuLeuProGlyValProPheLeuCysIleSerGly
||| ||| ||||||||| |||||||||||||||||||||||| ||||||
ArgAlaGluArgGluLeuLysGlnMetLeuProGlyValProPheLeuCysAlaSerGly
AGAGCGGAGAGGGAACTGAAGCAGATGCTTCCAGGGGTTCCTTTCCTCTGTGCATCAGGC
ThrLysThrGlnLysProPheLeuGlnGlyProPheLysValIleSerValAlaGlu >
|||||| ||| |||||||||||||||||| ||||||
SerThrThrGlnLeu---PheSerArgGlyProPheLysValIleArgValAlaLys++
TCCACCACCCAGCTC---TTCTCACGAGGGCCTTTCAAGGTCATCCGTGTGGCCAAGgt
>>> Target Intron 9 >>>> ValAspLeuSerCys<->AspLysAlaGluLysT
6331 bp ||||||||| ||||||||||||||||
++AlaAspLeuSerSerHisAspLysAlaGluLysT
agGCTGATTTATCATCTCACGACAAAGCTGAAAAAA
hrLeuSerTyrTyrGlnAlaArgLeuLeuSerLeuArgMetLysThrCysThrGlnAlaA
|||||||| ||| ||||||||||||||||||||| |||||| |||
hrLeuSerHisTyrLysGluArgLeuLeuSerLeuArgMetGluThrCysLeuHisAlaV
CCCTAAGCCACTACAAAGAACGTCTGCTGTCTCTCCGGATGGAGACCTGCCTGCACGCTG
laSerHisSerGlyMetAlaAlaThrHisGlnLysAlaValLysIleIleAlaTyrLysA
||| |||||| ||||||||||||||| |||||| ||||
alProHisTrpAlaProAlaAlaAlaArgGlnLysAlaValLysValIleAlaHisLysA
TGCCTCACTGGGCTCCGGCCGCTGCTCGCCAGAAGGCAGTGAAAGTAATCGCACACAAAA
snGlyAspGlyTyrArgAsnGlyLysLeuIleValAlaGlyThrPheProMet >>>>
||||| ||| |||||| ||||||||| ||||||||||||
snGlyAlaGlyPheGlyAspGlyLysPheIleValAlaArgThrPheProMet++
ACGGGGCTGGCTTTGGTGATGGGAAGTTCATCGTGGCCCGAACATTCCCCATGgt
Target Intron 10 >>>> LeuLeuThrGluCysThrGluGlnLeuGlyLeuAlaA
1639 bp |||||||||||||||||||||||||||||||||||||
++LeuLeuThrGluCysThrGluGlnLeuGlyLeuAlaA
agCTTCTTACAGAGTGCACAGAACAACTCGGGCTGGCCA
rgAlaAlaSerLysValTyrThrLysAspGlyThrProIlePheThrLeuArgAspLeuV
||||||||||| ||||||||| ||||||||| |||||||||||||
rgAlaAlaSerThrValTyrThrArgAspGlyThrAlaValHisSerLeuArgAspLeuV
GAGCGGCCTCCACAGTGTACACGAGAGATGGGACCGCAGTCCATTCCTTGCGTGATTTGG
alLeuTrpAlaLeuAspGluSerPheLeuGlnArgAspSerGluLysGlnLysGlnAspA
|||||||||||||| |||||| ||| ||| ||| ||| |
alLeuTrpAlaLeuGluGluSerCysIleGlnThrAspAlaGluGlyGlnArgThrGluA
TTCTATGGGCTCTGGAGGAGTCCTGTATCCAGACTGATGCTGAGGGACAGAGGACAGAGG
laAlaProValGlyLysGluGlnIleIleValGlu{L} >>>> Target Intron 1
|||||||| ||| ||| ||| {|} 2555 bp
laAlaProAlaGlyArgGluGluArgThrValGln{L}++
CAGCTCCTGCTGGAAGAGAAGAGAGAACTGTGCAA{A}gt
1 >>>> {ys}AsnProArgMetLysValLysAsnArgLeuPheAlaLysSerValThr
{||}||| ||| |||||| ||||||
++{ys}AsnLeuArgIleLysValGluSerLysPheLeuProAspSerValGly
ag{AA}AACCTGAGGATAAAAGTGGAAAGCAAGTTCCTTCCAGACTCCGTGGGG
SerAspSerLeuAspGlyIleAspLysSerLeuLeuThrLeuIleLeuArgAsnProIle
||||||||||||||||||||||||||||||||| ||| ||||||||||||
ProAspSerLeuAspGlyIleAspLysSerLeuLeuAlaLeuValLeuArgAsnProVal
CCGGATAGTTTGGATGGTATAGATAAGTCTTTGCTCGCCCTCGTCCTCAGAAATCCTGTT
AlaIleTrpValSerCysGlyGluProPheLeuProProAsn{G} >>>> Target I
||||||||||||||||||||||||||||||||||||||||||{|} 718
AlaIleTrpValSerCysGlyGluProPheLeuProProAsn{G}++
GCCATCTGGGTATCTTGCGGTGAACCATTTCTTCCTCCAAAT{G}gt
ntron 12 >>>> {lu}SerArgLysIleArgGluThrGluLeuAlaLysLysGlyGl
bp {||} ||| |||||||||||||||||||||||||||||
++{lu}ArgSerLysAspArgGluThrGluLeuAlaLysLysGlyGl
ag{AA}AGAAGCAAAGACAGAGAAACAGAACTGGCTAAAAAAGGACA
nAsnPheGly
||||||||||
nAsnPheGly
AAATTTTGGC
//
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