Basic information
Official Symbol CUL7
Descriptioncullin 7
Other AliasesKIAA0076, dJ20C7.5
Other DescriptionCUL-7; cullin-7
Mutation typepremature termination 252:E->TAG
LocationScaffold000238_1:982676 1003628 +

  ±  bp flank
WikiWikipedia GeneCard
Sequence
CUL7
GTCCCGCGGAGGCACGCCCACTCCCGCCTCTCCGCCTCGACCCCCTCGGG
GGGACCAGGTGCCGGGATGGTGGGGGAGCTCCGCTTCAGGGAATTCAGGG
TGCCTCTGGGCCCCGGCTTGCATGCCTACCCTGATGAGCTGATCCGCCAG
CGAGTGGGCCACGATGGGCATCTGGAGTACCAGATCCGCTGGCTCATCCT
TAGGCGTGGGGATGACGGCGATGTGGGCAGCGGCCAGGTGGACTGCAAGG
CCGAGCACATCCTGCTGTGGATGTCCAACGACGAGATCTATGCCAACTGC
CACAAGATGCTGGGCGAGGACGGCCAGGTGATCGGGCCCTCCCAGGAGTC
TGCAGGGGAGACTGGGGCCCTGGACAAAGCTGTGCTGGGCGAGATGGAAA
CCGACGTGAAGTCCCTGATTCAGAGGGCCCTGCGGCAGCTGGAGGAATGT
GTGGGCACTACCCCTCCAGCTGCTCTGCTTCACACTGTCCACGTGCTCAG
CGCCTACGCCAGCATCGAGCCCCTCACTGGCGTCTTCAGAGACCCGCAGG
TTCTCAGCTTGCTCATGCACATGCTGAGCAGCCCCGACTATCAGATCCGC
TGGAGCGCGGGCCGGATGATACAAGCCCTGTCCTCCCATGATGCCGGTGA
GGGCCAGCGTGGGTAGGAAGGGAGCACAGGAGAGGGGCTGGGTTGGCTCA
GGGACTCAGCACACTGCAGGGAGCCTCTGACCTCGCCAGTAAAGACGCGG
ACCCAGATCCTTCTGTCACTGAGCCAGCAAGAGGCCATTGAGAAACACCT
GGATTTTGACAGCCGCTGCGCGCTGCTAGCGTTGTTTGCACAGGCCACGC
TCGCGGAACATCCCATGTCTTTTGAGGGCATTCAGCTGCCACAGGTCCCA
GGAAGGCTGCTCTTCTGCCTGGTGAAGCACTATTTGAACGTCACCTCCCT
CCTGGATCAGCTGAATGACCATGCTGCGGAGCCAGGAGCCCAGAACAGCT
CTTCCCCAGAAGAGTCTAGTGGGGAGAGGGGTCGATTGGAGCTGGAGTTC
AGTATGGCCATGGGCACCCTGATCTCGGAGCTTGTGCAGGCCATGCGCTG
GGATCGGGCCTCCAGCAGACCAGGGAGCTTGGCACGATCCCCTTGTTCCA
TCTTCCAGCCTCAGCCTGCAGATGCAGGCCCAGGGCTCCCGCCTGCTCAG
GCCCAGCTCTCCCTCAGGAGGTCGAGGCGGTTTCGCCCTCGCTCTGAGTT
TGCTAGTGGCAATACCTACGCCTTATACGTGCGGGACATGCTGCAGCCAG
GCATGCGAGTGCGGATGCTGGATGATTACGAGGAGATCAGTGCTGGGGAC
CAGGGGGAGTTCCGGCAGAGCAACAGCGGTGTGCCCCCCGTGCAGGTGCT
GTGGGAGTCAACAGGTCGCACCTATTGGGTGCACTGGCACATGCTGGAGA
TCCTAGGCTTTGAGGAAGACATCGAGGGTGTGGTGGAGGCTGATGAATAC
CAGAAGGCAGGAGGCAGTGGAGCTCTGGGTGGAGCTCTGCCCTCCTGGCG
CTGGAAGCCCATGACAGAACTCTACGCCATGCCCTACGTGCCACCTGAGG
ATGAGGACACAGAGGAGAGTGAACACCTGACCCAGGCCGAGTGGTGGGAG
CTCCTCTTCTTCATCAAGAAGCTGCCTGAACCTGACCGCCAGGAGGTTCT
CCAGATCCTCCAGGAGAACCTAGATGGGGAGATTCTGGATGATGAGATTC
TGGCTGAGCTGGCCATGCCCATAGAGTTGGCCCAGGACCTGCTGCTGGCT
CTGCCACAGCGACTCGATGACAGCACCCTGAGGGACCTGCTCAACTGCCG
TGTCTACAGGAAGTATGGGCAGCCAGCCTACCCATCCCTTCTGGAAGCCC
AGCAAGATACCCTCCTGCTAGACACCCAGGCCCAGCCTCAGGAATCAGAA
GATGCAGCGAGAGTGGAAGTGAAAGAATCTCCATCTCAGAGCCCCAACAC
TCCCTTGCGGCAGCTGGTGGAAGGTTATGGTCCAGCGGGGAAGATCCTCC
TGGACCTAGAGCGAGTACTCAGTGCAGAGGGGATCCAGGACAGTGAGGTC
AAGCCTTTCCTGCTGCAGCTGCAGCGGCAGGCCCCGCCCCTCCCCCAGAG
CCTGGACACTCCAGCAACCAATAAGGCCCTGCATCTCACCGTTCTGAGAC
TCCTGATGCAGCTGGTGGACTTCCCTGAGGCACTGCTGCTCCCCTGGCAC
GAGGCCATGGACGCCTGCATGGTCTGCCTGCGGTCCCCAAACACTGACCG
AGAGGTGCTGCAGGAACTGATCTTCTTCCTGCACCGCCTGACCTCAGCGA
GCAGGGACTATGCTGTGGTGCTGAACCAGCTGGGAGCCCGAGAGGCCATC
TCCAAGGCCTTGGAAAAGCACCTGGGGAAGCTGGAGCTGGCTCAAGAGCT
GCGGGACATGGTGTTCAAGTGTGAGAAGCATGCCCACCTCTACCGGAAGC
TCACCACCAACATCCTGGGAGGCTGCATCCAGATGGTGCTGGGCCAGATC
GAAGACCACCGACGAACCCACCGGCCCATCAACATCCCCTTCTTTGATGT
GTTCCTCAGATATCTGTGCCAGGGCTCCAGTGTGGAGGTGAAGGAGGACA
AGTGCTGGGAGAAGGTGGAGGTGTCCTCCAACCCGCACCGGGCCAGCAAG
CTGACAGACCGCAACCCCAAGACCTACTGGGAGTCCAACGGCAGCGCGGG
CTCCCATCACATCACCTTGCACATGCGCCAAGGTGTCCTCATCAGGCAGC
TGACTCTTCTGGTGGCCAGTGAGGACTCAAGCTACATGCCGGCCCGGGTG
GTGGTGTGCGGGGGCGACAGCACCAGCTCTCTTAACACGGAACTCAACGC
GGTGAATGTGATGCCCTCTGCCAGCCGGGTGCCCCTCCTAGAGANNNNNN
NNNNNNNNNNNNNNNNNNNNNNTGAAACAGGCCCGTGTGCATTGCAGGGC
GGCATCGACACGCGGATTCGGGGCTTGGAGGTGCTGGGCCCCAAGCCCAC
GTTCTGGCCAGTGTTCCGGGAGCAGCTATGTCGTCACACACGCCTCTTTT
ACATGGTGCGGGCGCAGGCCTGGAGCCAGGACATAGCTGAGGACCGCAGG
AGCCTCCTGCACCTGAGTTCTAGACTCAATGGGGCTCTGCGCCACGAGCA
GAATTTTGCTGACCGCTTCCTCCCTGACGATGAGGCCGCCCAAGCCCTGG
GCAAGACCTGCTGGGAGGCCCTGGTCAGCCCCCTGGTGCAGAACATCACT
TCGCCTGATGACGATGGCATCAGCCCCCTGGGCTGGCTGCTGGACCAGTA
CCTGGAGTGTCGGGAAGCTGCCCACAACCCCCAGAGCCGCGCAGCAGCTT
TCTCCTCACGGGTGCGCCGCCTCACCCACCTGCTGGTGCACGTTGAGCCC
TGCGAGGCGCCTCCTCCTGCGGCGGCCACTCCTCGGCCCAAGGGCAGAAA
CAGAAGCCATGACTGGAGCTCCTTGGCCACCCGCGGCCTTCCGAGCAGCA
TCATGAGAAATCTGACCCGCTGTTGGCGGTCTGTGGTGGAGGAGCAGGTG
GACGGTTTTCTGACCTCACACTGGCAGGATGATGACTTTGTGCCACGCTA
CTGTGAGCATTTCAGTAACCTGCAGAAGTCCAGCTCCGAGCTGTTCGGGC
CCCGGGCGGCCTTCCTGCTGGCGCTGCAGAGTGGCTGTGCTGGTGCCTTG
CTGAAGCTCCCTTTTCTCAGAGCTGCCCATGTGAGCGAGCAGTTTGCCCG
GCACATCGACCAGCGGATCCAGGGCAGTCGGATTGGTGGAGCCCGGGGAA
TGGAGATGCTGGCACAACTGCTGCGCTGCCTGGAAACCGTCCTGCTTTTC
TCGGGCCTGGAGATAGCCACCACCTTTGAGCATTACTACCAGCAGTACAT
GGCGGACCGGCTCCTGGGCGTGGGCTCCAGCTGGCTGGAGGGGGCCGTGC
TGGAGCAGATCGGCCCGTGCTTCCCCAACCGCCTTCCGCAGCAGATGCTG
CAGAGTCTGAGCACCTCGGAGGAGCTGCAGCGCCAGTTCCATGTCTACCA
GCTCCAGCGGCTCGATCAGGAGCTCCTGAAGCTGGAGGACACAGAGAAGA
AGGTGCAGGTGGGCTTTGAGGCCGGTGGCCAGAAGTTCGAGAATGGGAAG
GAAGAGGAAGCTGGGGCAGCAGTGGCAGTGGACGTGGTGGAGGGAGAGGA
GGAGGAGAACGAGGACCTTTACTATGAAGGGACAATGCCAGAAGTGTCTG
TGCTTGTCCTGTCCCCACGCTGCTGGCCCGTCGCCTCCATCTGCCACACA
CTGAACCCCAGAACATGCCTGCCCTCCTACCTGAGGGGTACTTTGAACCG
ATACTCCAACTTCTACAATAAGAGTCAGAGCCACCTTGCCCTAGAGCAAA
GCTCACAGAGGCGACTGCAGTGGACGTGGCTGGGCCGGGCTGAGCTGCAG
TTTGGGGACCAGACCCTGCATGTGTCCACCGTACAGATGTGGCTGCTGCT
GTATCTCAACGATCTGAAGGCCATCTCTGTGGGCAGTCTGCTGAAGCTCT
CGGGGCTCTCCCCAGACACACTGAACCAGGCAGTTGAGCCTCTCACCTCT
TCAAGAGGCCCCTTGGACCTTCACGAGCAGAAGGATATGCCAGGAGGGGT
GCTGAAGATTCGAGATGGCGAGGAACCCAGGCCAAGAAGGGGCAGCGTGT
GGCTCATCCCACCTCAGACGTACGTGAAAGCTGAGGATGAAGAGGGCCGG
AACTTGGAGAAGAGGCGGANNNNNNNNNNNNNNNNNNNNNNNCGAATCCT
CAAGGCCCAGGGGGATGAGGGGCTGCACATTGACCAGCTTGTCTGTCTGG
TGCTGGAGGCGTGGCAGAAGGGCCCGTGTCCCCCCAGGGGTTTGGTCAGC
AGCCTGGGCAGGGGGTCCGCCTGCGGCAGTGCAGACGTCCTCTCCTGCAT
CCTGCACCTCCTGGGCAAGGGCACGCTGAGACGCCATGACGACCGGCCCC
AGATGCTGTCCTACGCAGTCCCTGTGACCGTGTTGGAGCCTCACACAGAG
TCCCTGAACCCAGGCTCCTCGGGCCCCAACCCGCCCCTCACCTTCCACAC
CCTGCAGATTCGCTCTCGGGGTGTGCCCTATGCCTCCTGCACGGGCACCC
AGAGCTTCTCTACCTTCCGG

Alignment
Align speciePep lengthPep align beginPep align endMutaion type and postion
Human1782311782Premature termination 252:E->TAG
 Instructions:
 *** -> premature termination codon;  # -> frame shift 

 Alignment:
 Human     pep sequence --->
 ||||||||||||||||||||||
 Treeshrew pep sequence --->
 Treeshrew cds sequence --->
  
 ValProArgArgHisAlaProSerArgLeuSerValSerThrProSerArgGlyPro{G}
 ||||||||||||||||||   ||||||||||||   ||||||||||||   ||||||{|}
 ValProArgArgHisAlaHisSerArgLeuSerAlaSerThrProSerGlyGlyPro{G}
 GTCCCGCGGAGGCACGCCCACTCCCGCCTCTCCGCCTCGACCCCCTCGGGGGGACCA{G}

   >>>> Target Intron 1 >>>>  {ly}AlaArgMetValGlyGluLeuArgTyr
             798 bp           {||}|||   ||||||||||||||||||   
 +-                         ++{ly}AlaGlyMetValGlyGluLeuArgPhe
 gc                         ag{GT}GCCGGGATGGTGGGGGAGCTCCGCTTC

 ArgGluPheArgValProLeuGlyProGlyLeuHisAlaTyrProAspGluLeuIleArg
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ArgGluPheArgValProLeuGlyProGlyLeuHisAlaTyrProAspGluLeuIleArg
 AGGGAATTCAGGGTGCCTCTGGGCCCCGGCTTGCATGCCTACCCTGATGAGCTGATCCGC

 GlnArgValGlyHisAspGlyHisProGluTyrGlnIleArgTrpLeuIleLeuArgArg
 ||||||||||||||||||||||||   |||||||||||||||||||||||||||||||||
 GlnArgValGlyHisAspGlyHisLeuGluTyrGlnIleArgTrpLeuIleLeuArgArg
 CAGCGAGTGGGCCACGATGGGCATCTGGAGTACCAGATCCGCTGGCTCATCCTTAGGCGT

 GlyAspGluGlyAspGlyGlySerGlyGlnValAspCysLysAlaGluHisIleLeuLeu
 ||||||   ||||||   ||||||||||||||||||||||||||||||||||||||||||
 GlyAspAspGlyAspValGlySerGlyGlnValAspCysLysAlaGluHisIleLeuLeu
 GGGGATGACGGCGATGTGGGCAGCGGCCAGGTGGACTGCAAGGCCGAGCACATCCTGCTG

 TrpMetSerLysAspGluIleTyrAlaAsnCysHisLysMetLeuGlyGluAspGlyGln
 |||||||||   ||||||||||||||||||||||||||||||||||||||||||||||||
 TrpMetSerAsnAspGluIleTyrAlaAsnCysHisLysMetLeuGlyGluAspGlyGln
 TGGATGTCCAACGACGAGATCTATGCCAACTGCCACAAGATGCTGGGCGAGGACGGCCAG

 ValIleGlyProSerGlnGluSerAlaGlyGluValGlyAlaLeuAspLysSerValLeu
 |||||||||||||||||||||||||||||||||   |||||||||||||||   ||||||
 ValIleGlyProSerGlnGluSerAlaGlyGluThrGlyAlaLeuAspLysAlaValLeu
 GTGATCGGGCCCTCCCAGGAGTCTGCAGGGGAGACTGGGGCCCTGGACAAAGCTGTGCTG

 GluGluMetGluThrAspValLysSerLeuIleGlnArgAlaLeuArgGlnLeuGluGlu
    |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 GlyGluMetGluThrAspValLysSerLeuIleGlnArgAlaLeuArgGlnLeuGluGlu
 GGCGAGATGGAAACCGACGTGAAGTCCCTGATTCAGAGGGCCCTGCGGCAGCTGGAGGAA

 CysValGlyThrIleProProAlaProLeuLeuHisThrValHisValLeuSerAlaTyr
 ||||||||||||   |||||||||   |||||||||||||||||||||||||||||||||
 CysValGlyThrThrProProAlaAlaLeuLeuHisThrValHisValLeuSerAlaTyr
 TGTGTGGGCACTACCCCTCCAGCTGCTCTGCTTCACACTGTCCACGTGCTCAGCGCCTAC

 AlaSerIleGluProLeuThrGlyValPheLysAspProArgValLeuAspLeuLeuMet
 ||||||||||||||||||||||||||||||   ||||||   ||||||   |||||||||
 AlaSerIleGluProLeuThrGlyValPheArgAspProGlnValLeuSerLeuLeuMet
 GCCAGCATCGAGCCCCTCACTGGCGTCTTCAGAGACCCGCAGGTTCTCAGCTTGCTCATG

 HisMetLeuSerSerProAspTyrGlnIleArgTrpSerAlaGlyArgMetIleGlnAla
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 HisMetLeuSerSerProAspTyrGlnIleArgTrpSerAlaGlyArgMetIleGlnAla
 CACATGCTGAGCAGCCCCGACTATCAGATCCGCTGGAGCGCGGGCCGGATGATACAAGCC

 LeuSerSerHisAspAlaGlyGluGlyGlnCysGlyGluGluGlyLysAlaGlyGluGly
 ||||||||||||||||||||||||||||||   |||   ||||||      |||||||||
 LeuSerSerHisAspAlaGlyGluGlyGlnArgGly***GluGlySerThrGlyGluGly
 CTGTCCTCCCATGATGCCGGTGAGGGCCAGCGTGGGTAGGAAGGGAGCACAGGAGAGGGG

 LeuGlyArgLeuArgAspSerGlnAspThrValAlaGlyAlaSerAspLeuIle{A}  >
 ||||||   ||||||||||||                                 { }   
 LeuGlyTrpLeuArgAspSerAlaHisCysArgGluProLeuThrSerProVal{L}-+ 
 CTGGGTTGGCTCAGGGACTCAGCACACTGCAGGGAGCCTCTGACCTCGCCAGTA{A}at 

 >>> Target Intron 2 >>>>  {rg}ThrArgThrGlnIleLeuLeuSerLeuSer
          790 bp           {  }||||||||||||||||||||||||||||||
                         ++{ys}ThrArgThrGlnIleLeuLeuSerLeuSer
                         ag{AG}ACGCGGACCCAGATCCTTCTGTCACTGAGC

 GlnGlnGluAlaIleGluLysHisLeuAspPheAspSerArgCysAlaLeuLeuAlaLeu
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 GlnGlnGluAlaIleGluLysHisLeuAspPheAspSerArgCysAlaLeuLeuAlaLeu
 CAGCAAGAGGCCATTGAGAAACACCTGGATTTTGACAGCCGCTGCGCGCTGCTAGCGTTG

 PheAlaGlnAlaThrLeuSerGluHisProMetSerPheGluGlyIleGlnLeuProGln
 ||||||||||||||||||   |||||||||||||||||||||||||||||||||||||||
 PheAlaGlnAlaThrLeuAlaGluHisProMetSerPheGluGlyIleGlnLeuProGln
 TTTGCACAGGCCACGCTCGCGGAACATCCCATGTCTTTTGAGGGCATTCAGCTGCCACAG

   >>>> Target Intron 3 >>>>  ValProGlyArgValLeuPheSerLeuValL
             120 bp           ||||||||||||   ||||||   |||||||
 ++                         ++ValProGlyArgLeuLeuPheCysLeuValL
 gt                         agGTCCCAGGAAGGCTGCTCTTCTGCCTGGTGA

 ysArgTyrLeuHisValThrSerLeuLeuAspGlnLeuAsnAspSerAlaAlaGluProG
 ||   ||||||   ||||||||||||||||||||||||||||||   |||||||||||||
 ysHisTyrLeuAsnValThrSerLeuLeuAspGlnLeuAsnAspHisAlaAlaGluProG
 AGCACTATTTGAACGTCACCTCCCTCCTGGATCAGCTGAATGACCATGCTGCGGAGCCAG

 lyAlaGlnAsnThrSerAlaProGluGluLeuSerGlyGluArgGlyGlnLeuGluLeuG
 |||||||||||   |||   |||||||||   |||||||||||||||   ||||||||||
 lyAlaGlnAsnSerSerSerProGluGluSerSerGlyGluArgGlyArgLeuGluLeuG
 GAGCCCAGAACAGCTCTTCCCCAGAAGAGTCTAGTGGGGAGAGGGGTCGATTGGAGCTGG

 luPheSerMetAlaMetGlyThrLeuIleSerGluLeuValGlnAlaMetArgTrpAspG
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
 luPheSerMetAlaMetGlyThrLeuIleSerGluLeuValGlnAlaMetArgTrpAspA
 AGTTCAGTATGGCCATGGGCACCCTGATCTCGGAGCTTGTGCAGGCCATGCGCTGGGATC

 lnAlaSerAspArgProArgSerSerAlaArgSerProGlySerIlePheGlnProGlnL
   ||||||   ||||||   |||   ||||||||||||   |||||||||||||||||| 
 rgAlaSerSerArgProGlySerLeuAlaArgSerProCysSerIlePheGlnProGlnP
 GGGCCTCCAGCAGACCAGGGAGCTTGGCACGATCCCCTTGTTCCATCTTCCAGCCTCAGC

 euAlaAspValSerProGlyLeuProAlaAlaGlnAlaGlnProSerPheArgArgSerA
   ||||||      ||||||||||||   ||||||||||||   |||   ||||||||||
 roAlaAspAlaGlyProGlyLeuProProAlaGlnAlaGlnLeuSerLeuArgArgSerA
 CTGCAGATGCAGGCCCAGGGCTCCCGCCTGCTCAGGCCCAGCTCTCCCTCAGGAGGTCGA

 rgArgPheArgProArgSerGluPheAlaSerGlyAsnThrTyrAlaLeuTyrValArgA
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 rgArgPheArgProArgSerGluPheAlaSerGlyAsnThrTyrAlaLeuTyrValArgA
 GGCGGTTTCGCCCTCGCTCTGAGTTTGCTAGTGGCAATACCTACGCCTTATACGTGCGGG

 spThrLeuGlnProGlyMetArgValArgMetLeuAspAspTyrGluGluIleSerAlaG
 ||   |||||||||||||||||||||||||||||||||||||||||||||||||||||||
 spMetLeuGlnProGlyMetArgValArgMetLeuAspAspTyrGluGluIleSerAlaG
 ACATGCTGCAGCCAGGCATGCGAGTGCGGATGCTGGATGATTACGAGGAGATCAGTGCTG

 lyAspGluGlyGluPheArgGlnSerAsnAsnGlyValProProValGln  >>>> Tar
 |||||   |||||||||||||||||||||   ||||||||||||||||||          
 lyAspGlnGlyGluPheArgGlnSerAsnSerGlyValProProValGln++        
 GGGACCAGGGGGAGTTCCGGCAGAGCAACAGCGGTGTGCCCCCCGTGCAGgt        

 get Intron 4 >>>>  ValPheTrpGluSerThrGlyArgThrTyrTrpValHisTr
   469 bp           |||   |||||||||||||||||||||||||||||||||||
                  ++ValLeuTrpGluSerThrGlyArgThrTyrTrpValHisTr
                  agGTGCTGTGGGAGTCAACAGGTCGCACCTATTGGGTGCACTG

 pHisMetLeuGluIleLeuGlyPheGluGluAspIleGluAspMetValGluAlaAspGl
 ||||||||||||||||||||||||||||||||||||||||      ||||||||||||||
 pHisMetLeuGluIleLeuGlyPheGluGluAspIleGluGlyValValGluAlaAspGl
 GCACATGCTGGAGATCCTAGGCTTTGAGGAAGACATCGAGGGTGTGGTGGAGGCTGATGA

 uTyrGlnGlyAlaValAlaSerArgValLeuGlyArg{A}  >>>> Target Intron
 |||||||   |||      |||      ||||||   {|}            87 bp   
 uTyrGlnLysAlaGlyGlySerGlyAlaLeuGlyGly{A}++                  
 ATACCAGAAGGCAGGAGGCAGTGGAGCTCTGGGTGGA{G}gt                  

  5 >>>>  {la}LeuProAlaTrpArgTrpArgProMetThrGluLeuTyrAlaValPr
          {||}||||||   |||||||||   |||||||||||||||||||||   ||
        ++{la}LeuProSerTrpArgTrpLysProMetThrGluLeuTyrAlaMetPr
        ag{CT}CTGCCCTCCTGGCGCTGGAAGCCCATGACAGAACTCTACGCCATGCC

 oTyrValLeuProGluAspGluAspThrGluGluCysGluHisLeuThrLeuAlaGluTr
 |||||||   ||||||||||||||||||||||||   ||||||||||||   ||||||||
 oTyrValProProGluAspGluAspThrGluGluSerGluHisLeuThrGlnAlaGluTr
 CTACGTGCCACCTGAGGATGAGGACACAGAGGAGAGTGAACACCTGACCCAGGCCGAGTG

 pTrpGluLeuLeuPhePheIleLysLysLeuAspGlyProAspHisGlnGluValLeuGl
 |||||||||||||||||||||||||||||||      ||||||   ||||||||||||||
 pTrpGluLeuLeuPhePheIleLysLysLeuProGluProAspArgGlnGluValLeuGl
 GTGGGAGCTCCTCTTCTTCATCAAGAAGCTGCCTGAACCTGACCGCCAGGAGGTTCTCCA

 nIleLeuGlnGluAsnLeuAspGlyGlu  >>>> Target Intron 6 >>>>  Ile
 ||||||||||||||||||||||||||||            299 bp           |||
 nIleLeuGlnGluAsnLeuAspGlyGlu++                         ++Ile
 GATCCTCCAGGAGAACCTAGATGGGGAGgt                         agATT

 LeuAspAspGluIleLeuAlaGluLeuAlaValProIleGluLeuAlaGlnAspLeuLeu
 ||||||||||||||||||||||||||||||   |||||||||||||||||||||||||||
 LeuAspAspGluIleLeuAlaGluLeuAlaMetProIleGluLeuAlaGlnAspLeuLeu
 CTGGATGATGAGATTCTGGCTGAGCTGGCCATGCCCATAGAGTTGGCCCAGGACCTGCTG

 LeuThrLeuProGlnArgLeuAsnAspSerAlaLeuArgAspLeuIleAsnCysHisVal
 |||   |||||||||||||||   ||||||   ||||||||||||   ||||||   |||
 LeuAlaLeuProGlnArgLeuAspAspSerThrLeuArgAspLeuLeuAsnCysArgVal
 CTGGCTCTGCCACAGCGACTCGATGACAGCACCCTGAGGGACCTGCTCAACTGCCGTGTC

 TyrLysLysTyrGlyProGluAlaLeuAlaGlyAsnGlnAlaTyrProSerLeuLeuGlu
 |||   ||||||                  |||      |||||||||||||||||||||
 TyrArgLysTyr------------------GlyGlnProAlaTyrProSerLeuLeuGlu
 TACAGGAAGTAT------------------GGGCAGCCAGCCTACCCATCCCTTCTGGAA

 AlaGlnGluAspValLeuLeuLeuAspAlaGlnAlaGlnAlaLysAspSerGluAspAla
 ||||||   |||   ||||||||||||   |||||||||         ||||||||||||
 AlaGlnGlnAspThrLeuLeuLeuAspThrGlnAlaGlnProGlnGluSerGluAspAla
 GCCCAGCAAGATACCCTCCTGCTAGACACCCAGGCCCAGCCTCAGGAATCAGAAGATGCA

 AlaLysValGlu{A}  >>>> Target Intron 7 >>>>  {la}LysGluProPro
 |||   ||||||{ }           2988 bp           {  }||||||   |||
 AlaArgValGlu{V}++                         ++{al}LysGluSerPro
 GCGAGAGTGGAA{G}gt                         ag{TG}AAAGAATCTCCA

 SerGlnSerProAsnThrProLeuGlnArgLeuValGluGlyTyrGlyProAlaGlyLys
 ||||||||||||||||||||||||      ||||||||||||||||||||||||||||||
 SerGlnSerProAsnThrProLeuArgGlnLeuValGluGlyTyrGlyProAlaGlyLys
 TCTCAGAGCCCCAACACTCCCTTGCGGCAGCTGGTGGAAGGTTATGGTCCAGCGGGGAAG

 IleLeuLeuAspLeuGluGlnAlaLeuSerSerGluGlyThrGlnGluAsnLysValLys
 ||||||||||||||||||      ||||||   ||||||   |||         ||||||
 IleLeuLeuAspLeuGluArgValLeuSerAlaGluGlyIleGlnAspSerGluValLys
 ATCCTCCTGGACCTAGAGCGAGTACTCAGTGCAGAGGGGATCCAGGACAGTGAGGTCAAG

 ProLeuLeuLeuGlnLeuGlnArgGlnProGlnProPheLeuAlaLeuMetGlnSerLeu
 |||   |||||||||||||||||||||      |||         |||   |||||||||
 ProPheLeuLeuGlnLeuGlnArgGlnAlaProPro---------LeuProGlnSerLeu
 CCTTTCCTGCTGCAGCTGCAGCGGCAGGCCCCGCCC---------CTCCCCCAGAGCCTG

 AspThrProGluThrAsnArgThrLeuHisLeuThrValLeu{Ar}  >>>> Target 
 |||||||||   ||||||      ||||||||||||||||||{||}            73
 AspThrProAlaThrAsnLysAlaLeuHisLeuThrValLeu{Ar}++            
 GACACTCCAGCAACCAATAAGGCCCTGCATCTCACCGTTCTG{AG}gt            

 Intron 8 >>>>  {g}IleLeuLysGlnLeuValAspPheProGluAlaLeuLeuLeu
  bp            {|}   |||   |||||||||||||||||||||||||||||||||
              ++{g}LeuLeuMetGlnLeuValAspPheProGluAlaLeuLeuLeu
              ag{A}CTCCTGATGCAGCTGGTGGACTTCCCTGAGGCACTGCTGCTC

 ProTrpHisGluAlaValAspAlaCysMetAlaCysLeuArgSerProAsnThrAspArg
 |||||||||||||||   ||||||||||||   |||||||||||||||||||||||||||
 ProTrpHisGluAlaMetAspAlaCysMetValCysLeuArgSerProAsnThrAspArg
 CCCTGGCACGAGGCCATGGACGCCTGCATGGTCTGCCTGCGGTCCCCAAACACTGACCGA

 Glu  >>>> Target Intron 9 >>>>  ValLeuGlnGluLeuIlePhePheLeuH
 |||           1760 bp           ||||||||||||||||||||||||||||
 Glu++                         ++ValLeuGlnGluLeuIlePhePheLeuH
 GAGgt                         agGTGCTGCAGGAACTGATCTTCTTCCTGC

 isArgLeuThrSerValSerArgAspTyrAlaValValLeuAsnGlnLeuGlyAlaArgA
 ||||||||||||||   |||||||||||||||||||||||||||||||||||||||||| 
 isArgLeuThrSerAlaSerArgAspTyrAlaValValLeuAsnGlnLeuGlyAlaArgG
 ACCGCCTGACCTCAGCGAGCAGGGACTATGCTGTGGTGCTGAACCAGCTGGGAGCCCGAG

 spAlaIleSerLysAlaLeuGluLysHisLeuGlyLysLeuGluLeuAlaGlnGluLeuA
   ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 luAlaIleSerLysAlaLeuGluLysHisLeuGlyLysLeuGluLeuAlaGlnGluLeuA
 AGGCCATCTCCAAGGCCTTGGAAAAGCACCTGGGGAAGCTGGAGCTGGCTCAAGAGCTGC

 rgAspMetValPheLysCysGluLysHisAlaHisLeuTyrArgLysLeuIleThrAsnI
 ||||||||||||||||||||||||||||||||||||||||||||||||||   |||||||
 rgAspMetValPheLysCysGluLysHisAlaHisLeuTyrArgLysLeuThrThrAsnI
 GGGACATGGTGTTCAAGTGTGAGAAGCATGCCCACCTCTACCGGAAGCTCACCACCAACA

 leLeuGlyGlyCysIleGln  >>>> Target Intron 10 >>>>  MetValLeuG
 ||||||||||||||||||||            268 bp            ||||||||||
 leLeuGlyGlyCysIleGln++                          ++MetValLeuG
 TCCTGGGAGGCTGCATCCAGgt                          agATGGTGCTGG

 lyGlnIleGluAspHisArgArgThrHisGlnProIleAsnIleProPhePheAspValP
 |||||||||||||||||||||||||||||   ||||||||||||||||||||||||||||
 lyGlnIleGluAspHisArgArgThrHisArgProIleAsnIleProPhePheAspValP
 GCCAGATCGAAGACCACCGACGAACCCACCGGCCCATCAACATCCCCTTCTTTGATGTGT

 heLeuArgTyrLeuCysGln{G}  >>>> Target Intron 11 >>>>  {ly}Ser
 ||||||||||||||||||||{|}             97 bp            {||}|||
 heLeuArgTyrLeuCysGln{G}++                          ++{ly}Ser
 TCCTCAGATATCTGTGCCAG{G}gt                          ag{GC}TCC

 SerValGluValLysGluAspLysCysTrpGluLysValGluValSerSerAsnProHis
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 SerValGluValLysGluAspLysCysTrpGluLysValGluValSerSerAsnProHis
 AGTGTGGAGGTGAAGGAGGACAAGTGCTGGGAGAAGGTGGAGGTGTCCTCCAACCCGCAC

 ArgAlaSerLysLeuThrAspHisAsnProLysThrTyrTrpGluSerAsnGlySerAla
 |||||||||||||||||||||   ||||||||||||||||||||||||||||||||||||
 ArgAlaSerLysLeuThrAspArgAsnProLysThrTyrTrpGluSerAsnGlySerAla
 CGGGCCAGCAAGCTGACAGACCGCAACCCCAAGACCTACTGGGAGTCCAACGGCAGCGCG

 GlySerHisTyrIleThrLeuHisMetArgArgGlyIleLeuIle{Ar}  >>>> Targ
 |||||||||   ||||||||||||||||||   |||   ||||||{||}           
 GlySerHisHisIleThrLeuHisMetArgGlnGlyValLeuIle{Ar}++         
 GGCTCCCATCACATCACCTTGCACATGCGCCAAGGTGTCCTCATC{AG}gt         

 et Intron 12 >>>>  {g}GlnLeuThrLeuLeuValAlaSerGluAspSerSerTy
  172 bp            {|}||||||||||||||||||||||||||||||||||||||
                  ++{g}GlnLeuThrLeuLeuValAlaSerGluAspSerSerTy
                  ag{G}CAGCTGACTCTTCTGGTGGCCAGTGAGGACTCAAGCTA

 rMetProAlaArgValValValCysGlyGlyAspSerThrSerSerLeuHisThrGluLe
 |||||||||||||||||||||||||||||||||||||||||||||||||   ||||||||
 rMetProAlaArgValValValCysGlyGlyAspSerThrSerSerLeuAsnThrGluLe
 CATGCCGGCCCGGGTGGTGGTGTGCGGGGGCGACAGCACCAGCTCTCTTAACACGGAACT

 uAsnSer  >>>> Target Intron 13 >>>>  ValAsnValMetProSerAlaSe
 ||||               295 bp            |||||||||||||||||||||||
 uAsnAla++                          ++ValAsnValMetProSerAlaSe
 CAACGCGgt                          agGTGAATGTGATGCCCTCTGCCAG

 rArgValIleLeuLeuGluAsnLeuThrArgPheTrpProIleIle{Gl}  >>>> Tar
 |||||||   |||||||||                           {  }          
 rArgValProLeuLeuGluUnkUnkUnkUnkUnkUnkUnkUnkUnk{Un}--        
 CCGGGTGCCCCTCCTAGAGANNNNNNNNNNNNNNNNNNNNNNNNNN{NN}nn        

 get Intron 14 >>>>  {n}IleArgIleLysArgCysGlnGlnGlyGlyIleAspT
   138 bp            { }                     ||||||||||||||||
                   ++{k}GluThrGlyProCysAlaLeuGlnGlyGlyIleAspT
                   ag{T}GAAACAGGCCCGTGTGCATTGCAGGGCGGCATCGACA

 hrArgIleArgGlyLeuGluIleLeuGlyProLysProThrPheTrpProValPheArgG
 ||||||||||||||||||||   |||||||||||||||||||||||||||||||||||||
 hrArgIleArgGlyLeuGluValLeuGlyProLysProThrPheTrpProValPheArgG
 CGCGGATTCGGGGCTTGGAGGTGCTGGGCCCCAAGCCCACGTTCTGGCCAGTGTTCCGGG

 luGlnLeuCysArgHisThrArgLeuPheTyrMetValArgAlaGlnAlaTrpSerGlnA
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 luGlnLeuCysArgHisThrArgLeuPheTyrMetValArgAlaGlnAlaTrpSerGlnA
 AGCAGCTATGTCGTCACACACGCCTCTTTTACATGGTGCGGGCGCAGGCCTGGAGCCAGG

 spMetAlaGluAspArgArgSerLeuLeuHisLeuSerSer{Ar}  >>>> Target I
 ||   ||||||||||||||||||||||||||||||||||||{||}            135
 spIleAlaGluAspArgArgSerLeuLeuHisLeuSerSer{Ar}++             
 ACATAGCTGAGGACCGCAGGAGCCTCCTGCACCTGAGTTCT{AG}gt             

 ntron 15 >>>>  {g}LeuAsnGlyAlaLeuArgGlnGluGlnAsnPheAlaAspArg
 4 bp           {|}||||||||||||||||||   |||||||||||||||||||||
              ++{g}LeuAsnGlyAlaLeuArgHisGluGlnAsnPheAlaAspArg
              ag{A}CTCAATGGGGCTCTGCGCCACGAGCAGAATTTTGCTGACCGC

 PheLeuProAspAspGluAlaAlaGlnAlaLeuGlyLysThrCysTrpGluAlaLeuVal
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 PheLeuProAspAspGluAlaAlaGlnAlaLeuGlyLysThrCysTrpGluAlaLeuVal
 TTCCTCCCTGACGATGAGGCCGCCCAAGCCCTGGGCAAGACCTGCTGGGAGGCCCTGGTC

 SerProValValGlnAsnIleThrSerPro{A}  >>>> Target Intron 16 >>>
 ||||||   |||||||||||||||||||||{|}            321 bp         
 SerProLeuValGlnAsnIleThrSerPro{A}++                         
 AGCCCCCTGGTGCAGAACATCACTTCGCCT{G}gt                         

 >  {sp}GluAspGlyIleSerProLeuGlyTrpLeuLeuAspGlnTyrLeuGluCysGl
    {||}   ||||||||||||||||||||||||||||||||||||||||||||||||  
  ++{sp}AspAspGlyIleSerProLeuGlyTrpLeuLeuAspGlnTyrLeuGluCysAr
  ag{AT}GACGATGGCATCAGCCCCCTGGGCTGGCTGCTGGACCAGTACCTGGAGTGTCG

 nGluAlaValPheAsnProGlnSerArgGlyProAlaPhePheSerArgValArgArgLe
  ||||||      |||||||||||||||      ||||||   |||||||||||||||||
 gGluAlaAlaHisAsnProGlnSerArgAlaAlaAlaPheSerSerArgValArgArgLe
 GGAAGCTGCCCACAACCCCCAGAGCCGCGCAGCAGCTTTCTCCTCACGGGTGCGCCGCCT

 uThrHisLeuLeuValHisValGluProCysGluAlaProProProValValAlaThrPr
 ||||||||||||||||||||||||||||||||||||||||||||||      ||||||||
 uThrHisLeuLeuValHisValGluProCysGluAlaProProProAlaAlaAlaThrPr
 CACCCACCTGCTGGTGCACGTTGAGCCCTGCGAGGCGCCTCCTCCTGCGGCGGCCACTCC

 oArgPro{L}  >>>> Target Intron 17 >>>>  {ys}GlyArgAsnArgSerH
 |||||||{|}            220 bp            {||}||||||||||||||||
 oArgPro{L}++                          ++{ys}GlyArgAsnArgSerH
 TCGGCCC{A}gt                          ag{AG}GGCAGAAACAGAAGCC

 isAspTrpSerSerLeuAlaThrArgGlyLeuProSerSerIleMetArgAsnLeuThrA
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 isAspTrpSerSerLeuAlaThrArgGlyLeuProSerSerIleMetArgAsnLeuThrA
 ATGACTGGAGCTCCTTGGCCACCCGCGGCCTTCCGAGCAGCATCATGAGAAATCTGACCC

 rgCysTrpArgAlaValValGluLysGln  >>>> Target Intron 18 >>>>  V
 |||||||||||   |||||||||   |||             86 bp            |
 rgCysTrpArgSerValValGluGluGln++                          ++V
 GCTGTTGGCGGTCTGTGGTGGAGGAGCAGgt                          agG

 alAsnAsnPheLeuThrSerSerTrpArgAspAspAspPheValProArgTyrCysGluH
 ||      ||||||||||||   |||   |||||||||||||||||||||||||||||||
 alAspGlyPheLeuThrSerHisTrpGlnAspAspAspPheValProArgTyrCysGluH
 TGGACGGTTTTCTGACCTCACACTGGCAGGATGATGACTTTGTGCCACGCTACTGTGAGC

 isPheAsnIleLeuGlnAsnSerSerSerGluLeuPheGlyProArgAlaAlaPheLeuL
 |||||      ||||||   ||||||||||||||||||||||||||||||||||||||||
 isPheSerAsnLeuGlnLysSerSerSerGluLeuPheGlyProArgAlaAlaPheLeuL
 ATTTCAGTAACCTGCAGAAGTCCAGCTCCGAGCTGTTCGGGCCCCGGGCGGCCTTCCTGC

 euAlaLeuGlnAsnGlyCysAlaGlyAlaLeuLeuLysLeuProPheLeuLysAlaAlaH
 |||||||||||   ||||||||||||||||||||||||||||||||||||   |||||||
 euAlaLeuGlnSerGlyCysAlaGlyAlaLeuLeuLysLeuProPheLeuArgAlaAlaH
 TGGCGCTGCAGAGTGGCTGTGCTGGTGCCTTGCTGAAGCTCCCTTTTCTCAGAGCTGCCC

 is  >>>> Target Intron 19 >>>>  ValSerGluGlnPheAlaArgHisIleA
 ||            2303 bp           ||||||||||||||||||||||||||||
 is++                          ++ValSerGluGlnPheAlaArgHisIleA
 ATgt                          agGTGAGCGAGCAGTTTGCCCGGCACATCG

 spGlnGlnIleGlnGlySerArgIleGlyGlyAlaGlnGluMetGluArgLeuAlaGlnL
 |||||   |||||||||||||||||||||||||||      ||||||   ||||||||||
 spGlnArgIleGlnGlySerArgIleGlyGlyAlaArgGlyMetGluMetLeuAlaGlnL
 ACCAGCGGATCCAGGGCAGTCGGATTGGTGGAGCCCGGGGAATGGAGATGCTGGCACAAC

 euGlnGlnCysLeuGlnAlaValLeuIlePheSerGlyLeuGluIleAlaThrThrPheG
 ||      ||||||      ||||||   |||||||||||||||||||||||||||||||
 euLeuArgCysLeuGluThrValLeuLeuPheSerGlyLeuGluIleAlaThrThrPheG
 TGCTGCGCTGCCTGGAAACCGTCCTGCTTTTCTCGGGCCTGGAGATAGCCACCACCTTTG

 luHisTyrTyr{Gl}  >>>> Target Intron 20 >>>>  {n}HisTyrMetAla
 |||||||||||{||}            148 bp            {|}   |||||||||
 luHisTyrTyr{Gl}++                          ++{n}GlnTyrMetAla
 AGCATTACTAC{CA}gt                          ag{G}CAGTACATGGCG

 AspArgLeuLeuGlyValValSerSerTrpLeuGluGlyAlaValLeuGluGlnIleGly
 ||||||||||||||||||   |||||||||||||||||||||||||||||||||||||||
 AspArgLeuLeuGlyValGlySerSerTrpLeuGluGlyAlaValLeuGluGlnIleGly
 GACCGGCTCCTGGGCGTGGGCTCCAGCTGGCTGGAGGGGGCCGTGCTGGAGCAGATCGGC

 ProCysPheProAsnArgLeuProGlnGlnMetLeuGlnSerLeuSerThrSerLysGlu
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||   |||
 ProCysPheProAsnArgLeuProGlnGlnMetLeuGlnSerLeuSerThrSerGluGlu
 CCGTGCTTCCCCAACCGCCTTCCGCAGCAGATGCTGCAGAGTCTGAGCACCTCGGAGGAG

 LeuGlnArgGlnPheHisValTyrGlnLeuGlnGlnLeuAspGlnGluLeuLeuLysLeu
 |||||||||||||||||||||||||||||||||   ||||||||||||||||||||||||
 LeuGlnArgGlnPheHisValTyrGlnLeuGlnArgLeuAspGlnGluLeuLeuLysLeu
 CTGCAGCGCCAGTTCCATGTCTACCAGCTCCAGCGGCTCGATCAGGAGCTCCTGAAGCTG

 GluAspThrGluLysLysIleGln  >>>> Target Intron 21 >>>>  ValGly
 ||||||||||||||||||   |||             94 bp            ||||||
 GluAspThrGluLysLysValGln++                          ++ValGly
 GAGGACACAGAGAAGAAGGTGCAGgt                          agGTGGGC

 LeuGlyAlaSerGlyLysGluHisLysSerGluLysGluGluGluAlaGlyAlaAlaAla
       |||   |||                  ||||||||||||||||||||||||   
 PheGluAlaGlyGlyGlnLysPheGluAsnGlyLysGluGluGluAlaGlyAlaAlaVal
 TTTGAGGCCGGTGGCCAGAAGTTCGAGAATGGGAAGGAAGAGGAAGCTGGGGCAGCAGTG

 ValValAspValAlaGluGlyGluGluGluGluGluGluAsnGluAspLeuTyrTyrGlu
    |||||||||   ||||||      |||||||||||||||||||||||||||||||||
 AlaValAspValValGluGly------GluGluGluGluAsnGluAspLeuTyrTyrGlu
 GCAGTGGACGTGGTGGAGGGA------GAGGAGGAGGAGAACGAGGACCTTTACTATGAA

 GlyAlaMetProGluValSerValLeuValLeuSerArgHisSerTrpProValAlaSer
 |||   ||||||||||||||||||||||||||||||         |||||||||||||||
 GlyThrMetProGluValSerValLeuValLeuSerProArgCysTrpProValAlaSer
 GGGACAATGCCAGAAGTGTCTGTGCTTGTCCTGTCCCCACGCTGCTGGCCCGTCGCCTCC

 IleCysHisThrLeuAsnProArgThrCysLeuProSerTyrLeuArgGlyThrLeuAsn
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 IleCysHisThrLeuAsnProArgThrCysLeuProSerTyrLeuArgGlyThrLeuAsn
 ATCTGCCACACACTGAACCCCAGAACATGCCTGCCCTCCTACCTGAGGGGTACTTTGAAC

 ArgTyrSerAsnPheTyrAsnLys{S}  >>>> Target Intron 22 >>>>  {er
 ||||||||||||||||||||||||{|}            2071 bp           {||
 ArgTyrSerAsnPheTyrAsnLys{S}++                          ++{er
 CGATACTCCAACTTCTACAATAAG{A}gt                          ag{GT

 }GlnSerHisProAlaLeuGluArgGlySerGlnArgArgLeuGlnTrpThrTrpLeuGl
 }|||||||||   |||||||||      ||||||||||||||||||||||||||||||||
 }GlnSerHisLeuAlaLeuGluGlnSerSerGlnArgArgLeuGlnTrpThrTrpLeuGl
 }CAGAGCCACCTTGCCCTAGAGCAAAGCTCACAGAGGCGACTGCAGTGGACGTGGCTGGG

 yTrpAlaGluLeuGlnPheGlyAsnGlnThrLeuHisValSerThrValGlnMetTrpLe
 |   ||||||||||||||||||   |||||||||||||||||||||||||||||||||||
 yArgAlaGluLeuGlnPheGlyAspGlnThrLeuHisValSerThrValGlnMetTrpLe
 CCGGGCTGAGCTGCAGTTTGGGGACCAGACCCTGCATGTGTCCACCGTACAGATGTGGCT

 uLeuLeuTyrLeuAsnAspLeuLys  >>>> Target Intron 23 >>>>  AlaVa
 |||||||||||||||||||||||||             93 bp            |||  
 uLeuLeuTyrLeuAsnAspLeuLys++                          ++AlaIl
 GCTGCTGTATCTCAACGATCTGAAGgt                          agGCCAT

 lSerValGluSerLeuLeuAlaPheSerGlyLeuSerAlaAspMetLeuAsnGlnAlaIl
  ||||||   |||||||||      ||||||||||||   |||   ||||||||||||  
 eSerValGlySerLeuLeuLysLeuSerGlyLeuSerProAspThrLeuAsnGlnAlaVa
 CTCTGTGGGCAGTCTGCTGAAGCTCTCGGGGCTCTCCCCAGACACACTGAACCAGGCAGT

 eGlyProLeuThrSerSerArgGlyProLeuAspLeuHisGluGlnLysAspIleProGl
     ||||||||||||||||||||||||||||||||||||||||||||||||   |||||
 lGluProLeuThrSerSerArgGlyProLeuAspLeuHisGluGlnLysAspMetProGl
 TGAGCCTCTCACCTCTTCAAGAGGCCCCTTGGACCTTCACGAGCAGAAGGATATGCCAGG

 y{G}  >>>> Target Intron 24 >>>>  {ly}ValLeuLysIleArgAspGlyS
 |{|}             74 bp            {||}||||||||||||||||||||| 
 y{G}++                          ++{ly}ValLeuLysIleArgAspGly-
 A{G}gt                          ag{GG}GTGCTGAAGATTCGAGATGGC-

 erLysGluProArgSerArgTrpAspIleValArgLeuIleProProGlnThrTyrLeuG
      |||||||||   |||         |||   |||||||||||||||||||||    
 --GluGluProArgProArgArgGlySerValTrpLeuIleProProGlnThrTyrValL
 --GAGGAACCCAGGCCAAGAAGGGGCAGCGTGTGGCTCATCCCACCTCAGACGTACGTGA

 lnAlaGluGlyGluAspGlyGlnAsnLeuGluLysArgArgAsnLeuLeuAsnCysLeuI
   ||||||   |||   |||   ||||||||||||||||||                   
 ysAlaGluAspGluGluGlyArgAsnLeuGluLysArgArgUnkUnkUnkUnkUnkUnkU
 AAGCTGAGGATGAAGAGGGCCGGAACTTGGAGAAGAGGCGGANNNNNNNNNNNNNNNNNN

 leVal  >>>> Target Intron 25 >>>>  ArgIleLeuLysAlaHisGlyAspG
                  400 bp            |||||||||||||||   |||||||
 nkUnk--                          -+ArgIleLeuLysAlaGlnGlyAspG
 NNNNNnn                          ngCGAATCCTCAAGGCCCAGGGGGATG

 luGlyLeuHisIleAspGlnLeuValCysLeu  >>>> Target Intron 26 >>>>
 ||||||||||||||||||||||||||||||||            215 bp          
 luGlyLeuHisIleAspGlnLeuValCysLeu++                          
 AGGGGCTGCACATTGACCAGCTTGTCTGTCTGgt                          

   ValLeuGluAlaTrpGlnLysGlyProCysProProArgGlyLeuValSerSerLeuG
   ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ++ValLeuGluAlaTrpGlnLysGlyProCysProProArgGlyLeuValSerSerLeuG
 agGTGCTGGAGGCGTGGCAGAAGGGCCCGTGTCCCCCCAGGGGTTTGGTCAGCAGCCTGG

 lyLysGlySerAlaCysSerSerThrAspValLeuSerCysIleLeuHisLeuLeuGlyL
 ||   ||||||||||||   |||   ||||||||||||||||||||||||||||||||||
 lyArgGlySerAlaCysGlySerAlaAspValLeuSerCysIleLeuHisLeuLeuGlyL
 GCAGGGGGTCCGCCTGCGGCAGTGCAGACGTCCTCTCCTGCATCCTGCACCTCCTGGGCA

 ysGlyThrLeuArgArgHisAspAspArgProGlnValLeuSerTyrAlaValProValT
 |||||||||||||||||||||||||||||||||||   ||||||||||||||||||||||
 ysGlyThrLeuArgArgHisAspAspArgProGlnMetLeuSerTyrAlaValProValT
 AGGGCACGCTGAGACGCCATGACGACCGGCCCCAGATGCTGTCCTACGCAGTCCCTGTGA

 hrValMetGluProHisThrGluSerLeuAsnProGlySerSerGlyProAsnProProL
 |||||   ||||||||||||||||||||||||||||||||||||||||||||||||||||
 hrValLeuGluProHisThrGluSerLeuAsnProGlySerSerGlyProAsnProProL
 CCGTGTTGGAGCCTCACACAGAGTCCCTGAACCCAGGCTCCTCGGGCCCCAACCCGCCCC

 euThrPheHisThrLeuGlnIleArgSerArgGlyValProTyrAlaSerCysThrAlaT
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||   |
 euThrPheHisThrLeuGlnIleArgSerArgGlyValProTyrAlaSerCysThrGlyT
 TCACCTTCCACACCCTGCAGATTCGCTCTCGGGGTGTGCCCTATGCCTCCTGCACGGGCA

 hrGlnSerPheSerThrPheArg
 |||||||||||||||||||||||
 hrGlnSerPheSerThrPheArg
 CCCAGAGCTTCTCTACCTTCCGG
//