| Basic information |
| Official Symbol | CDKN1B |
| Description | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Other Aliases | CDKN4, KIP1, MEN1B, MEN4, P27KIP1 |
| Other Description | cyclin-dependent kinase inhibitor 1B |
| Mutation type | Insert and frame-shift 176-177:I-H^TA |
| Location | Scaffold143728_1:480835 476758 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| CDKN1B |
GGGAGCCCGAGCCTGGAGCCGATGGACGCCAGACAGGCAGAGCACCCCAA GCCCTCCGCCTGCAGAAACCTCTTCGGCCCGGTGAACCACGAAGAGTTAA CCCGGGACTTGGAGAAGCACTGCAGAGACATGGAAGAAGCCAGCCAGCGC AAGTGGAATTTCGATTTCCAGAATCACAAGCCCCTGGAGGGCAAATACGA GTGGCAGGGGGGGGAGAAGGGCAGCCTGCCCGAGTTTTACTGCAGACCCC CGCGGCCCCCCAAAGGCGCCTGCAAGGTGCCGGCGCAGGAGAGCCAGGAT GTCAGCGGGGGCCGCCAGGCGGTGCCTTTAATCGGGGCTCAGGCAAACTC AGAGGACACGCACTTGGTAGACCAAAAGACTGACCCGTCAGACGGCCAGA CCGGGCTGGCCGAGCAGTGCGCAGGGGTGAGGAAGCGACCTGCGGCGGAC GATACATCACGGCTTGATGAAGCAAGGAAGAGAGACATGAAAGATTTTAA ACATATCGCTGACTCCATGGAATGGACATCCTGTATAAGCACTGAAAAGC AACAACACAATAACACTAAAATGTTAGGCACTCTTAAA |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 205 | 9 | 205 | Insert and frame-shift 176-177:I-H^TA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
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Treeshrew pep sequence --->
Treeshrew cds sequence --->
GlySerProSerLeuGluArgMetAspAlaArgGlnAlaGluHisProLysProSerAlaCy
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GlySerProSerLeuGluProMetAspAlaArgGlnAlaGluHisProLysProSerAlaCy
GGGAGCCCGAGCCTGGAGCCGATGGACGCCAGACAGGCAGAGCACCCCAAGCCCTCCGCCTG
sArgAsnLeuPheGlyProValAspHisGluGluLeuThrArgAspLeuGluLysHisCysA
|||||||||||||||||||||| |||||||||||||||||||||||||||||||||||||
sArgAsnLeuPheGlyProValAsnHisGluGluLeuThrArgAspLeuGluLysHisCysA
CAGAAACCTCTTCGGCCCGGTGAACCACGAAGAGTTAACCCGGGACTTGGAGAAGCACTGCA
rgAspMetGluGluAlaSerGlnArgLysTrpAsnPheAspPheGlnAsnHisLysProLeu
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rgAspMetGluGluAlaSerGlnArgLysTrpAsnPheAspPheGlnAsnHisLysProLeu
GAGACATGGAAGAAGCCAGCCAGCGCAAGTGGAATTTCGATTTCCAGAATCACAAGCCCCTG
GluGlyLysTyrGluTrpGlnGluValGluLysGlySerLeuProGluPheTyrTyrArgPr
||||||||||||||||||||| ||||||||||||||||||||||||||| |||||
GluGlyLysTyrGluTrpGlnGlyGlyGluLysGlySerLeuProGluPheTyrCysArgPr
GAGGGCAAATACGAGTGGCAGGGGGGGGAGAAGGGCAGCCTGCCCGAGTTTTACTGCAGACC
oProArgProProLysGlyAlaCysLysValProAlaGlnGluSerGlnAspValSerGlyS
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
oProArgProProLysGlyAlaCysLysValProAlaGlnGluSerGlnAspValSerGlyG
CCCGCGGCCCCCCAAAGGCGCCTGCAAGGTGCCGGCGCAGGAGAGCCAGGATGTCAGCGGGG
erArgProAlaAlaProLeuIleGlyAlaProAlaAsnSerGluAspThrHisLeuValAsp
||| ||| ||||||||||||||| ||||||||||||||||||||||||||||||
lyArgGlnAlaValProLeuIleGlyAlaGlnAlaAsnSerGluAspThrHisLeuValAsp
GCCGCCAGGCGGTGCCTTTAATCGGGGCTCAGGCAAACTCAGAGGACACGCACTTGGTAGAC
ProLysThrAspProSerAspSerGlnThrGlyLeuAlaGluGlnCysAlaGlyIleArgLy
|||||||||||||||||| |||||||||||||||||||||||||||||| |||||
GlnLysThrAspProSerAspGlyGlnThrGlyLeuAlaGluGlnCysAlaGlyValArgLy
CAAAAGACTGACCCGTCAGACGGCCAGACCGGGCTGGCCGAGCAGTGCGCAGGGGTGAGGAA
sArgProAlaThrAsp{A} >>>> Target Intron 1 >>>> {sp}ThrSerLeuL
|||||||||| |||{|} 3488 bp {||}|||||| |
sArgProAlaAlaAsp{A}++ ++{sp}ThrSerArgL
GCGACCTGCGGCGGAC{G}gt ag{AT}ACATCACGGC
euAspGluAlaArgLysIleTyrMetLysIleLeuLysIle--HisIleAlaAspPheMetG
||||||||||||||||| |||||| ||| ##|||||||||||| ||||
euAspGluAlaArgLysArgAspMetLysAspPheLys---##HisIleAlaAspSerMetG
TTGATGAAGCAAGGAAGAGAGACATGAAAGATTTTAAA---TACATATCGCTGACTCCATGG
luTrpThrSerCysIleSerThrGluLysGlnGlnHisAsnAsnThrLysIleLeuGlyThr
|||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||
luTrpThrSerCysIleSerThrGluLysGlnGlnHisAsnAsnThrLysMetLeuGlyThr
AATGGACATCCTGTATAAGCACTGAAAAGCAACAACACAATAACACTAAAATGTTAGGCACT
LeuLys
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LeuLys
CTTAAA
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