Basic information
Official Symbol CASR
Descriptioncalcium-sensing receptor
Other AliasesCAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, NSHPT, PCAR1
Other Descriptionextracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor
Mutation typeDelete and frame-shift 545:L->CC
LocationScaffold139927_1:374898 408697 -

  ±  bp flank
WikiWikipedia GeneCard
Sequence
CASR 
ATGACATTTTATAGCTGCTGTTTGATCCTGGTGGCTCTTGTCTGGCACACCTCTGCATAT
GGGCCTGACCAGCGAGCCCAGAAGAAAGGGGACATTATCCTTGGGGGACTCTTTCCTATT
CACTTCGGAGTAGCAGCCAAAGATCAAGATCTAAAATCAAGGCCAGAGTCTGTGGAATGT
ATCTATAATTTCCGTGGTTTTCGCTGGTTACAAGCTATGATATTTGCCATAGAGGAGATA
AACAGCAGTCCGGCCCTTCTCCCCAAACATGACGCTGGGGTACAGGATATTTGACACTTG
CAACACCGTTTCCAAGGCCTTGGAGGCCACCCTGAGTTTTGTGGCCCAGAACAAAATCGA
TTCTCTGAACCTTGATGAGTTCTGTAACTGCTCAGACCACATCCCCTCCACCATTGCTGT
GGTGGGAGCAACTGGCTCAGGCATCTCCACAGCGGTGGCAAACCTGCTGGGGCTCTTCTA
CATTCCACAGGTCAGCTATGCCTCCTCCAGCAGACTCCTCAGCAACAAGAACCAGTTCAA
GTCCTTCCTCCGTACTATCCCCAATGATGAACACCAGGCCACTGCTATGGCGGACATCAT
CGAGTACTTCCGCTGGAACTGGGTGGGCACAATTGCAGCTGATGATGACTATGGGCGGCC
AGGGATTGAGAAGTTCCGAGAGGAAGCTGAAGAGAGGGACATCTGCATCGACTTCAGTGA
ACTCATCTCCCAGTACTCTGATGAGGAAGAGATCCAGCAAGTGGTGGAGGTGATCCAGAA
TTCTACAGCTAAAGTCATTGTTGTTTTCTCCAGTGGCCCAGACCTTGAACCTCTCATCAA
GGAGATAGTCCGGCGCAATATCACAGGCAGGATCTGGCTAGCCAGTGAGGCCTGGGCCAG
CTCCTCCTTGATCGCCATGCCTGAGTACTTCCATGTGGTCGGAGGTACCATTGGATTTGC
TCTGAAGGCTGGGCAGATTCCAGGGTTCCGGGAATTTCTGCAGAAAGTCCATCCCAGAAA
GTCTGTCCACAATGGTTTTGCCAAAGAGTTTTGGGAAGAAACATTTAATTGCCACCTCCA
AGAAGGTGCTAAAGGACCTTTACCTGTGGACACCTTCCTGAGAGGTCATGAAGAAGGTGG
TGGCAGAGTAGGCAACAGCTCCACTGCCTTCCGACCCCTCTGTACAGGGGATGAGAACAT
CAGCAGTGTCGAGACCCCTTACATGGATTACACACATTTACGGATATCCTACAACGTATA
CCTAGCAGTCTACTCCATCGCTCATGCCTTACAAGACATATATACCTGCTTACCTGGGCG
AGGGCTCTTCACCAATGGTTCCTGTGCAGACATCAAGAAGGTCGAGGCTTGGCAGGTCCT
GAAGCACCTTCGACATCTAAACTTTACCAACAATATGGGCGAGCAAGTGACTTTCGATGA
GTGTGGTGATCTGGTGGGAAACTACTCCATCATCAACTGGCACCTCTCCCCAGAGGATGG
CTCCATCATGTTTAAGGAAGTTGGGTATTACAACGTCTATGCCAAGAAGGGAGAGAGACT
CTTCATCAACGAGGAGAAAATATTGTGGAGTGGGTTCTCCAGGGAGCCATTCATTTTCAT
GCTCTCTGTCCCCAGGTGCCGTTCTCCAACTGCAGCCGAGACTGCCTGGCAGGGACCAGG
AAAGGGATCATTGAAGGAGAACCCACCTGCTGCTTCGAGTGTGTGGAGTGTCCAGATGGG
GAGTACAGCGATGAGACAGCCAGTGCCTGTGACAAGTGCCCAGATGACTTCTGGTCCAAT
GAGAACCACACTTCCTGCATTGCCAAGGAGATTGAGTTTCTGTCGTGGACGGAGCCCTTT
GGAATCGCACTCACCCTCTTTGCTGTGCTGGGCATTTTCCTGACTGCCTTTGTCCTGGGT
GTCTTCATCAAGTTCCGCAACACGCCCATCGTCAAGGCCACTAACCGAGAGCTGTCCTAC
CTCCTCCTCTTCTCCCTGCTCTGCTGCTTCTCCAGCTCCCTGTTCTTCATCGGGGAGCCC
CAGGACTGGACGTGCCGCCTGCGCCAGCCGGCCTTCGGTATCAGCTTTGTGCTCTGCATC
TCGTGCATCCTGGTGAAGACCAACCGCGTCCTCCTGGTGTTTGAGGCCAAGATCCCCACC
AGCTTCCATCGCAAGTGGTGGGGGCTCAACCTGCAGTTCCTGCTGGTTTTCCTCTGCACC
TTCATGCAGATCGTCATCTGTGTGATCTGGCTCTACACCGCACCCCCCTCCAGCTACCGT
AACCATGAGCTAGAGGACGAGATCATCTTCATCACATGCCACGAGGGCTCGCTCATGGCC
TTGGGCTTCCTGATTGGCTACACCTGTCTGCTGGCTGCCATCTGCTTCTTCTTTGCCTTC
AAGTCCCGGAAACTGCCGGAGAACTTCAACGAAGCCAAGTTCATCACCTTCAGCATGCTC
ATCTTCTTCATCGTCTGGATCTCCTTCATCCCGGCCTATGCCAGCACCTACGGCAAGTTC
GTCTCTGCCGTGGAGGTGATCGCCATCCTGGCGGCCAGTTTTGGCTTGCTGGCCTGCATC
TTCTTCAACAAGGTCTACATCATCCTCTTCAAGCCGGCCCGTAACACCATCGAGGAGGTG
CGCTGCAGCACCGCTGCTCACGCTTTCAAGGTGGCGGCCCGGGCCACGCTGCGCCGCAGC
AACGTCTCCCGCAAGCGCTCCAGCAGCCTCGGGGGCTCCACAGGGTCCACCCCCTCATCC
TCCATCAGCAGCAAGAGCAACAGCGAAGACCCCTTCCCACAGCCCGAGAGGCAGAAACAG
CAGCACCCACTGGCCCTGACCCAGCAGGAGCCGCAGCCGCAGCAGTCGCAGCAGCCCCGG
TGCAAGCAGAAGGTCATCTTCGGCAGTGGCACAGTCACCTTCTCCCTGAGCTTTGACGAG
CCTCAGAAGAACACCACCGCTCACAGGAATTCCACACACCAGAACTCCCTGGAGACACAG
AAAGGCAGCGATGCCCTGACCAGACACCAGGCACTGCTCCCGCTGCAGTGCGGGGAGAAT
GACTCAGAACCGGCCACCCAGGACACAGGCCTGCAGGGGCCTGTCGGGGGCGACCACCCG
CCAGAGATGGAGGACCCTGAAGAGATGTCCCCAGCCCTCGTGGTATCCAACTCACGGAGC
TTTGTCATCAGCAGTGGCAGCAGCACAGGCACAGAGAACATCCTGCATTCG
Alignment
Align speciePep lengthPep align beginPep align endMutaion type and postion
Human108811088Delete and frame-shift 545:L->CC
 Instructions:
 *** -> premature termination codon;  # -> frame shift 

 Alignment:
 Human     pep sequence --->
 ||||||||||||||||||||||
 Treeshrew pep sequence --->
 Treeshrew cds sequence --->
  
 MetAlaPheTyrSerCysCysTrpValLeuLeuAlaLeuThrTrpHisThrSerAlaTyr
 |||   |||||||||||||||      |||   ||||||   ||||||||||||||||||
 MetThrPheTyrSerCysCysLeuIleLeuValAlaLeuValTrpHisThrSerAlaTyr
 ATGACATTTTATAGCTGCTGTTTGATCCTGGTGGCTCTTGTCTGGCACACCTCTGCATAT

 GlyProAspGlnArgAlaGlnLysLysGlyAspIleIleLeuGlyGlyLeuPheProIle
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 GlyProAspGlnArgAlaGlnLysLysGlyAspIleIleLeuGlyGlyLeuPheProIle
 GGGCCTGACCAGCGAGCCCAGAAGAAAGGGGACATTATCCTTGGGGGACTCTTTCCTATT

 HisPheGlyValAlaAlaLysAspGlnAspLeuLysSerArgProGluSerValGluCys
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 HisPheGlyValAlaAlaLysAspGlnAspLeuLysSerArgProGluSerValGluCys
 CACTTCGGAGTAGCAGCCAAAGATCAAGATCTAAAATCAAGGCCAGAGTCTGTGGAATGT

 Ile{Ar}  >>>> Target Intron 1 >>>>  {g}TyrAsnPheArgGlyPheArg
 |||{||}           3803 bp           {|}|||||||||||||||||||||
 Ile{Ar}++                         ++{g}TyrAsnPheArgGlyPheArg
 ATC{AG}gt                         ag{G}TATAATTTCCGTGGTTTTCGC

 TrpLeuGlnAlaMetIlePheAlaIleGluGluIleAsnSerSerProAlaLeuLeuPro
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 TrpLeuGlnAlaMetIlePheAlaIleGluGluIleAsnSerSerProAlaLeuLeuPro
 TGGTTACAAGCTATGATATTTGCCATAGAGGAGATAAACAGCAGTCCGGCCCTTCTCCCC

 AsnLeuThrLeuGlyTyrArgIlePheAspThrCysAsnThrValSerLysAlaLeuGlu
 |||   ||||||||||||||||||||||||||||||||||||||||||||||||||||||
 AsnMetThrLeuGlyTyrArgIlePheAspThrCysAsnThrValSerLysAlaLeuGlu
 AACATGACGCTGGGGTACAGGATATTTGACACTTGCAACACCGTTTCCAAGGCCTTGGAG

 AlaThrLeuSerPheValAlaGlnAsnLysIleAspSerLeuAsnLeuAspGluPheCys
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 AlaThrLeuSerPheValAlaGlnAsnLysIleAspSerLeuAsnLeuAspGluPheCys
 GCCACCCTGAGTTTTGTGGCCCAGAACAAAATCGATTCTCTGAACCTTGATGAGTTCTGT

 AsnCysSerGluHisIleProSerThrIleAlaValValGlyAlaThrGlySerGlyVal
 |||||||||   |||||||||||||||||||||||||||||||||||||||||||||   
 AsnCysSerAspHisIleProSerThrIleAlaValValGlyAlaThrGlySerGlyIle
 AACTGCTCAGACCACATCCCCTCCACCATTGCTGTGGTGGGAGCAACTGGCTCAGGCATC

 SerThrAlaValAlaAsnLeuLeuGlyLeuPheTyrIleProGln  >>>> Target I
 |||||||||||||||||||||||||||||||||||||||||||||           7272
 SerThrAlaValAlaAsnLeuLeuGlyLeuPheTyrIleProGln++             
 TCCACAGCGGTGGCAAACCTGCTGGGGCTCTTCTACATTCCACAGgt             

 ntron 2 >>>>  ValSerTyrAlaSerSerSerArgLeuLeuSerAsnLysAsnGlnP
  bp           ||||||||||||||||||||||||||||||||||||||||||||||
             ++ValSerTyrAlaSerSerSerArgLeuLeuSerAsnLysAsnGlnP
             agGTCAGCTATGCCTCCTCCAGCAGACTCCTCAGCAACAAGAACCAGT

 heLysSerPheLeuArgThrIleProAsnAspGluHisGlnAlaThrAlaMetAlaAspI
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 heLysSerPheLeuArgThrIleProAsnAspGluHisGlnAlaThrAlaMetAlaAspI
 TCAAGTCCTTCCTCCGTACTATCCCCAATGATGAACACCAGGCCACTGCTATGGCGGACA

 leIleGluTyrPheArgTrpAsnTrpValGlyThrIleAlaAlaAspAspAspTyrGlyA
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 leIleGluTyrPheArgTrpAsnTrpValGlyThrIleAlaAlaAspAspAspTyrGlyA
 TCATCGAGTACTTCCGCTGGAACTGGGTGGGCACAATTGCAGCTGATGATGACTATGGGC

 rgProGlyIleGluLysPheArgGluGluAlaGluGluArgAspIleCysIleAspPheS
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 rgProGlyIleGluLysPheArgGluGluAlaGluGluArgAspIleCysIleAspPheS
 GGCCAGGGATTGAGAAGTTCCGAGAGGAAGCTGAAGAGAGGGACATCTGCATCGACTTCA

 erGluLeuIleSerGlnTyrSerAspGluGluGluIleGlnHisValValGluValIleG
 |||||||||||||||||||||||||||||||||||||||||   ||||||||||||||||
 erGluLeuIleSerGlnTyrSerAspGluGluGluIleGlnGlnValValGluValIleG
 GTGAACTCATCTCCCAGTACTCTGATGAGGAAGAGATCCAGCAAGTGGTGGAGGTGATCC

 lnAsnSerThrAlaLysValIleValValPheSerSerGlyProAspLeuGluProLeuI
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 lnAsnSerThrAlaLysValIleValValPheSerSerGlyProAspLeuGluProLeuI
 AGAATTCTACAGCTAAAGTCATTGTTGTTTTCTCCAGTGGCCCAGACCTTGAACCTCTCA

 leLysGluIleValArgArgAsnIleThrGlyLysIleTrpLeuAlaSerGluAlaTrpA
 ||||||||||||||||||||||||||||||||   |||||||||||||||||||||||||
 leLysGluIleValArgArgAsnIleThrGlyArgIleTrpLeuAlaSerGluAlaTrpA
 TCAAGGAGATAGTCCGGCGCAATATCACAGGCAGGATCTGGCTAGCCAGTGAGGCCTGGG

 laSerSerSerLeuIleAlaMetProGlnTyrPheHisValValGlyGlyThrIleGlyP
 ||||||||||||||||||||||||||   |||||||||||||||||||||||||||||||
 laSerSerSerLeuIleAlaMetProGluTyrPheHisValValGlyGlyThrIleGlyP
 CCAGCTCCTCCTTGATCGCCATGCCTGAGTACTTCCATGTGGTCGGAGGTACCATTGGAT

 heAlaLeuLysAlaGlyGlnIleProGlyPheArgGluPheLeuLysLysValHisProA
 ||||||||||||||||||||||||||||||||||||||||||||   |||||||||||||
 heAlaLeuLysAlaGlyGlnIleProGlyPheArgGluPheLeuGlnLysValHisProA
 TTGCTCTGAAGGCTGGGCAGATTCCAGGGTTCCGGGAATTTCTGCAGAAAGTCCATCCCA

 rgLysSerValHisAsnGlyPheAlaLysGluPheTrpGluGluThrPheAsnCysHisL
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 rgLysSerValHisAsnGlyPheAlaLysGluPheTrpGluGluThrPheAsnCysHisL
 GAAAGTCTGTCCACAATGGTTTTGCCAAAGAGTTTTGGGAAGAAACATTTAATTGCCACC

 euGlnGluGlyAlaLysGlyProLeuProValAspThrPheLeuArgGlyHisGluGluS
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
 euGlnGluGlyAlaLysGlyProLeuProValAspThrPheLeuArgGlyHisGluGluG
 TCCAAGAAGGTGCTAAAGGACCTTTACCTGTGGACACCTTCCTGAGAGGTCATGAAGAAG

 erGlyAspArgPheSerAsnSerSerThrAlaPheArgProLeuCysThrGlyAspGluA
   |||   |||      |||||||||||||||||||||||||||||||||||||||||||
 lyGlyGlyArgValGlyAsnSerSerThrAlaPheArgProLeuCysThrGlyAspGluA
 GTGGTGGCAGAGTAGGCAACAGCTCCACTGCCTTCCGACCCCTCTGTACAGGGGATGAGA

 snIleSerSerValGluThrProTyrIleAspTyrThrHisLeuArgIleSerTyrAsnV
 ||||||||||||||||||||||||||   |||||||||||||||||||||||||||||||
 snIleSerSerValGluThrProTyrMetAspTyrThrHisLeuArgIleSerTyrAsnV
 ACATCAGCAGTGTCGAGACCCCTTACATGGATTACACACATTTACGGATATCCTACAACG

 alTyrLeuAlaValTyrSerIleAlaHisAlaLeuGlnAspIleTyrThrCysLeuProG
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 alTyrLeuAlaValTyrSerIleAlaHisAlaLeuGlnAspIleTyrThrCysLeuProG
 TATACCTAGCAGTCTACTCCATCGCTCATGCCTTACAAGACATATATACCTGCTTACCTG

 lyArgGlyLeuPheThrAsnGlySerCysAlaAspIleLysLysValGluAlaTrpGln 
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
 lyArgGlyLeuPheThrAsnGlySerCysAlaAspIleLysLysValGluAlaTrpGln+
 GGCGAGGGCTCTTCACCAATGGTTCCTGTGCAGACATCAAGAAGGTCGAGGCTTGGCAGg

  >>>> Target Intron 3 >>>>  ValLeuLysHisLeuArgHisLeuAsnPheTh
           9882 bp           ||||||||||||||||||||||||||||||||
 +                         ++ValLeuLysHisLeuArgHisLeuAsnPheTh
 t                         agGTCCTGAAGCACCTTCGACATCTAAACTTTAC

 rAsnAsnMetGlyGluGlnValThrPheAspGluCysGlyAspLeuValGlyAsnTyrSe
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 rAsnAsnMetGlyGluGlnValThrPheAspGluCysGlyAspLeuValGlyAsnTyrSe
 CAACAATATGGGCGAGCAAGTGACTTTCGATGAGTGTGGTGATCTGGTGGGAAACTACTC

 rIleIleAsnTrpHisLeuSerProGluAspGlySerIleValPheLysGluValGlyTy
 ||||||||||||||||||||||||||||||||||||||||   |||||||||||||||||
 rIleIleAsnTrpHisLeuSerProGluAspGlySerIleMetPheLysGluValGlyTy
 CATCATCAACTGGCACCTCTCCCCAGAGGATGGCTCCATCATGTTTAAGGAAGTTGGGTA

 rTyrAsnValTyrAlaLysLysGlyGluArgLeuPheIleAsnGluGluLysIleLeuTr
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 rTyrAsnValTyrAlaLysLysGlyGluArgLeuPheIleAsnGluGluLysIleLeuTr
 TTACAACGTCTATGCCAAGAAGGGAGAGAGACTCTTCATCAACGAGGAGAAAATATTGTG

 pSerGlyPheSerArgGlu  >>>> Target Intron 4 >>>>  ProLeuThrPhe
 |||||||||||||||||||           7369 bp           |||      |||
 pSerGlyPheSerArgGlu++                         --ProPheIlePhe
 GAGTGGGTTCTCCAGGGAGgt                         agCCATTCATTTTC

 ValLeuSerValLeuGlnValProPheSerAsnCysSerArgAspCysLeuAlaGlyThr
    |||||||||   |||||||||||||||||||||||||||||||||||||||||||||
 MetLeuSerVal---GlnValProPheSerAsnCysSerArgAspCysLeuAlaGlyThr
 ATGCTCTCTGTCCC#CAGGTGCCGTTCTCCAACTGCAGCCGAGACTGCCTGGCAGGGACC

 ArgLysGlyIleIleGluGlyGluProThrCysCysPheGluCysValGluCysProAsp
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ArgLysGlyIleIleGluGlyGluProThrCysCysPheGluCysValGluCysProAsp
 AGGAAAGGGATCATTGAAGGAGAACCCACCTGCTGCTTCGAGTGTGTGGAGTGTCCAGAT

 GlyGluTyrSerAspGluThr{A}  >>>> Target Intron 5 >>>>  {sp}Ala
 |||||||||||||||||||||{|}           2237 bp           {||}|||
 GlyGluTyrSerAspGluThr{A}++                         ++{sp}Ala
 GGGGAGTACAGCGATGAGACA{G}gt                         ag{AT}GCC

 SerAlaCysAsnLysCysProAspAspPheTrpSerAsnGluAsnHisThrSerCysIle
 |||||||||   ||||||||||||||||||||||||||||||||||||||||||||||||
 SerAlaCysAspLysCysProAspAspPheTrpSerAsnGluAsnHisThrSerCysIle
 AGTGCCTGTGACAAGTGCCCAGATGACTTCTGGTCCAATGAGAACCACACTTCCTGCATT

 AlaLysGluIleGluPheLeuSerTrpThrGluProPheGlyIleAlaLeuThrLeuPhe
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 AlaLysGluIleGluPheLeuSerTrpThrGluProPheGlyIleAlaLeuThrLeuPhe
 GCCAAGGAGATTGAGTTTCTGTCGTGGACGGAGCCCTTTGGAATCGCACTCACCCTCTTT

 AlaValLeuGlyIlePheLeuThrAlaPheValLeuGlyValPheIleLysPheArgAsn
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 AlaValLeuGlyIlePheLeuThrAlaPheValLeuGlyValPheIleLysPheArgAsn
 GCTGTGCTGGGCATTTTCCTGACTGCCTTTGTCCTGGGTGTCTTCATCAAGTTCCGCAAC

 ThrProIleValLysAlaThrAsnArgGluLeuSerTyrLeuLeuLeuPheSerLeuLeu
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ThrProIleValLysAlaThrAsnArgGluLeuSerTyrLeuLeuLeuPheSerLeuLeu
 ACGCCCATCGTCAAGGCCACTAACCGAGAGCTGTCCTACCTCCTCCTCTTCTCCCTGCTC

 CysCysPheSerSerSerLeuPhePheIleGlyGluProGlnAspTrpThrCysArgLeu
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 CysCysPheSerSerSerLeuPhePheIleGlyGluProGlnAspTrpThrCysArgLeu
 TGCTGCTTCTCCAGCTCCCTGTTCTTCATCGGGGAGCCCCAGGACTGGACGTGCCGCCTG

 ArgGlnProAlaPheGlyIleSerPheValLeuCysIleSerCysIleLeuValLysThr
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ArgGlnProAlaPheGlyIleSerPheValLeuCysIleSerCysIleLeuValLysThr
 CGCCAGCCGGCCTTCGGTATCAGCTTTGTGCTCTGCATCTCGTGCATCCTGGTGAAGACC

 AsnArgValLeuLeuValPheGluAlaLysIleProThrSerPheHisArgLysTrpTrp
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 AsnArgValLeuLeuValPheGluAlaLysIleProThrSerPheHisArgLysTrpTrp
 AACCGCGTCCTCCTGGTGTTTGAGGCCAAGATCCCCACCAGCTTCCATCGCAAGTGGTGG

 GlyLeuAsnLeuGlnPheLeuLeuValPheLeuCysThrPheMetGlnIleValIleCys
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 GlyLeuAsnLeuGlnPheLeuLeuValPheLeuCysThrPheMetGlnIleValIleCys
 GGGCTCAACCTGCAGTTCCTGCTGGTTTTCCTCTGCACCTTCATGCAGATCGTCATCTGT

 ValIleTrpLeuTyrThrAlaProProSerSerTyrArgAsnGlnGluLeuGluAspGlu
 ||||||||||||||||||||||||||||||||||||||||||   |||||||||||||||
 ValIleTrpLeuTyrThrAlaProProSerSerTyrArgAsnHisGluLeuGluAspGlu
 GTGATCTGGCTCTACACCGCACCCCCCTCCAGCTACCGTAACCATGAGCTAGAGGACGAG

 IleIlePheIleThrCysHisGluGlySerLeuMetAlaLeuGlyPheLeuIleGlyTyr
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 IleIlePheIleThrCysHisGluGlySerLeuMetAlaLeuGlyPheLeuIleGlyTyr
 ATCATCTTCATCACATGCCACGAGGGCTCGCTCATGGCCTTGGGCTTCCTGATTGGCTAC

 ThrCysLeuLeuAlaAlaIleCysPhePhePheAlaPheLysSerArgLysLeuProGlu
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ThrCysLeuLeuAlaAlaIleCysPhePhePheAlaPheLysSerArgLysLeuProGlu
 ACCTGTCTGCTGGCTGCCATCTGCTTCTTCTTTGCCTTCAAGTCCCGGAAACTGCCGGAG

 AsnPheAsnGluAlaLysPheIleThrPheSerMetLeuIlePhePheIleValTrpIle
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 AsnPheAsnGluAlaLysPheIleThrPheSerMetLeuIlePhePheIleValTrpIle
 AACTTCAACGAAGCCAAGTTCATCACCTTCAGCATGCTCATCTTCTTCATCGTCTGGATC

 SerPheIleProAlaTyrAlaSerThrTyrGlyLysPheValSerAlaValGluValIle
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 SerPheIleProAlaTyrAlaSerThrTyrGlyLysPheValSerAlaValGluValIle
 TCCTTCATCCCGGCCTATGCCAGCACCTACGGCAAGTTCGTCTCTGCCGTGGAGGTGATC

 AlaIleLeuAlaAlaSerPheGlyLeuLeuAlaCysIlePhePheAsnLysIleTyrIle
 |||||||||||||||||||||||||||||||||||||||||||||||||||   ||||||
 AlaIleLeuAlaAlaSerPheGlyLeuLeuAlaCysIlePhePheAsnLysValTyrIle
 GCCATCCTGGCGGCCAGTTTTGGCTTGCTGGCCTGCATCTTCTTCAACAAGGTCTACATC

 IleLeuPheLysProSerArgAsnThrIleGluGluValArgCysSerThrAlaAlaHis
 |||||||||||||||   ||||||||||||||||||||||||||||||||||||||||||
 IleLeuPheLysProAlaArgAsnThrIleGluGluValArgCysSerThrAlaAlaHis
 ATCCTCTTCAAGCCGGCCCGTAACACCATCGAGGAGGTGCGCTGCAGCACCGCTGCTCAC

 AlaPheLysValAlaAlaArgAlaThrLeuArgArgSerAsnValSerArgLysArgSer
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 AlaPheLysValAlaAlaArgAlaThrLeuArgArgSerAsnValSerArgLysArgSer
 GCTTTCAAGGTGGCGGCCCGGGCCACGCTGCGCCGCAGCAACGTCTCCCGCAAGCGCTCC

 SerSerLeuGlyGlySerThrGlySerThrProSerSerSerIleSerSerLysSerAsn
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 SerSerLeuGlyGlySerThrGlySerThrProSerSerSerIleSerSerLysSerAsn
 AGCAGCCTCGGGGGCTCCACAGGGTCCACCCCCTCATCCTCCATCAGCAGCAAGAGCAAC

 SerGluAspProPheProGlnProGluArgGlnLysGlnGlnGlnProLeuAlaLeuThr
 ||||||||||||||||||||||||||||||||||||||||||   |||||||||||||||
 SerGluAspProPheProGlnProGluArgGlnLysGlnGlnHisProLeuAlaLeuThr
 AGCGAAGACCCCTTCCCACAGCCCGAGAGGCAGAAACAGCAGCACCCACTGGCCCTGACC

 GlnGlnGluGlnGlnGlnGlnProLeuThrLeuProGlnGlnGlnArgSerGlnGlnGln
 |||||||||   |||                  |||||||||            ||||||
 GlnGlnGluProGln------------------ProGlnGln---------SerGlnGln
 CAGCAGGAGCCGCAG------------------CCGCAGCAG---------TCGCAGCAG

 ProArgCysLysGlnLysValIlePheGlySerGlyThrValThrPheSerLeuSerPhe
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 ProArgCysLysGlnLysValIlePheGlySerGlyThrValThrPheSerLeuSerPhe
 CCCCGGTGCAAGCAGAAGGTCATCTTCGGCAGTGGCACAGTCACCTTCTCCCTGAGCTTT

 AspGluProGlnLysAsnAlaMetAlaHisArgAsnSerThrHisGlnAsnSerLeuGlu
 ||||||||||||||||||      ||||||||||||||||||||||||||||||||||||
 AspGluProGlnLysAsnThrThrAlaHisArgAsnSerThrHisGlnAsnSerLeuGlu
 GACGAGCCTCAGAAGAACACCACCGCTCACAGGAATTCCACACACCAGAACTCCCTGGAG

 AlaGlnLysSerSerAspThrLeuThrArgHisGluProLeuLeuProLeuGlnCysGly
    ||||||   ||||||   ||||||||||||      |||||||||||||||||||||
 ThrGlnLysGlySerAspAlaLeuThrArgHisGlnAlaLeuLeuProLeuGlnCysGly
 ACACAGAAAGGCAGCGATGCCCTGACCAGACACCAGGCACTGCTCCCGCTGCAGTGCGGG

 GluThrAspLeuAspLeuThrValGlnGluThrGlyLeuGlnGlyProValGlyGlyAsp
 |||   |||               |||   ||||||||||||||||||||||||||||||
 GluAsnAspSerGluProAlaThrGlnAspThrGlyLeuGlnGlyProValGlyGlyAsp
 GAGAATGACTCAGAACCGGCCACCCAGGACACAGGCCTGCAGGGGCCTGTCGGGGGCGAC

 GlnArgProGluValGluAspProGluGluLeuSerProAlaLeuValValSerSerSer
       ||||||   |||||||||||||||   |||||||||||||||||||||   |||
 HisProProGluMetGluAspProGluGluMetSerProAlaLeuValValSerAsnSer
 CACCCGCCAGAGATGGAGGACCCTGAAGAGATGTCCCCAGCCCTCGTGGTATCCAACTCA

 GlnSerPheValIleSerGlyGlyGlySerThrValThrGluAsnValValAsnSer
    |||||||||||||||   |||   ||||||   |||||||||         |||
 ArgSerPheValIleSerSerGlySerSerThrGlyThrGluAsnIleLeuHisSer
 CGGAGCTTTGTCATCAGCAGTGGCAGCAGCACAGGCACAGAGAACATCCTGCATTCG


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