| Basic information |
| Official Symbol | C14orf37 |
| Description | chromosome 14 open reading frame 37 |
| Other Aliases | c14_5376 |
| Other Description | uncharacterized protein C14orf37 |
| Mutation type | Insert and frame-shift 33-34:C-H^A |
| Location | Scaffold000133_1:2546219 2681563 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| C14orf37 |
AATTACTGGAATTGTCAACTCTGCCAATTTATGTGCCGTTTCTCTTCCAC TATGAGCAGACCGACTGTATCACACATTTGTCTGGCTTTCTATAGTCTTC TAGTTCTCAATTTTGCCACACAATGTCTGGCCTTTCCCAAAGTGGAAAGG AGAGGGGTAGAACATGTTCATGTAGAAGAAGGGCAGTCGGAGAGGATGAG CACAGATGACCTAGAAAGCAGCTCTGCTACTTCAAAGTGGACACCCCAAC GGGTAGTCTCAGAAGATCCAATGCTAGTGTCAGCAGGACCATCAGCCACG TCATTAAATAAAGTGTTCTCGATCAACAAAGAAACACATCTTCTAGAAGT TGGATTCATACCATCTAATAGCCCCAGTGTTTACACAGCCACTGAGCCAG TGGTCTTAGCAGGTGAAAAAGTATTCAGTTCTAGCCAACAAGAGGGAGTG TCTCCTGAAAGCAGACTTTCCAAAGCCATATTAACTGTTTCAACAGTGTC TCTAAATATTGATGGAAAAGGGGAACCTTTAAGCAGTACCCATGTTCAGC CCATGGTAGAAAGGACCACAGATGCCACACAAGGTTTTCCAAAGTATGGG GATGATCAACTGTTTGCAACAGAAAGTCAGGAAGGAGTTCGTTTGGGACA GTCATCTTCATCCCATGTGAATACTAAGGAAATGCTAACCACTAATCTGA GGCCTGAGGAATCTGAAGCAGACACAGGCCATCGGACAACTTTGTTTCCT GGTGCGAAGGCCACAGCAGACACTGAGCCTGCAAGCCTCTTGCCTGGTTG GGAGAAACCTTCACAGATGACAGCTGATAATACCCAGGTTACTGCTGCGA AGCACTCACTCACCACTTCCGAGTACCTCCTAAGTGTTGAGCCAGAAACT GACAGCATGTTGGGAGCCCCAGAAATCACAGAGAGTGTGAGCACAGCTGT TCCAGCCGCTTCTATCTTCAGTGATGAGTGGGATGACACCAAAGTAGAGA GTGTAAGCCAGATAAGGAACCCAAAGCTGGGAGATAGTGCAGAAACACAG GTGAGAGTGGAAACATCTCGGACAGCACCAGCAAGCCATGATGGTATGGA AGGGGGCCAACCTTTGACAGAGGCTGCAGAGGTGGCTGTGGGGCTGCCTG AAGAAAAAATACACGTGGGGACACCCCTGCCTATATTGCAGGGGGAGGAG CAATCACCTGCCTTCACCCATCAAAGTTCCTTTGGTCCAACAAGTCTGAT GGAAGATTCGAACGTTTCCGTTGTGAACCTGTTTCAAAGTGCAGGAGGTG TCACGGAATCCACAAAGGAAAACGATGCCATATTTTTCTTAGAGACTACT GTTTCTGTCTCAGAATATGAGTCGGAGGCGTATCGACTGTTGGGAAATAC ATTGAAAGACATTATCACTCAAGAGATGACAACCGCTGTTCAAGAACCAG AAGCCACTTTGTCTTTGGTCACTACCTTGGAGGTTACCAGAGACAACACT CAGACTGAGAAAGAAACGGAGGTGCTCTCTCCTGTGTCTGAAGCTCATGG TGTTACTCAGCTGTCCAGAAGATGGGAGACTCTGGCCACTACAGTTTCTA CGACAGCCATGCCATTGTCTTTGGAAGTTACTCCTGCAATGGAAGACCTA ACGGATACAATCACAGGTCCAGATGAAGAGTTCACATCAGTTTGGGGCTC TCCGGTGACACCCCCTGGAATAATGGCGGAGGCGCCCAGCAGTTCTCCAG CACTTCTTGTTTCTGAGACACCATCTGAGAGAACTGTTGTTCCATCCATC ACTCGCGTTAATACAGCTGCCACATATGGCCTGGACCAACCCGAATCTGA AGAGGGAGAAGATGATGAAGATGAAGAGGATGAAGAAGATGAAGATGAAG AAGAGGAAGATGAGGAAGAAGATGAAGAAGACAAAGATGCAGATTCCCTG GATGAGAGCTTGGATGGTGACACTGAGCTGCCAGCATTTACTGTCCCTGG AGTCACATCCCAGGAGCCTGGTCTTGAGCAGGGAAGCCTGGACCCATTGG ACGGAGTCACCTACCAAGTGCCTGACCCCATTGAGTGGGAACAGGAGAAT CAAGGCCTGGTGAGAAGCTGGATGGAAAAACTGAAAGACAAGGCTGGATA CATGTCTGGGATGCTGGTGCCTGTAGGGGTTGGGATAGCTGGAGCCTTGT TCATCTTGGGAGCGCTCTACAGCATTAAGGTTATGAATCGCAGAAGGAGA AATGGCTTCAAAAGGCATAAAAGAAAGCAGAGAGAATTCAACAGTATGCA AGATCGAGTCATGCTCTTAGCTGACAGCTCTGAAGATGAATTT |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 812 | 22 | 812 | Insert and frame-shift 33-34:C-H^A |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
AsnTyrTrpThrCysGlnLeuCysGlnCysThrCys-HisPheSerSerThrMetArg
||||||||| ||||||||||||||| |||# |||||||||||||||
AsnTyrTrpAsnCysGlnLeuCysGlnPheMetCys#ArgPheSerSerThrMetSer
AATTACTGGAATTGTCAACTCTGCCAATTTATGTGCACGTTTCTCTTCCACTATGAGC
GlyProIleValLeuHisIleCysLeuAlaPheCysSerLeuLeuLeuPheSerValA
||| ||| |||||||||||||||||| ||||||||| |
ArgProThrValSerHisIleCysLeuAlaPheTyrSerLeuLeuValLeuAsnPheA
AGACCGACTGTATCACACATTTGTCTGGCTTTCTATAGTCTTCTAGTTCTCAATTTTG
laThrGlnCysLeuAlaPheProLysIleGluArgArgArgGluIleAlaHisValHi
|||||||||||||||||||||||||| ||| |||||| ||||||||
laThrGlnCysLeuAlaPheProLysValGlu---ArgArgGlyValGluHisValHi
CCACACAATGTCTGGCCTTTCCCAAAGTGGAA---AGGAGAGGGGTAGAACATGTTCA
sAlaGluLysGlyGlnSerAspLysMetAsnThrAspAspLeuGluAsnSerSerVal
| ||| ||||||||| ||| ||||||||||||||| ||||||
sValGluGluGlyGlnSerGluArgMetSerThrAspAspLeuGluSerSerSerAla
TGTAGAAGAAGGGCAGTCGGAGAGGATGAGCACAGATGACCTAGAAAGCAGCTCTGCT
ThrSerLysGlnThrProGlnLeuValValSerGluAspProMetMetMetSerAlaV
||||||||| ||||||||| ||||||||||||||||||||| ||||||
ThrSerLysTrpThrProGlnArgValValSerGluAspProMetLeuValSerAlaG
ACTTCAAAGTGGACACCCCAACGGGTAGTCTCAGAAGATCCAATGCTAGTGTCAGCAG
alProSerAlaThrSerLeuAsnLysAlaPheSerIleAsnLysGluThrGlnProGl
|||||||||||||||||||||||| |||||||||||||||||||||
lyProSerAlaThrSerLeuAsnLysValPheSerIleAsnLysGluThrHisLeuLe
GACCATCAGCCACGTCATTAAATAAAGTGTTCTCGATCAACAAAGAAACACATCTTCT
yGlnAlaGlyLeuMetGlnThrGluArgProGlyValSerThrProThrGluSerGly
||| ||| ||| ||| ||||||
uGluValGlyPheIleProSerAsnSerProSerValTyrThrAlaThrGluProVal
AGAAGTTGGATTCATACCATCTAATAGCCCCAGTGTTTACACAGCCACTGAGCCAGTG
ValProSerAlaGluGluValPheGlySerSerGlnProGluArgIleSerProGluS
||| ||| |||||| ||||||||| ||| ||||||||||
ValLeuAlaGlyGluLysValPheSerSerSerGlnGlnGluGlyValSerProGluS
GTCTTAGCAGGTGAAAAAGTATTCAGTTCTAGCCAACAAGAGGGAGTGTCTCCTGAAA
erGlyLeuAlaLysAlaMetLeuThrIleAlaIleThrAlaThrProSerLeuThrVa
|| ||| |||||| |||||| ||| ||||||
erArgLeuSerLysAlaIleLeuThrVal---------SerThrValSerLeuAsnIl
GCAGACTTTCCAAAGCCATATTAACTGTT---------TCAACAGTGTCTCTAAATAT
lAspGluLysGluGluLeuLeuThrSerThrAsnPheGlnProIleValGluGluIle
||| ||| ||| ||| |||||| |||||| ||||||
eAspGlyLysGlyGluProLeuSerSerThrHisValGlnProMetValGluArgThr
TGATGGAAAAGGGGAACCTTTAAGCAGTACCCATGTTCAGCCCATGGTAGAAAGGACC
ThrGluThrThrLysGlyPheLeuLysTyrMetAspAsnGlnSerPheAlaThrGluS
||| ||| |||||| |||||| ||| ||| |||||||||||||
ThrAspAlaThrGlnGlyPheProLysTyrGlyAspAspGlnLeuPheAlaThrGluS
ACAGATGCCACACAAGGTTTTCCAAAGTATGGGGATGATCAACTGTTTGCAACAGAAA
erGlnGluGlyValGlyLeuGlyHisSerProSerSerTyrValAsnThrLysGluMe
|||||||||||||| |||||| ||| |||||| |||||||||||||||||
erGlnGluGlyValArgLeuGlyGlnSerSerSerSerHisValAsnThrLysGluMe
GTCAGGAAGGAGTTCGTTTGGGACAGTCATCTTCATCCCATGTGAATACTAAGGAAAT
tLeuThrThrAsnProLysThrGluLysPheGluAlaAspThrAspHisArgThrThr
||||||||||||| ||| |||||||||||| ||||||||||||
tLeuThrThrAsnLeuArgProGluGluSerGluAlaAspThrGlyHisArgThrThr
GCTAACCACTAATCTGAGGCCTGAGGAATCTGAAGCAGACACAGGCCATCGGACAACT
SerPheProGlyAlaGluSerThrAlaGlySerGluProGlySerLeuThrProAspL
|||||||||||| |||||| |||||| |||||| |||
LeuPheProGlyAlaLysAlaThrAlaAspThrGluProAlaSerLeuLeuProGlyT
TTGTTTCCTGGTGCGAAGGCCACAGCAGACACTGAGCCTGCAAGCCTCTTGCCTGGTT
ysGluLysProSerGlnMetThrAlaAspAsnThrGlnAlaAlaAlaThrLysGlnPr
|||||||||||||||||||||||||||||||||||| ||| |||
rpGluLysProSerGlnMetThrAlaAspAsnThrGlnValThrAlaAlaLysHisSe
GGGAGAAACCTTCACAGATGACAGCTGATAATACCCAGGTTACTGCTGCGAAGCACTC
oLeuGluThrSerGluTyrThrLeuSerValGluProGluThrAspSerLeuLeuGly
||| |||||||||||| ||||||||||||||||||||||||||| ||||||
rLeuThrThrSerGluTyrLeuLeuSerValGluProGluThrAspSerMetLeuGly
ACTCACCACTTCCGAGTACCTCCTAAGTGTTGAGCCAGAAACTGACAGCATGTTGGGA
AlaProGluValThrValSerValSerThrAlaValProAlaAlaSerAlaLeuSerA
||||||||| ||| |||||||||||||||||||||||||||||| ||||
AlaProGluIleThrGluSerValSerThrAlaValProAlaAlaSerIlePheSerA
GCCCCAGAAATCACAGAGAGTGTGAGCACAGCTGTTCCAGCCGCTTCTATCTTCAGTG
spGluTrpAspAspThrLysLeuGluSerValSerArgIleArgThrProLysLeuGl
|||||||||||||||||||| |||||||||||| |||||| |||||||||||
spGluTrpAspAspThrLysValGluSerValSerGlnIleArgAsnProLysLeuGl
ATGAGTGGGATGACACCAAAGTAGAGAGTGTAAGCCAGATAAGGAACCCAAAGCTGGG
yAspAsnGluGluThrGlnValArgThrGluMetSerGlnThrAlaGlnValSerHis
|||| ||||||||||||||| ||| ||| |||||| ||||||
yAspSerAlaGluThrGlnValArgValGluThrSerArgThrAlaProAlaSerHis
AGATAGTGCAGAAACACAGGTGAGAGTGGAAACATCTCGGACAGCACCAGCAAGCCAT
GluGlyMetGluGlyGlyGlnProTrpThrGluAlaAlaGlnValAlaLeuGlyLeuP
||||||||||||||||||||| |||||||||||| |||||| |||||||
AspGlyMetGluGlyGlyGlnProLeuThrGluAlaAlaGluValAlaValGlyLeuP
GATGGTATGGAAGGGGGCCAACCTTTGACAGAGGCTGCAGAGGTGGCTGTGGGGCTGC
roGluGlyGluThrHisThrGlyThrAlaLeuLeuIleAlaHisGlyAsnGluArgSe
||||| ||| |||||| ||| ||| ||| ||| ||
roGluGluLysIleHisValGlyThrProLeuProIleLeuGlnGlyGluGluGlnSe
CTGAAGAAAAAATACACGTGGGGACACCCCTGCCTATATTGCAGGGGGAGGAGCAATC
rProAlaPheThrAspGlnSerSerPheThrProThrSerLeuMetGluAspMetLys
||||||||||||| |||||||||||| |||||||||||||||||||||
rProAlaPheThrHisGlnSerSerPheGlyProThrSerLeuMetGluAspSerAsn
ACCTGCCTTCACCCATCAAAGTTCCTTTGGTCCAACAAGTCTGATGGAAGATTCGAAC
ValSerIleValAsnLeuLeuGlnSerThrGlyAspPheThrGluSerThrLysGluA
|||||| ||||||||| |||||| ||| |||||||||||||||||||
ValSerValValAsnLeuPheGlnSerAlaGlyGlyValThrGluSerThrLysGluA
GTTTCCGTTGTGAACCTGTTTCAAAGTGCAGGAGGTGTCACGGAATCCACAAAGGAAA
snAspAlaLeuPhePheLeuGluThrThrValSerValSerValTyrGluSerGluAl
|||||||| |||||||||||||||||||||||||||||| ||||||||||||||
snAspAlaIlePhePheLeuGluThrThrValSerValSerGluTyrGluSerGluAl
ACGATGCCATATTTTTCTTAGAGACTACTGTTTCTGTCTCAGAATATGAGTCGGAGGC
aAspGlnLeuLeuGlyAsnThrMetLys{A} >>>> Target Intron 1 >>>>
| ||||||||||||||| |||{|} 8641 bp
aTyrArgLeuLeuGlyAsnThrLeuLys{A}++
GTATCGACTGTTGGGAAATACATTGAAA{G}gt
{sp}IleIleThrGlnGluMetThrThrAlaValGlnGluProAspAlaThrLeuS
{||}||||||||||||||||||||||||||||||||||||||| ||||||||||
++{sp}IleIleThrGlnGluMetThrThrAlaValGlnGluProGluAlaThrLeuS
ag{AC}ATTATCACTCAAGAGATGACAACCGCTGTTCAAGAACCAGAAGCCACTTTGT
erMetValThrGlnGluGlnValAlaThrLeuGluLeuIleArgAspSerGlyLysTh
|| |||||| ||||||||| |||||| ||
erLeuValThr---------------ThrLeuGluValThrArgAspAsnThrGlnTh
CTTTGGTCACT---------------ACCTTGGAGGTTACCAGAGACAACACTCAGAC
rGluGluGluLysGluAspProSerProValSerAspValProGlyValThrGlnLeu
|||| ||| ||| |||||||||||| |||||||||||||||
rGluLysGluThrGluValLeuSerProValSerGluAlaHisGlyValThrGlnLeu
TGAGAAAGAAACGGAGGTGCTCTCTCCTGTGTCTGAAGCTCATGGTGTTACTCAGCTG
SerArgArgTrpGluProLeuAlaThrThrIleSerThrThrValValProLeuSerP
||||||||||||||| |||||||||||| ||||||||| |||||||||
SerArgArgTrpGluThrLeuAlaThrThrValSerThrThrAlaMetProLeuSerL
TCCAGAAGATGGGAGACTCTGGCCACTACAGTTTCTACGACAGCCATGCCATTGTCTT
heGluValThrProThrValGlu{G} >>>> Target Intron 2 >>>> {lu
|||||||||||| |||{ } 2876 bp {
euGluValThrProAlaMetGlu{A}++ ++{sp
TGGAAGTTACTCCTGCAATGGAA{G}gt ag{AC
}GlnMetAspThrValThrGlyProAsnGluGluPheThrProValLeuGlySerPro
} |||||| ||||||||| |||||||||||| ||| |||||||||
}LeuThrAspThrIleThrGlyProAspGluGluPheThrSerValTrpGlySerPro
}CTAACGGATACAATCACAGGTCCAGATGAAGAGTTCACATCAGTTTGGGGCTCTCCG
ValThrProProGlyIleMetValGlyGluProSerIleSerProAlaLeuProAlaL
||||||||||||||||||||| |||||| ||||||||||||
ValThrProProGlyIleMetAlaGluAlaProSerSerSerProAlaLeuLeuValS
GTGACACCCCCTGGAATAATGGCGGAGGCGCCCAGCAGTTCTCCAGCACTTCTTGTTT
euGluAlaSerSerGluArgArgThrValValProSerIleThrArgValAsnThrAl
||| |||||| ||||||||||||||||||||||||||||||||||||||
erGluThrProSerGlu---ArgThrValValProSerIleThrArgValAsnThrAl
CTGAGACACCATCTGAG---AGAACTGTTGTTCCATCCATCACTCGCGTTAATACAGC
aAlaSerTyrGlyLeuAspGlnLeuGluSerGlu{G} >>>> Target Intron
|||| ||||||||||||||| |||||||||{|} 34130 bp
aAlaThrTyrGlyLeuAspGlnProGluSerGlu{G}++
TGCCACATATGGCCTGGACCAACCCGAATCTGAA{G}gt
3 >>>> {lu}GlyGlnGluAspGluAspGluGluAspGluGluAspGluAspGluG
{||}||| |||||||||||||||||||||||||||||||||||||
++{lu}GlyGluAspAspGluAspGluGluAspGluGluAspGluAspGluG
ag{AG}GGAGAAGATGATGAAGATGAAGAGGATGAAGAAGATGAAGATGAAG
luGluGluAspGluGluGluAspGluGluAspLysAspAlaAspSerLeuAspGluGl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luGluGluAspGluGluGluAspGluGluAspLysAspAlaAspSerLeuAspGluSe
AAGAGGAAGATGAGGAAGAAGATGAAGAAGACAAAGATGCAGATTCCCTGGATGAGAG
yLeuAspGlyAspThrGluLeuProGlyPheThrLeuProGlyIleThrSerGlnGlu
|||||||||||||||||||||||| |||||| |||||| ||||||||||||
rLeuAspGlyAspThrGluLeuProAlaPheThrValProGlyValThrSerGlnGlu
CTTGGATGGTGACACTGAGCTGCCAGCATTTACTGTCCCTGGAGTCACATCCCAGGAG
ProGlyLeuGluGluGlyAsnMetAspLeuLeuGluGlyAlaThrTyrGlnValProA
|||||||||||| ||| ||| ||| ||| ||||||||||||||||
ProGlyLeuGluGlnGlySerLeuAspProLeuAspGlyValThrTyrGlnValProA
CCTGGTCTTGAGCAGGGAAGCCTGGACCCATTGGACGGAGTCACCTACCAAGTGCCTG
spAlaLeuGluTrpGluGlnGlnAsnGlnGlyLeu{V} >>>> Target Intron
|| |||||||||||| ||||||||||||{|} 79283 bp
spProIleGluTrpGluGlnGluAsnGlnGlyLeu{V}++
ACCCCATTGAGTGGGAACAGGAGAATCAAGGCCTG{G}gt
4 >>>> {al}ArgSerTrpMetGluLysLeuLysAspLys >>>> Target I
{||}|||||||||||||||||||||||||||||| 7829
++{al}ArgSerTrpMetGluLysLeuLysAspLys++
ag{TG}AGAAGCTGGATGGAAAAACTGAAAGACAAGgt
ntron 5 >>>> AlaGlyTyrMetSerGlyMetLeuValProValGlyValGlyIl
bp ||||||||||||||||||||||||||||||||||||||||||||
++AlaGlyTyrMetSerGlyMetLeuValProValGlyValGlyIl
agGCTGGATACATGTCTGGGATGCTGGTGCCTGTAGGGGTTGGGAT
eAlaGlyAlaLeuPheIleLeuGlyAlaLeuTyrSerIleLysValMetAsnArgArg
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
eAlaGlyAlaLeuPheIleLeuGlyAlaLeuTyrSerIleLysValMetAsnArgArg
AGCTGGAGCCTTGTTCATCTTGGGAGCGCTCTACAGCATTAAGGTTATGAATCGCAGA
ArgArgAsnGlyPheLysArgHisLysArgLys >>>> Target Intron 6 >>
||||||||||||||||||||||||||||||||| 242 bp
ArgArgAsnGlyPheLysArgHisLysArgLys++
AGGAGAAATGGCTTCAAAAGGCATAAAAGAAAGgt
>> GlnArgGluPheAsnSerMetGlnAspArgValMetLeuLeuAlaAspSerSer
||||||||||||||||||||||||||||||||||||||||||||||||||||||
++GlnArgGluPheAsnSerMetGlnAspArgValMetLeuLeuAlaAspSerSer
agCAGAGAGAATTCAACAGTATGCAAGATCGAGTCATGCTCTTAGCTGACAGCTCT
GluAspGluPhe
||||||||||||
GluAspGluPhe
GAAGATGAATTT
//
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