| Basic information |
| Official Symbol | BBC3 |
| Description | BCL2 binding component 3 |
| Other Aliases | JFY-1, JFY1, PUMA |
| Other Description | bcl-2-binding component 3; p53 up-regulated modulator of apoptosis |
| Mutation type | premature termination 144:Q->TAG |
| Location | Scaffold000067_1:5075462 5067323 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| BBC3 |
TCTGCCCGGGCATGTCCCTGCCAGGTGCCCGGGGGCTTCCCCCTCCTGAG TCCGCCAGCTCCGGCCACAGGCCCCAGGGAGCGCCATGGCCCGCGCACGC CAGGAGGGCAGCTCCCCGGAGCCCGTAGAGGGCTTGGCCCGCGACGGCCC GCGCCCCTTCCCGCTCGGCCGTCTGATGCCCTCAGCTGTGTCCTGCGGCC TCTGCGAGCCTGGCCTGCCCGCTGCCCCCGCCCCCCTGCTGCCTGCTGCC CACCTCNNNNNNNNNNCCCACCTCTGCGCCCCCACCGCAGCCCTGGGGGG CTCTCGCTGGCCTGGGGGGCCCCGCAGCCGGCCCCGAGGCCCGCGACCGG ACGGTCCTCAGCCATCTATCTCGCCAGCGGAGCAGCACCTGGAGTCTCCT GTACCTAGTGCCCCGGGGGCCCTGGCGGGCGGTCCCACCCAGGCGGCCCC GGGAGTCCGGGGGGAGGAGGAGCAGTGGGCCCGAGAGATCGGGGCCCAGC TGCGGCGGATGGCGGACGACCTCAACGCGCAGTACGAGCGGCGGAGACAA GAAGAGCAGCAACGGCACCGCCCCTCGCCCTGGAGGGTCCTGTACAATCT TATCCTGGGACTCCTGCCCTTACCCAGGGGCCACAGAGCCCCCGAGATGG AGCCCAATTAGGTGCCTGCACCCGCCCGGCCGACGTCAGGGCCTCGGGGG GCAGGACCCTCCGTCCTGACGCCCTGGCCAGCGCGGGGAACTTCTTCTGC ACCATG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 261 | 7 | 261 | Premature termination 144:Q->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
SerAlaGlnAlaCysProCysGlnValProArgAlaAlaSerThrThrTrpValProCys
|||||| ||||||||||||||||||||| |||
SerAlaArgAlaCysProCysGlnValProGlyGlyPheProLeuLeuSerProProAla
TCTGCCCGGGCATGTCCCTGCCAGGTGCCCGGGGGCTTCCCCCTCCTGAGTCCGCCAGCT
Gln{I} >>>> Target Intron 1 >>>> {le}CysGlyProArgGluArgHis
{ } 3371 bp { } ||||||||||||||||||
Pro{A}++ --{la}ThrGlyProArgGluArgHis
CCG{G}gt tc{CC}ACAGGCCCCAGGGAGCGCCAT
GlyProArgThrProGlyGlyGlnLeuProGlyAlaArgArgGlyProGlyProArgArg
||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||
GlyProArgThrProGlyGlyGlnLeuProGlyAlaArgArgGlyLeuGlyProArgArg
GGCCCGCGCACGCCAGGAGGGCAGCTCCCCGGAGCCCGTAGAGGGCTTGGCCCGCGACGG
ProAlaProLeuProAlaArgProProGlyAlaLeuGlySerValLeuArgProLeuArg
|||||||||||||||||||||||| |||||| ||||||||||||||||||
ProAlaProLeuProAlaArgProSerAspAlaLeuSerCysValLeuArgProLeuArg
CCCGCGCCCCTTCCCGCTCGGCCGTCTGATGCCCTCAGCTGTGTCCTGCGGCCTCTGCGA
AlaArgProGlyCysArgProArgArgProHisProAlaAlaArgCysLeuProLeuArg
||| ||| |||||| ||||||||| ||| |||
AlaTrpProAlaArgCysProArg------ProProAlaAlaCysCysProProUnkUnk
GCCTGGCCTGCCCGCTGCCCCCGC------CCCCCTGCTGCCTGCTGCCCACCTCNNNNN
Pro{Hi} >>>> Target Intron 2 >>>> {s}ArgProThrArgArgHisArg
{ } 578 bp { } ||| ||| ||||||
Unk{Un}-- -+{k}ProProLeuArgProHisArg
NNN{NN}nn tg{C}CCACCTCTGCGCCCCCACCGC
ArgProGlyGlyPheProLeuAlaTrpGlySerProGlnProAlaProArgProAlaPro
||||||||| |||||||||||| ||||||||||||||||||||||||
SerProGlyGlyLeuSerLeuAlaTrpGlyAlaProGlnProAlaProArgProAlaThr
AGCCCTGGGGGGCTCTCGCTGGCCTGGGGGGCCCCGCAGCCGGCCCCGAGGCCCGCGACC
Gly{Ar} >>>> Target Intron 3 >>>> {g}SerSerAlaLeuAlaLeuAla
|||{||} 1401 bp {|}||||||||| ||||||
Gly{Ar}++ ++{g}SerSerAlaIleTyrLeuAla
GGA{CG}gt ag{G}TCCTCAGCCATCTATCTCGCC
GlyGlyAlaAlaProGlyValAlaArgAlaGlnArgProGlyGlySerGlyGlyArgSer
|||||||||||||||||| ||||||||| ||||||||||||
SerGlyAlaAlaProGlyValSerCysThr***CysProGlyGlyProGlyGlyArgSer
AGCGGAGCAGCACCTGGAGTCTCCTGTACCTAGTGCCCCGGGGGCCCTGGCGGGCGGTCC
HisProGlyGlyProGlySerProArgGlyGlyGlyThrValGlyProGlyAspArgGly
|||||||||||||||||||||||| ||||||||| ||||||||| |||||||||
HisProGlyGlyProGlySerProGlyGlyGlyGlyAlaValGlyProArgAspArgGly
CACCCAGGCGGCCCCGGGAGTCCGGGGGGAGGAGGAGCAGTGGGCCCGAGAGATCGGGGC
ProAlaAlaAlaAspGlyGlyArgProGlnArgThrValArgAlaAla{G} >>>> Ta
||||||||||||||||||||||||||||||||| ||||||||||||{|}
ProAlaAlaAlaAspGlyGlyArgProGlnArgAlaValArgAlaAla{G}++
CCAGCTGCGGCGGATGGCGGACGACCTCAACGCGCAGTACGAGCGGCG{G}gt
rget Intron 4 >>>> {lu}ThrArgGlyAlaAlaAlaAlaProProLeuThrLeu
2034 bp {||}|||||| |||||| |||||||||||| |||
++{lu}ThrArgArgAlaAlaThrAlaProProLeuAlaLeu
ag{AG}ACAAGAAGAGCAGCAACGGCACCGCCCCTCGCCCTG
GluGlyProValGlnSerHisHisGlyThrProAlaLeuThrGlnGlyProGlnSerPro
|||||||||||||||||| ||||||||||||||||||||||||||||||||||||
GluGlyProValGlnSerTyrProGlyThrProAlaLeuThrGlnGlyProGlnSerPro
GAGGGTCCTGTACAATCTTATCCTGGGACTCCTGCCCTTACCCAGGGGCCACAGAGCCCC
ArgAspGlyAlaGlnLeuGlyAlaCysThrArgProValAspValArgAspSerGlyGly
|||||||||||||||||||||||||||||||||||| ||||||||| |||||||||
ArgAspGlyAlaGlnLeuGlyAlaCysThrArgProAlaAspValArgAlaSerGlyGly
CGAGATGGAGCCCAATTAGGTGCCTGCACCCGCCCGGCCGACGTCAGGGCCTCGGGGGGC
ArgProLeuProProProAspThrLeuAlaSerAlaGlyAspPheLeuCysThrMet
||| ||| |||||| ||||||||||||||| ||| |||||||||
ArgThrLeu---ArgProAspAlaLeuAlaSerAlaGlyAsnPhePheCysThrMet
AGGACCCTC---CGTCCTGACGCCCTGGCCAGCGCGGGGAACTTCTTCTGCACCATG
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