| Basic information |
| Official Symbol | ATP7B |
| Description | ATPase, Cu++ transporting, beta polypeptide |
| Other Aliases | RP11-327P2.1, PWD, WC1, WD, WND |
| Other Description | ATPase, Cu(2+)- transporting, beta polypeptide; Wilson disease-associated protein; copper pump 2; copper-transporting ATPase 2 |
| Mutation type | Delete and frame-shift 1127:L->CA |
| Location | Scaffold000402_1:5671895 5720532 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| ATP7B |
ATCTTATCTAAACTTTCATTGCCCACTCATGCCTGGGAACCAGCAATGAAGCAGAGTTTT GCCTTTGACAACGTTGGCTATGAAGATGGTCTGGACAGCGTGTACCCTTCTTCTGCAACA GCAACCACCAACATCAGCATTCTGGGCATGACTTGCCAGTCGTGTGTAAAGTCCATCGAG GGCAGGATTTCTGGTTTGAAAGGCATCATAAGCATTAAGGTTTCCCTGGAACAAGGCATT GCAACTGTGAAATATGTGCCATCAGTTATGAGTCTGCAACAGATTTGCCATGAAATTGGG GACATGGGCTTTGAGGCCAGTGTTACAGAAGGAAAGGCTGCCTCCTGGCCCTCAAGGTCC TCACCTGCCCAGGAGGCTGTAGTCAAACTCCGGATAGAGGGTATGACCTGCCAGTCCTGT GTCAGCTCCATCGAAGGCAAGATCAGAAAATTGCAAGGAGTAGTAAGAGTCAAAGTCTCT CTTGGCAACCAAGAGGCAGTCATCACTTACCAGCCTTATCTTATTCAACCCGAAGACCTC AGGGACCATGTAAATGACATGGGATTTGAAGCTGCCATCAAGAATAAAATGACCCCCTTA AGTCTGGGACCAATTGATATTGGACGATTACAAAGCACTAACCCAAAGAGACTTTCGGCT TCTGCAAACCAGAATTTCAATAATTCTGAGACCTTGGAAGGAAGCCAAGGAAGCCACGTG GTCACCACACAACTGACAGTCGATGGAATGCACTGTAAGTCTTGTGTCTTGAATATTGAA GAAAATATAGGCCAGCTTCCAGGAGTTCAAAATATTCAAGTGTCCTTGGAGAACAGAACT GCCCAAGTACAATATGACCCTTCTTGTATTACCCCAGTGTCTCTGAAGAGGGCCATTGAG GCACTTCCACCTGGGAACTTTAAAGTTTCTGTTCCTGATGGGGTAGAAGGGAAGGGGACA GATAATGGGTCTTCTAGTCCTCATTCCTATGGCTCCCCCCAAAGAAACCAGGGACAGAGC ATGTACAGTACTGTGGTGCTCAGAATTGCTGGCATGACCTGTGCATCCTGTGTCCAGTCC ATTGAAGACGTGATCTCCCAACGGGAAGGTGTGCAGCAAATATCAGTCTCTCTGGCTGAA GGGACTGGAACGGTTCTTTATGATCCCTCTGTGATTAGCCCAGAAGAACTCAAAGCTGCT GTGGAAGACATGGGATTCGAGGCTTCAGTCATTCCTAACTATTCTACCAACCATGTTGGA AGCCACAATGTTGGGAATTATGTGGCCCAAACTGCAGGTGGTGTACCTGTGTCTGTGCAG GGAGTGGCTCCCCACACTGGGGGACTCTCTAAAAACCATGAGTCTGGCCGCTTATCAAAG TCCCCACAATCCACTGGAACGGTGGCACCACAGAAGTGCTTTTTACAGATCAAAGGCATG ACCTGTGCGTCCTGTGTGTCTAACATAGAAAGAAATCTTCAGAAAGAAGCTGTGCTGTCC GTGCTGGTTGCCTTGATGGCAGGAAAGGCCGAGGTGAAGTATAATCCAGAGATCATTCAG CCCGTCGAGATAGCTCAGCTCATCCAGGACCTGGGCTTTGAGGCAGCCGTCATGGAAGAC TACACAGGTTCAGGGGGCGACCTGGAGCTGATTATCACTGGGATGACCTGCGCTTCCTGT GTTCACAACATAGAGTCCAAGCTCACAAGGACAAATGGCATCACCTACGCCTCTGTAGCC CTTGCCACCAGCAAAGCCCATATTAAGTTTGATCCTGAAATTATTGGTCCACGGGATATT ATCAAAATTATTGAGGAAATTGGCTTTCATGCTTCCCTGGCCCAGAGAAACCCCAGCGCT CATCACTTGGACCACAAGATGGAAATAAAGTGGAAGAAGTCTTTCCTGTGTAGCCTGGTG TTTGGCATTCCCGTTATGGGCTTGATGATCTACATGTTAATACCCAGCAATGAGCCGCAT GAGGCGATGGTCCTGGACCACAACATCATCCCAGGACTGTCCATTCTGAATCTCATCTTC TTTATCTTGTGTACCTTCGTACAGTTCCTTGGTGGGTGGTACTTCTATGTTCAGGCCTAC AAATCCCTGAGACACAGGTCAGCCAACATGGACGTGCTCATCGTCCTGGCAACAAGCATT GCCTATGTCTACTCTCTGGTGATCCTGGTGGTCGCAGTGGCCGAGAAGGCTGAGAGAAGC CCTGTGACGTTCTTTGACACGCCCCCTATGCTGTTTGTGTTCATTGCTCTGGGACGGTGG CTGGAACACGTGGCAAAGAGCAAAACCTCAGAAGCCCTTGCCAAACTCATGTCTCTCCAG GCCACAGAAGCCACTGTTGTGACCCTTGGGGAGGACAACCTAATTATTGAGGAGCAAGTA CCCATGGAGCTGGTGCAACGGGGTGATATCATCAAGGTTGTCCCTGGGGGAAAATTCCCC GTGGATGGGAAAGTCTTGGAAGGCAATACCATGGCTGACGAGTCCCTCATCACAGAAGCC ATGCCAGTTACCAAGAAACCCGGAAGCATTGTTATCGCAGGGTCTATAAATGCCCATGGC TCTGTGCTCATTGAAGCCACCCATGTGGGCAATGAGACCACTTTGGCTCAGATTGTGAAG TTGGTGGAAGAGGCTCAGATGTCAAAGGCACCTATTCAGCAACTGGCTGACCGGTTTAGT GGATATTTTGTCCCATTTATCATCATCATTTCAACTTTGACGCTGGTGGTATGGATTGTA ATCGGTTTTATCGATTTTGGTGTTGTTCAGAAATATTTTCCTAACCCCCACAAGCATATT TCCCAGACAGAGGTGATCATCCGGTTTGCATTCCAGACTTCCATCACGGTGCTGTGCATT GCCTGCCCCTGTTCCCTGGGGCTGGCCACACCTACGGCTGTCATGGTGGGCACTGGGGTG GCTGCCCAGAACGGTGTGCTCATCAAGGGAGGCAAGCCTCTGGAAATGGCCCACAAGATA AAGACTGTGATGTTTGACAAAACTGGCACCATTACCCATGGGGTCCCCAGAGTCATGAGG GTCCTCCTGCTTGTGGACGTGGCTGCGCTCCCCCTCAGAAAGGTCCTGGCTGTGGTGGGG ACTGCAGAAGCCAGCAGCGAGCACCCCTTGGGCGTGGCCGTCACCAAGTACTGTAAAGAG GTACTTGGAACAGAGACCTTAGGATACTGCACGGATTTCCAGGCAGTGCCAGGTTGCGGA ATTGGCTGTAAAGTCAGCAGCGTGGAAGCCATCTTGGCCCCTGGTGAGTGCCCACTGGGA GAGCAGGCCAGTCACCAGAGCAGGCTGGCCACCCCCCTACAGAGAAAGATGCAGCCCCCC AGACCTTCTCTGTGCTGATTGGAAACCGTGAATGGATGAGGCGCAATGGCCTAACTATTT CCAGCGACGTCAGTGACGCCATGACAGATCATGAGATGAAAGGACAGACCGCCATCTTGG CAGCTATTGATGTGCTATGTGGGATGATTGCCATCGCAGACGCTGTCAAGCCGGAGGCCG CCCTGGCTGTGCACACCCTCAAAAACATGGGCGTGGATGTCGTTCTGATCACAGGGGATA ACCGGAAGACAGCCAGAGCCATTGCCACCCAGGTTGGCATCAACAAAGTCTTTGCAGAGG TTCTGCCTTCTCACAAGGTGGCCAAGGTCCAGGAACTCCAGAACAAGGGCAAGAAAGTCG CCATGGTGGGAGACGGGGTTAATGACTCCCCGGCCTTGGCCCAGGCTGATGTTGGCATCG CTATTGGGACTGGCACAGATGTGGCCATTGAGGCAGCTGACGTCGTCCTCATCAGAAATG ATTTACTTGATGTGGTGGCTAGCATTCACCTTTCCAAGCGGACGGTCCGGAGAATCCGAG TCAATCTGGTCCTGGCATTGATTTATAACCTGGTTGGGATCCCCATTGCAGCAGTCTTCA TGCCTCTCGGCATCGTGTTGCAGCCATGGATGGGCTCGGCGGCCATGGCAGCCTCCTCTG TGTCTGTGGTGCTCTCATCTCTGCAGCTCAAGTATAAGAAGCCTGACCTGGAGAGGTACG AGGCCCAGGCCCACGGCCGCATGAAGCCCCTGAGTGCATCGCAGGTCAGCGTGCACATCG GCATGGACGACCGGCAGCGGGACTCTCCCAGGGCCACACCATGGGACCAGGTCAGCTACG TCAGCCAAGTGTCTCTGTCCTCCCTGACGTCCGACAGGCTGTCTCGGCACAGCACCATGG TGGACGACGGCGGGGACAAATGGTCTCTGCTTCTGAATGACAGGGATGACGAACAGTACA TC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 1465 | 18 | 1465 | Delete and frame-shift 1127:L->CA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
IleLeuSerLysLeuSerLeuProThrArgAlaTrpGluProAlaMetLysLysSerPhe
||||||||||||||||||||||||||| ||||||||||||||||||||| ||||||
IleLeuSerLysLeuSerLeuProThrHisAlaTrpGluProAlaMetLysGlnSerPhe
ATCTTATCTAAACTTTCATTGCCCACTCATGCCTGGGAACCAGCAATGAAGCAGAGTTTT
AlaPheAspAsnValGlyTyrGluGlyGlyLeuAspGlyLeuGlyProSerSerGlnVal
|||||||||||||||||||||||| ||||||||| |||||||||
AlaPheAspAsnValGlyTyrGluAspGlyLeuAspSerValTyrProSerSerAlaThr
GCCTTTGACAACGTTGGCTATGAAGATGGTCTGGACAGCGTGTACCCTTCTTCTGCAACA
AlaThrSerThrValArgIleLeuGlyMetThrCysGlnSerCysValLysSerIleGlu
|||||| ||||||||||||||||||||||||||||||||||||||||||
AlaThrThrAsnIleSerIleLeuGlyMetThrCysGlnSerCysValLysSerIleGlu
GCAACCACCAACATCAGCATTCTGGGCATGACTTGCCAGTCGTGTGTAAAGTCCATCGAG
AspArgIleSerAsnLeuLysGlyIleIleSerMetLysValSerLeuGluGlnGlySer
||||||||| |||||||||||||||||| |||||||||||||||||||||
GlyArgIleSerGlyLeuLysGlyIleIleSerIleLysValSerLeuGluGlnGlyIle
GGCAGGATTTCTGGTTTGAAAGGCATCATAAGCATTAAGGTTTCCCTGGAACAAGGCATT
AlaThrValLysTyrValProSerValValCysLeuGlnGlnValCysHisGlnIleGly
||||||||||||||||||||||||||| ||||||||| |||||| ||||||
AlaThrValLysTyrValProSerValMetSerLeuGlnGlnIleCysHisGluIleGly
GCAACTGTGAAATATGTGCCATCAGTTATGAGTCTGCAACAGATTTGCCATGAAATTGGG
AspMetGlyPheGluAlaSerIleAlaGluGlyLysAlaAlaSerTrpProSerArgSer
||||||||||||||||||||| |||||||||||||||||||||||||||||||||
AspMetGlyPheGluAlaSerValThrGluGlyLysAlaAlaSerTrpProSerArgSer
GACATGGGCTTTGAGGCCAGTGTTACAGAAGGAAAGGCTGCCTCCTGGCCCTCAAGGTCC
LeuProAlaGlnGluAlaValValLysLeuArgValGluGlyMetThrCysGlnSerCys
|||||||||||||||||||||||||||||| ||||||||||||||||||||||||
SerProAlaGlnGluAlaValValLysLeuArgIleGluGlyMetThrCysGlnSerCys
TCACCTGCCCAGGAGGCTGTAGTCAAACTCCGGATAGAGGGTATGACCTGCCAGTCCTGT
ValSerSerIleGluGlyLysValArgLysLeuGlnGlyValValArgValLysValSer
||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||
ValSerSerIleGluGlyLysIleArgLysLeuGlnGlyValValArgValLysValSer
GTCAGCTCCATCGAAGGCAAGATCAGAAAATTGCAAGGAGTAGTAAGAGTCAAAGTCTCT
LeuSerAsnGlnGluAlaValIleThrTyrGlnProTyrLeuIleGlnProGluAspLeu
||| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuGlyAsnGlnGluAlaValIleThrTyrGlnProTyrLeuIleGlnProGluAspLeu
CTTGGCAACCAAGAGGCAGTCATCACTTACCAGCCTTATCTTATTCAACCCGAAGACCTC
ArgAspHisValAsnAspMetGlyPheGluAlaAlaIleLysSerLysValAlaProLeu
|||||||||||||||||||||||||||||||||||||||||| ||| ||||||
ArgAspHisValAsnAspMetGlyPheGluAlaAlaIleLysAsnLysMetThrProLeu
AGGGACCATGTAAATGACATGGGATTTGAAGCTGCCATCAAGAATAAAATGACCCCCTTA
SerLeuGlyProIleAspIleGluArgLeuGlnSerThrAsnProLysArgProLeuSer
||||||||||||||||||||| |||||||||||||||||||||||||||
SerLeuGlyProIleAspIleGlyArgLeuGlnSerThrAsnProLysArgLeuSerAla
AGTCTGGGACCAATTGATATTGGACGATTACAAAGCACTAACCCAAAGAGACTTTCGGCT
SerAlaAsnGlnAsnPheAsnAsnSerGluThrLeu<->GlyHisGlnGlySerHisVal
|||||||||||||||||||||||||||||||||||| ||| |||||||||||||||
SerAlaAsnGlnAsnPheAsnAsnSerGluThrLeuGluGlySerGlnGlySerHisVal
TCTGCAAACCAGAATTTCAATAATTCTGAGACCTTGGAAGGAAGCCAAGGAAGCCACGTG
ValThrLeuGlnLeuArgIleAspGlyMetHisCysLysSerCysValLeuAsnIleGlu
|||||| |||||| |||||||||||||||||||||||||||||||||||||||
ValThrThrGlnLeuThrValAspGlyMetHisCysLysSerCysValLeuAsnIleGlu
GTCACCACACAACTGACAGTCGATGGAATGCACTGTAAGTCTTGTGTCTTGAATATTGAA
GluAsnIleGlyGlnLeuLeuGlyValGlnSerIleGlnValSerLeuGluAsnLysThr
|||||||||||||||||| ||||||||| ||||||||||||||||||||| |||
GluAsnIleGlyGlnLeuProGlyValGlnAsnIleGlnValSerLeuGluAsnArgThr
GAAAATATAGGCCAGCTTCCAGGAGTTCAAAATATTCAAGTGTCCTTGGAGAACAGAACT
AlaGlnValLysTyrAspProSerCysThrSerProValAlaLeuGlnArgAlaIleGlu
||||||||| ||||||||||||||| |||||| ||| ||||||||||||
AlaGlnValGlnTyrAspProSerCysIleThrProValSerLeuLysArgAlaIleGlu
GCCCAAGTACAATATGACCCTTCTTGTATTACCCCAGTGTCTCTGAAGAGGGCCATTGAG
AlaLeuProProGlyAsnPheLysValSerLeuProAspGlyAlaGluGlySerGlyThr
|||||||||||||||||||||||||||||| ||||||||| |||||| ||||||
AlaLeuProProGlyAsnPheLysValSerValProAspGlyValGluGlyLysGlyThr
GCACTTCCACCTGGGAACTTTAAAGTTTCTGTTCCTGATGGGGTAGAAGGGAAGGGGACA
AspHisArgSerSerSerSerHisSerProGlySerProProArgAsnGlnValGlnGly
||| ||||||||| |||||| ||||||||| ||||||||| |||
AspAsnGlySerSerSerProHisSerTyrGlySerProGlnArgAsnGlnGlyGlnSer
GATAATGGGTCTTCTAGTCCTCATTCCTATGGCTCCCCCCAAAGAAACCAGGGACAGAGC
ThrCysSerThrThrLeuIleAlaIleAlaGlyMetThrCysAlaSerCysValHisSer
|||||| |||||||||||||||||||||||||||||| |||
MetTyrSerThrValValLeuArgIleAlaGlyMetThrCysAlaSerCysValGlnSer
ATGTACAGTACTGTGGTGCTCAGAATTGCTGGCATGACCTGTGCATCCTGTGTCCAGTCC
IleGluGlyMetIleSerGlnLeuGluGlyValGlnGlnIleSerValSerLeuAlaGlu
|||||| ||||||||| ||||||||||||||||||||||||||||||||||||
IleGluAspValIleSerGlnArgGluGlyValGlnGlnIleSerValSerLeuAlaGlu
ATTGAAGACGTGATCTCCCAACGGGAAGGTGTGCAGCAAATATCAGTCTCTCTGGCTGAA
GlyThrAlaThrValLeuTyrAsnProSerValIleSerProGluGluLeuArgAlaAla
|||||| |||||||||||| ||||||||||||||||||||||||||| ||||||
GlyThrGlyThrValLeuTyrAspProSerValIleSerProGluGluLeuLysAlaAla
GGGACTGGAACGGTTCTTTATGATCCCTCTGTGATTAGCCCAGAAGAACTCAAAGCTGCT
IleGluAspMetGlyPheGluAlaSerValValSer{G} >>>> Target Intron
||||||||||||||||||||||||||| {|} 10527 bp
ValGluAspMetGlyPheGluAlaSerValIlePro{G}++
GTGGAAGACATGGGATTCGAGGCTTCAGTCATTCCT{G}gt
1 >>>> {lu}SerCysSerThrAsnProLeuGlyAsnHisSerAlaGlyAsnSerMet
{||} ||||||||| ||| ||| ||||||
++{lu}AsnTyrSerThrAsnHisValGlySerHisAsnValGlyAsnTyrVal
ag{AA}AACTATTCTACCAACCATGTTGGAAGCCACAATGTTGGGAATTATGTG
ValGlnThrThrAspGlyThrProThrSerValGlnGluValAlaProHisThrGlyArg
|||||| ||| ||| ||||||||| ||||||||||||||||||
AlaGlnThrAlaGlyGlyValProValSerValGlnGlyValAlaProHisThrGlyGly
GCCCAAACTGCAGGTGGTGTACCTGTGTCTGTGCAGGGAGTGGCTCCCCACACTGGGGGA
LeuProAlaAsnHisAlaProAspIleLeuAlaLysSerProGlnSerThrArgAlaVal
||| |||||| ||| |||||||||||||||||| |||
LeuSerLysAsnHisGluSerGlyArgLeuSerLysSerProGlnSerThrGlyThrVal
CTCTCTAAAAACCATGAGTCTGGCCGCTTATCAAAGTCCCCACAATCCACTGGAACGGTG
AlaProGlnLysCysPheLeuGlnIleLysGlyMetThrCysAlaSerCysValSerAsn
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AlaProGlnLysCysPheLeuGlnIleLysGlyMetThrCysAlaSerCysValSerAsn
GCACCACAGAAGTGCTTTTTACAGATCAAAGGCATGACCTGTGCGTCCTGTGTGTCTAAC
IleGluArgAsnLeuGlnLysGluAla{G} >>>> Target Intron 2 >>>> {
|||||||||||||||||||||||||||{|} 1853 bp {
IleGluArgAsnLeuGlnLysGluAla{G}++ ++{
ATAGAAAGAAATCTTCAGAAAGAAGCT{G}gt ag{
ly}ValLeuSerValLeuValAlaLeuMetAlaGlyLysAlaGluIleLysTyrAspPro
||}|||||||||||||||||||||||||||||||||||||||||| |||||| |||
ly}ValLeuSerValLeuValAlaLeuMetAlaGlyLysAlaGluValLysTyrAsnPro
GT}GTGCTGTCCGTGCTGGTTGCCTTGATGGCAGGAAAGGCCGAGGTGAAGTATAATCCA
GluValIleGlnProLeuGluIleAlaGlnPheIleGlnAspLeuGlyPheGluAlaAla
||| ||||||||| |||||||||||| |||||||||||||||||||||||||||
GluIleIleGlnProValGluIleAlaGlnLeuIleGlnAspLeuGlyPheGluAlaAla
GAGATCATTCAGCCCGTCGAGATAGCTCAGCTCATCCAGGACCTGGGCTTTGAGGCAGCC
ValMetGluAspTyrAlaGlySerAspGlyAsnIleGluLeuThr >>>> Target I
||||||||||||||| |||||| ||| |||||| 4638
ValMetGluAspTyrThrGlySerGlyGlyAspLeuGluLeuIle++
GTCATGGAAGACTACACAGGTTCAGGGGGCGACCTGGAGCTGATTgt
ntron 3 >>>> IleThrGlyMetThrCysAlaSerCysValHisAsnIleGluSerL
bp ||||||||||||||||||||||||||||||||||||||||||||||
++IleThrGlyMetThrCysAlaSerCysValHisAsnIleGluSerL
agATCACTGGGATGACCTGCGCTTCCTGTGTTCACAACATAGAGTCCA
ysLeuThrArgThrAsnGlyIleThrTyrAlaSerValAlaLeuAlaThrSerLysAlaL
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ysLeuThrArgThrAsnGlyIleThrTyrAlaSerValAlaLeuAlaThrSerLysAlaH
AGCTCACAAGGACAAATGGCATCACCTACGCCTCTGTAGCCCTTGCCACCAGCAAAGCCC
euValLysPheAspProGluIleIleGlyProArgAspIleIleLysIleIleGlu >>
|||||||||||||||||||||||||||||||||||||||||||||||||||
isIleLysPheAspProGluIleIleGlyProArgAspIleIleLysIleIleGlu++
ATATTAAGTTTGATCCTGAAATTATTGGTCCACGGGATATTATCAAAATTATTGAGgt
>> Target Intron 4 >>>> GluIleGlyPheHisAlaSerLeuAlaGlnArgAs
2489 bp |||||||||||||||||||||||||||||||||||
++GluIleGlyPheHisAlaSerLeuAlaGlnArgAs
agGAAATTGGCTTTCATGCTTCCCTGGCCCAGAGAAA
nProAsnAlaHisHisLeuAspHisLysMetGluIleLys{Gl} >>>> Target In
|||| |||||||||||||||||||||||||||||||||{||} 1599
nProSerAlaHisHisLeuAspHisLysMetGluIleLys{Gl}++
CCCCAGCGCTCATCACTTGGACCACAAGATGGAAATAAAG{CA}gt
tron 5 >>>> {n}TrpLysLysSerPheLeuCysSerLeuValPheGlyIleProVa
bp {|}||||||||||||||||||||||||||||||||||||||||||||
++{n}TrpLysLysSerPheLeuCysSerLeuValPheGlyIleProVa
ag{G}TGGAAGAAGTCTTTCCTGTGTAGCCTGGTGTTTGGCATTCCCGT
lMetAlaLeuMetIleTyrMetLeuIleProSerAsnGluProHisGlnSerMetValLe
|||| ||||||||||||||||||||||||||||||||||||||| ||||||||
lMetGlyLeuMetIleTyrMetLeuIleProSerAsnGluProHisGluAlaMetValLe
TATGGGCTTGATGATCTACATGTTAATACCCAGCAATGAGCCGCATGAGGCGATGGTCCT
uAspHisAsnIleIleProGlyLeuSerIleLeuAsnLeuIlePhePheIleLeuCysTh
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
uAspHisAsnIleIleProGlyLeuSerIleLeuAsnLeuIlePhePheIleLeuCysTh
GGACCACAACATCATCCCAGGACTGTCCATTCTGAATCTCATCTTCTTTATCTTGTGTAC
rPheValGln >>>> Target Intron 6 >>>> LeuLeuGlyGlyTrpTyrPhe
|||||||||| 1882 bp ||||||||||||||||||
rPheValGln++ ++PheLeuGlyGlyTrpTyrPhe
CTTCGTACAGgt agTTCCTTGGTGGGTGGTACTTC
TyrValGlnAlaTyrLysSerLeuArgHisArgSerAlaAsnMetAspValLeuIleVal
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TyrValGlnAlaTyrLysSerLeuArgHisArgSerAlaAsnMetAspValLeuIleVal
TATGTTCAGGCCTACAAATCCCTGAGACACAGGTCAGCCAACATGGACGTGCTCATCGTC
LeuAlaThrSerIleAlaTyrValTyrSerLeuValIleLeuValValAlaValAlaGlu
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuAlaThrSerIleAlaTyrValTyrSerLeuValIleLeuValValAlaValAlaGlu
CTGGCAACAAGCATTGCCTATGTCTACTCTCTGGTGATCCTGGTGGTCGCAGTGGCCGAG
LysAlaGluArgSerProValThrPhePheAspThrProProMetLeuPheValPheIle
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LysAlaGluArgSerProValThrPhePheAspThrProProMetLeuPheValPheIle
AAGGCTGAGAGAAGCCCTGTGACGTTCTTTGACACGCCCCCTATGCTGTTTGTGTTCATT
AlaLeuGlyArgTrpLeuGluHisLeuAlaLys >>>> Target Intron 7 >>>>
|||||||||||||||||||||||| |||||| 1149 bp
AlaLeuGlyArgTrpLeuGluHisValAlaLys++
GCTCTGGGACGGTGGCTGGAACACGTGGCAAAGgt
SerLysThrSerGluAlaLeuAlaLysLeuMetSerLeuGlnAlaThrGluAlaThrV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
++SerLysThrSerGluAlaLeuAlaLysLeuMetSerLeuGlnAlaThrGluAlaThrV
agAGCAAAACCTCAGAAGCCCTTGCCAAACTCATGTCTCTCCAGGCCACAGAAGCCACTG
alValThrLeuGlyGluAspAsnLeuIleIle{Ar} >>>> Target Intron 8 >
||||||||||||||||||||||||||||||||{||} 5102 bp
alValThrLeuGlyGluAspAsnLeuIleIle{Ar}++
TTGTGACCCTTGGGGAGGACAACCTAATTATT{AG}gt
>>> {g}GluGluGlnValProMetGluLeuValGlnArgGlyAspIleValLysValV
{|}|||||||||||||||||||||||||||||||||||||||||| |||||||
++{g}GluGluGlnValProMetGluLeuValGlnArgGlyAspIleIleLysValV
ag{A}GAGGAGCAAGTACCCATGGAGCTGGTGCAACGGGGTGATATCATCAAGGTTG
alProGlyGlyLysPheProValAspGlyLysValLeuGluGlyAsnThrMetAlaAspG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
alProGlyGlyLysPheProValAspGlyLysValLeuGluGlyAsnThrMetAlaAspG
TCCCTGGGGGAAAATTCCCCGTGGATGGGAAAGTCTTGGAAGGCAATACCATGGCTGACG
luSerLeuIleThr{G} >>>> Target Intron 9 >>>> {ly}GluAlaMetP
||||||||||||||{|} 110 bp {||}||||||||||
luSerLeuIleThr{G}++ ++{ly}GluAlaMetP
AGTCCCTCATCACA{G}gt ag{GA}GAAGCCATGC
roValThrLysLysProGlySerThrValIleAlaGlySerIleAsnAlaHisGlySerV
||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||
roValThrLysLysProGlySerIleValIleAlaGlySerIleAsnAlaHisGlySerV
CAGTTACCAAGAAACCCGGAAGCATTGTTATCGCAGGGTCTATAAATGCCCATGGCTCTG
alLeuIleLysAlaThrHisValGlyAsnAspThrThrLeuAlaGlnIleValLysLeuV
|||||||| |||||||||||||||||| ||||||||||||||||||||||||||||
alLeuIleGluAlaThrHisValGlyAsnGluThrThrLeuAlaGlnIleValLysLeuV
TGCTCATTGAAGCCACCCATGTGGGCAATGAGACCACTTTGGCTCAGATTGTGAAGTTGG
alGluGluAlaGlnMetSerLys >>>> Target Intron 10 >>>> AlaProI
||||||||||||||||||||||| 222 bp |||||||
alGluGluAlaGlnMetSerLys++ ++AlaProI
TGGAAGAGGCTCAGATGTCAAAGgt agGCACCTA
leGlnGlnLeuAlaAspArgPheSerGlyTyrPheValProPheIleIleIleMetSerT
||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||
leGlnGlnLeuAlaAspArgPheSerGlyTyrPheValProPheIleIleIleIleSerT
TTCAGCAACTGGCTGACCGGTTTAGTGGATATTTTGTCCCATTTATCATCATCATTTCAA
hrLeuThrLeuValValTrpIleValIleGlyPheIleAspPheGlyValValGlnArgT
|||||||||||||||||||||||||||||||||||||||||||||||||||||||| |
hrLeuThrLeuValValTrpIleValIleGlyPheIleAspPheGlyValValGlnLysT
CTTTGACGCTGGTGGTATGGATTGTAATCGGTTTTATCGATTTTGGTGTTGTTCAGAAAT
yrPhePro >>>> Target Intron 11 >>>> AsnProAsnLysHisIleSerG
|||||||| 2946 bp |||||| |||||||||||||
yrPhePro++ ++AsnProHisLysHisIleSerG
ATTTTCCTgt agAACCCCCACAAGCATATTTCCC
lnThrGluValIleIleArgPheAlaPheGlnThrSerIleThrValLeuCysIleAlaC
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnThrGluValIleIleArgPheAlaPheGlnThrSerIleThrValLeuCysIleAlaC
AGACAGAGGTGATCATCCGGTTTGCATTCCAGACTTCCATCACGGTGCTGTGCATTGCCT
ysProCysSerLeuGlyLeuAlaThrProThrAlaValMetValGlyThrGlyValAlaA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ysProCysSerLeuGlyLeuAlaThrProThrAlaValMetValGlyThrGlyValAlaA
GCCCCTGTTCCCTGGGGCTGGCCACACCTACGGCTGTCATGGTGGGCACTGGGGTGGCTG
laGlnAsnGlyIleLeuIleLysGlyGlyLysProLeuGluMetAlaHisLys >>>>
||||||||||| |||||||||||||||||||||||||||||||||||||||
laGlnAsnGlyValLeuIleLysGlyGlyLysProLeuGluMetAlaHisLys++
CCCAGAACGGTGTGCTCATCAAGGGAGGCAAGCCTCTGGAAATGGCCCACAAGgt
Target Intron 12 >>>> IleLysThrValMetPheAspLysThrGlyThrIleT
2946 bp |||||||||||||||||||||||||||||||||||||
++IleLysThrValMetPheAspLysThrGlyThrIleT
agATAAAGACTGTGATGTTTGACAAAACTGGCACCATTA
hrHisGlyValProArgValMetArgValLeuLeuLeuGlyAspValAlaThrLeuProL
|||||||||||||||||||||||||||||||||||||| ||||||||| |||||||
hrHisGlyValProArgValMetArgValLeuLeuLeuValAspValAlaAlaLeuProL
CCCATGGGGTCCCCAGAGTCATGAGGGTCCTCCTGCTTGTGGACGTGGCTGCGCTCCCCC
euArgLysValLeuAlaValValGlyThrAlaGluAlaSerSerGluHisProLeuGlyV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euArgLysValLeuAlaValValGlyThrAlaGluAlaSerSerGluHisProLeuGlyV
TCAGAAAGGTCCTGGCTGTGGTGGGGACTGCAGAAGCCAGCAGCGAGCACCCCTTGGGCG
alAlaValThrLysTyrCysLysGlu >>>> Target Intron 13 >>>> GluL
|||||||||||||||||||||||||| 1732 bp |
alAlaValThrLysTyrCysLysGlu++ ++ValL
TGGCCGTCACCAAGTACTGTAAAGAGgt agGTAC
euGlyThrGluThrLeuGlyTyrCysThrAspPheGlnAlaValProGlyCysGlyIleG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euGlyThrGluThrLeuGlyTyrCysThrAspPheGlnAlaValProGlyCysGlyIleG
TTGGAACAGAGACCTTAGGATACTGCACGGATTTCCAGGCAGTGCCAGGTTGCGGAATTG
lyCysLysValSerAsnValGluGlyIleLeuAlaHisSerGluArgProLeuSerAlaP
|||||||||||||| |||||| ||||||||| ||| ||||||
lyCysLysValSerSerValGluAlaIleLeuAlaProGlyGluCysProLeuGlyGluG
GCTGTAAAGTCAGCAGCGTGGAAGCCATCTTGGCCCCTGGTGAGTGCCCACTGGGAGAGC
roAlaSerHisLeuAsnGluAlaGlySerLeuProAlaGluLys >>>> Target In
||||||||| |||||| ||| |||||| 1952
lnAlaSerHis---GluGlnAlaGlyHisProProThrGluLys++
AGGCCAGTCACCA#GAGCAGGCTGGCCACCCCCCTACAGAGAAAgg
tron 14 >>>> AspAlaValProGlnThrPheSerValLeuIleGlyAsnArgGluT
bp |||||| |||||||||||||||||||||||||||||||||||||
--AspAlaAlaProGlnThrPheSerValLeuIleGlyAsnArgGluT
taGATGCAGCCCCCCAGACCTTCTCTGTGCTGATTGGAAACCGTGAAT
rpLeuArgArgAsnGlyLeuThrIleSerSerAspValSerAspAlaMetThrAspHisG
|| |||||||||||||||||||||||||||||||||||||||||||||||||||||||
rpMetArgArgAsnGlyLeuThrIleSerSerAspValSerAspAlaMetThrAspHisG
GGATGAGGCGCAATGGCCTAACTATTTCCAGCGACGTCAGTGACGCCATGACAGATCATG
luMetLysGlyGlnThrAlaIleLeuValAlaIleAsp{G} >>>> Target Intro
|||||||||||||||||||||||||| |||||||||{|} 1193 bp
luMetLysGlyGlnThrAlaIleLeuAlaAlaIleAsp{G}++
AGATGAAAGGACAGACCGCCATCTTGGCAGCTATTGAT{G}gt
n 15 >>>> {ly}ValLeuCysGlyMetIleAlaIleAlaAspAlaValLysGlnGlu
{||}||||||||||||||||||||||||||||||||||||||| |||
++{ly}ValLeuCysGlyMetIleAlaIleAlaAspAlaValLysProGlu
ag{GT}GTGCTATGTGGGATGATTGCCATCGCAGACGCTGTCAAGCCGGAG
AlaAlaLeuAlaValHisThrLeuGlnSerMetGlyValAspValValLeuIleThrGly
|||||||||||||||||||||||| ||||||||||||||||||||||||||||||
AlaAlaLeuAlaValHisThrLeuLysAsnMetGlyValAspValValLeuIleThrGly
GCCGCCCTGGCTGTGCACACCCTCAAAAACATGGGCGTGGATGTCGTTCTGATCACAGGG
AspAsnArgLysThrAlaArgAlaIleAlaThrGln >>>> Target Intron 16
|||||||||||||||||||||||||||||||||||| 1911 bp
AspAsnArgLysThrAlaArgAlaIleAlaThrGln++
GATAACCGGAAGACAGCCAGAGCCATTGCCACCCAGgt
>>>> ValGlyIleAsnLysValPheAlaGluValLeuProSerHisLysValAlaLys
||||||||||||||||||||||||||||||||||||||||||||||||||||||
++ValGlyIleAsnLysValPheAlaGluValLeuProSerHisLysValAlaLys
agGTTGGCATCAACAAAGTCTTTGCAGAGGTTCTGCCTTCTCACAAGGTGGCCAAG
ValGlnGluLeuGlnAsnLysGlyLysLysValAlaMetValGlyAspGlyValAsnAsp
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ValGlnGluLeuGlnAsnLysGlyLysLysValAlaMetValGlyAspGlyValAsnAsp
GTCCAGGAACTCCAGAACAAGGGCAAGAAAGTCGCCATGGTGGGAGACGGGGTTAATGAC
SerProAlaLeuAlaGlnAlaAspMetGlyValAlaIleGlyThrGlyThrAspValAla
|||||||||||||||||||||||| ||| |||||||||||||||||||||||||||
SerProAlaLeuAlaGlnAlaAspValGlyIleAlaIleGlyThrGlyThrAspValAla
TCCCCGGCCTTGGCCCAGGCTGATGTTGGCATCGCTATTGGGACTGGCACAGATGTGGCC
IleGluAlaAlaAspValValLeuIleArg >>>> Target Intron 17 >>>>
|||||||||||||||||||||||||||||| 78 bp
IleGluAlaAlaAspValValLeuIleArg++ ++
ATTGAGGCAGCTGACGTCGTCCTCATCAGAgt ag
AsnAspLeuLeuAspValValAlaSerIleHisLeuSerLysArgThrValArgArgIle
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AsnAspLeuLeuAspValValAlaSerIleHisLeuSerLysArgThrValArgArgIle
AATGATTTACTTGATGTGGTGGCTAGCATTCACCTTTCCAAGCGGACGGTCCGGAGAATC
ArgIleAsnLeuValLeuAlaLeuIleTyrAsnLeuValGlyIleProIleAlaAla{G}
||| |||||||||||||||||||||||||||||||||||||||||||||||||||{|}
ArgValAsnLeuValLeuAlaLeuIleTyrAsnLeuValGlyIleProIleAlaAla{G}
CGAGTCAATCTGGTCCTGGCATTGATTTATAACCTGGTTGGGATCCCCATTGCAGCA{G}
>>>> Target Intron 18 >>>> {ly}ValPheMetProIleGlyIleValLe
1205 bp {||}|||||||||||| |||||||||||
++ ++{ly}ValPheMetProLeuGlyIleValLe
gt ag{GT}GTCTTCATGCCTCTCGGCATCGTGTT
uGlnProTrpMetGlySerAlaAlaMetAlaAlaSerSerValSerValValLeuSerSe
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
uGlnProTrpMetGlySerAlaAlaMetAlaAlaSerSerValSerValValLeuSerSe
GCAGCCATGGATGGGCTCGGCGGCCATGGCAGCCTCCTCTGTGTCTGTGGTGCTCTCATC
rLeuGlnLeuLys{Cy} >>>> Target Intron 19 >>>> {s}TyrLysLysP
|||||||||||||{||} 757 bp {|}||||||||||
rLeuGlnLeuLys{Cy}++ ++{s}TyrLysLysP
TCTGCAGCTCAAG{TG}gt ag{C}TATAAGAAGC
roAspLeuGluArgTyrGluAlaGlnAlaHisGlyHisMetLysProLeuThrAlaSerG
||||||||||||||||||||||||||||||||||| |||||||||||| |||||||
roAspLeuGluArgTyrGluAlaGlnAlaHisGlyArgMetLysProLeuSerAlaSerG
CTGACCTGGAGAGGTACGAGGCCCAGGCCCACGGCCGCATGAAGCCCCTGAGTGCATCGC
lnValSerValHisIleGlyMetAspAspArgTrpArgAspSerProArgAlaThrProT
|||||||||||||||||||||||||||||||| |||||||||||||||||||||||||
lnValSerValHisIleGlyMetAspAspArgGlnArgAspSerProArgAlaThrProT
AGGTCAGCGTGCACATCGGCATGGACGACCGGCAGCGGGACTCTCCCAGGGCCACACCAT
rpAspGlnValSerTyrValSerGlnValSerLeuSerSerLeuThrSerAspLysProS
||||||||||||||||||||||||||||||||||||||||||||||||||||| |
rpAspGlnValSerTyrValSerGlnValSerLeuSerSerLeuThrSerAspArgLeuS
GGGACCAGGTCAGCTACGTCAGCCAAGTGTCTCTGTCCTCCCTGACGTCCGACAGGCTGT
erArgHisSerAlaAlaAlaAspAspAspGlyAspLysTrpSerLeuLeuLeuAsnGlyA
||||||||||| |||||| ||||||||||||||||||||||||||| |
erArgHisSerThrMetValAspAspGlyGlyAspLysTrpSerLeuLeuLeuAsnAspA
CTCGGCACAGCACCATGGTGGACGACGGCGGGGACAAATGGTCTCTGCTTCTGAATGACA
rgAspGluGluGlnTyrIle
||||| ||||||||||||
rgAspAspGluGlnTyrIle
GGGATGACGAACAGTACATC
//
|