| Basic information |
| Official Symbol | ARHGEF18 |
| Description | Rho/Rac guanine nucleotide exchange factor (GEF) 18 |
| Other Aliases | P114-RhoGEF |
| Other Description | 114 kDa Rho-specific guanine nucleotide exchange factor; P114-RHO-GEF; Rho-specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor 18; SA-RhoGEF; p114RhoGEF; rho guanine nucleotide exchange factor 18; septin-associated RhoGEF |
| Mutation type | Insert and frame-shift 51-52:P-G^CG |
| Location | Scaffold148210_1:615286 592582 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| ARHGEF18 |
GTCACAGTGGGGTCCAATTTCCTGCCCGCCATCCCCGCTGCTCCAGCCAA TACAGCACGGGAAGACGCGGCTTTCTTTTCTAGAAGGATCCCACCGAGGC ATAAAAACGGCGCAGCCCCCGCCTGGCACCGCGCCGGGTCCGGAGCCCCG CGCGCAAAGATGGGGAACGCGCATTCCAAAGGCGGCGACCGACGGGGCGC GCTCCCCGGCCGCCCCGAGCTGTCTTTCTACGGGTCTTTCCCCAGGAAAT GGAGCGAGAACGTCTTCTTGGATCACGAGCTCCTGACCTCCAAGATCCTG TCGGTGCTGCGGCCGCAGCCCGAGCGCGGCTTCCCGGCCGGCGACCTGGA CCTGCGCTACCCGGCTCGCTTTCTCAGCCCCAACTCTGTCTTTGCCTCTG TCGCAGCCTCGCTCAAGGAGCACCCCCACAGCGCCCTCCTGGCCGATGGC AGCCCTGCCCTGTCCAGGAATGTCGGCATGACGGTCTCTCAGAAAGGGGG TCCGCAGCCTACACCGAGCCCGGCTGGAACTGGGGCGCGACCCGGACCAG TCCCAGGAGAGATGGACGAAGCCGACTCCCTGTCTTTAAAGTTCAGGCAG GCAGCCGACGACTCTCTGTCCCTCGCATCTTCGAATNNNNNNNNNNNNNN NNCCCAAGATCCCTCCACGGCCTCGCTGAGGAGCGAGATCGAATCAGATG CCCACGAGTTCGAGGCCGAGTCCTGGAGCCTCGCCGTGGACTCGGCCTAC GCCAAGAAGCAGAAGCGCGAGGTGGTTAAAAGGCAGGATGTCCTTTACGA GCTGATGCAGACGGAGGCGCACCACGTGCGGACGCTCAAGATCATGCTGA AGGTGTACTCCAGGGCGCTGCAGGAGGAGCTGCAGTTCAGCGGCCCGGCC GTCAGCCGCCTCTTCCCCTGCGCCGACGACCTGCTGGACATGCACGGCCA CTTCCTCTCCCGCCTCAAGGAGCGCCGCCAGGAGTCGCTGGAGGAGGGCA GCGACCGGAATTACGTCATCCAGAGGGTTGGGGACCTCCTGGTGCAGCAG TTTTCAGGTGAGAACGGGGAGAGGATGAAAGAAAAGTACGGAATCTTCTG CAGCGGCCACAACGAGGCCGTCAGCCATTACAAGCTGCTGATGCAACAGA ACAAGAAGTTTCAAAACTTGATCAAGAGAATCGGCAACTTCCCCATCGTG CGGCGGCTCGGCGTGCAGGAGTGTGTCCTGCTGGTCACCCAGCGCATTAC CAAGTACCCGGTGCTGGTGGAGCGCGTCATCCAGAACACGGAAGCTGGCA CCGAGGACCACGCAGACCTGACCCAGGCCCTGAGCCTCATCAAGGACATC ATCTCACAAGTGGACGCCAAGGTCAGCGAGCACGAGAAGGGCCAGCGCCT CAGGGAGATCGCGGGCAAGATGGACCTGAAGTCCTCCAGCAAGCTCAAGA ACGGGCTCGCCTTCCGGAAGGAGGACATGCTACAGCGGCAGCTCCAGCTG GCGGGCACGCTGTGCTGGAAGTCCACGTCCGGGCGCTTGAAAGATGTCCT TGCGGTCCTGTTGACCGACGTGCTTTTGCTGCTGCAAGAGAAGGATCAGA AGTACGTGTTTGCCTCTGTGGACTCGAAGCCGCCCGTCATCTCCCTGCAG AAGCTCATCGTGAGGGAGGTGGCCAACGAGGAGAAGGCCATGTTCCTGAT CAGCGCGTCGCGGCAGGGGCCCGAGATGTACGAGATCCACACCGGCTCCA AGGAGGACAGGAACGCCTGGATGGCGCACATCCGCAGGGCCGTGGAGAGC TGTCCAGACGAGGAGGACGGCCTCTTCAGTGAGGCAGAGGAGGAGCGGAA GGTGGCCGAGGCCCGGAGCATGAGGCTCAAGGACTTTCAAGAGCGGCTGA GCCAGAAGGACCAGCTGATCGCCCAGAGCCTGCTGGAGAAGCAGCAGATC TACCTGGAGATGGCAGAGCTGAGCGGGCTCGAGGACCCTCCTCAGTCACA CGCCCTCTTCCGCGGGGGGAACCCCTCCGAGATCCTGCAGGGGGAGCAGA TTCTCAATTCAGCCATGAGTGAGATCGAGGGCATCCAAGGCCTGATCTGC AGGCGGCTGAGCAGCACCAACGACCAGGCGAATGACGGAGGCTCCGCAGG CCTGCCCCGGAGGGCCGAGACCTTCGGGGGCTTCGACAGCACGAGCAGCC CCAGCAAGGATGGCAGTTTTAAGAAGGTCTGCAGCACCGACCCCAGGCCC CAAGACTGCCGAGGCCCCGTGGGCAGCTCAGACGCAAGGCTCAGCAATAG TGACAGCCTGGAATCACCACAGGCGATCGAGGATCCTGACGTGGAGACTG GTCCTCGGCTCCCCTTGATCCTGGAATCCGAGCTTGTCCAGCGGATCCAG ACGCTGTCCCGGCTGCTGCTCAGCCTCCAGGCAGTCATCGCCAGGCAGGA CAGCTACGTGGAGATGCAGCGTGCCGCCATGCAGGAGCGCGAGAAGCAGT TCCGGCTGCAGTCGACGCGCGGGGACCTGCTGCTG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 1173 | 2 | 850 | Insert and frame-shift 51-52:P-G^CG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
ValThrValGlyThrAsnIleLeuProSerArgProAlaAlaSerAlaAsnThrAlaArg
|||||||||||| ||| |||||| ||||||||| |||||||||||||||
ValThrValGlySerAsnPheLeuProAlaIleProAlaAlaProAlaAsnThrAlaArg
GTCACAGTGGGGTCCAATTTCCTGCCCGCCATCCCCGCTGCTCCAGCCAATACAGCACGG
GluAspAlaAlaLeuPheSerArgArgIleProProArgHisLysAsnGlyAlaAlaGln
|||||||||||| ||||||||||||||||||||||||||||||||||||||||||
GluAspAlaAlaPhePheSerArgArgIleProProArgHisLysAsnGlyAlaAlaPro
GAAGACGCGGCTTTCTTTTCTAGAAGGATCCCACCGAGGCATAAAAACGGCGCAGCCCCC
ProGlyAlaAlaProGlyProGlyAlaPro--GlyAlaAsnMetGlyAsnAlaHisSerL
||| |||||||||## ||| |||||||||||||||||||
AlaTrpHisArgAlaGlySerGlyAlaPro##ArgAlaLysMetGlyAsnAlaHisSerL
GCCTGGCACCGCGCCGGGTCCGGAGCCCCGCGCGCGCAAAGATGGGGAACGCGCATTCCA
ysSerGlyAspArgHisSerAlaLeuProGlyArgProGluLeuSerPheTyrGlySerP
|| ||||||||| ||||||||||||||||||||||||||||||||||||||||
ysGlyGlyAspArgArgGlyAlaLeuProGlyArgProGluLeuSerPheTyrGlySerP
AAGGCGGCGACCGACGGGGCGCGCTCCCCGGCCGCCCCGAGCTGTCTTTCTACGGGTCTT
heProArgLysTrpSerGluAsnValPheLeuAspAsnGluLeuLeuThrSerLysIleL
||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||
heProArgLysTrpSerGluAsnValPheLeuAspHisGluLeuLeuThrSerLysIleL
TCCCCAGGAAATGGAGCGAGAACGTCTTCTTGGATCACGAGCTCCTGACCTCCAAGATCC
euSerValLeuArgProGlnSerGluArgGlyPheArgAlaGly<-><->AspLeuArgT
|||||||||||||||||||| |||||||||||| |||||| ||||||||||
euSerValLeuArgProGlnProGluArgGlyPheProAlaGlyAspLeuAspLeuArgT
TGTCGGTGCTGCGGCCGCAGCCCGAGCGCGGCTTCCCGGCCGGCGACCTGGACCTGCGCT
yrProThrHisPheLeuSerThrAsnSerValLeuAlaSerValThrAlaSerLeuLysG
||||| ||||||||| ||||||||| ||||||||| |||||||||||||
yrProAlaArgPheLeuSerProAsnSerValPheAlaSerValAlaAlaSerLeuLysG
ACCCGGCTCGCTTTCTCAGCCCCAACTCTGTCTTTGCCTCTGTCGCAGCCTCGCTCAAGG
luHisProArgGlyThrLeuLeuSerAspGlySerProAlaLeuSerArgAsnValGlyM
|||||||| |||||| ||||||||||||||||||||||||||||||||||
luHisProHisSerAlaLeuLeuAlaAspGlySerProAlaLeuSerArgAsnValGlyM
AGCACCCCCACAGCGCCCTCCTGGCCGATGGCAGCCCTGCCCTGTCCAGGAATGTCGGCA
etThrValSerGlnLysGlyGlyProGlnProThrProSerProAlaGlyProGlyThrG
|||||||||||||||||||||||||||||||||||||||||||||||||| |||
etThrValSerGlnLysGlyGlyProGlnProThrProSerProAlaGlyThrGlyAlaA
TGACGGTCTCTCAGAAAGGGGGTCCGCAGCCTACACCGAGCCCGGCTGGAACTGGGGCGC
lnLeu{Gl} >>>> Target Intron 1 >>>> {y}ProIleThrGlyGluMetA
{||} 759 bp {|}||| ||||||||||
rgPro{Gl}++ ++{y}ProValProGlyGluMetA
GACCC{GG}gt ag{A}CCAGTCCCAGGAGAGATGG
spGluAlaAspSerAlaPheLeuLysPheLysGlnThrAlaAspAspSerLeuSerLeuT
|||||||||||||| ||||||||| ||| |||||||||||||||||||||
spGluAlaAspSerLeuSerLeuLysPheArgGlnAlaAlaAspAspSerLeuSerLeuA
ACGAAGCCGACTCCCTGTCTTTAAAGTTCAGGCAGGCAGCCGACGACTCTCTGTCCCTCG
hrSerProAsnThrGluSerIlePhe >>>> Target Intron 2 >>>> ValGl
||| ||| 469 bp
laSerSerAsnUnkUnkUnkUnkUnk-- --UnkGl
CATCTTCGAATNNNNNNNNNNNNNNNnn nnNCCCA
uAspProTyrThrAlaSerLeuArgSerGluIleGluSerAspGlyHisGluPheGluAl
|||||| ||||||||||||||||||||||||||||||||| ||||||||||||||
nAspProSerThrAlaSerLeuArgSerGluIleGluSerAspAlaHisGluPheGluAl
AGATCCCTCCACGGCCTCGCTGAGGAGCGAGATCGAATCAGATGCCCACGAGTTCGAGGC
aGluSerTrpSerLeuAlaValAspAlaAlaTyrAlaLysLysGlnLysArgGluValVa
||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||
aGluSerTrpSerLeuAlaValAspSerAlaTyrAlaLysLysGlnLysArgGluValVa
CGAGTCCTGGAGCCTCGCCGTGGACTCGGCCTACGCCAAGAAGCAGAAGCGCGAGGTGGT
lLysArgGlnAspValLeuTyr{G} >>>> Target Intron 3 >>>> {lu}Le
||||||||||||||||||||||{|} 1962 bp {||}||
lLysArgGlnAspValLeuTyr{G}++ ++{lu}Le
TAAAAGGCAGGATGTCCTTTAC{G}gt ag{AG}CT
uMetGlnThrGluValHisHisValArgThrLeuLysIleMetLeuLysValTyrSerAr
||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||
uMetGlnThrGluAlaHisHisValArgThrLeuLysIleMetLeuLysValTyrSerAr
GATGCAGACGGAGGCGCACCACGTGCGGACGCTCAAGATCATGCTGAAGGTGTACTCCAG
gAlaLeuGlnGluGluLeuGlnPheSerSerLysAlaIleGlyArgLeuPheProCysAl
|||||||||||||||||||||||||||| ||| |||||||||||||||||
gAlaLeuGlnGluGluLeuGlnPheSerGlyProAlaValSerArgLeuPheProCysAl
GGCGCTGCAGGAGGAGCTGCAGTTCAGCGGCCCGGCCGTCAGCCGCCTCTTCCCCTGCGC
aAspAspLeuLeuGluThrHisSerHisPheLeuAlaArgLeuLysGluArgArgGlnGl
||||||||||||| ||| ||||||||| |||||||||||||||||||||||
aAspAspLeuLeuAspMetHisGlyHisPheLeuSerArgLeuLysGluArgArgGlnGl
CGACGACCTGCTGGACATGCACGGCCACTTCCTCTCCCGCCTCAAGGAGCGCCGCCAGGA
uSerLeuGluGluGlySerAspArgAsnTyrValIleGlnLysIleGlyAspLeuLeuVa
|||||||||||||||||||||||||||||||||||||||| ||||||||||||||
uSerLeuGluGluGlySerAspArgAsnTyrValIleGlnArgValGlyAspLeuLeuVa
GTCGCTGGAGGAGGGCAGCGACCGGAATTACGTCATCCAGAGGGTTGGGGACCTCCTGGT
lGlnGln >>>> Target Intron 4 >>>> PheSerGlyGluAsnGlyGluArg
||||||| 2624 bp ||||||||||||||||||||||||
lGlnGln++ ++PheSerGlyGluAsnGlyGluArg
GCAGCAGgt agTTTTCAGGTGAGAACGGGGAGAGG
MetLysGluLysTyrGlyValPheCysSerGlyHisAsnGluAlaValSerHisTyrLys
|||||||||||||||||| |||||||||||||||||||||||||||||||||||||||
MetLysGluLysTyrGlyIlePheCysSerGlyHisAsnGluAlaValSerHisTyrLys
ATGAAAGAAAAGTACGGAATCTTCTGCAGCGGCCACAACGAGGCCGTCAGCCATTACAAG
LeuLeuLeuGlnGlnAsnLysLysPheGlnAsnLeuIleLys >>>> Target Intr
|||||| ||||||||||||||||||||||||||||||||| 2479 bp
LeuLeuMetGlnGlnAsnLysLysPheGlnAsnLeuIleLys++
CTGCTGATGCAACAGAACAAGAAGTTTCAAAACTTGATCAAGgt
on 5 >>>> LysIleGlyAsnPheSerIleValArgArgLeuGlyValGlnGluCysI
|||||||||||| ||||||||||||||||||||||||||||||
++ArgIleGlyAsnPheProIleValArgArgLeuGlyValGlnGluCysV
agAGAATCGGCAACTTCCCCATCGTGCGGCGGCTCGGCGTGCAGGAGTGTG
leLeuLeuValThrGlnArgIleThrLysTyrProValLeuValGluArgIleIleGlnA
|||||||||||||||||||||||||||||||||||||||||||||||| |||||||
alLeuLeuValThrGlnArgIleThrLysTyrProValLeuValGluArgValIleGlnA
TCCTGCTGGTCACCCAGCGCATTACCAAGTACCCGGTGCTGGTGGAGCGCGTCATCCAGA
snThrGlu{A} >>>> Target Intron 6 >>>> {la}GlyThrGluAspTyrG
||||||||{|} 3205 bp {||}||||||||||||
snThrGlu{A}++ ++{la}GlyThrGluAspHisA
ACACGGAA{G}gt ag{CT}GGCACCGAGGACCACG
luAspLeuThrGlnAlaLeuAsnLeuIleLysAspIleIleSerGlnValAspAlaLysV
|||||||||||||||||| |||||||||||||||||||||||||||||||||||||
laAspLeuThrGlnAlaLeuSerLeuIleLysAspIleIleSerGlnValAspAlaLysV
CAGACCTGACCCAGGCCCTGAGCCTCATCAAGGACATCATCTCACAAGTGGACGCCAAGG
alSerGluCysGluLysGlyGlnArgLeuArgGluIleAlaGlyLysMetAspLeuLysS
|||||||| |||||||||||||||||||||||||||||||||||||||||||||||||
alSerGluHisGluLysGlyGlnArgLeuArgGluIleAlaGlyLysMetAspLeuLysS
TCAGCGAGCACGAGAAGGGCCAGCGCCTCAGGGAGATCGCGGGCAAGATGGACCTGAAGT
erSerSerLysLeuLysAsnGlyLeuThrPheArgLysGluAspMetLeuGlnArgGlnL
|||||||||||||||||||||||||| |||||||||||||||||||||||||||||||
erSerSerLysLeuLysAsnGlyLeuAlaPheArgLysGluAspMetLeuGlnArgGlnL
CCTCCAGCAAGCTCAAGAACGGGCTCGCCTTCCGGAAGGAGGACATGCTACAGCGGCAGC
euHisLeuGluGlyMetLeuCysTrpLysThrThrSerGlyArgLeuLys{A} >>>>
|| ||| ||| |||||||||||| ||||||||||||||||||{|}
euGlnLeuAlaGlyThrLeuCysTrpLysSerThrSerGlyArgLeuLys{A}++
TCCAGCTGGCGGGCACGCTGTGCTGGAAGTCCACGTCCGGGCGCTTGAAA{G}gt
Target Intron 7 >>>> {sp}IleLeuAlaIleLeuLeuThrAspValLeuLeuL
1190 bp {||} |||||| ||||||||||||||||||||||
++{sp}ValLeuAlaValLeuLeuThrAspValLeuLeuL
ag{AT}GTCCTTGCGGTCCTGTTGACCGACGTGCTTTTGC
euLeuGlnGluLysAspGlnLysTyrValPheAlaSerVal >>>> Target Intro
||||||||||||||||||||||||||||||||||||||||| 1483 bp
euLeuGlnGluLysAspGlnLysTyrValPheAlaSerVal++
TGCTGCAAGAGAAGGATCAGAAGTACGTGTTTGCCTCTGTGgt
n 8 >>>> AspSerLysProProValIleSerLeuGlnLysLeuIleValArgGluVa
||||||||||||||||||||||||||||||||||||||||||||||||||
++AspSerLysProProValIleSerLeuGlnLysLeuIleValArgGluVa
agGACTCGAAGCCGCCCGTCATCTCCCTGCAGAAGCTCATCGTGAGGGAGGT
lAlaAsnGluGluLysAlaMetPheLeuIleSerAlaSerLeuGlnGlyProGluMetTy
|||||||||||||||||||||||||||||||||||||||| |||||||||||||||||
lAlaAsnGluGluLysAlaMetPheLeuIleSerAlaSerArgGlnGlyProGluMetTy
GGCCAACGAGGAGAAGGCCATGTTCCTGATCAGCGCGTCGCGGCAGGGGCCCGAGATGTA
rGluIleTyrThrSerSerLysGluAspArgAsnAlaTrpMetAlaHisIleGlnArgAl
||||||| ||| |||||||||||||||||||||||||||||||||||| |||||
rGluIleHisThrGlySerLysGluAspArgAsnAlaTrpMetAlaHisIleArgArgAl
CGAGATCCACACCGGCTCCAAGGAGGACAGGAACGCCTGGATGGCGCACATCCGCAGGGC
aValGlu{Se} >>>> Target Intron 9 >>>> {r}CysProAspGluGluGl
|||||||{||} 1358 bp {|}|||||||||||||||
aValGlu{Se}+- ++{r}CysProAspGluGluAs
CGTGGAG{AG}gc ag{C}TGTCCAGACGAGGAGGA
uGlyProPheSerLeuProGluGluGluArgLysValValGluAlaArgAlaThrArgLe
||| |||||| |||||||||||||||||| ||||||||| |||||
pGlyLeuPheSerGluAlaGluGluGluArgLysValAlaGluAlaArgSerMetArgLe
CGGCCTCTTCAGTGAGGCAGAGGAGGAGCGGAAGGTGGCCGAGGCCCGGAGCATGAGGCT
uArgAspPheGln{G} >>>> Target Intron 10 >>>> {lu}ArgLeuSerM
| |||||||||{|} 2159 bp {||}|||||||||
uLysAspPheGln{G}++ ++{lu}ArgLeuSerG
CAAGGACTTTCAA{G}gt ag{AG}CGGCTGAGCC
etLysAspGlnLeuIleAlaGlnSerLeuLeuGluLysGlnGlnIleTyrLeuGluMetA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnLysAspGlnLeuIleAlaGlnSerLeuLeuGluLysGlnGlnIleTyrLeuGluMetA
AGAAGGACCAGCTGATCGCCCAGAGCCTGCTGGAGAAGCAGCAGATCTACCTGGAGATGG
laGluMetGlyGlyLeuGluAspLeuProGlnProArgGlyLeuPheArgGlyGlyAspP
||||| |||||||||||| |||||| ||||||||||||||| |
laGluLeuSerGlyLeuGluAspProProGlnSerHisAlaLeuPheArgGlyGlyAsnP
CAGAGCTGAGCGGGCTCGAGGACCCTCCTCAGTCACACGCCCTCTTCCGCGGGGGGAACC
roSerGluThrLeuGlnGlyGluLeuIleLeuLysSerAlaMetSerGlu{I} >>>>
|||||||| |||||||||||| |||||| |||||||||||||||{|}
roSerGluIleLeuGlnGlyGluGlnIleLeuAsnSerAlaMetSerGlu{I}++
CCTCCGAGATCCTGCAGGGGGAGCAGATTCTCAATTCAGCCATGAGTGAG{A}gt
Target Intron 11 >>>> {le}GluGlyIleGlnSerLeuIleCysArgGlnLeu
675 bp {||}|||||||||||| |||||||||||| |||
++{le}GluGlyIleGlnGlyLeuIleCysArgArgLeu
ag{TC}GAGGGCATCCAAGGCCTGATCTGCAGGCGGCTG
GlySerAlaAsnGlyGlnAlaGluAspGlyGlySerSerThrGlyProProArgArgAla
||| ||| |||||| |||||||||||| ||| ||||||||||||
SerSerThrAsnAspGlnAlaAsnAspGlyGlySerAla---GlyLeuProArgArgAla
AGCAGCACCAACGACCAGGCGAATGACGGAGGCTCCGCA---GGCCTGCCCCGGAGGGCC
GluThrPheAlaGlyTyrAspCysThrAsnSerProThrLys{A} >>>> Target I
||||||||| ||| ||| ||| |||||| |||{ } 489
GluThrPheGlyGlyPheAspSerThrSerSerProSerLys{A}++
GAGACCTTCGGGGGCTTCGACAGCACGAGCAGCCCCAGCAAG{G}gt
ntron 12 >>>> {sn}GlySerPheLysLysLysValSerSerThrAspProArgPr
bp { }||||||||| ||||||||| |||||||||||||||||
++{sp}GlySerPhe---LysLysValCysSerThrAspProArgPr
ag{AT}GGCAGTTTT---AAGAAGGTCTGCAGCACCGACCCCAGGCC
oArgAspTrpArgGlyProProAsnSerProAspLeuLysLeuSerAspSerAspIlePr
| ||| ||||||||| ||| ||| |||||| ||||||
oGlnAspCysArgGlyProValGlySerSerAspAlaArgLeuSerAsnSerAsp-----
CCAAGACTGCCGAGGCCCCGTGGGCAGCTCAGACGCAAGGCTCAGCAATAGTGAC-----
oGlySerSerGluGluSerProGlnVal >>>> Target Intron 13 >>>> Va
||| |||||||||||| 1122 bp
-------SerLeuGluSerProGlnAla++ ++Il
-------AGCCTGGAATCACCACAGGCGgt agAT
lGluAlaProGlyThrGluSerAspProArgLeuProThrValLeuGluSerGlu >>>
||| ||| ||| |||||||||||| ||||||||||||
eGluAspProAspValGluThrGlyProArgLeuProLeuIleLeuGluSerGlu++
CGAGGATCCTGACGTGGAGACTGGTCCTCGGCTCCCCTTGATCCTGGAATCCGAGgt
> Target Intron 14 >>>> LeuValGlnArgIleGlnThrLeuSerGlnLeuLe
94 bp ||||||||||||||||||||||||||| |||||
++LeuValGlnArgIleGlnThrLeuSerArgLeuLe
agCTTGTCCAGCGGATCCAGACGCTGTCCCGGCTGCT
uLeuAsnLeuGln >>>> Target Intron 15 >>>> AlaValIleAlaHisGl
|||| |||||| 100 bp |||||||||||| ||
uLeuSerLeuGln++ ++AlaValIleAlaArgGl
GCTCAGCCTCCAGgt agGCAGTCATCGCCAGGCA
nAspSerTyrValGluThrGlnArgAlaAlaIleGlnGluArgGluLysGlnPheArgLe
|||||||||||||||| |||||||||||| ||||||||||||||||||||||||||
nAspSerTyrValGluMetGlnArgAlaAlaMetGlnGluArgGluLysGlnPheArgLe
GGACAGCTACGTGGAGATGCAGCGTGCCGCCATGCAGGAGCGCGAGAAGCAGTTCCGGCT
uGlnSerThrArgGlyAsnLeuLeuLeu
|||||||||||||||| |||||||||
uGlnSerThrArgGlyAspLeuLeuLeu
GCAGTCGACGCGCGGGGACCTGCTGCTG
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