| Basic information |
| Official Symbol | ANKK1 |
| Description | ankyrin repeat and kinase domain containing 1 |
| Other Aliases | PKK2 |
| Other Description | X-kinase; ankyrin repeat and protein kinase domain-containing protein 1; protein kinase PKK2; sgK288; sugen kinase 288 |
| Mutation type | Insert and frame-shift 424-425:V-D^A, Insert and frame-shift 83-84:I-V^AT, premature termination 92:Q->TGA |
| Location | Scaffold000311_2:8022949 8035894 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| ANKK1 |
GCCCTCCCCGTCTTCACTCGCGACGACTTCGAGGGCGACTGGCGCCGGGT GGCCAGCGGCGGCTTCGGCCAGGTGTTCCAGGCGCGGCACAAGCGCTGGC GGACCGAGTACGCCATTAAGTGGTCCCCCTGCCTCCAGCCGGACGCCAGC AGCTCCGATGTGAACTGCCTTATTGAAGAAGCAGCCAAGATGGAGAATAT CAAGTTTCAGCACGTGTCCATCTACGGAGTGTGCACGTGACCGCTGGGCA TCGTGATGGAGTTCATGGCCAACGGCTCCCTGGAGAAGATGCTGCCCACT CACAGCCTCAGCTGGCAGCTCAAGTTCTGCATCATCCACAAGACCAGCTT GGCCATGAACTTCCTCCACAGTAGCAAGCCACCTCTGCTCCACCTGGACC TCAAGTCTGGCAACATCCTCCTGGACAGCAACGTGCACGTTCAGATCTCA GACTTCGGCCTGACCAAGTGGATGGAGCAGTCGACCCGGATGCAGTACAT TGAGAGGTCGGCCCTGCGGGGCACGCTCAGCTACATCCCCCCTGAGGTGT TCCTGGAGAGTACAGAGTCACTCAGGGAGCATTTCCCCATCCGCAGCTTC GGGATTGTCATCTGGGAGCTCCTCACGCAGAAGAAACCGTACTCAGGGTT CAACATGATGACCACCATTGTCCGAGTAGCCGCGGGTATGCGGCCCTCCC TGCAGCCTGTCTCCGATGAGTGGCCAGGCGAGGCCCAGCAGATGGTGGGC CTGATGAGGGGCTGCTGGGACCAGGACCCCAAGAACGGCTTTGCAGGAGC AGACGTCACAGTGGAGACAGACATGCTGCTGGCCCTGCTGCAGAGTGCTG TGGCTGACCCGGAGAGCAAGGCCCTGGCCAGGAAGGTGTCCTGTAAACCA CCACTGCACCGGCCCCAGAAGGTGAGTGCAGCGGCAACCCTGCCCCCGCT CCCGGCAGATTCAGGAGACTACTTAAAGCGGGCCCTGCAGCTCTCTGACA GCGAGAACTCGATCCCGAGCGATGAAGAGAACAAGGTCACCCCCCTCCAC TTCCTGGTGACACAGGGCAGTGTGGAGCAGGTGAGGCTGCTGCTGGCCCA CGAGGTCGGCGTGGACTGCCAGACGGCCTCCGGCTACACGCCCCTCCTCA TCGCCGCCCAGGACCAGCAGCCCGACCTCTGTGCCCTGCTCCTGGCACAC GGCGCAGACGCCGACCTGGCAGACGAGGACGGCTGGACCCCTCTGCACTT TGCAGCCCAGAACGGGGACGACCGTACCACCCGCCTGCTCCTGGACCACG GGGCCCGTGTGGATGCCCAGGAGCATGAGGGCTGGACCCCGCTCCACCTG GCCACGCAGAACAACTTCGAGAATGTGGCGCGGCTTCTGGTCTCCCGCCA GGCTGACCCCAACCTGCGTGAGGCTGAGGGCAAGACCCCCCTCCATGTAG CCGCCTACTTTGGCCATGTCAGATTGGTCAAGCTGCTGACAGGCCAGGGG GCTGAGCTGGATGCTCCGCAGAAGAACCTGAGGACCCCACTGCACCTGGC GGTGGAGCGCGGGAAAGTGCGGGCCATCCAGCACCTGCTGAAGAGTGGGG CGGCCCCCGACGCCCTGGACCAGAGCGGCTACAGCCCACTGCATATCGCG GCTGCCAGGGGCAAGTACCTCATCTGCAAGATGCTGCTCAGGTATGGGGC CAGCCCCGAGCTGCCCACCCAGCAGGGCTGGACTCCTCTGCACCTGGCAG TTTACAAGGGCCACCTAGAGATCATCCACCTGCTGGCTGAGAGCCACGCA GACTTGGGTGCTCTCGGAGGCATGAGCTGGACCCCCCTGCACCTGGCTGC CCGCCATGGGGAGGAGGTGGTGGTGTCGGCCCTGCTGCAGTGTGGGGCTG ACCCCAATGCCGCTGAGCAGTCAGGCTGGACACCCCTCCACCTGGCGGTC CAGAGGGGTGCCTTCCTGAGTGTCATCAACCTCCTGGAGCACCACACGGA TGTCTGTGCCTGCAACAAGGTGGGCTGGACACCTGCCCACCTGGCAGCCG TCAAGGGCAACACGGCCATCCTCAAAGTGCTGGTCAAGGCCGGAGCCCAG CTGGATGTCCAAGACAGAGGGGGCTGCACGCCCTTACAGCTGGCCCTCCG CAGCCAAAAGCAGGGCATCGTGGCCTTCCCCGAGGGCAAGGAGCCCTCCC TGGCCATTGTGGGCGGCACTGAGCCAGGAGCCCAGACGGAGGTT |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 765 | 12 | 765 | Insert and frame-shift 424-425:V-D^A, Insert and frame-shift 83-84:I-V^AT, Premature termination 92:Q->TGA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
SerLeuProValPheThrArgAspAspPheGluGlyAspTrpArgLeuValAlaSerGly
|||||||||||||||||||||||||||||||||||||||||| ||||||||||||
AlaLeuProValPheThrArgAspAspPheGluGlyAspTrpArgArgValAlaSerGly
GCCCTCCCCGTCTTCACTCGCGACGACTTCGAGGGCGACTGGCGCCGGGTGGCCAGCGGC
GlyPheSerGlnValPheGlnAlaArgHisArgArgTrpArgThrGluTyrAlaIleLys
|||||| ||||||||||||||||||||| |||||||||||||||||||||||||||
GlyPheGlyGlnValPheGlnAlaArgHisLysArgTrpArgThrGluTyrAlaIleLys
GGCTTCGGCCAGGTGTTCCAGGCGCGGCACAAGCGCTGGCGGACCGAGTACGCCATTAAG
CysAlaProCysLeuProProAspAlaAla{Se} >>>> Target Intron 1 >>>
||||||||| ||||||||| {||} 5960 bp
TrpSerProCysLeuGlnProAspAlaSer{Se}++
TGGTCCCCCTGCCTCCAGCCGGACGCCAGC{AG}gt
> {r}SerAspValAsnTyrLeuIleGluGluAlaAlaLysMetLysLysIleLysPhe
{|}|||||||||||| |||||||||||||||||||||||| |||||||||
++{r}SerAspValAsnCysLeuIleGluGluAlaAlaLysMetGluAsnIleLysPhe
ag{C}TCCGATGTGAACTGCCTTATTGAAGAAGCAGCCAAGATGGAGAATATCAAGTTT
GlnHisIle--ValSerIleTyrGlyValCysLysGlnProLeuGlyIleValMetGluP
|||||| ##||||||||||||||||||||| ||||||||||||||||||||||
GlnHis---##ValSerIleTyrGlyValCysThr***ProLeuGlyIleValMetGluP
CAGCAC---ATGTGTCCATCTACGGAGTGTGCACGTGACCGCTGGGCATCGTGATGGAGT
heMetAlaAsnGlySerLeuGluLysValLeuSerThrHisSerLeuCysTrpLysLeuA
|||||||||||||||||||||||||| ||| |||||||||||| ||| |||
heMetAlaAsnGlySerLeuGluLysMetLeuProThrHisSerLeuSerTrpGlnLeuL
TCATGGCCAACGGCTCCCTGGAGAAGATGCTGCCCACTCACAGCCTCAGCTGGCAGCTCA
rgPheArgIleIleHisGluThrSerLeuAlaMetAsnPheLeuHisSerIleLysProP
||| ||||||||| |||||||||||||||||||||||||||||| |||||||
ysPheCysIleIleHisLysThrSerLeuAlaMetAsnPheLeuHisSerSerLysProP
AGTTCTGCATCATCCACAAGACCAGCTTGGCCATGAACTTCCTCCACAGTAGCAAGCCAC
roLeuLeuHisLeuAspLeuLysProGlyAsnIleLeuLeuAspSerAsnMetHisValL
||||||||||||||||||||||| |||||||||||||||||||||||| ||||||
roLeuLeuHisLeuAspLeuLysSerGlyAsnIleLeuLeuAspSerAsnValHisValG
CTCTGCTCCACCTGGACCTCAAGTCTGGCAACATCCTCCTGGACAGCAACGTGCACGTTC
ys >>>> Target Intron 2 >>>> IleSerAspPheGlyLeuSerLysTrpMe
1408 bp |||||||||||||||||| ||||||||
ln++ ++IleSerAspPheGlyLeuThrLysTrpMe
AGgt agATCTCAGACTTCGGCCTGACCAAGTGGAT
tGluGlnSerThrArgMetGlnTyrIleGluArgSerAlaLeuArgGlyMetLeuSerTy
||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||
tGluGlnSerThrArgMetGlnTyrIleGluArgSerAlaLeuArgGlyThrLeuSerTy
GGAGCAGTCGACCCGGATGCAGTACATTGAGAGGTCGGCCCTGCGGGGCACGCTCAGCTA
rIleProProGluMetPheLeuGluSerAsn{L} >>>> Target Intron 3 >>>
||||||||||||| |||||||||||| { } 207 bp
rIleProProGluValPheLeuGluSerThr{G}++
CATCCCCCCTGAGGTGTTCCTGGAGAGTACA{G}gt
> {ys}AlaProGlyProLysTyrAspValTyrSerPheAlaIleValIleTrpGluLe
{ } |||||| |||||||||||||||||
+-{lu}SerLeuArgGluHisPheProIleArgSerPheGlyIleValIleTrpGluLe
aa{AG}TCACTCAGGGAGCATTTCCCCATCCGCAGCTTCGGGATTGTCATCTGGGAGCT
uLeuThrGlnLysLysProTyrSer{G} >>>> Target Intron 4 >>>> {ly
|||||||||||||||||||||||||{|} 625 bp {||
uLeuThrGlnLysLysProTyrSer{G}++ ++{ly
CCTCACGCAGAAGAAACCGTACTCA{G}gt ag{GG
}PheAsnMetMetMetIleIleIleArgValAlaAlaGlyMetArgProSerLeuGlnPr
}|||||||||||| ||| |||||||||||||||||||||||||||||||||||
}PheAsnMetMetThrThrIleValArgValAlaAlaGlyMetArgProSerLeuGlnPr
}TTCAACATGATGACCACCATTGTCCGAGTAGCCGCGGGTATGCGGCCCTCCCTGCAGCC
oValSerAspGlnTrpProSerGluAlaGlnGlnMetValAspLeuMetLysArgCysTr
|||||||||| |||||| |||||||||||||||||| |||||| |||||
oValSerAspGluTrpProGlyGluAlaGlnGlnMetValGlyLeuMetArgGlyCysTr
TGTCTCCGATGAGTGGCCAGGCGAGGCCCAGCAGATGGTGGGCCTGATGAGGGGCTGCTG
pAspGlnAspProLysLysArgProCys{P} >>>> Target Intron 5 >>>>
|||||||||||||||| { } 639 bp
pAspGlnAspProLysAsnGlyPheAla{G}++ -+
GGACCAGGACCCCAAGAACGGCTTTGCA{G}gt tg
{he}LeuAspIleThrIleGluThrAspIleLeuLeuSerLeuLeuGlnSerArgValAl
{ } ||| ||| ||||||||| |||||| |||||||||||| |||||
{ly}AlaAspValThrValGluThrAspMetLeuLeuAlaLeuLeuGlnSerAlaValAl
{GA}GCAGACGTCACAGTGGAGACAGACATGCTGCTGGCCCTGCTGCAGAGTGCTGTGGC
aValProGluSerLysAlaLeuAlaArgLysValSerCysLysLeuSerLeuArgGlnPr
| ||||||||||||||||||||||||||||||||||||||| ||| ||
aAspProGluSerLysAlaLeuAlaArgLysValSerCysLysProProLeuHisArgPr
TGACCCGGAGAGCAAGGCCCTGGCCAGGAAGGTGTCCTGTAAACCACCACTGCACCGGCC
oGlyGluValAsnGluAsp{I} >>>> Target Intron 6 >>>> {le}SerGl
| ||| { } 1860 bp { }
oGlnLysValSerAlaAla{A}+- --{la}ThrLe
CCAGAAGGTGAGTGCAGCG{G}gc tt{CA}ACCCT
nGluLeuMetAspSerAspSerGlyAsnTyrLeuLysArgAlaLeuGlnLeuSerAspAr
||||||||| ||||||||||||||||||||||||||||||
uProProLeuProAlaAspSerGlyAspTyrLeuLysArgAlaLeuGlnLeuSerAspSe
GCCCCCGCTCCCGGCAGATTCAGGAGACTACTTAAAGCGGGCCCTGCAGCTCTCTGACAG
gLysAsnLeuValProArgAspGluGluLeuCysIleTyrGluAsnLysValThrProLe
||| ||| |||||| ||||||||||||||||||||
rGluAsnSerIleProSerAspGlu---------------GluAsnLysValThrProLe
CGAGAACTCGATCCCGAGCGATGAA---------------GAGAACAAGGTCACCCCCCT
uHisPheLeuValAlaGlnGlySerValGluGlnValArgLeuLeuLeuAlaHisGluVa
||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||
uHisPheLeuValThrGlnGlySerValGluGlnValArgLeuLeuLeuAlaHisGluVa
CCACTTCCTGGTGACACAGGGCAGTGTGGAGCAGGTGAGGCTGCTGCTGGCCCACGAGGT
lAspValAspCysGlnThrAlaSerGlyTyrThrProLeuLeuIleAlaAlaGlnAspGl
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lGlyValAspCysGlnThrAlaSerGlyTyrThrProLeuLeuIleAlaAlaGlnAspGl
CGGCGTGGACTGCCAGACGGCCTCCGGCTACACGCCCCTCCTCATCGCCGCCCAGGACCA
nGlnProAspLeuCysAlaLeuLeuLeuAlaHisGlyAlaAspAlaAsnArgVal-AspG
|||||||||||||||||||||||||||||||||||||||||||||| #||||
nGlnProAspLeuCysAlaLeuLeuLeuAlaHisGlyAlaAspAlaAspLeuAla#AspG
GCAGCCCGACCTCTGTGCCCTGCTCCTGGCACACGGCGCAGACGCCGACCTGGCAAGACG
luAspGlyTrpAlaProLeuHisPheAlaAlaGlnAsnGlyAspAspGlyThrAlaArgL
||||||||||| ||||||||||||||||||||||||||||||||| ||| ||||
luAspGlyTrpThrProLeuHisPheAlaAlaGlnAsnGlyAspAspArgThrThrArgL
AGGACGGCTGGACCCCTCTGCACTTTGCAGCCCAGAACGGGGACGACCGTACCACCCGCC
euLeuLeuAspHisGlyAlaCysValAspAlaGlnGluArgGluGlyTrpThrProLeuH
|||||||||||||||||||| ||||||||||||||| |||||||||||||||||||
euLeuLeuAspHisGlyAlaArgValAspAlaGlnGluHisGluGlyTrpThrProLeuH
TGCTCCTGGACCACGGGGCCCGTGTGGATGCCCAGGAGCATGAGGGCTGGACCCCGCTCC
isLeuAlaAlaGlnAsnAsnPheGluAsnValAlaArgLeuLeuValSerArgGlnAlaA
|||||||| |||||||||||||||||||||||||||||||||||||||||||||||||
isLeuAlaThrGlnAsnAsnPheGluAsnValAlaArgLeuLeuValSerArgGlnAlaA
ACCTGGCCACGCAGAACAACTTCGAGAATGTGGCGCGGCTTCTGGTCTCCCGCCAGGCTG
spProAsnLeuHisGluAlaGluGlyLysThrProLeuHisValAlaAlaTyrPheGlyH
||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||
spProAsnLeuArgGluAlaGluGlyLysThrProLeuHisValAlaAlaTyrPheGlyH
ACCCCAACCTGCGTGAGGCTGAGGGCAAGACCCCCCTCCATGTAGCCGCCTACTTTGGCC
isValSerLeuValLysLeuLeuThrSerGlnGlyAlaGluLeuAspAlaGlnGlnArgA
||||| |||||||||||||||||| ||||||||||||||||||||| ||| |
isValArgLeuValLysLeuLeuThrGlyGlnGlyAlaGluLeuAspAlaProGlnLysA
ATGTCAGATTGGTCAAGCTGCTGACAGGCCAGGGGGCTGAGCTGGATGCTCCGCAGAAGA
snLeuArgThrProLeuHisLeuAlaValGluArgGlyLysValArgAlaIleGlnHisL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
snLeuArgThrProLeuHisLeuAlaValGluArgGlyLysValArgAlaIleGlnHisL
ACCTGAGGACCCCACTGCACCTGGCGGTGGAGCGCGGGAAAGTGCGGGCCATCCAGCACC
euLeuLysSerGlyAlaValProAspAlaLeuAspGlnSerGlyTyrGlyProLeuHisT
||||||||||||||||| ||||||||||||||||||||||||||| |||||||||
euLeuLysSerGlyAlaAlaProAspAlaLeuAspGlnSerGlyTyrSerProLeuHisI
TGCTGAAGAGTGGGGCGGCCCCCGACGCCCTGGACCAGAGCGGCTACAGCCCACTGCATA
hrAlaAlaAlaArgGlyLysTyrLeuIleCysLysMetLeuLeuArgTyrGlyAlaSerL
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
leAlaAlaAlaArgGlyLysTyrLeuIleCysLysMetLeuLeuArgTyrGlyAlaSerP
TCGCGGCTGCCAGGGGCAAGTACCTCATCTGCAAGATGCTGCTCAGGTATGGGGCCAGCC
euGluLeuProThrHisGlnGlyTrpThrProLeuHisLeuAlaAlaTyrLysGlyHisL
|||||||||||| ||||||||||||||||||||||||||| |||||||||||||
roGluLeuProThrGlnGlnGlyTrpThrProLeuHisLeuAlaValTyrLysGlyHisL
CCGAGCTGCCCACCCAGCAGGGCTGGACTCCTCTGCACCTGGCAGTTTACAAGGGCCACC
euGluIleIleHisLeuLeuAlaGluSerHisAlaAsnMetGlyAlaLeuGlyAlaValA
||||||||||||||||||||||||||||||||||| ||||||||||||
euGluIleIleHisLeuLeuAlaGluSerHisAlaAspLeuGlyAlaLeuGlyGlyMetS
TAGAGATCATCCACCTGCTGGCTGAGAGCCACGCAGACTTGGGTGCTCTCGGAGGCATGA
snTrpThrProLeuHisLeuAlaAlaArgHisGlyGluGluAlaValValSerAlaLeuL
||||||||||||||||||||||||||||||||||||||| ||||||||||||||||
erTrpThrProLeuHisLeuAlaAlaArgHisGlyGluGluValValValSerAlaLeuL
GCTGGACCCCCCTGCACCTGGCTGCCCGCCATGGGGAGGAGGTGGTGGTGTCGGCCCTGC
euGlnCysGlyAlaAspProAsnAlaAlaGluGlnSerGlyTrpThrProLeuHisLeuA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euGlnCysGlyAlaAspProAsnAlaAlaGluGlnSerGlyTrpThrProLeuHisLeuA
TGCAGTGTGGGGCTGACCCCAATGCCGCTGAGCAGTCAGGCTGGACACCCCTCCACCTGG
laValGlnArgSerThrPheLeuSerValIleAsnLeuLeuGluHisHisAlaAsnValH
||||||||||| ||||||||||||||||||||||||||||||||| |||
laValGlnArgGlyAlaPheLeuSerValIleAsnLeuLeuGluHisHisThrAspValC
CGGTCCAGAGGGGTGCCTTCCTGAGTGTCATCAACCTCCTGGAGCACCACACGGATGTCT
isAlaArgAsnLysValGlyTrpThrProAlaHisLeuAlaAlaLeuLysGlyAsnThrA
||| |||||||||||||||||||||||||||||||||||| |||||||||||||
ysAlaCysAsnLysValGlyTrpThrProAlaHisLeuAlaAlaValLysGlyAsnThrA
GTGCCTGCAACAAGGTGGGCTGGACACCTGCCCACCTGGCAGCCGTCAAGGGCAACACGG
laIleLeuLysValLeuValGluAlaGlyAlaGlnLeuAspValGlnAspGlyValSerC
|||||||||||||||||||| ||||||||||||||||||||||||||| |
laIleLeuLysValLeuValLysAlaGlyAlaGlnLeuAspValGlnAspArgGlyGlyC
CCATCCTCAAAGTGCTGGTCAAGGCCGGAGCCCAGCTGGATGTCCAAGACAGAGGGGGCT
ysThrProLeuGlnLeuAlaLeuArgSerArgLysGlnGlyIleMetSerPheLeuGluG
||||||||||||||||||||||||||||| |||||||||||| ||| ||||
ysThrProLeuGlnLeuAlaLeuArgSerGlnLysGlnGlyIleValAlaPheProGluG
GCACGCCCTTACAGCTGGCCCTCCGCAGCCAAAAGCAGGGCATCGTGGCCTTCCCCGAGG
lyLysGluProSerValAlaThrLeuGlyGlySerLysProGlyAlaGluMetGluIle
|||||||||||||| ||| |||||| ||||||||| |||
lyLysGluProSerLeuAlaIleValGlyGlyThrGluProGlyAlaGlnThrGluVal
GCAAGGAGCCCTCCCTGGCCATTGTGGGCGGCACTGAGCCAGGAGCCCAGACGGAGGTT
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