| Basic information |
| Official Symbol | AMHR2 |
| Description | anti-Mullerian hormone receptor, type II |
| Other Aliases | AMHR, MISR2, MISRII, MRII |
| Other Description | AMH type II receptor; MIS type II receptor; Mullerian inhibiting substance type II receptor; anti-Muellerian hormone type II receptor; anti-Muellerian hormone type-2 receptor |
| Mutation type | Insert and frame-shift 538-539:A-P^GC |
| Location | Scaffold146740_1:401811 413074 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| AMHR2 |
ATGCTGGGGACTCTGGGGCTTTGGGCATTGCTTCCCGCAGCCGTGCAAGC ACCCCCAAACAGGCGGATCTGCGTGTTCTTTGAGGCCCCAGGAGTGCAGG GAAGCACAAGGACACTAGGAGAGCTGTTAGATGCAGGACCAGGGCCCCCC AGGATTGTCCGCTGCCTCTACAGTCGCTGCTGCTTTGGGATCTGGAACCT GACCCAAGACCGGGCGCAGGTGGAGATGCAAGGATGCCGGGACAGTGATG GGCCAGGCTGTGAGTCCCGCCATTGTGACCCAAGCCCCCGAGCCCAGCCC AGCCCTGCCTCCACTCTCTTCACCTGCTCCTGTGGCACTGACTTCTGCAA TGCCAATTACAGCCATCTGACTTCTCTGGGGAAACCTGGGACTCCTGGCT CCCAGGGTCCCCAGGCTGCCCCAGGTGAGCCCATGTGGATGCAGGTTCTG TTGCTGCTGGGACTGCTCCTCTTCCTCCTGCTGCTGCTGGGCAGCATCAT CCTGGCCCTGCTACAGAGAAAGGCGTATGGAGTGCGAGGTGGGCCAGAGC CAGAGCCAGAGCCAGAGCCAGAGCCTGAGCCAGGCAGAGCCTGGAGTGAG GCGCTGCCGGAGCTGCCTGAGCTGTGCTTCTCCCAGGTAATCCAGGAAGG AGGTAACACAGTCGTGTGGGCTGGGAGGCTGCAAGGTGAGCTGGTAGCCA TCAAGACCTTCCCACCGAGGGCTGTGGCCCAGTTCCAAGCTGAGAGAGCA CTGTATGAGCTGCCAGGCCTACGGCATGACCATATTGTCCGCTTCATCGC TGCCAGCTGGGGGGGTCCTGTTCCCTTGCCCTCCGGGCCCCTGTTGGTAC TGGAACTGCACCCCAAGGGCTCCCTCTGCCACTTCTTGACCCAGTACACC AGTGACTGGGCAAGATCCCTGCGGATGGCACTGTCCCTGGCCCAAGGTCT GGCATTTCTCCACGAGGAGCGCTGGCAGGATGGTCAGTATAAACCAGGGA TCGCGCACCGAGATCTGAGCAGCCAGAATGTGCTCATTCGGGAAGATGGC TCATGTGTCATTGGAGACCTGGGCCTTGCCCTGGTGCTCCCCAGCCACAC CCAGCCCCCTGCCTGGGCCCCTGCTGAGCCCCGAGGCCCAGCTGCCATCA TGGAGGCTGGCACCCAGAGGTACATGGCCCCAGAGCTCTTGGACAAGACT CTGGACCTACAGGACTGGGGCCTGGCCCTCCGGCGAGCTGATGTTTACTC TCTGGCTCTACTCCTGTGGGAGATTCTGAGCCGCTGCCCAGACTTGAGGC CTGACAGCAGACCACCACCCTTCCAACTGGCGTATGAGGCAGAACTGGGC AGCACCCCCACCACCTGTGAGCTATGGGCCTTGGCAGTGGAAGAGAGGAG GCGCCCCTACATCCCATCGGCCTGGGGCTGCTTTGCTACAGACCCTGGTG GACTACGGGAGCTCCTCGAGGACTCTTGGGATGCAGACCCAGAAGCACGG CTGACAGCCGAGTGTGTACACCAGCGCCTGGCTGCCCTGGCTCATCTGCA GGGGACCCCTCCTTTCCCATGGGGCTGTCCACATGGCTGCCTGTCTCTCT GCCCAGAATGTTCCTCAATTCCTCCTGTCATTCTCCCCCATAGGCCTCAG CTGAGTACCTGCCACTTCAGTGTTCAG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 573 | 1 | 556 | Insert and frame-shift 538-539:A-P^GC |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetLeuGlySerLeuGlyLeuTrpAlaLeuLeuProThrAlaValGlu{A} >>>> Ta
||||||||| |||||||||||||||||||||||| |||||| {|}
MetLeuGlyThrLeuGlyLeuTrpAlaLeuLeuProAlaAlaValGln{A}++
ATGCTGGGGACTCTGGGGCTTTGGGCATTGCTTCCCGCAGCCGTGCAA{G}gt
rget Intron 1 >>>> {la}ProProAsnArgArgThrCysValPhePheGluAla
299 bp {||}||||||||||||||| ||||||||||||||||||
++{la}ProProAsnArgArgIleCysValPhePheGluAla
ag{CA}CCCCCAAACAGGCGGATCTGCGTGTTCTTTGAGGCC
ProGlyValArgGlySerThrLysThrLeuGlyGluLeuLeuAspThrGlyThrGluLeu
||||||||| ||||||||| ||||||||||||||||||||| |||
ProGlyValGlnGlySerThrArgThrLeuGlyGluLeuLeuAspAlaGlyProGlyPro
CCAGGAGTGCAGGGAAGCACAAGGACACTAGGAGAGCTGTTAGATGCAGGACCAGGGCCC
ProArgAlaIleArgCysLeuTyrSerArgCysCysPheGlyIleTrpAsnLeuThrGln
|||||| ||||||||||||||||||||||||||||||||||||||||||||||||
ProArgIleValArgCysLeuTyrSerArgCysCysPheGlyIleTrpAsnLeuThrGln
CCCAGGATTGTCCGCTGCCTCTACAGTCGCTGCTGCTTTGGGATCTGGAACCTGACCCAA
AspArgAlaGlnValGluMetGln{G} >>>> Target Intron 2 >>>> {ly}
||||||||||||||||||||||||{|} 225 bp {||}
AspArgAlaGlnValGluMetGln{G}++ ++{ly}
GACCGGGCGCAGGTGGAGATGCAA{G}gt ag{GA}
CysArgAspSerAspGluProGlyCysGluSerLeuHisCysAspProSerProArgAla
||||||||||||||| ||||||||||||||| ||||||||||||||||||||||||
CysArgAspSerAspGlyProGlyCysGluSerArgHisCysAspProSerProArgAla
TGCCGGGACAGTGATGGGCCAGGCTGTGAGTCCCGCCATTGTGACCCAAGCCCCCGAGCC
HisProSerProGlySerThrLeuPheThrCysSerCysGlyThrAspPheCysAsnAla
||||||||| |||||||||||||||||||||||||||||||||||||||||||||
GlnProSerProAlaSerThrLeuPheThrCysSerCysGlyThrAspPheCysAsnAla
CAGCCCAGCCCTGCCTCCACTCTCTTCACCTGCTCCTGTGGCACTGACTTCTGCAATGCC
AsnTyrSerHisLeuProProProGlySerProGlyThrProGlySerGlnGlyProGln
||||||||||||||| ||| ||||||||||||||||||||||||||||||
AsnTyrSerHisLeuThrSerLeuGlyLysProGlyThrProGlySerGlnGlyProGln
AATTACAGCCATCTGACTTCTCTGGGGAAACCTGGGACTCCTGGCTCCCAGGGTCCCCAG
AlaAlaPro{G} >>>> Target Intron 3 >>>> {ly}GluSerIleTrpMet
|||||||||{|} 262 bp {||}||| ||||||
AlaAlaPro{G}++ ++{ly}GluProMetTrpMet
GCTGCCCCA{G}gt ag{GT}GAGCCCATGTGGATG
<->AlaLeuValLeuLeuGlyLeuPheLeuLeuLeuLeuLeuLeuLeuGlySerIleIle
||| |||||||||||| ||| |||||||||||||||||||||||||||
GlnValLeuLeuLeuLeuGlyLeuLeuLeuPheLeuLeuLeuLeuLeuGlySerIleIle
CAGGTTCTGTTGCTGCTGGGACTGCTCCTCTTCCTCCTGCTGCTGCTGGGCAGCATCATC
Leu{A} >>>> Target Intron 4 >>>> {la}LeuLeuGlnArgLysAsnTyr
|||{|} 163 bp {||}||||||||||||||| |||
Leu{A}++ ++{la}LeuLeuGlnArgLysAlaTyr
CTG{G}gt ag{CC}CTGCTACAGAGAAAGGCGTAT
ArgValArgGly<-><-><-><->GluProValProGluProArgProAspSerGlyArg
||||||||| |||||| ||||||||| ||| ||||||
GlyValArgGlyGlyProGluProGluProGluProGluProGluProGluProGlyArg
GGAGTGCGAGGTGGGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCTGAGCCAGGCAGA
AspTrpSerValGluLeuGlnGluLeuProGluLeuCysPheSerGln >>>> Targe
|||||| ||| |||||||||||||||||||||||||||
AlaTrpSerGluAlaLeuProGluLeuProGluLeuCysPheSerGln++
GCCTGGAGTGAGGCGCTGCCGGAGCTGCCTGAGCTGTGCTTCTCCCAGgt
t Intron 5 >>>> ValIleArgGluGlyGlyHisAlaValValTrpAlaGlyGlnL
133 bp |||||| ||||||||| ||||||||||||||| |
++ValIleGlnGluGlyGlyAsnThrValValTrpAlaGlyArgL
agGTAATCCAGGAAGGAGGTAACACAGTCGTGTGGGCTGGGAGGC
euGlnGlyLysLeuValAlaIleLysAlaPheProProArgSerValAlaGlnPheGlnA
|||||||| ||||||||||||||| |||||||||||| ||||||||||||||||
euGlnGlyGluLeuValAlaIleLysThrPheProProArgAlaValAlaGlnPheGlnA
TGCAAGGTGAGCTGGTAGCCATCAAGACCTTCCCACCGAGGGCTGTGGCCCAGTTCCAAG
laGluArgAlaLeuTyrGluLeuProGlyLeuGlnHisAspHisIleValArgPheIleT
|||||||||||||||||||||||||||||||| ||||||||||||||||||||||||
laGluArgAlaLeuTyrGluLeuProGlyLeuArgHisAspHisIleValArgPheIleA
CTGAGAGAGCACTGTATGAGCTGCCAGGCCTACGGCATGACCATATTGTCCGCTTCATCG
hrAlaSerArgGlyGlyProGlyArgLeuLeuSerGlyProLeuLeuValLeuGluLeuH
|||||| ||||||||| ||| ||||||||||||||||||||||||||||
laAlaSerTrpGlyGlyProValProLeuProSerGlyProLeuLeuValLeuGluLeuH
CTGCCAGCTGGGGGGGTCCTGTTCCCTTGCCCTCCGGGCCCCTGTTGGTACTGGAACTGC
isProLys >>>> Target Intron 6 >>>> GlySerLeuCysHisTyrLeuTh
|||||||| 6937 bp ||||||||||||||| |||||
isProLys++ ++GlySerLeuCysHisPheLeuTh
ACCCCAAGgt agGGCTCCCTCTGCCACTTCTTGAC
rGlnTyrThrSerAspTrpGlySerSerLeuArgMetAlaLeuSerLeuAlaGlnGlyLe
||||||||||||||||||| |||||||||||||||||||||||||||||||||||
rGlnTyrThrSerAspTrpAlaArgSerLeuArgMetAlaLeuSerLeuAlaGlnGlyLe
CCAGTACACCAGTGACTGGGCAAGATCCCTGCGGATGGCACTGTCCCTGGCCCAAGGTCT
uAlaPheLeuHisGluGluArgTrpGlnAsn{G} >>>> Target Intron 7 >>>
|||||||||||||||||||||||||||| {|} 135 bp
uAlaPheLeuHisGluGluArgTrpGlnAsp{G}++
GGCATTTCTCCACGAGGAGCGCTGGCAGGAT{G}gt
> {ly}GlnTyrLysProGlyIleAlaHisArgAspLeuSerSerGlnAsnValLeuIl
{||}|||||||||||||||||||||||||||||||||||||||||||||||||||||
++{ly}GlnTyrLysProGlyIleAlaHisArgAspLeuSerSerGlnAsnValLeuIl
ag{GT}CAGTATAAACCAGGGATCGCGCACCGAGATCTGAGCAGCCAGAATGTGCTCAT
eArgGluAspGlySerCysAlaIleGlyAspLeuGlyLeuAlaLeuValLeuProGlyLe
||||||||||||||||||| |||||||||||||||||||||||||||||||||
eArgGluAspGlySerCysValIleGlyAspLeuGlyLeuAlaLeuValLeuProSerHi
TCGGGAAGATGGCTCATGTGTCATTGGAGACCTGGGCCTTGCCCTGGTGCTCCCCAGCCA
uThrGlnProProAlaTrpThrProThrGlnProGlnGlyProAlaAlaIleMetGlu
|||||||||||||||||| ||| ||| |||||||||||||||||||||
sThrGlnProProAlaTrpAlaProAlaGluProArgGlyProAlaAlaIleMetGlu++
CACCCAGCCCCCTGCCTGGGCCCCTGCTGAGCCCCGAGGCCCAGCTGCCATCATGGAGgt
>>>> Target Intron 8 >>>> AlaGlyThrGlnArgTyrMetAlaProGluLeu
195 bp |||||||||||||||||||||||||||||||||
++AlaGlyThrGlnArgTyrMetAlaProGluLeu
agGCTGGCACCCAGAGGTACATGGCCCCAGAGCTC
LeuAspLysThrLeuAspLeuGlnAspTrpGlyMetAlaLeuArgArgAlaAspIleTyr
||||||||||||||||||||||||||||||||| |||||||||||||||||| |||
LeuAspLysThrLeuAspLeuGlnAspTrpGlyLeuAlaLeuArgArgAlaAspValTyr
TTGGACAAGACTCTGGACCTACAGGACTGGGGCCTGGCCCTCCGGCGAGCTGATGTTTAC
SerLeuAlaLeuLeuLeuTrpGluIleLeuSerArgCysProAspLeuArgPro{A} >
||||||||||||||||||||||||||||||||||||||||||||||||||||||{|}
SerLeuAlaLeuLeuLeuTrpGluIleLeuSerArgCysProAspLeuArgPro{A}++
TCTCTGGCTCTACTCCTGTGGGAGATTCTGAGCCGCTGCCCAGACTTGAGGCCT{G}gt
>>> Target Intron 9 >>>> {sp}SerSerProProProPheGlnLeuAlaTyr
167 bp {||}||| ||||||||||||||||||||||||
++{sp}SerArgProProProPheGlnLeuAlaTyr
ag{AC}AGCAGACCACCACCCTTCCAACTGGCGTAT
GluAlaGluLeuGlyAsnThrProThrSerAspGluLeuTrpAlaLeuAlaValGlnGlu
||||||||||||||| ||||||||| ||||||||||||||||||||| |||
GluAlaGluLeuGlySerThrProThrThrCysGluLeuTrpAlaLeuAlaValGluGlu
GAGGCAGAACTGGGCAGCACCCCCACCACCTGTGAGCTATGGGCCTTGGCAGTGGAAGAG
ArgArgArgProTyrIleProSerThrTrpArgCysPheAlaThr >>>> Target I
|||||||||||||||||||||||| ||| |||||||||||| 106
ArgArgArgProTyrIleProSerAlaTrpGlyCysPheAlaThr++
AGGAGGCGCCCCTACATCCCATCGGCCTGGGGCTGCTTTGCTACAgt
ntron 10 >>>> AspProAspGlyLeuArgGluLeuLeuGluAspCysTrpAspAla
9 bp |||||| |||||||||||||||||||||||| |||||||||
++AspProGlyGlyLeuArgGluLeuLeuGluAspSerTrpAspAla
agGACCCTGGTGGACTACGGGAGCTCCTCGAGGACTCTTGGGATGCA
AspProGluAlaArgLeuThrAlaGluCysValGlnGlnArgLeuAlaAlaLeuAlaHis
||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||
AspProGluAlaArgLeuThrAlaGluCysValHisGlnArgLeuAlaAlaLeuAlaHis
GACCCAGAAGCACGGCTGACAGCCGAGTGTGTACACCAGCGCCTGGCTGCCCTGGCTCAT
ProGlnGluSerHisProPheProGluSerCysProArgGlyCysProProLeuCysPro
||| ||||||||| |||||| |||||| |||||||||
LeuGlnGlyThrProProPheProTrpGlyCysProHisGlyCysLeuSerLeuCysPro
CTGCAGGGGACCCCTCCTTTCCCATGGGGCTGTCCACATGGCTGCCTGTCTCTCTGCCCA
GluAspCysThrSerIleProAla--ProThrIleLeuProCysArgProGlnArgSerA
||| ||| ||||||||| ##||| ||||||||| ||||||||| |||
Glu---CysSerSerIlePro---##ProValIleLeuProHisArgProGlnLeuSerT
GAA---TGTTCCTCAATTCCT---GCCCTGTCATTCTCCCCCATAGGCCTCAGCTGAGTA
laCysHisPheSerValGln
||||||||||||||||||
hrCysHisPheSerValGln
CCTGCCACTTCAGTGTTCAG
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