| Basic information |
| Official Symbol | AKT1S1 |
| Description | AKT1 substrate 1 (proline-rich) |
| Other Aliases | Lobe, PRAS40 |
| Other Description | 40 kDa proline-rich AKT substrate; proline-rich AKT1 substrate 1; proline-rich Akt substrate, 40 kDa |
| Mutation type | Insert and frame-shift 9-10P-M^CC |
| Location | Scaffold000673_1:371166 377003 + |
| Wiki | Wikipedia GeneCard |
| Sequence |
| AKT1S1 |
ATGTCTTTTGAGGGCGGCGACGGCGCCTGGCCGCCATGCTGGCTACGGGCGCGCGGATGG CGTCAGGGCGCCCCGAGGAGCTGTGGGAGGCCGTAGTGGGAGCAGCCGAGCGCTTCCGGG CACGGACGGGCACGGAGCTGGGTCTGCTGGCCTTGGCCCACCGGGCTGCTGCTGCTGCCC GGCCCCCCGGGCCACCCCCCATCCCACAGCCGCCCAGCCCAGCGCCCAGCCCACCCCGGC CTGCTCTGGCCAGGGAGGATGACGACGACGAGGAGGACGAGCCCACAGAGACAGAGACCT CTGGGGATCGGCTGGGCGTGAGCGATAATGGACTCTTTGTGATGGACGAGGATACCACCC TCCAGGACCTGCCCCCCTTCTGTGAGTCGGACCCTGAGAGCACAGACGGCAGCCTGAGCG AGGAGACCCCCACTGGCCCCCCAGCGTACTCAGTGCCCCCTGCCACAGCCCTGCCCACTC AGCAGTATGCCAAGTCCCTGCCCGTGTCCGTGCCCGTCTGGGCCTTCAAGGAGAAGAGGA CAGAGGCGCGGTCGTCGGATGAGGAGAATGGGCAGCCCTCATCGCCCGACTTGGACCGCA TCGCGGCGAGTATGCGTGCCCTAGTGCTGCGCGAGGCCGAGGACACCCACGTCTTCGGGG ACCTTCCGCGGCCACGGCTCAACACCAGCGACTTCCAGAAGCTAAAGCGGAAATAC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 276 | 1 | 276 | Insert and frame-shift 9-10P-M^CC |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetSerPheGluGlyGlyAspGlyAlaGlyProAla--MetLeuAlaThrGly{Th} >>>
||||||||||||||||||||||||||| ||| ##|||||||||||||||{||}
MetSerPheGluGlyGlyAspGlyAlaTrpPro---##MetLeuAlaThrGly{Th}++
ATGTCTTTTGAGGGCGGCGACGGCGCCTGGCCG---CCATGCTGGCTACGGGC{AC}gt
> Target Intron 1 >>>> {r}AlaArgMetAlaSerGlyArgProGluGluLeuTr
2694 bp {|}|||||||||||||||||||||||||||||||||||
++{r}AlaArgMetAlaSerGlyArgProGluGluLeuTr
ag{G}GCGCGGATGGCGTCAGGGCGCCCCGAGGAGCTGTG
pGluAlaValValGlyAlaAlaGluArgPheArgAlaArgThrGlyThrGluLeuValLeuL
||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||
pGluAlaValValGlyAlaAlaGluArgPheArgAlaArgThrGlyThrGluLeuGlyLeuL
GGAGGCCGTAGTGGGAGCAGCCGAGCGCTTCCGGGCACGGACGGGCACGGAGCTGGGTCTGC
euThrAlaAlaProProProProProArgProGlyProCysAlaTyrAlaAlaHisGlyArg
||
eu------------------------------------------------------------
TG------------------------------------------------------------
GlyAlaLeuAlaGluAlaAlaArgArgCysLeuHisAspIleAlaLeuAlaHisArgAla
||||||||||||||||||
------------------------------------------AlaLeuAlaHisArgAla
------------------------------------------GCCTTGGCCCACCGGGCT
AlaThrAlaAlaArgProProAlaProProProAlaProGlnProProSerProThrPro
||| ||||||||||||||| ||||||||| |||||||||||||||||| |||
AlaAlaAlaAlaArgProProGlyProProProIleProGlnProProSerProAlaPro
GCTGCTGCTGCCCGGCCCCCCGGGCCACCCCCCATCCCACAGCCGCCCAGCCCAGCGCCC
SerProProArgProThrLeuAlaArgGluAspAsnGluGluAspGluAspGluProThr
||||||||||||||| ||||||||||||||| |||||||||||||||
SerProProArgProAlaLeuAlaArgGluAspAspAspAspGluGluAspGluProThr
AGCCCACCCCGGCCTGCTCTGGCCAGGGAGGATGACGACGACGAGGAGGACGAGCCCACA
GluThrGluThrSerGlyGluGlnLeuGlyIleSerAspAsnGly{G} >>>>
|||||||||||||||||| |||||| ||||||||||||{|}
GluThrGluThrSerGlyAspArgLeuGlyValSerAspAsnGly{G}+-
GAGACAGAGACCTCTGGGGATCGGCTGGGCGTGAGCGATAATGGA{G}gg
Target Intron 1 >>>> {ly}LeuPheValMetAspGluAspAlaThrLeu
1189 bp {||}||||||||||||||||||||| ||||||
++{ly}LeuPheValMetAspGluAspThrThrLeu
ag{GT}CTCTTTGTGATGGACGAGGATACCACCCTC
GlnAspLeuProProPheCysGluSerAspProGluSerThrAsp{A} >>>> Tar
|||||||||||||||||||||||||||||||||||||||||||||{|}
GlnAspLeuProProPheCysGluSerAspProGluSerThrAsp{A}++
CAGGACCTGCCCCCCTTCTGTGAGTCGGACCCTGAGAGCACAGAC{G}gt
get Intron 2 >>>> {sp}GlySerLeuSerGluGluThrProAlaGlyProProThr
69 bp {||}|||||||||||||||||||||||| |||||||||
++{sp}GlySerLeuSerGluGluThrProThrGlyProProAla
ag{AT}GGCAGCCTGAGCGAGGAGACCCCCACTGGCCCCCCAGCG
CysSerValProProAlaSerAlaLeuProThrGlnGlnTyrAlaLysSerLeuProValSe
||||||||||||||| |||||||||||||||||||||||||||||||||||||||||
TyrSerValProProAlaThrAlaLeuProThrGlnGlnTyrAlaLysSerLeuProValSe
TACTCAGTGCCCCCTGCCACAGCCCTGCCCACTCAGCAGTATGCCAAGTCCCTGCCCGTGTC
rValProValTrpGlyPheLysGluLysArgThrGluAlaArgSerSerAspGluGluAsnG
||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||
rValProValTrpAlaPheLysGluLysArgThrGluAlaArgSerSerAspGluGluAsnG
CGTGCCCGTCTGGGCCTTCAAGGAGAAGAGGACAGAGGCGCGGTCGTCGGATGAGGAGAATG
lyPro >>>> Target Intron 3 >>>> ProSerSerProAspLeuAspArgIleA
|| 1161 bp ||||||||||||||||||||||||||||
lyGln++ ++ProSerSerProAspLeuAspArgIleA
GGCAGgt agCCCTCATCGCCCGACTTGGACCGCATCG
laAlaSerMetArgAlaLeuValLeuArgGluAlaGluAspThrGlnValPheGlyAspLeu
|||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||
laAlaSerMetArgAlaLeuValLeuArgGluAlaGluAspThrHisValPheGlyAspLeu
CGGCGAGTATGCGTGCCCTAGTGCTGCGCGAGGCCGAGGACACCCACGTCTTCGGGGACCTT
ProArgProArgLeuAsnThrSerAspPheGlnLysLeuLysArgLysTyr
|||||||||||||||||||||||||||||||||||||||||||||||||||
ProArgProArgLeuAsnThrSerAspPheGlnLysLeuLysArgLysTyr
CCGCGGCCACGGCTCAACACCAGCGACTTCCAGAAGCTAAAGCGGAAATAC
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